EKS-MAM-00422

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00422

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/SGK	541.0	9.2E-163	98	355	258

Status

Unreviewed

Ensembl Protein

ENSMMUP00000010660

UniProt Accession

F7GPM7;

Protein Name

Protein Synonyms/Alias

Gene Name

SGK1

Gene Synonyms/Alias

SGK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000008140	ENSMMUP00000033107	ENSMMUT00000040036
ENSMMUG00000008140	ENSMMUP00000033106	ENSMMUT00000040035
ENSMMUG00000008140	ENSMMUP00000010660	ENSMMUT00000011374
ENSMMUG00000008140	ENSMMUP00000003840	ENSMMUT00000004068

Organism

Macaca mulatta

Functional Description

Protein Length

431

Protein Sequence
(FASTA)

MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK HPEVQSILKI 60

SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF LKVIGKGSFG KVLLARHKAE 120

EVFYAVKVLQ KKAILKKKEE KHIMSERNVL LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN 180

GGELFYHLQR ERCFLEPRAR FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD 240

FGLCKENIEH NSTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR 300

NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK SHVFFSLINW 360

DDLINKKITP PFNPNVSGPN DLRHFDPEFT EEPVPNSIGK SPDSILVTAS VKEAAEAFLG 420

FSYAPPTDSF L 431

Nucleotide Sequence
(FASTA)

ATGACGGTGA AAACCGAGGC AGCTAAGGGC ACCCTCACTT ACTCCAGGAT GAGGGGCATG 60

GTGGCAATTC TCATCGCTTT CATGAAGCAA AGGAGGATGG GCCTGAACGA CTTTATTCAG 120

AAGATTGCCA ATAACTCCTA TGCATGCAAA CACCCTGAAG TTCAGTCCAT CTTGAAAATC 180

TCCCAACCTC AGGAGCCTGA GCTTATGAAT GCCAACCCTT CTCCTCCACC AAGTCCTTCT 240

CAGCAAATCA ACCTTGGCCC ATCGTCCAAT CCTCATGCTA AACCATCTGA CTTTCACTTC 300

TTGAAAGTGA TTGGGAAGGG CAGTTTTGGA AAGGTTCTTC TAGCAAGACA CAAGGCAGAA 360

GAAGTATTCT ATGCAGTCAA AGTTTTACAG AAGAAAGCAA TCCTGAAAAA GAAAGAGGAG 420

AAGCATATTA TGTCGGAGCG GAATGTTCTG CTGAAGAATG TGAAACACCC TTTCCTGGTG 480

GGCCTTCACT TCTCTTTCCA GACTGCTGAC AAATTGTACT TTGTCCTAGA CTACATTAAT 540

GGTGGAGAGT TGTTCTACCA TCTCCAGAGG GAACGCTGCT TCCTGGAACC ACGGGCTCGT 600

TTCTATGCTG CTGAAATAGC CAGTGCCTTG GGCTACCTGC ACTCACTGAA CATCGTTTAT 660

AGAGACTTAA AACCAGAGAA TATTTTGCTA GATTCACAGG GACACATTGT CCTTACCGAC 720

TTCGGACTCT GCAAGGAGAA CATTGAACAC AACAGCACGA CATCCACCTT CTGTGGCACG 780

CCGGAGTATC TCGCACCTGA GGTGCTTCAT AAGCAGCCTT ATGACAGGAC CGTGGACTGG 840

TGGTGCCTGG GAGCCGTCTT GTATGAGATG CTGTATGGCC TGCCTCCTTT TTATAGCCGA 900

AACACAGCTG AAATGTACGA CAACATTCTG AACAAGCCCC TCCAGTTGAA ACCAAATATT 960

ACAAATTCCG CAAGACACCT CCTGGAGGGC CTCCTGCAGA AGGACAGGAC GAAGCGGCTG 1020

GGAGCCAAGG ATGACTTTAT GGAGATTAAG AGTCATGTCT TCTTCTCGCT AATTAACTGG 1080

GATGATCTCA TTAATAAGAA GATTACTCCC CCTTTTAACC CAAATGTGAG TGGGCCCAAT 1140

GACCTGCGGC ACTTTGACCC TGAGTTTACT GAAGAGCCTG TCCCCAATTC CATCGGCAAG 1200

TCCCCCGACA GCATCCTCGT CACAGCCAGC GTCAAGGAAG CTGCTGAGGC TTTCCTAGGC 1260

TTTTCCTACG CGCCTCCCAC GGACTCTTTC CTCTGA 1296

Domain Profile

S: 1     fdflkvigkgsfgkvllakrkadekfyavkvlqkkailkkkeekhimaernvllknvkhp  60

         f+flkvigkgsfgkvlla++ka+e+fyavkvlqkkailkkkeekhim+ernvllknvkhp

Q: 98    FHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHP  157

         9***********************************************************

S: 61    flvglhysfqtaeklyfvldyvnggelffhlqrersfleprarfyaaeiasalgylhsln  120

         flvglh+sfqta+klyfvldy+nggelf+hlqrer+fleprarfyaaeiasalgylhsln

Q: 158   FLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLN  217

         ************************************************************

S: 121   ivyrdlkpenilldskghvvltdfglckeeieaedttstfcgtpeylapevlrkkpydrt  180

         ivyrdlkpenillds+gh+vltdfglcke+ie+++ttstfcgtpeylapevl+k+pydrt

Q: 218   IVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNSTTSTFCGTPEYLAPEVLHKQPYDRT  277

         ************************************************************

S: 181   vdwwclgavlyemlyglppfysrdvaemydnilnkplqlkpgisvaalelleellekdrk  240

         vdwwclgavlyemlyglppfysr++aemydnilnkplqlkp+i+++a++lle+ll+kdr+

Q: 278   VDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRT  337

         ************************************************************

S: 241   krlgakedfleiknhvff  258

         krlgak+df+eik+hvff

Q: 338   KRLGAKDDFMEIKSHVFF  355

         *****************9

Domain Sequence
(FASTA)

FHFLKVIGKG SFGKVLLARH KAEEVFYAVK VLQKKAILKK KEEKHIMSER NVLLKNVKHP 60

FLVGLHFSFQ TADKLYFVLD YINGGELFYH LQRERCFLEP RARFYAAEIA SALGYLHSLN 120

IVYRDLKPEN ILLDSQGHIV LTDFGLCKEN IEHNSTTSTF CGTPEYLAPE VLHKQPYDRT 180

VDWWCLGAVL YEMLYGLPPF YSRNTAEMYD NILNKPLQLK PNITNSARHL LEGLLQKDRT 240

KRLGAKDDFM EIKSHVFF 258

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0035091	; F:phosphatidylinositol binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007154	; P:cell communication
GO:0006974	; P:response to DNA damage stimulus

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR001683	; Phox.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013