EPS-MAM-00027

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00027

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	170.2	1.2E-49	276	503	228

Status

Unreviewed

Ensembl Protein

ENSMMUP00000010872

UniProt Accession

F7H947;

Protein Name

Protein Synonyms/Alias

Protein phosphatase 1G;

Gene Name

PPM1G

Gene Synonyms/Alias

PPM1G;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000008293	ENSMMUP00000010875	ENSMMUT00000011600
ENSMMUG00000008293	ENSMMUP00000010872	ENSMMUT00000011597

Organism

Macaca mulatta

Functional Description

Protein Length

547

Protein Sequence
(FASTA)

MGAYLSQPNT VKCSGDGVGA PRLPLPYGFS AMQGWRVSME DAHNCIPELD SETAMFSVYD 60

GHGGEEVALY CAKYLPDIIK DQKAYKEGKL QKALEDAFLA IDAKLTTEEV IKELAQIAGR 120

PTEDEDEKEK VADEDDVDNE EAALLHEEAT MTIEELLTRY GQNCHKGPPH SKSGAGTGEE 180

PGSQGLNGEA GPEDSTRETP SQENGPTAKA YTGFSSNSER GTEAGQVGEP GIPTGEAGPS 240

CSSASDKLPR VAKSKFFEDS EDESDEAEEE EEDSEECSEE EDGYSSEEAE NEEDEDDTEE 300

AEEDDEEEEE EEMMVPGMEG KEEPGSDSGT TAVVALIRGK QLIVANAGDS RCVVSEAGKA 360

LDMSYDHKPE DEVELARIKN AGGKVTMDGR VNGGLNLSRA IGDHFYKRNK NLPPEEQMIS 420

ALPDIKVLTL TDDHEFMVIA CDGIWNVMSS QEVVDFIQSK ISQRDENGEL RLLSSIVEEL 480

LDQCLAPDTS GDGTGCDNMT CIIICFKPRN TAELQPESGK RKLEEVLSTE GAEENGNSDK 540

KKKAKRD 547

Nucleotide Sequence
(FASTA)

ATGGGTGCCT ATCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 60

CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 120

GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT 180

GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 240

GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT 300

ATTGATGCCA AACTGACCAC TGAGGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA 360

CCCACTGAGG ATGAAGATGA AAAGGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 420

GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 480

GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGCTGGGAC AGGCGAGGAA 540

CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT 600

TCACAGGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT 660

GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGAGAGGC TGGGCCTTCC 720

TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 780

GAGGATGAGT CAGATGAGGC GGAGGAGGAA GAGGAAGACA GTGAGGAATG CAGTGAGGAA 840

GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG 900

GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAAGAGATGA TGGTGCCAGG GATGGAAGGC 960

AAAGAGGAGC CTGGCTCTGA CAGTGGTACA ACAGCGGTGG TGGCCCTCAT AAGAGGGAAG 1020

CAGTTGATTG TAGCCAACGC AGGAGACTCT CGCTGTGTGG TATCTGAGGC TGGCAAAGCT 1080

TTAGACATGT CCTATGATCA CAAACCAGAG GATGAAGTAG AACTAGCACG CATCAAGAAT 1140

GCTGGTGGCA AGGTCACCAT GGATGGGCGA GTCAACGGGG GCCTCAACCT CTCCAGAGCC 1200

ATTGGGGACC ACTTCTATAA GAGAAACAAG AACCTGCCAC CTGAGGAACA GATGATTTCA 1260

GCCCTTCCTG ACATCAAGGT GCTGACTCTC ACTGACGACC ATGAATTCAT GGTCATTGCC 1320

TGTGATGGCA TCTGGAATGT GATGAGCAGC CAGGAAGTTG TAGACTTCAT TCAATCAAAG 1380

ATCAGCCAGC GTGATGAAAA TGGGGAGCTT CGGTTATTGT CATCCATTGT GGAAGAGCTG 1440

CTGGATCAGT GCCTGGCACC AGACACTTCT GGGGATGGTA CAGGGTGTGA CAACATGACC 1500

TGCATCATCA TCTGCTTCAA GCCCCGAAAC ACAGCAGAGC TCCAGCCAGA GAGTGGCAAG 1560

CGGAAACTAG AGGAAGTGCT CTCTACTGAG GGGGCTGAAG AAAATGGCAA CAGCGACAAG 1620

AAGAAGAAGG CCAAGCGGGA CTAG 1644

Domain Profile

S: 52    fcseklheilaeelesseseerkvkkalakaFlstdeelkv..leeksldidksGstavv  109

          cse+   +  ee e +e++e++ ++a ++  ++ +ee++v  +e k++  + sG+tavv

Q: 276   ECSEEEDGYSSEEAE-NEEDEDDTEEAEEDDEEEEEEEMMVpgMEGKEEPGSDSGTTAVV  334

         555555555555544.5666666666666666777777744114444445556*******

S: 110   alikdsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvl  169

         ali++++l+van+GdSr+v +  gka+ +s dHkp+ e El+Ri++agg+v+ +   Rv+

Q: 335   ALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDG--RVN  392

         ******************************************************9..***

S: 170   GvLavsRalGdlylk.........pyvtpePevtshrltsedefliLasDGlwdvvsnee  220

         G L++sRa+Gd ++k         +++++ P++ + +lt ++ef+++a+DG+w+v+s++e

Q: 393   GGLNLSRAIGDHFYKrnknlppeeQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQE  452

         ************************************************************

S: 221   avslvrdvle......kkeaeqeaakkLvklalargsk......dnvsaiv  259

         +v+++++ ++      + + ++++ ++L++++la  ++      dn++ i+

Q: 453   VVDFIQSKISqrdengELRLLSSIVEELLDQCLAPDTSgdgtgcDNMTCII  503

         *******99988776666677889999999999999987777777777766

Domain Sequence
(FASTA)

ECSEEEDGYS SEEAENEEDE DDTEEAEEDD EEEEEEEMMV PGMEGKEEPG SDSGTTAVVA 60

LIRGKQLIVA NAGDSRCVVS EAGKALDMSY DHKPEDEVEL ARIKNAGGKV TMDGRVNGGL 120

NLSRAIGDHF YKRNKNLPPE EQMISALPDI KVLTLTDDHE FMVIACDGIW NVMSSQEVVD 180

FIQSKISQRD ENGELRLLSS IVEELLDQCL APDTSGDGTG CDNMTCII 228

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0035970	; P:peptidyl-threonine dephosphorylation

KEGG

mcc:700695

;

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 2.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013