EKS-MAM-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	264.3	2.0E-78	195	445	251

Status

Unreviewed

Ensembl Protein

ENSMMUP00000010171

UniProt Accession

F7C2W0;

Protein Name

Protein Synonyms/Alias

Integrin-linked protein kinase;

Gene Name

ILK

Gene Synonyms/Alias

ILK; EGK_06531;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000007741	ENSMMUP00000010171	ENSMMUT00000010842

Organism

Macaca mulatta

Functional Description

Protein Length

452

Protein Sequence
(FASTA)

MDDIFTQCRE GNAVAVRLWL DNTENDLNQG DDHGFSPLHW ACREGRSAVV EMLIMRGARI 60

NVMNRGDDTP LHLAASHGHR DIVQKLLQYK ADINAVNEHG NVPLHYACFW GQDQVAEDLV 120

ANGALVSICN KYGEMPVDKA KAPLRELLRE RAEKMGQNLN RIPYKDTFWK GTTRTRPRNG 180

TLNKHSGIDF KQLNFLTKLN ENHSGELWKG RWQGNDIVVK VLKVRDWSTR KSRDFNEECP 240

RLRIFSHPNV LPVLGACQSP PAPHPTLITH WMPYGSLYNV LHEGTNFVVD QSQAVKFALD 300

MARGMAFLHT LEPLIPRHAL NSRSVMIDED MTARISMADV KFSFQCPGRM YAPAWVAPEA 360

LQKKPEDTNR RSADMWSFAV LLWELVTREV PFADLSNMEI GMKVALEGLR PTIPPGISPH 420

VCKLMKICMN EDPAKRPKFD MIVPILEKMQ DK 452

Nucleotide Sequence
(FASTA)

ATGGACGACA TTTTCACTCA GTGCCGGGAG GGCAACGCAG TCGCCGTTCG CCTGTGGCTG 60

GACAACACGG AGAACGATCT CAACCAGGGG GACGATCATG GCTTCTCCCC CTTGCACTGG 120

GCCTGCCGAG AGGGCCGCTC TGCTGTGGTT GAGATGTTGA TCATGCGGGG GGCACGGATC 180

AATGTAATGA ACCGTGGGGA TGACACCCCC CTGCATCTGG CAGCCAGTCA TGGACACCGT 240

GATATTGTAC AGAAGCTATT GCAGTACAAG GCAGACATCA ATGCAGTGAA TGAACATGGG 300

AATGTGCCCC TGCACTATGC CTGTTTTTGG GGACAAGACC AAGTGGCAGA GGACCTGGTG 360

GCAAATGGGG CCCTTGTCAG CATCTGTAAC AAGTATGGAG AGATGCCTGT GGACAAAGCC 420

AAGGCACCCC TGAGAGAGCT TCTCCGAGAG CGGGCAGAGA AGATGGGCCA GAATCTCAAC 480

CGTATTCCAT ACAAGGACAC ATTCTGGAAG GGGACCACCC GCACTCGGCC CCGAAATGGA 540

ACCCTGAACA AACACTCTGG CATTGACTTC AAACAGCTTA ACTTCCTGAC GAAGCTCAAC 600

GAGAATCACT CTGGAGAGCT ATGGAAGGGC CGCTGGCAGG GCAATGACAT TGTCGTGAAG 660

GTGCTGAAGG TTCGAGACTG GAGTACAAGG AAGAGCAGGG ACTTCAATGA AGAGTGTCCC 720

CGGCTCAGGA TTTTCTCGCA TCCAAATGTG CTCCCAGTGC TAGGTGCCTG TCAGTCTCCA 780

CCTGCTCCTC ATCCTACTCT CATCACACAC TGGATGCCAT ATGGATCCCT CTACAATGTA 840

CTACATGAAG GCACCAATTT CGTCGTAGAC CAGAGCCAGG CTGTGAAGTT TGCTTTGGAC 900

ATGGCAAGGG GCATGGCCTT CCTACACACA CTAGAGCCCC TCATCCCACG ACATGCGCTC 960

AATAGCCGTA GTGTAATGAT TGATGAGGAC ATGACTGCCC GAATTAGCAT GGCTGATGTC 1020

AAGTTCTCTT TCCAATGTCC TGGTCGCATG TATGCACCTG CCTGGGTAGC CCCTGAAGCT 1080

CTGCAGAAAA AGCCTGAAGA CACAAACAGA CGCTCAGCAG ACATGTGGAG TTTTGCAGTG 1140

CTTCTGTGGG AACTGGTGAC ACGGGAGGTA CCCTTTGCTG ATCTTTCCAA TATGGAGATT 1200

GGAATGAAGG TGGCATTGGA AGGCCTTCGG CCTACCATCC CACCAGGTAT TTCCCCTCAT 1260

GTGTGTAAGC TCATGAAGAT CTGCATGAAC GAAGACCCTG CAAAGCGACC CAAATTTGAC 1320

ATGATTGTGC CTATCCTGGA GAAGATGCAG GACAAGTAG 1359

Domain Profile

S: 3     leeligsgafgkvykakwrkkevavKklreeaeekekleklereakllsklshpniiell  62

         + ++++++++g+++k++w++++++vK l++++++++k++++++e+ +l+ +shpn++ +l

Q: 195   FLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVL  254

         67899*******************************************************

S: 63    Gvcleepn..lllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseapk  120

         G+c+++p+   +l+++++++gsL+nvlhe ++ ++d++++v++al++ArGma+Lh+ +p

Q: 255   GACQSPPAphPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPL  314

         ******99745**********************************************997

S: 121   kiihrdLksknvLlseekktlkicdFGtarelskstkmsaa.gtlawmaPEvlkeekvs.  178

          i ++ L+s++v++ +e++t++i++ +++++   s+++  + +++aw+aPE+l++++ +

Q: 315   -IPRHALNSRSVMI-DEDMTARISM-ADVKF---SFQCPGRmYAPAWVAPEALQKKPEDt  368

         .*************.**********.88888...78999998**************9998

S: 179   ..eksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkec  236

           +++D+wS++v+LWel+trevP++dls+++i +kval+glr++ip+ ++++++kLmk c

Q: 369   nrRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKIC  428

         8899********************************************************

S: 237   wnedpekRpsfseivks  253

         +nedp+kRp+f++iv +

Q: 429   MNEDPAKRPKFDMIVPI  445

         **************986

Domain Sequence
(FASTA)

FLTKLNENHS GELWKGRWQG NDIVVKVLKV RDWSTRKSRD FNEECPRLRI FSHPNVLPVL 60

GACQSPPAPH PTLITHWMPY GSLYNVLHEG TNFVVDQSQA VKFALDMARG MAFLHTLEPL 120

IPRHALNSRS VMIDEDMTAR ISMADVKFSF QCPGRMYAPA WVAPEALQKK PEDTNRRSAD 180

MWSFAVLLWE LVTREVPFAD LSNMEIGMKV ALEGLRPTIP PGISPHVCKL MKICMNEDPA 240

KRPKFDMIVP I 251

Keyword

ANK repeat; Complete proteome; Integrin; Kinase; Reference proteome; Repeat; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0001658	; P:branching involved in ureteric bud morphogenesis
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0007229	; P:integrin-mediated signaling pathway
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0008284	; P:positive regulation of cell proliferation
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0042327	; P:positive regulation of phosphorylation
GO:0045893	; P:positive regulation of transcription, DNA-dependent

KEGG

mcc:709944

;

InterPros

IPR002110	; Ankyrin_rpt.
IPR020683	; Ankyrin_rpt-contain_dom.
IPR016253	; Integrin-linked_kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.

Pfam

PF12796	; Ank_2; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00248

; ANK; 3.

Prosites

PS50297	; ANK_REP_REGION; 1.
PS50088	; ANK_REPEAT; 3.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013