EKS-MAM-00090

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00090

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/PIKK	457.0	7.0E-137	2232	2558	327

Status

Unreviewed

Ensembl Protein

ENSMMUP00000038552

UniProt Accession

F7HT00;

Protein Name

Protein Synonyms/Alias

Gene Name

ATR

Gene Synonyms/Alias

ATR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000007927	ENSMMUP00000010409	ENSMMUT00000011100
ENSMMUG00000007927	ENSMMUP00000038552	ENSMMUT00000045519

Organism

Macaca mulatta

Functional Description

Protein Length

2583

Protein Sequence
(FASTA)

MGEHGVELAS MIPALRELGS ATPEEYNAVV QKPRQILCQF IDRILTDVNV VAVELVKKTD 60

SQPTSVMLLD FIQHIMKSSP LMFVNVNGSH EAKGSCIEFS NWIITRLLRI AATPSCHLLH 120

KKICEVICSL LFLFKSKSPA IFGVLTKELL QLFEDLVYLH RRNVMGHAVE WPVVISRFLS 180

QLDEHMGYLQ SAPLRLISMQ NLEFIEVTLL TVLTRIIAIV FFRRQELLLW QIGCVLLEYG 240

SPKIKSLAIS FLTELFQLGG LPAQPASTFF SSFLELLKHL VEMDTDQLKL YEEPLSKLIK 300

TLFPFEAEAY RNIEPVYLNM LLEKLCVMFE DGVLMRLKSD LLKAALCHLL QYFLKFVPAG 360

YESALQVRKV YVTNICKALL DVLGIQVDAE YLLGPLYAAL KVESMEIIEE IQCQTQQENL 420

SSNSDGISPK RRRLSSSLNP SKRAPKQTED PTFKDCQHKS KKKPSVVITW MSLDFYTKVL 480

KSCRSLLETV QKPDLEATID KVVKIYDALI YMQVNSSFED HVLEDLCGML SLPWIYSHSD 540

DGCLKLTTFA TNLLTLSHRI SDSYSPQAQS RCVFLLTLFP RRIFLEWRTA VYNWALQSSH 600

EVIRASCVSG FFILLQQQNS CNRVPKILID KVKDDSDIIK KEFASILGQL VCTLHGMFYL 660

TSSLTEPFSE HEHVDLFCRN LKATSQHECS SSQLKASVCK PFLFLLKKKT PSAVKLAFID 720

NLHHLCKHLD FREDETDVKA VLGTLLNLME DPDKDVRVAF SGNIKHILES LDSEDGFIKE 780

LFVLRMKEAY THAQISRDYE LKDTLILTTG DIGRAAKGDL VPFALLHLLH CLLSKSASVS 840

GAAYTEIRAL VAAKSVKLQN FFSQYKKPIC QFLVESLHSS QMTALPSTPC QNADMRKQDV 900

AHQREMALNT LSEIANVFDF PDLNRFLTRT LQVLLPDLAA KASPAASALI RTLGKQLNVN 960

RREILINNFK YIFSHLVCSC SKDELERALH YLKNETEIEL GSLLRQDFQG LHNELLLRIG 1020

EHYQQVFNGL SILASFASSD DPYQGPRDII SPELMADYLQ PKLLGILAFF NMQLLSSSVG 1080

IEDKKMALNS LMSLMKLMGP KHVSSVRVKM MTTLRTGLRF KDEFPELCCR AWDCFVRCLD 1140

HACLGSLLSH VIVALLPLIH IQPKETAAIF HYLIIENRDA VQDFLHEIYF LPDHPELKKI 1200

KAILQEYRKE TSESTDLQTT LQLSMKAIQH ENVDVRIHAL TSLKETLYKN QEKLIKYATD 1260

SETVEPIISQ LVTVLLKGCQ DANSQARLLC GECLGELGAI DPGRLDFSTT ETQGKDFTFV 1320

TGVEDSSFAY GLLMELTRAY LAYADNSRAQ DSAAYAIQEL LSIYDCREME TNGPGHQLWR 1380

RFPEHVREIL EPHLNTRYKS SQKSTDWSGV KKPIYLSKLG SNFAEWSASW AGYLITKVRH 1440

DLASKIFTCC SIMMKHDFKV TIYLLPHILV YVLLGCNQED QQEVYAEIMA VLKHDDQHTI 1500

NTQDIASDLC QLSTQTVFSM LDHLTQWARH KFQALKAEKC PHSKSNRNKV DSLVSTVDYE 1560

DYQSVTRFLD LIPQDTLAVA SFRSKAYTRA VMHFESFITE KKQNIQEHLG FLQKLYAAMH 1620

EPDGVAGVSA IRKAEPSLKE QILEHESLGL LRDATACYDR AIQLEPDQII HYHGVVKSML 1680

GLGQLSTVIT QVNGVHANRS EWTDELNTYR VEAAWKLSQW DLVENYLAAD GKSTTWSVRL 1740

GQLLLSAKKR DITAFYDTLK LVRAEQIVPL SAASFERGSY QRGYEYIVRL HMLCELEHSI 1800

KPLFQHSPGD SSQEDSLNWV ARLEMTQNSY RAKEPILALR RALLSLNKRP DYDEMVGECW 1860

LQSARVARKA GHHQTAYNAL LNAGESRLAE LYVERAKWLW SKGDVHQALI VLQKGVELCF 1920

PENETPPEGK NMLIHGRAML LVGRFMEETA NFESNAIMKK YKAMDVTACL PEWEDGHFYL 1980

AKYYDKLMPM VTDNKMEKQG DLIRYIVLHF GRSLQYGNQF IYQSMPRMLT LWLDYGTKAY 2040

EWERSTGRSD RVQMRNDLGK INKVITEHTN YLAPYQFLTA FSQLISRICH SHDEVFVVLM 2100

EIIAKVFLAY PQQAMWMMTA VSKSSYPMRV NRCKEILNKA IHMKKSLEKF VGDATRLTDK 2160

LLELCNKPVD GSSSTLSMRT HFKMLKKLVE EATFSEILIP LQSVMIPTLP SILGTHANHA 2220

SHEPFPGHWA YIAGFDDMVE ILASLQKPKK ISLKGSDGKF YIMMCKPKDD LRKDCRLMEF 2280

NSLINKCLRK DAESRRRELH IRTYAVIPLN DECGIIEWVN NTAGLRPILT KLYKEKGVYM 2340

TGKELRQCML PKSAALSEKL KVFREFLLPR HPPIFHEWFL RTFPDPTSWY SSRSAYCRST 2400

AVMSMVGYIL GLGDRHGENI LFDSLTGECV HVDFNCLFNK GETFEVPEIV PFRLTHNMVN 2460

GMGPMGTEGL FRRACEVTMR LMRDQREPLM SVLKTFLHDP LVEWSKPVKG HSKAPLNETG 2520

EVVNEKAKTH VLDIEQRLQG VIKTRNRVTG LPLSIEGHVH YLIQEATDEN LLCQMYLGWT 2580

PYM 2583

Nucleotide Sequence
(FASTA)

ATGGGGGAAC ATGGTGTGGA GCTGGCTTCC ATGATCCCCG CCTTGCGGGA GCTCGGCAGT 60

GCCACACCAG AGGAATATAA TGCAGTTGTA CAGAAACCAA GACAAATTCT ATGTCAGTTC 120

ATTGACCGGA TACTTACAGA TGTAAATGTT GTTGCTGTAG AACTTGTAAA GAAAACTGAC 180

TCTCAGCCGA CCTCCGTAAT GTTGCTTGAT TTCATCCAGC ATATCATGAA ATCCTCCCCA 240

CTTATGTTTG TAAATGTGAA TGGAAGCCAT GAGGCCAAAG GCAGTTGTAT TGAATTCAGT 300

AATTGGATCA TAACAAGACT TCTGCGGATT GCAGCAACTC CCTCCTGTCA TTTGTTACAC 360

AAGAAAATCT GTGAAGTCAT CTGTTCATTA TTATTTCTTT TTAAAAGCAA GAGTCCTGCT 420

ATTTTTGGGG TACTCACGAA AGAATTATTA CAACTTTTTG AAGACTTGGT TTACCTCCAT 480

AGAAGAAATG TGATGGGTCA TGCTGTGGAA TGGCCAGTGG TCATTAGCCG ATTTTTAAGT 540

CAATTAGATG AACACATGGG ATATTTACAA TCAGCTCCTT TGCGGTTGAT AAGTATGCAA 600

AATTTAGAAT TTATTGAAGT CACTTTATTA ACGGTTCTTA CTCGTATTAT TGCAATTGTG 660

TTTTTTAGAA GGCAAGAACT CTTACTTTGG CAGATAGGTT GTGTACTGCT AGAGTATGGT 720

AGTCCAAAAA TTAAATCACT AGCAATTAGC TTTTTAACTG AACTTTTTCA GCTTGGAGGA 780

CTACCAGCAC AACCAGCTAG CACTTTTTTC AGCTCATTTT TGGAATTATT AAAACACCTT 840

GTAGAAATGG ATACTGACCA ATTGAAACTC TATGAAGAGC CATTATCAAA GCTGATAAAG 900

ACACTATTTC CCTTTGAAGC AGAAGCTTAT AGAAATATTG AACCTGTCTA TTTAAATATG 960

CTGCTGGAAA AACTCTGTGT CATGTTTGAA GATGGTGTGC TCATGCGGCT TAAGTCTGAT 1020

TTGCTAAAAG CAGCTTTGTG CCATTTACTG CAGTATTTTC TTAAATTTGT GCCAGCTGGG 1080

TATGAATCTG CTTTACAAGT CAGGAAGGTC TATGTGACAA ATATTTGTAA AGCTCTTTTG 1140

GATGTGCTTG GAATTCAGGT AGATGCAGAG TACTTGTTGG GCCCACTTTA TGCAGCTTTG 1200

AAAGTGGAAA GTATGGAAAT CATTGAGGAG ATTCAATGCC AAACTCAACA GGAAAACCTC 1260

AGCAGTAATA GTGATGGAAT ATCACCCAAA AGGCGTCGTC TCAGCTCATC TCTAAACCCT 1320

TCTAAAAGAG CACCAAAACA GACTGAGGAC CCTACTTTCA AGGACTGTCA ACACAAATCC 1380

AAGAAGAAAC CTTCTGTAGT GATAACTTGG ATGTCATTGG ATTTTTACAC AAAAGTGCTT 1440

AAGAGCTGTA GAAGTTTGTT AGAAACTGTT CAGAAACCAG ACCTGGAGGC AACCATTGAT 1500

AAGGTGGTGA AAATTTATGA TGCTTTGATT TATATGCAAG TAAACAGTTC ATTTGAAGAT 1560

CATGTCCTGG AAGATTTATG TGGAATGCTC TCACTTCCAT GGATTTATTC CCATTCTGAT 1620

GATGGCTGTT TAAAGTTAAC CACATTTGCC ACTAATCTTC TAACATTAAG CCATAGGATT 1680

TCAGATAGCT ATTCACCACA GGCACAGTCA CGATGTGTGT TTCTTCTGAC TCTGTTTCCA 1740

AGAAGAATAT TCCTTGAATG GAGAACAGCA GTTTACAACT GGGCCCTGCA GAGCTCCCAT 1800

GAAGTAATCC GGGCTAGTTG TGTTAGTGGA TTTTTTATCT TATTGCAGCA GCAGAATTCT 1860

TGTAACAGAG TTCCCAAGAT TCTAATAGAT AAAGTCAAAG ATGATTCTGA CATTATCAAG 1920

AAAGAATTTG CTTCTATACT TGGTCAACTT GTCTGTACCC TTCATGGCAT GTTTTATCTG 1980

ACAAGCTCTT TAACAGAACC TTTCTCTGAA CATGAACATG TGGACCTCTT CTGTAGGAAC 2040

TTGAAAGCCA CTTCTCAACA TGAATGTTCA TCTTCTCAAC TAAAAGCGTC TGTTTGCAAG 2100

CCATTCCTTT TCCTACTAAA AAAGAAAACA CCTAGTGCAG TAAAACTTGC TTTCATAGAT 2160

AATCTGCATC ATCTTTGTAA GCATCTTGAT TTTAGAGAAG ATGAAACAGA TGTAAAAGCA 2220

GTTCTTGGAA CTTTATTAAA TTTAATGGAA GATCCAGACA AAGATGTTAG AGTGGCTTTT 2280

AGTGGAAATA TCAAGCATAT ATTGGAATCC TTGGACTCTG AAGATGGATT TATAAAGGAG 2340

CTTTTTGTCT TAAGAATGAA GGAAGCATAT ACACATGCCC AAATATCAAG AGATTATGAG 2400

CTGAAGGATA CCTTGATTCT TACAACAGGG GATATTGGAA GGGCCGCAAA AGGAGATTTG 2460

GTACCTTTTG CACTCTTGCA CTTATTGCAT TGTTTGTTAT CCAAGTCAGC ATCTGTCTCT 2520

GGAGCAGCAT ACACAGAAAT TAGAGCTCTG GTTGCAGCTA AAAGTGTTAA ACTGCAAAAT 2580

TTTTTCAGCC AGTATAAGAA ACCCATTTGT CAGTTTTTGG TAGAATCCCT TCACTCTAGT 2640

CAGATGACAG CACTTCCGAG TACTCCATGC CAGAATGCTG ACATGCGAAA ACAAGATGTG 2700

GCTCACCAAA GAGAAATGGC TTTAAATACC TTGTCTGAAA TTGCCAACGT TTTCGACTTT 2760

CCTGATCTTA ATCGTTTTCT TACTAGGACA TTACAAGTTC TACTACCCGA TCTTGCTGCC 2820

AAAGCAAGCC CTGCAGCTTC TGCTCTCATT CGAACTTTAG GAAAACAATT AAATGTCAAT 2880

CGTAGAGAGA TTTTAATAAA CAACTTCAAA TATATTTTTT CTCATTTGGT CTGTTCTTGT 2940

TCCAAAGATG AATTAGAACG TGCCCTTCAT TATCTGAAGA ATGAAACAGA AATTGAACTG 3000

GGGAGCCTGT TGAGACAAGA TTTCCAAGGA TTGCATAATG AATTATTGCT GCGTATTGGA 3060

GAACACTATC AACAGGTTTT CAATGGTTTG TCAATACTTG CCTCATTTGC ATCCAGTGAT 3120

GATCCGTATC AGGGCCCAAG AGATATCATA TCACCTGAAC TGATGGCTGA TTATTTACAA 3180

CCCAAATTGT TGGGCATTTT GGCTTTTTTT AACATGCAGT TACTGAGCTC TAGTGTTGGC 3240

ATTGAAGATA AGAAAATGGC CTTGAACAGT TTGATGTCTT TGATGAAGTT AATGGGACCC 3300

AAACATGTCA GTTCTGTGAG GGTGAAGATG ATGACCACAC TGAGAACTGG CCTTCGATTC 3360

AAGGATGAAT TTCCTGAATT GTGTTGCAGA GCTTGGGACT GCTTTGTTCG TTGCCTGGAT 3420

CATGCTTGTC TGGGCTCCCT TCTCAGTCAT GTAATAGTAG CTTTGTTACC TCTTATACAC 3480

ATCCAGCCTA AAGAAACTGC AGCTATCTTT CACTACCTCA TAATTGAAAA CAGGGATGCT 3540

GTGCAAGATT TTCTTCATGA AATATATTTT TTACCTGATC ATCCAGAATT AAAAAAGATA 3600

AAAGCCATTC TCCAGGAATA CAGAAAGGAG ACCTCTGAGA GCACGGATCT TCAAACAACT 3660

CTTCAGCTCT CTATGAAGGC CATTCAGCAT GAAAATGTCG ATGTTCGTAT TCATGCTCTT 3720

ACAAGCTTGA AGGAAACCTT GTATAAAAAT CAGGAAAAAC TGATAAAGTA TGCAACAGAC 3780

AGTGAAACAG TAGAACCTAT TATCTCACAG TTGGTGACAG TGCTTTTGAA AGGTTGCCAA 3840

GATGCAAACT CTCAAGCTCG GTTGCTCTGT GGGGAATGTT TAGGGGAATT GGGGGCGATA 3900

GACCCAGGTC GATTAGATTT CTCAACAACT GAAACTCAGG GAAAAGATTT TACGTTTGTG 3960

ACTGGAGTAG AAGATTCAAG CTTTGCCTAT GGATTATTGA TGGAACTAAC AAGAGCTTAC 4020

CTTGCGTATG CTGATAATAG CCGAGCTCAA GATTCAGCTG CCTATGCCAT TCAGGAGTTG 4080

CTTTCTATTT ATGACTGTAG AGAGATGGAG ACCAATGGCC CAGGTCACCA ATTGTGGAGG 4140

AGATTTCCTG AGCATGTTCG GGAAATACTA GAACCTCATC TAAATACCAG ATACAAGAGT 4200

TCTCAGAAGT CAACCGATTG GTCTGGAGTA AAGAAGCCAA TTTACTTAAG TAAATTGGGT 4260

AGTAACTTTG CAGAATGGTC AGCATCTTGG GCAGGTTATC TTATAACAAA GGTTCGGCAT 4320

GATCTTGCCA GTAAAATTTT CACCTGCTGT AGCATTATGA TGAAGCATGA TTTCAAAGTG 4380

ACCATCTATC TTCTTCCACA TATTCTGGTG TATGTCTTAC TGGGTTGTAA TCAAGAAGAT 4440

CAGCAGGAGG TTTATGCAGA AATTATGGCA GTTCTAAAGC ATGACGATCA GCATACCATA 4500

AATACCCAAG ACATTGCATC TGATCTGTGT CAACTCAGTA CACAGACTGT GTTCTCCATG 4560

CTTGACCATC TCACCCAGTG GGCAAGGCAC AAATTTCAGG CACTGAAAGC TGAGAAATGT 4620

CCACACAGTA AATCAAACAG AAATAAGGTA GACTCATTGG TATCTACTGT GGATTATGAA 4680

GACTATCAGA GTGTAACTCG TTTTCTAGAC CTCATACCCC AGGATACTCT GGCAGTAGCT 4740

TCCTTTCGCT CCAAAGCATA CACACGAGCT GTAATGCACT TTGAATCATT TATTACAGAA 4800

AAGAAGCAAA ATATTCAGGA ACATCTTGGA TTTTTACAGA AATTGTATGC TGCTATGCAT 4860

GAACCTGATG GAGTGGCCGG AGTCAGCGCA ATTAGAAAGG CAGAACCATC TCTAAAAGAA 4920

CAGATCCTTG AACATGAAAG CCTTGGTTTG CTGAGGGATG CCACTGCTTG TTATGATAGG 4980

GCTATTCAGC TAGAACCAGA CCAGATCATT CATTATCATG GTGTAGTAAA GTCCATGTTA 5040

GGTCTTGGTC AGCTGTCTAC TGTTATCACT CAGGTGAATG GAGTGCATGC TAACAGGTCC 5100

GAGTGGACAG ATGAATTAAA CACTTACAGA GTGGAAGCAG CTTGGAAATT GTCACAGTGG 5160

GATTTGGTGG AAAACTATTT GGCAGCAGAT GGAAAATCTA CAACATGGAG TGTCAGACTG 5220

GGACAGCTAT TATTATCAGC CAAAAAAAGA GATATCACAG CTTTTTATGA CACATTGAAG 5280

CTAGTGAGAG CAGAACAAAT TGTACCTCTT TCAGCTGCAA GCTTTGAAAG AGGCTCTTAC 5340

CAACGAGGAT ATGAATATAT TGTGAGATTG CACATGTTGT GTGAGTTGGA GCATAGCATC 5400

AAACCACTTT TCCAGCATTC TCCAGGTGAC AGTTCTCAAG AAGATTCTCT AAACTGGGTA 5460

GCTCGACTAG AAATGACCCA GAATTCCTAC AGAGCCAAGG AGCCTATCCT GGCTCTCCGG 5520

AGGGCTTTAC TAAGCCTCAA CAAAAGACCA GATTACGATG AAATGGTTGG AGAATGCTGG 5580

CTGCAGAGTG CCAGAGTAGC TAGAAAGGCT GGTCACCACC AGACAGCCTA CAATGCTCTC 5640

CTTAATGCAG GGGAATCACG ACTCGCTGAA CTGTATGTGG AAAGGGCAAA GTGGCTCTGG 5700

TCCAAGGGTG ATGTTCACCA GGCACTAATT GTTCTTCAAA AAGGTGTTGA ATTATGTTTT 5760

CCTGAAAATG AAACCCCACC TGAGGGTAAG AACATGTTAA TCCATGGTCG AGCTATGCTA 5820

CTAGTGGGCC GATTTATGGA AGAAACAGCT AACTTTGAAA GCAATGCCAT TATGAAAAAA 5880

TATAAGGCAA TGGATGTGAC CGCGTGCCTG CCAGAATGGG AGGATGGGCA TTTTTACCTT 5940

GCCAAGTACT ATGACAAATT GATGCCCATG GTCACAGACA ACAAAATGGA AAAGCAAGGT 6000

GATCTCATCC GGTATATAGT TCTTCATTTT GGCAGATCTC TACAATATGG AAATCAGTTC 6060

ATATATCAGT CAATGCCACG AATGTTAACT CTATGGCTTG ATTATGGTAC AAAGGCATAT 6120

GAATGGGAAA GAAGTACTGG CCGTTCCGAT CGTGTACAGA TGAGGAATGA TTTGGGTAAA 6180

ATAAACAAGG TTATCACAGA GCATACAAAC TATTTAGCTC CATATCAATT TTTGACTGCT 6240

TTTTCACAAT TGATCTCTCG AATTTGTCAT TCTCATGATG AAGTTTTTGT TGTCTTGATG 6300

GAAATAATAG CCAAAGTATT TCTAGCCTAT CCTCAACAAG CAATGTGGAT GATGACAGCT 6360

GTGTCAAAGT CTTCTTATCC CATGCGTGTG AACAGATGCA AGGAAATCCT AAATAAAGCC 6420

ATTCATATGA AAAAATCCTT AGAGAAGTTT GTTGGAGATG CAACTCGCCT AACAGATAAG 6480

CTTCTAGAAT TGTGCAATAA ACCGGTTGAT GGAAGTAGTT CCACATTAAG CATGAGGACT 6540

CATTTTAAAA TGCTTAAAAA ACTGGTAGAA GAAGCAACAT TTAGTGAAAT CCTCATTCCT 6600

CTGCAATCAG TCATGATACC TACACTTCCA TCAATTCTGG GTACCCATGC TAACCATGCT 6660

AGCCATGAGC CATTTCCTGG ACATTGGGCC TATATTGCAG GGTTTGATGA TATGGTGGAA 6720

ATTCTTGCTT CTCTTCAGAA ACCAAAGAAG ATTTCTTTAA AAGGGTCAGA TGGAAAGTTC 6780

TACATCATGA TGTGTAAGCC AAAAGATGAC CTGAGAAAGG ATTGTAGACT AATGGAATTC 6840

AATTCCTTGA TTAATAAGTG CTTAAGAAAA GATGCAGAGT CTCGTAGAAG AGAGCTTCAT 6900

ATTCGAACAT ATGCAGTTAT TCCACTGAAT GATGAATGTG GGATTATTGA ATGGGTGAAC 6960

AACACTGCTG GTTTGAGACC TATTCTGACC AAACTATATA AGGAAAAAGG AGTGTATATG 7020

ACAGGAAAAG AACTTCGCCA GTGTATGCTA CCAAAGTCAG CAGCTTTATC TGAAAAACTC 7080

AAAGTATTCC GAGAATTTCT CCTGCCCAGG CATCCTCCTA TTTTTCATGA GTGGTTTCTG 7140

AGAACATTCC CTGATCCTAC ATCATGGTAC AGTAGTAGAT CAGCATACTG CCGTTCCACT 7200

GCAGTAATGT CAATGGTTGG TTATATTCTG GGGCTTGGAG ACCGTCATGG TGAAAATATT 7260

CTCTTTGATT CTTTGACTGG TGAATGCGTA CATGTAGATT TCAACTGTCT TTTCAATAAG 7320

GGAGAAACCT TTGAAGTTCC AGAAATTGTA CCATTTCGCC TGACTCATAA TATGGTTAAT 7380

GGAATGGGTC CTATGGGAAC AGAGGGTCTT TTTCGAAGAG CATGTGAAGT TACAATGAGG 7440

CTTATGCGTG ATCAGCGAGA GCCTTTAATG AGTGTCTTAA AGACTTTTCT ACATGATCCT 7500

CTTGTGGAGT GGAGTAAACC AGTGAAAGGG CATTCCAAAG CACCACTGAA TGAAACTGGA 7560

GAAGTTGTCA ACGAAAAGGC CAAGACCCAT GTTCTTGACA TTGAGCAGCG ACTACAAGGT 7620

GTAATCAAGA CTCGAAATAG AGTGACAGGA CTGCCATTAT CTATTGAAGG ACATGTGCAT 7680

TACCTTATAC AAGAAGCTAC TGATGAAAAC TTACTATGCC AGATGTATCT TGGTTGGACC 7740

CCATATATGT GA 7752

Domain Profile

S: 1     iagfderveilaskqkpkklllrGsdgkeypyLvkgkeDlrqdervlqlfslvNtlLakd  60

         iagfd++veilas+qkpkk++l+Gsdgk+y++++k+k+Dlr+d+r+++++sl+N++L+kd

Q: 2232  IAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCRLMEFNSLINKCLRKD  2291

         89**********************************************************

S: 61    ketsrrkLkirtykVvplstrsgliewventvsLkellkklvekkavlldqpisyrykdl  120

         +e++rr+L+irty+V+pl++++g+iewv+nt++L+ +l+kl+++k+v++        + +

Q: 2292  AESRRRELHIRTYAVIPLNDECGIIEWVNNTAGLRPILTKLYKEKGVYM--------TGK  2343

         *************************************************........599

S: 121   stvqarkpklkhlklslevfkevlenlvpkdllkklllekfpspeewfelrkaytrslAv  180

         + +q++ pk+++l+++l+vf+e+l +++p+ ++++++l++fp+p++w+++r+ay+rs+Av

Q: 2344  ELRQCMLPKSAALSEKLKVFREFLLPRHPP-IFHEWFLRTFPDPTSWYSSRSAYCRSTAV  2402

         *****************************8.*****************************

S: 181   islvgyiLgLgdrhlenllidqetgevvhidfgvafekaktqlkvpekvPFRLTrnivna  240

         +s+vgyiLgLgdrh en+l+d+ tge+vh+df++ f+k++t ++vpe+vPFRLT+n+vn+

Q: 2403  MSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFNKGET-FEVPEIVPFRLTHNMVNG  2461

         *****************************************.******************

S: 241   lgvtgveGvfrasceavlrvlreskeklltiLevflydplvdwkk.....kkktsketee  295

         +g++g+eG+fr++ce ++r++r+++e l+++L++fl+dplv+w+k     +k++ +et+e

Q: 2462  MGPMGTEGLFRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKpvkghSKAPLNETGE  2521

         *************************************************99*********

S: 296   elaekakaealkikkllskvekaenavatrdllllee  332

         +++ekak++ l+i+++l++v k++n+v+ ++l+++++

Q: 2522  VVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGH  2558

         ********************************99987

Domain Sequence
(FASTA)

IAGFDDMVEI LASLQKPKKI SLKGSDGKFY IMMCKPKDDL RKDCRLMEFN SLINKCLRKD 60

AESRRRELHI RTYAVIPLND ECGIIEWVNN TAGLRPILTK LYKEKGVYMT GKELRQCMLP 120

KSAALSEKLK VFREFLLPRH PPIFHEWFLR TFPDPTSWYS SRSAYCRSTA VMSMVGYILG 180

LGDRHGENIL FDSLTGECVH VDFNCLFNKG ETFEVPEIVP FRLTHNMVNG MGPMGTEGLF 240

RRACEVTMRL MRDQREPLMS VLKTFLHDPL VEWSKPVKGH SKAPLNETGE VVNEKAKTHV 300

LDIEQRLQGV IKTRNRVTGL PLSIEGH 327

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0001741	; C:XY body
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071480	; P:cellular response to gamma radiation
GO:0034644	; P:cellular response to UV
GO:0000077	; P:DNA damage checkpoint
GO:0006281	; P:DNA repair
GO:0008156	; P:negative regulation of DNA replication
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0043517	; P:positive regulation of DNA damage response, signal transduction by p53 class mediator
GO:0046777	; P:protein autophosphorylation
GO:0043393	; P:regulation of protein binding
GO:0090399	; P:replicative senescence

KEGG

InterPros

IPR011989	; ARM-like.
IPR016024	; ARM-type_fold.
IPR003152	; FATC.
IPR021133	; HEAT_type_2.
IPR011009	; Kinase-like_dom.
IPR000403	; PI3/4_kinase_cat_dom.
IPR018936	; PI3/4_kinase_CS.
IPR003151	; PIK-rel_kinase_FAT.
IPR014009	; PIK_FAT.
IPR011990	; TPR-like_helical.
IPR012993	; UME.

Pfam

PF02259	; FAT; 1.
PF02260	; FATC; 1.
PF00454	; PI3_PI4_kinase; 1.
PF08064	; UME; 1.

SMARTs

SM00146	; PI3Kc; 1.
SM00802	; UME; 1.

Prosites

PS51189	; FAT; 1.
PS51190	; FATC; 1.
PS50077	; HEAT_REPEAT; 1.
PS00916	; PI3_4_KINASE_2; 1.
PS50290	; PI3_4_KINASE_3; 1.

Prints

Created Date

20-Feb-2013