EKS-MAM-00423

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00423

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	530.1	2.0E-159	35	292	258

Status

Unreviewed

Ensembl Protein

ENSMMUP00000010405

UniProt Accession

F7AR06;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK2

Gene Synonyms/Alias

SGK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000007925	ENSMMUP00000037957	ENSMMUT00000044938
ENSMMUG00000007925	ENSMMUP00000037955	ENSMMUT00000044936
ENSMMUG00000007925	ENSMMUP00000037956	ENSMMUT00000044937
ENSMMUG00000007925	ENSMMUP00000010405	ENSMMUT00000011096

Organism

Macaca mulatta

Functional Description

Protein Length

367

Protein Sequence
(FASTA)

MNSNPAGTTS PQPSKANGNI NLGPSANPNA RPTDFDFLKV IGKGNYGKVL LAKRKSDGTF 60

YAVKVLQKKS ILKKKEQSHI MAERSVLLKN VRHPFLVGLR YSFQTPEKLY FVLDYVNGGE 120

LFFHLQRERR FLEPRARFYA AEVASAIGYL HSLNIIYRDL KPENILLDCQ GHVVLTDFGL 180

CKEGVEPEET TSTFCGTPEY LAPEVLRKEP YDRAVDWWCL GAVLYEMLHG LPPFYSQDVS 240

QMYENILHQP LQIPGGRTVA ACDLLQSLLH KDQRQRLGSK ADFLEIKNHV FFSPINWDDL 300

YHKRLTPPFN PNVAGPADLK HFDPEFTQEA VSKSIGCTPD TVASSSGASS AFLGFSYAPE 360

DDDILDC 367

Nucleotide Sequence
(FASTA)

ATGAACTCTA ACCCAGCTGG GACCACCAGT CCACAGCCCT CCAAGGCCAA TGGGAACATC 60

AACCTGGGGC CTTCAGCCAA CCCAAATGCC CGGCCCACGG ACTTCGACTT CCTCAAAGTC 120

ATCGGCAAAG GGAACTATGG GAAGGTCCTG CTGGCCAAGC GCAAGTCTGA TGGGACGTTC 180

TATGCAGTGA AGGTGCTGCA GAAAAAGTCC ATCTTAAAGA AGAAAGAGCA GAGTCACATC 240

ATGGCAGAGC GCAGTGTACT TCTGAAGAAT GTGCGGCACC CCTTCCTCGT GGGCCTGCGC 300

TACTCCTTCC AGACACCTGA GAAGCTCTAC TTCGTGCTCG ACTATGTCAA CGGGGGAGAG 360

CTCTTCTTCC ACCTGCAGCG GGAGCGTCGG TTCCTGGAGC CCCGGGCCAG GTTCTACGCT 420

GCCGAGGTGG CCAGCGCCAT TGGCTACCTG CACTCCCTCA ACATCATTTA CAGGGACCTG 480

AAACCAGAGA ACATTCTCTT GGACTGCCAG GGACACGTGG TGCTGACGGA TTTTGGCCTC 540

TGCAAGGAAG GTGTAGAGCC TGAAGAGACC ACATCCACGT TCTGTGGTAC CCCCGAGTAC 600

TTGGCACCTG AAGTGCTTCG GAAAGAGCCT TATGATCGGG CGGTAGACTG GTGGTGCTTG 660

GGGGCAGTCC TCTACGAGAT GCTGCACGGC CTGCCGCCCT TCTACAGCCA AGACGTGTCC 720

CAGATGTATG AGAACATTCT GCACCAGCCG CTACAGATCC CTGGGGGCCG GACGGTGGCC 780

GCCTGTGACC TCCTGCAAAG CCTTCTCCAC AAGGACCAGA GGCAGCGGCT GGGCTCCAAA 840

GCAGACTTTC TGGAGATTAA GAACCATGTA TTCTTCAGCC CTATAAACTG GGATGACCTG 900

TACCACAAGA GGCTAACTCC ACCCTTCAAC CCAAATGTGG CAGGACCTGC TGACTTGAAG 960

CATTTTGACC CAGAGTTCAC CCAGGAAGCT GTGTCCAAGT CCATTGGCTG TACCCCTGAC 1020

ACTGTGGCCA GCAGCTCTGG GGCCTCAAGT GCATTTCTGG GATTTTCTTA CGCGCCAGAG 1080

GATGATGACA TCCTGGATTG CTAG 1104

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         fdflkvigkg++gkvllakrk+d++fyavkvlqkk+ilkkke++himaer+vllknv+hp

Q: 35    FDFLKVIGKGNYGKVLLAKRKSDGTFYAVKVLQKKSILKKKEQSHIMAERSVLLKNVRHP  94

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvgl+ysfqt+eklyfvldyvnggelffhlqrer+fleprarfyaae+asa+gylhsln

Q: 95    FLVGLRYSFQTPEKLYFVLDYVNGGELFFHLQRERRFLEPRARFYAAEVASAIGYLHSLN  154

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         i+yrdlkpenilld++ghvvltdfglcke++e e+ttstfcgtpeylapevlrk+pydr+

Q: 155   IIYRDLKPENILLDCQGHVVLTDFGLCKEGVEPEETTSTFCGTPEYLAPEVLRKEPYDRA  214

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyeml+glppfys+dv++my+nil++plq+++g++vaa++ll++ll+kd++

Q: 215   VDWWCLGAVLYEMLHGLPPFYSQDVSQMYENILHQPLQIPGGRTVAACDLLQSLLHKDQR  274

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         +rlg+k+dfleiknhvff

Q: 275   QRLGSKADFLEIKNHVFF  292

         *****************9

Domain Sequence
(FASTA)

FDFLKVIGKG NYGKVLLAKR KSDGTFYAVK VLQKKSILKK KEQSHIMAER SVLLKNVRHP 60

FLVGLRYSFQ TPEKLYFVLD YVNGGELFFH LQRERRFLEP RARFYAAEVA SAIGYLHSLN 120

IIYRDLKPEN ILLDCQGHVV LTDFGLCKEG VEPEETTSTF CGTPEYLAPE VLRKEPYDRA 180

VDWWCLGAVL YEMLHGLPPF YSQDVSQMYE NILHQPLQIP GGRTVAACDL LQSLLHKDQR 240

QRLGSKADFL EIKNHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0015459	; F:potassium channel regulator activity
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013