EKS-MAM-00162
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00162
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RSKb431.32.2E-129415674260
StatusUnreviewed
Ensembl ProteinENSMMUP00000009993
UniProt AccessionF6SDH6;
Protein NameRibosomal protein S6 kinase
Protein Synonyms/Alias
Gene NameRPS6KA4
Gene Synonyms/Alias RPS6KA4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000007610ENSMMUP00000009995ENSMMUT00000010652
ENSMMUG00000007610ENSMMUP00000009993ENSMMUT00000010650
OrganismMacaca mulatta
Functional Description
Protein Length772
Protein Sequence
(FASTA)
MGDEDEDESC AVELRITEAN LTGHEEKVSV ENFELLKVLG TGAYGKVFLV RKAGGHDAGK 60
LYAMKVLRKA ALVQRAKTQE HTRTERSVLE LVRQAPFLVT LHYAFQTDAK LHLILDYVSG 120
GEMFTHLYQR QYFKEAEVRV YGGEIVLALE HLHKLGIIYR DLKLENVLLD SEGHIVLTDF 180
GLSKEFLTEE KERTFSFCGT IEYMAPEIIR SKAGHGKAVD WWSLGILLFE LLTGASPFTL 240
EGERNTQAEV SRRILKCSPP FPPRIGPVAQ DLLQRLLCKD PKKRLGAGPQ GAQEVRNHPF 300
FQGLDWAALA ARKIPAPFRP QIRSELDVGN FAEEFTRLEP VYSPPGSPPP GDPRIFQGYS 360
FVAPSILFDH NNAVMTDVLE APGAGDPPGR AAVARSAMMQ DSPFFQQYEL DLREPALGQG 420
SFSVCRRCRQ RQSGQEFAVK ILSRRLEANT QREVAALRLC QSHPNVVNLH EVHHDQLHTY 480
LVLELLRGGE LLEHIRKKRH FSESEASQIL RSLVSAVSFM HEEAGVVHRD LKPENILYAD 540
DTPGAPVKII DFGFARLRPQ SPGVPMQTPC FTLQYAAPEL LAQQGYDESC DLWSLGVILY 600
MMLSGQVPFQ GASGQGGQSQ AAEIMCKIRE GRFSLDGEAW QGVSEEAKEL VRGLLTVDPT 660
KRLKLEGLRD SSWLQDGSAR SSPPLRTPDV LESSGPAVRS GLNATFMAFN RGKREGFFLK 720
SVENAPLAKR RKQKLRSATA SRRGSPAPAA PGRAPTAAKG APRRANGPLP PS 772
Nucleotide Sequence
(FASTA)
ATGGGGGACG AAGACGAGGA TGAGAGCTGC GCCGTGGAGC TGCGGATCAC TGAAGCCAAC 60
CTGACCGGGC ACGAGGAGAA GGTGAGCGTG GAGAACTTCG AGCTGCTCAA GGTGCTGGGC 120
ACGGGAGCCT ACGGCAAGGT GTTCCTGGTG CGGAAGGCGG GCGGGCATGA CGCGGGGAAG 180
CTGTACGCCA TGAAGGTGCT GCGCAAGGCG GCGCTGGTGC AGCGCGCCAA GACGCAGGAG 240
CACACGCGCA CCGAGCGCTC CGTGCTGGAG CTGGTGCGCC AGGCGCCCTT CCTGGTCACG 300
CTGCACTACG CTTTCCAGAC GGATGCCAAG CTGCACCTCA TCCTGGACTA TGTGAGCGGC 360
GGAGAGATGT TCACCCACCT CTACCAGCGC CAGTACTTCA AGGAGGCTGA GGTGCGCGTG 420
TATGGGGGTG AGATCGTGCT GGCCCTGGAA CACCTGCACA AGCTCGGCAT CATTTACCGA 480
GACCTGAAAC TGGAGAATGT GCTGCTGGAC TCCGAGGGCC ACATTGTCCT CACGGACTTC 540
GGGCTGAGCA AGGAGTTCCT GACGGAGGAG AAAGAGCGGA CCTTCTCCTT CTGTGGCACC 600
ATTGAGTACA TGGCCCCGGA AATCATCCGT AGCAAGGCGG GTCATGGCAA GGCTGTGGAC 660
TGGTGGAGCC TGGGCATCTT GCTCTTCGAG CTGCTGACGG GAGCCTCGCC CTTCACCCTG 720
GAGGGTGAGA GGAACACGCA GGCTGAGGTG TCTCGACGGA TCCTGAAGTG CTCCCCTCCC 780
TTCCCCCCTC GGATCGGGCC CGTGGCGCAG GACCTGCTGC AGCGGCTGCT TTGCAAGGAT 840
CCCAAGAAGC GATTGGGCGC GGGGCCCCAG GGGGCACAGG AAGTCCGGAA CCACCCTTTC 900
TTCCAGGGCC TAGATTGGGC TGCTCTGGCT GCCAGGAAGA TTCCAGCCCC ATTCCGGCCC 960
CAAATCCGCT CAGAGCTGGA TGTGGGCAAC TTTGCAGAGG AATTCACTCG GCTGGAGCCT 1020
GTCTACTCAC CCCCTGGCAG CCCCCCACCT GGGGACCCCC GCATCTTTCA GGGATACTCC 1080
TTTGTGGCAC CCTCCATCCT CTTCGACCAC AACAATGCGG TGATGACCGA TGTGCTGGAA 1140
GCGCCTGGTG CTGGAGACCC GCCAGGTCGG GCAGCGGTGG CCAGGAGCGC TATGATGCAG 1200
GACTCGCCCT TCTTCCAGCA GTACGAGCTG GACCTGCGGG AGCCTGCTCT GGGCCAGGGC 1260
AGCTTCTCTG TGTGTCGCCG CTGCCGCCAG CGCCAGAGCG GCCAGGAGTT CGCAGTCAAG 1320
ATCCTCAGTC GCAGGCTGGA GGCGAACACG CAGCGCGAAG TGGCTGCCCT GCGCCTGTGC 1380
CAGTCACATC CCAACGTGGT GAATCTGCAC GAGGTGCATC ACGACCAGCT GCACACGTAC 1440
CTGGTTCTGG AGCTACTGCG GGGTGGGGAG CTGCTGGAGC ACATCCGCAA GAAGCGGCAC 1500
TTCAGTGAGT CGGAAGCGAG CCAGATCCTG CGCAGCCTCG TGTCGGCCGT GAGCTTCATG 1560
CACGAGGAGG CGGGCGTGGT GCACCGCGAC CTCAAGCCAG AGAACATCCT GTACGCTGAC 1620
GACACGCCCG GGGCCCCGGT GAAGATCATC GACTTCGGGT TCGCGCGGCT GCGGCCGCAG 1680
AGTCCCGGGG TGCCCATGCA GACGCCCTGC TTCACGCTGC AGTACGCTGC CCCGGAGCTG 1740
CTGGCCCAGC AGGGCTACGA CGAGTCCTGC GACCTTTGGA GCCTCGGTGT CATTTTGTAC 1800
ATGATGCTGT CGGGACAGGT CCCCTTCCAG GGGGCCTCTG GCCAGGGCGG GCAGAGCCAG 1860
GCGGCCGAGA TCATGTGCAA AATCCGCGAA GGGCGCTTCT CCCTTGACGG GGAGGCCTGG 1920
CAGGGCGTAT CCGAGGAAGC CAAGGAGCTG GTCCGAGGGC TCCTGACTGT GGACCCCACC 1980
AAGCGGCTGA AGCTCGAGGG ACTGCGGGAC AGCTCGTGGC TGCAAGACGG CAGCGCGCGC 2040
TCCTCGCCCC CGCTCCGGAC GCCCGACGTG CTCGAGTCCT CTGGGCCCGC AGTGCGCTCG 2100
GGTCTCAACG CCACCTTCAT GGCGTTCAAC CGGGGCAAGC GGGAGGGCTT CTTCCTGAAG 2160
AGCGTGGAGA ACGCACCCCT GGCCAAGCGG CGGAAGCAGA AGCTGCGGAG CGCCACCGCC 2220
TCCCGCCGGG GCTCCCCCGC ACCAGCCGCC CCGGGTCGAG CCCCCACCGC CGCCAAGGGG 2280
GCCCCCCGCC GAGCCAATGG CCCCCTGCCC CCCTCCTAA 2319
Domain Profile
S: 5     edlGvGsysvckrcvhkatnqefavkiidks.krdtseeieillryeqhpnivtlkdvyd  63
           lG+Gs+svc+rc++++++qefavki++++ +++t++e+++l+++++hpn+v+l++v++
Q: 415   PALGQGSFSVCRRCRQRQSGQEFAVKILSRRlEANTQREVAALRLCQSHPNVVNLHEVHH  474
         579*********************************************************
S: 64    dgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheq.Gvvhrdlkpe  122
         d++++ylvlell+GGell++i+kk++fse+eas+ilr+lv+av+++he+ Gvvhrdlkpe
Q: 475   DQLHTYLVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEaGVVHRDLKPE  534
         ***********************************************999**********
S: 123   nilyvdesdnaesikiidfGfaklkraeng.llktpcytlnfvapevlkrqGydeacdlw  181
         nily+d++++a+ +kiidfGfa+l+++++g +++tpc+tl+++ape+l++qGyde+cdlw
Q: 535   NILYADDTPGAP-VKIIDFGFARLRPQSPGvPMQTPCFTLQYAAPELLAQQGYDESCDLW  593
         ************.*****************99****************************
S: 182   slGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlvsk  237
         slGv+ly+ml+G+vpf    ++g++++a+ei++ki+eG+fsl+Geaw++vseeak+lv++
Q: 594   SLGVILYMMLSGQVPFqgasGQGGQSQAAEIMCKIREGRFSLDGEAWQGVSEEAKELVRG  653
         ****************999889**************************************
S: 238   lltvdpakrlkleqllkhswl  258
         lltvdp+krlkle+l+ +swl
Q: 654   LLTVDPTKRLKLEGLRDSSWL  674
         ********************7
Domain Sequence
(FASTA)
PALGQGSFSV CRRCRQRQSG QEFAVKILSR RLEANTQREV AALRLCQSHP NVVNLHEVHH 60
DQLHTYLVLE LLRGGELLEH IRKKRHFSES EASQILRSLV SAVSFMHEEA GVVHRDLKPE 120
NILYADDTPG APVKIIDFGF ARLRPQSPGV PMQTPCFTLQ YAAPELLAQQ GYDESCDLWS 180
LGVILYMMLS GQVPFQGASG QGGQSQAAEI MCKIREGRFS LDGEAWQGVS EEAKELVRGL 240
LTVDPTKRLK LEGLRDSSWL 260
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00156
EKS-ANC-00159
EKS-BOT-00164
EKS-CAJ-00168
EKS-CAF-00171
EKS-CAP-00163
EKS-EQC-00155
EKS-FEC-00154
EKS-GAA-00194
EKS-HOS-00170
EKS-ICT-00159
EKS-LOA-00163
EKS-MAE-00060
EKS-MUM-00169
EKS-MUP-00168
EKS-NOL-00157
EKS-ORN-00204
EKS-OTG-00168
EKS-PAT-00154
EKS-PES-00145
EKS-RAN-00161
EKS-SAH-00158
EKS-SUS-00141
EKS-TAR-00211
EKS-TEN-00204
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0043987; P:histone H3-S10 phosphorylation
GO:0043988; P:histone H3-S28 phosphorylation
GO:0070498; P:interleukin-1-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0035066; P:positive regulation of histone acetylation
GO:0033129; P:positive regulation of histone phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
KEGG
mcc:717574;
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR016239; Ribosomal_S6_kinase_II.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
PF00433; Pkinase_C; 1.
SMARTs
SM00133; S_TK_X; 1.
SM00220; S_TKc; 2.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 2.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00108; PROTEIN_KINASE_ST; 2.
Prints
Created Date20-Feb-2013