EKS-MAM-00114

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00114

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/NAK	395.0	2.8E-118	68	331	264

Status

Unreviewed

Ensembl Protein

ENSMMUP00000010340

UniProt Accession

F7B6I7;

Protein Name

Protein Synonyms/Alias

Gene Name

AAK1

Gene Synonyms/Alias

AAK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000007868	ENSMMUP00000010340	ENSMMUT00000011027

Organism

Macaca mulatta

Functional Description

Protein Length

809

Protein Sequence
(FASTA)

KKKKKKKSRN HRYFALLLPI RKMKKFFDSR REQGGSGLGS GSSGGGGSTS GLGSGYIGRV 60

FGIGRQQVTV DEVLAEGGFA IVFLVRTSNG MKCALKRMFV NNEHDLQVCK REIQIMRDLS 120

GHKNIVGYID SSINNVSSGD VWEVLILMDF CRGGQVVNLM NQRLQTGFTE NEVLQIFCDT 180

CEAVARLHQC KTPIIHRDLK VENILLHDRG HYVLCDFGSA TNKFQNPQTE GVNAVEDEIK 240

KYTTLSYRAP EMVNLYSGKI ITTKADIWAL GCLLYKLCYF TLPFGESQVA ICDGNFTIPD 300

NSRYSQDMHC LIRYMLEPDP DKRPDIYQVS YFSFKLLKKE CPIPNVQNSP IPAKLPEPVK 360

ASEAAAKKTQ PKARLTDPIP TTETSIAPRQ RPKAGQTQPN PGILPIQPAL TPRKRATVQP 420

PPQAAGSSNQ PGLLASVPQP KPQAPPSQPL PQTQAKQPQA PPAPQQTPST QAQGLPTQAQ 480

ATPQHQQQLF LKQQQQQQQQ PPPPQQQPAG TFYQQQQQAQ TQQFQAVHPA TQQPAIAQFP 540

VVSQGGSQQQ LMQNFYQQQQ QQQQQQQQQL ATALHQQQLM TQQAALQQKP TVAAGQQPQP 600

PPAAAPQPAP AQEPAIQAPV RQQPKVQTTP PPAVQGQKVG SLTPPSSPKT QRAGHRRILS 660

DVTHSAVFGV PASKSTQLLQ AAAAEASLNK SKYVVLPLCR SYLCERGLPA AAKVSSENAP 720

RLCHVCASQD SARMNEWCFV SPGKHPEKLG GSAESLIPGF QSTQGDAFAT TSFSAGTAEK 780

RKGGQTVDSG LPLLSVSDPF IPLQVPDAP 809

Nucleotide Sequence
(FASTA)

AAAAAAAAAA AAAAAAAAAA ATCTAGAAAC CATCGGTATT TTGCTTTGCT GCTCCCTATT 60

CGCAAGATGA AGAAGTTTTT CGACTCCCGG CGAGAGCAGG GCGGCTCTGG CCTGGGCTCC 120

GGCTCTAGCG GAGGAGGGGG CAGCACCTCG GGCCTGGGCA GTGGCTACAT CGGAAGAGTC 180

TTTGGCATCG GGCGACAGCA GGTCACAGTG GACGAGGTGT TGGCGGAAGG TGGATTTGCT 240

ATTGTATTTC TGGTGAGGAC AAGCAATGGG ATGAAATGTG CCTTGAAACG CATGTTTGTC 300

AACAATGAGC ATGATCTCCA GGTGTGCAAG AGAGAAATCC AGATAATGAG GGACCTGTCA 360

GGGCACAAGA ATATTGTGGG TTACATTGAT TCTAGTATCA ACAATGTGAG TAGCGGTGAT 420

GTATGGGAAG TGCTCATTCT GATGGACTTT TGTAGAGGTG GCCAGGTGGT AAACCTGATG 480

AACCAGCGCC TGCAAACAGG CTTTACAGAG AACGAAGTGC TCCAGATATT TTGTGATACC 540

TGTGAGGCTG TTGCCCGCCT GCATCAATGC AAAACCCCTA TTATCCACCG GGACCTGAAG 600

GTTGAAAATA TCCTCTTGCA TGACCGAGGC CACTATGTCC TGTGTGACTT TGGAAGTGCC 660

ACCAACAAAT TCCAGAATCC ACAAACTGAG GGAGTCAATG CAGTAGAAGA TGAGATTAAG 720

AAATATACAA CGCTGTCTTA TCGAGCACCA GAAATGGTCA ACCTGTACAG TGGCAAAATC 780

ATCACTACGA AGGCAGACAT TTGGGCTCTT GGATGTTTGT TGTATAAATT ATGCTACTTC 840

ACTTTACCAT TTGGGGAGAG TCAGGTGGCA ATTTGTGATG GAAACTTCAC AATTCCTGAT 900

AATTCTCGAT ATTCTCAAGA CATGCACTGC CTAATTAGAT ATATGTTGGA ACCAGACCCT 960

GACAAAAGGC CGGATATTTA CCAGGTGTCC TACTTCTCAT TTAAGCTACT CAAGAAAGAG 1020

TGCCCAATTC CAAATGTACA GAACTCTCCC ATTCCTGCAA AGCTTCCTGA ACCAGTGAAA 1080

GCCAGTGAGG CAGCTGCAAA AAAGACCCAG CCAAAGGCCA GACTGACAGA TCCCATTCCC 1140

ACCACAGAGA CTTCAATTGC ACCCCGCCAG AGGCCTAAAG CTGGGCAGAC TCAGCCGAAC 1200

CCAGGAATCC TTCCCATCCA GCCCGCCCTG ACGCCCCGGA AGAGGGCCAC TGTTCAGCCC 1260

CCACCTCAGG CTGCAGGATC CAGCAATCAG CCTGGCCTTT TAGCCAGTGT TCCCCAACCA 1320

AAACCCCAAG CGCCACCCAG CCAGCCTCTG CCACAAACTC AGGCCAAGCA GCCACAGGCT 1380

CCTCCCGCTC CACAGCAGAC GCCTTCCACT CAGGCCCAGG GTCTGCCCAC TCAGGCCCAG 1440

GCCACACCCC AGCACCAGCA GCAACTCTTC CTCAAGCAGC AACAGCAGCA GCAACAACAG 1500

CCACCACCAC CACAGCAGCA ACCGGCAGGC ACGTTTTACC AGCAGCAGCA GCAGGCCCAG 1560

ACTCAGCAGT TTCAGGCAGT ACATCCAGCA ACCCAGCAAC CAGCAATTGC TCAGTTCCCT 1620

GTGGTGTCCC AGGGAGGCTC TCAACAGCAG CTAATGCAGA ATTTCTACCA GCAGCAGCAG 1680

CAACAACAAC AACAGCAACA GCAACAGCTG GCCACAGCCC TGCATCAACA ACAGCTGATG 1740

ACTCAGCAGG CTGCCTTGCA GCAAAAGCCC ACTGTGGCAG CAGGACAGCA GCCCCAGCCA 1800

CCGCCAGCTG CAGCCCCACA GCCAGCCCCT GCCCAGGAGC CAGCGATTCA AGCCCCAGTA 1860

AGACAACAGC CAAAGGTTCA GACAACCCCA CCTCCTGCCG TCCAGGGACA GAAAGTTGGA 1920

TCTCTCACTC CACCCTCATC CCCCAAAACC CAGCGTGCTG GGCACAGGCG TATTCTCAGT 1980

GACGTAACCC ACAGTGCCGT CTTTGGGGTC CCTGCCAGCA AATCAACCCA GCTGCTCCAG 2040

GCAGCTGCAG CTGAGGCCAG TCTCAATAAG TCCAAGTATG TGGTGCTTCC TCTTTGTCGT 2100

TCTTACCTCT GTGAGCGAGG TCTGCCTGCG GCTGCTAAAG TCAGTTCAGA GAATGCCCCT 2160

CGCCTCTGCC ATGTGTGTGC CTCACAAGAT TCTGCTAGAA TGAACGAGTG GTGTTTTGTC 2220

TCCCCAGGCA AACATCCCGA GAAGCTTGGA GGCTCAGCTG AGAGTTTGAT CCCAGGCTTT 2280

CAATCAACCC AAGGTGATGC TTTTGCTACG ACCTCATTTT CTGCTGGAAC TGCTGAAAAA 2340

AGGAAGGGTG GGCAGACTGT GGACTCTGGC CTCCCACTTC TAAGTGTGTC TGATCCTTTC 2400

ATTCCTCTTC AAGTACCTGA TGCACCA 2427

Domain Profile

S: 1     vriekvlaeGGfalvylaedastgekyalKrilvneeedleeikrEieimkklsghkniv  60

         v++++vlaeGGfa+v+l++ +s+g k+alKr++vn+e+dl+ +krEi+im++lsghkniv

Q: 68    VTVDEVLAEGGFAIVFLVR-TSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIV  126

         6899***************.99**************************************

S: 61    klvdssvkeekdngskevlllleyckkgslvdllnkrlekgelseaeilkilldvtrava  120

          ++dss+++ ++++++evl+l+++c+ g++v+l+n+rl++g ++e+e+l+i++d+++ava

Q: 127   GYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG-FTENEVLQIFCDTCEAVA  185

         ************9***************************9.******************

S: 121   alHalsvpliHRDlkveNillsdegelvlcDlGSattaileveskqelsalqeeiekntt  180

         +lH++++p+iHRDlkveNill+d+g++vlcD+GSat+++++++ +++++a+++ei+k+tt

Q: 186   RLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQ-TEGVNAVEDEIKKYTT  244

         *******************************************.9***************

S: 181   lsyrsPElidlysnlvideksDiWaLGcllYklcffesPfeesvklailngkysiPensr  240

         lsyr+PE+++lys+++i++k+DiWaLGcllYklc+f+ Pf+es ++ai++g+++iP+nsr

Q: 245   LSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES-QVAICDGNFTIPDNSR  303

         *******************************************.****************

S: 241   yseklkslikkmlevdpeeRptiaqvle  268

         ys+++++li++mle+dp++Rp+i+qv++

Q: 304   YSQDMHCLIRYMLEPDPDKRPDIYQVSY  331

         **************************87

Domain Sequence
(FASTA)

VTVDEVLAEG GFAIVFLVRT SNGMKCALKR MFVNNEHDLQ VCKREIQIMR DLSGHKNIVG 60

YIDSSINNVS SGDVWEVLIL MDFCRGGQVV NLMNQRLQTG FTENEVLQIF CDTCEAVARL 120

HQCKTPIIHR DLKVENILLH DRGHYVLCDF GSATNKFQNP QTEGVNAVED EIKKYTTLSY 180

RAPEMVNLYS GKIITTKADI WALGCLLYKL CYFTLPFGES QVAICDGNFT IPDNSRYSQD 240

MHCLIRYMLE PDPDKRPDIY QVSY 264

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0045747	; P:positive regulation of Notch signaling pathway
GO:0050821	; P:protein stabilization
GO:2000369	; P:regulation of clathrin-mediated endocytosis
GO:0032880	; P:regulation of protein localization

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013