EKS-MAM-00170
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00170
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC454.22.7E-136338601264
StatusUnreviewed
Ensembl ProteinENSMMUP00000031468
UniProt AccessionF7HNV1;
Protein NameProtein kinase C
Protein Synonyms/Alias
Gene NamePRKCG
Gene Synonyms/Alias PRKCG;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000007972ENSMMUP00000031468ENSMMUT00000038368
ENSMMUG00000007972ENSMMUP00000010458ENSMMUT00000011153
ENSMMUG00000007972ENSMMUP00000031469ENSMMUT00000038369
OrganismMacaca mulatta
Functional Description
Protein Length676
Protein Sequence
(FASTA)
MAGLGPGGGD SEGGPRPLFC RKGALRQKVV HEVKSHKFTA RFFKQPTFCS HCTDFIWGIG 60
KQGLQCQVCS FVVHRRCHEF VTFECPGAGK GPQTDVRRSQ HKYFIYSIGL DPHNSSYCQQ 120
LIFLKVTQDM DQERCEMNVH RRCVRSVPSL CGVDHTERRG RLQLEIRAPT ADEIHITVGE 180
ARNLIPMDPN GLSDPYVKLK LIPDPRNLTK QKTRTVKATL NPVWNETFVF NLKPGDVERR 240
LSVEVWDWDR TSRNDFMGAM SFGVSELLKA PVDGWYKLLN QEEGEYYNVP VADADNCSLL 300
QKFEYSRAPP WGAKAASPTD PKRCFFGASP GRLHISDFSF LMVLGKGSFG KVMLAERRGS 360
DELYAIKILK KDVIVQDDDV DCTLVEKRVL ALGGRGPGGR PHFLTQLHST FQTPDRLYFV 420
MEYVTGGDLM YHIQQLGKFK EPHAAFYAAE IAIGLFFLHN QGIIYRDLKL DNVMLDAEGH 480
IKITDFGMCK ENVFPGTTTR TFCGTPDYIA PEIIAYQPYG KSVDWWSFGV LLYEMLAGQP 540
PFDGEDEEEL FQAIMEQTVT YPKSLSREAV AICKGFLTKH PGKRLGSGPD GEPTIRAHGF 600
FRWIDWERLE RLEIPPPFRP RPCGRSGENF DKFFTRAAPA LTPPDRLVLA SIDQADFQGF 660
TYVNPDFVHP DARSPT 676
Nucleotide Sequence
(FASTA)
ATGGCTGGTC TGGGCCCCGG CGGAGGCGAT TCAGAGGGGG GACCCCGGCC CCTGTTTTGC 60
AGAAAGGGGG CTCTGAGGCA GAAGGTGGTC CACGAAGTCA AGAGCCACAA GTTCACCGCT 120
CGCTTCTTCA AGCAGCCCAC CTTCTGCAGC CACTGCACCG ACTTCATCTG GGGTATCGGA 180
AAGCAAGGCC TGCAATGTCA AGTCTGCAGC TTTGTGGTCC ATCGACGATG CCACGAATTT 240
GTGACCTTCG AGTGTCCAGG CGCTGGGAAG GGCCCCCAGA CGGACGTGCG GAGATCCCAA 300
CATAAGTATT TTATATACAG TATAGGATTG GATCCACACA ACAGCTCATA TTGCCAGCAG 360
TTGATCTTCT TAAAAGTAAC GCAAGACATG GATCAAGAGC GCTGCGAGAT GAACGTGCAC 420
CGGCGCTGTG TGCGTAGCGT GCCCTCCCTG TGCGGTGTGG ACCACACCGA GCGCCGCGGG 480
CGCCTGCAGC TGGAGATCCG GGCTCCCACT GCAGATGAGA TCCACATAAC GGTTGGCGAG 540
GCCCGTAACC TTATTCCTAT GGACCCCAAT GGTCTCTCTG ATCCCTATGT GAAACTGAAG 600
CTCATCCCAG ACCCTCGGAA CCTGACGAAA CAGAAAACCC GAACGGTGAA AGCCACGCTA 660
AATCCTGTGT GGAATGAGAC CTTTGTGTTC AACCTGAAGC CTGGGGATGT GGAGCGCCGG 720
CTCAGCGTGG AGGTGTGGGA CTGGGACCGG ACCTCCCGCA ACGACTTCAT GGGTGCCATG 780
TCCTTTGGCG TCTCAGAGCT GCTCAAGGCG CCAGTGGATG GCTGGTACAA GTTACTGAAC 840
CAGGAGGAGG GCGAGTATTA CAATGTGCCG GTGGCCGATG CTGACAACTG CAGCCTCCTC 900
CAGAAGTTTG AGTATTCTCG AGCCCCTCCC TGGGGGGCCA AGGCAGCTAG TCCCACCGAC 960
CCCAAGCGCT GCTTCTTCGG GGCAAGCCCA GGACGTCTGC ACATCTCCGA CTTCAGCTTC 1020
CTCATGGTTC TAGGAAAAGG CAGTTTTGGG AAGGTGATGC TGGCCGAGCG CAGAGGCTCT 1080
GATGAGCTCT ACGCCATCAA AATCCTGAAA AAGGACGTGA TCGTCCAGGA TGACGACGTG 1140
GACTGCACGC TGGTGGAGAA ACGCGTGCTG GCGCTGGGGG GCCGGGGTCC TGGCGGTCGG 1200
CCCCACTTCC TCACCCAACT CCACTCCACC TTCCAGACCC CGGACCGCCT GTATTTCGTG 1260
ATGGAGTACG TCACCGGGGG AGACTTGATG TACCACATTC AACAGCTGGG CAAGTTTAAG 1320
GAGCCCCATG CAGCGTTCTA CGCAGCAGAA ATCGCCATCG GCCTCTTCTT CCTTCACAAT 1380
CAGGGCATCA TCTACAGGGA CCTGAAGCTG GACAATGTGA TGCTGGATGC TGAGGGACAC 1440
ATCAAGATCA CTGACTTCGG CATGTGTAAG GAGAACGTCT TCCCCGGGAC GACAACCCGC 1500
ACCTTCTGCG GGACCCCGGA CTACATAGCC CCGGAGATCA TTGCCTACCA GCCCTATGGG 1560
AAGTCTGTCG ATTGGTGGTC CTTTGGAGTT CTGCTGTATG AGATGTTGGC AGGACAGCCT 1620
CCCTTCGATG GGGAGGACGA AGAGGAGCTG TTTCAGGCCA TCATGGAACA AACTGTCACC 1680
TACCCCAAGT CGCTTTCCCG GGAAGCCGTG GCCATCTGCA AGGGGTTCCT GACCAAGCAC 1740
CCAGGGAAGC GCCTGGGCTC AGGGCCTGAT GGGGAACCTA CCATCCGTGC ACATGGCTTT 1800
TTCCGCTGGA TTGACTGGGA ACGGCTGGAA CGATTGGAGA TCCCGCCTCC TTTCAGACCC 1860
CGCCCGTGTG GCCGCAGCGG CGAGAACTTT GACAAGTTCT TCACGCGGGC GGCGCCAGCG 1920
CTGACCCCTC CAGACCGCCT AGTCCTGGCC AGCATCGACC AGGCCGATTT CCAGGGCTTT 1980
ACCTACGTGA ACCCCGACTT CGTGCATCCG GATGCCCGCA GCCCCACC 2028
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlal.....  55
         f++l+vlGkGsfgkv+lae++++delyaik+lkkdv++qdddv++tlvekrvlal     
Q: 338   FSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALggrgp  397
         89*****************************************************66666
S: 56    askkpflvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkf  115
           +++fl+ql+s+fqt drl+fv+eyv+GGdlm+hiq+ +k+ke++a+fyaaei+++l+f
Q: 398   GGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFF  457
         67889*******************************************************
S: 116   lhekgiiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkee  175
         lh++giiyrdlkldnv+ldaeGhik++dfG+cke+++ g+tt+tfcGtPdyiaPei++++
Q: 458   LHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQ  517
         ************************************************************
S: 176   eygksvdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkgll  235
         +ygksvdww++Gvllyemlagq+Pf+gede+elf++i+e++v+yPksls+eav+i+kg+l
Q: 518   PYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFL  577
         ************************************************************
S: 236   tkdpekrlGvkeegeedikehaff  259
         tk+p krlG+ ++ge +i++h ff
Q: 578   TKHPGKRLGSGPDGEPTIRAHGFF  601
         ***********************8
Domain Sequence
(FASTA)
FSFLMVLGKG SFGKVMLAER RGSDELYAIK ILKKDVIVQD DDVDCTLVEK RVLALGGRGP 60
GGRPHFLTQL HSTFQTPDRL YFVMEYVTGG DLMYHIQQLG KFKEPHAAFY AAEIAIGLFF 120
LHNQGIIYRD LKLDNVMLDA EGHIKITDFG MCKENVFPGT TTRTFCGTPD YIAPEIIAYQ 180
PYGKSVDWWS FGVLLYEMLA GQPPFDGEDE EELFQAIMEQ TVTYPKSLSR EAVAICKGFL 240
TKHPGKRLGS GPDGEPTIRA HGFF 264
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>
EKS-AIM-00164
EKS-ANC-00163
EKS-BOT-00172
EKS-CAJ-00176
EKS-CAF-00179
EKS-CAP-00172
EKS-EQC-00169
EKS-FEC-00162
EKS-GOG-00170
EKS-HOS-00178
EKS-ICT-00167
EKS-LOA-00170
EKS-MUM-00177
EKS-MUP-00176
EKS-NOL-00165
EKS-ORC-00161
EKS-OTG-00178
EKS-POA-00170
EKS-RAN-00167
EKS-SUS-00147
EKS-TUT-00154
Gene Ontology
GO:0005737; C:cytoplasm
GO:0030425; C:dendrite
GO:0005634; C:nucleus
GO:0005886; C:plasma membrane
GO:0097060; C:synaptic membrane
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0007635; P:chemosensory behavior
GO:0060384; P:innervation
GO:0035556; P:intracellular signal transduction
GO:0042177; P:negative regulation of protein catabolic process
GO:0031397; P:negative regulation of protein ubiquitination
GO:0032425; P:positive regulation of mismatch repair
GO:0043278; P:response to morphine
GO:0048265; P:response to pain
GO:0007268; P:synaptic transmission
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013