EKS-MAM-00183

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00183

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	452.3	7.4E-136	49	303	255

Status

Unreviewed

Ensembl Protein

ENSMMUP00000010893

UniProt Accession

F7H6T2;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKX

Gene Synonyms/Alias

PRKX;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000008306	ENSMMUP00000010893	ENSMMUT00000011618
ENSMMUG00000008306	ENSMMUP00000041277	ENSMMUT00000048238

Organism

Macaca mulatta

Functional Description

Protein Length

358

Protein Sequence
(FASTA)

MEAPGLAEAA AAESDPRKVA EETPDGAPAL CPSPEARSPE PPAYRLQDFD TLATVGTGTF 60

GRVHLVKEKT AKHFFALKVM SIPDVIRLKQ EQHVHNEKSV LKEVSHPFLI RLFWTWHDER 120

FLYMLMEYVP GGELFSYLRN RGRFSSTTGL FYSAEIICAI EYLHSKEIVY RDLKPENILL 180

DRDGHIKLTD FGFAKKLVDR TWTLCGTPEY LAPEVIQSKG HGRAVDWWAL GILIFEMLSG 240

FPPFFDDNPF GIYQKILAGK IDFPRHLDFH VKDLIKKLLV VDRTRRLGNM KNGANDVKRH 300

RWFHSVDWEA VPQRKLKPPI VPKIAGDGDT SNFETYPEND WDTAAPVPQK DLEIFKNF 358

Nucleotide Sequence
(FASTA)

ATGGAGGCGC CCGGGCTGGC CGAGGCGGCC GCGGCGGAGA GCGACCCCCG CAAGGTGGCG 60

GAGGAGACCC CCGACGGGGC GCCCGCGCTC TGCCCCAGCC CCGAGGCGCG GTCGCCGGAG 120

CCGCCTGCCT ACCGCCTGCA GGACTTTGAC ACGCTGGCCA CCGTGGGCAC TGGGACGTTC 180

GGGCGGGTGC ACCTGGTGAA GGAGAAGACA GCCAAGCATT TCTTCGCTCT CAAGGTGATG 240

AGCATTCCCG ATGTCATCCG CCTGAAGCAG GAGCAGCACG TGCACAATGA GAAGTCTGTC 300

CTGAAGGAAG TCAGTCACCC GTTTCTCATC AGGCTGTTCT GGACGTGGCA TGACGAGCGC 360

TTCCTCTACA TGCTCATGGA GTATGTGCCG GGCGGGGAGC TCTTCAGCTA CCTGCGCAAC 420

CGGGGGCGCT TCTCCAGCAC CACGGGGCTC TTCTACTCTG CGGAGATCAT CTGTGCCATC 480

GAGTACCTGC ACTCCAAGGA GATCGTCTAC AGAGACTTGA AGCCGGAGAA CATCCTGCTG 540

GATAGGGATG GCCACATCAA GCTCACGGAC TTTGGGTTCG CCAAGAAGCT GGTAGACAGG 600

ACTTGGACCC TCTGTGGAAC ACCCGAGTAC CTGGCCCCGG AAGTCATTCA GAGCAAGGGC 660

CACGGAAGGG CCGTGGACTG GTGGGCCCTC GGCATCCTGA TATTCGAGAT GCTCTCGGGG 720

TTTCCTCCGT TTTTTGATGA CAACCCGTTT GGCATTTATC AGAAAATTCT TGCAGGCAAA 780

ATAGATTTCC CCAGACATTT GGATTTCCAT GTAAAAGACC TCATTAAGAA ACTGCTCGTG 840

GTTGACAGAA CAAGGCGATT AGGAAACATG AAGAACGGGG CAAATGATGT GAAACGCCAT 900

CGGTGGTTCC ACTCTGTGGA CTGGGAAGCT GTTCCGCAGA GAAAACTGAA GCCCCCCATC 960

GTGCCCAAGA TAGCTGGCGA CGGCGACACT TCCAACTTCG AAACTTACCC CGAGAATGAC 1020

TGGGACACAG CTGCACCCGT GCCGCAGAAG GATTTAGAAA TCTTCAAGAA TTTCTGA 1077

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         f++l+t+GtG+fGrv+lv+ek++k+++alkv+s+ +v++lkq +hv+nek+vlk+v++pf

Q: 49    FDTLATVGTGTFGRVHLVKEKTAKHFFALKVMSIPDVIRLKQEQHVHNEKSVLKEVSHPF  108

         7899********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         l++l+++++de++ly+++eyv+GGelfsylr+++rfs++++ fy+aei++a+eylhs+++

Q: 109   LIRLFWTWHDERFLYMLMEYVPGGELFSYLRNRGRFSSTTGLFYSAEIICAIEYLHSKEI  168

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         +yrdlkpen+lld++G+ik+tdfGfakk+ drtwtlcGtpeylape+iqskg+++avdww

Q: 169   VYRDLKPENILLDRDGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWW  228

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alG+li+e+l+G+ppffdd+p+ iy+ki++gk++fp++l+ ++kdl+kkll+vd+t+rlg

Q: 229   ALGILIFEMLSGFPPFFDDNPFGIYQKILAGKIDFPRHLDFHVKDLIKKLLVVDRTRRLG  288

         ************************************************************

S: 241   nlkngvedikehkwf  255

         n+kng++d+k+h+wf

Q: 289   NMKNGANDVKRHRWF  303

         **************9

Domain Sequence
(FASTA)

FDTLATVGTG TFGRVHLVKE KTAKHFFALK VMSIPDVIRL KQEQHVHNEK SVLKEVSHPF 60

LIRLFWTWHD ERFLYMLMEY VPGGELFSYL RNRGRFSSTT GLFYSAEIIC AIEYLHSKEI 120

VYRDLKPENI LLDRDGHIKL TDFGFAKKLV DRTWTLCGTP EYLAPEVIQS KGHGRAVDWW 180

ALGILIFEML SGFPPFFDDN PFGIYQKILA GKIDFPRHLD FHVKDLIKKL LVVDRTRRLG 240

NMKNGANDVK RHRWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013