EKS-MAM-00439

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00439

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	495.2	7.7E-149	76	342	267

Status

Unreviewed

Ensembl Protein

ENSMMUP00000010991

UniProt Accession

F7HMH6;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPB

Gene Synonyms/Alias

CDC42BPB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000008380	ENSMMUP00000010991	ENSMMUT00000011721

Organism

Macaca mulatta

Functional Description

Protein Length

1705

Protein Sequence
(FASTA)

MSAKVRLKKL EQLLLDGPWR NESALSVETL LDVLVCLYTE CSHSALRRDK YVAEFLEWAK 60

PFTQLVKEMQ LHREDFEIIK VIGRGAFGEV AVVKMKNTER IYAMKILNKW EMLKRAETAC 120

FREERDVLVN GDCQWITALH YAFQDENHLY LVMDYYVGGD LLTLLSKFED KLPEDMARFY 180

IGEMVLAIDS IHQLHYVHRD IKPDNVLLDV NGHIRLADFG SCLKMNDDGT VQSSVAVGTP 240

DYISPEILQA MEDGMGKYGP ECDWWSLGVC MYEMLYGETP FYAESLVETY GKIMNHEERF 300

QFPSHVTDVS EEAKDLIQRL ICSRERRLGQ NGIEDFKKHA FFEGLNWENI RNLEAPYIPD 360

VSSPSDTSNF DVDDDVLRNT EILPPGSHTG FSGLHLPFIG FTFTTESCFS DRGSLKSIMQ 420

SNTLTKDEDV QRDLEHSLQM EAYERRIRRL EQEKLELSRK LQESTQTVQS LHGSSRALSN 480

SNRDKEIKKL NEEIERLKNK IADSNRLERQ LEDTVALRQE REDSTQRLRG LEKQHRVVRQ 540

EKEELHKQLV EASERLKSQA KELKDAHQQR KLALQEFSEL NERMAELRAQ KQKVSRQLRD 600

KEEEMEVATQ KVDAMRQEMR RAEKLRKELE AQLDDAVAEA SKERKLREHS ENFCKQMESE 660

LEALKMKQGG RGAGATLEHQ QEISKIKSEL EKKVLFYEEE LVRREASHVL EVKNVKKEVH 720

DSESHQLALQ KEILMLKDKL EKSRRERHNE MEEAVGTVKD KYERERAMLF DENKKLTAEN 780

EKLCSFVDKL TAQNRQLEDE LQDLAAKKES VAHWEAQIAE IIQWVSDEKD ARGYLQALAS 840

KMTEELEALR SSSLGSRTLD PLWKVRRSQK LDMSARLELQ SALEAEIRAK QLVQEELRKV 900

KDANLTLESK LKDSEAKNRE LLEEMEILKK KMEEKFRADT GLKLPDFQDS IFEYFNTAPL 960

AHDLTFRTSS ASEQETQAPK PETSPSMSVA ASEQQEDMAR PPQRPSAVPL PTTQALALAG 1020

PKPKAHQFSI KSFSSPTQCS HCTSLMVGLI RQGYACEVCS FACHVSCKDS APQVCPIPPE 1080

QSKRPLGVDV QRGIGTAYKG HVKVPKPTGV KKGWQRAYAV VCDCKLFLYD LPEGKSTQPG 1140

VIASQVLDLR SVEVDTSAPV APGVRGSSRA VAAVCSFGVT ASLLGAPSKT SSLLILTENE 1200

NEKRKWVGIL EGLQSILHKN RLRNQVVHVP LEAYDSSLPL IKAVLTAAIV DADRIAVGLE 1260

EGLYVIEVTR DVIVRAADCK KVHQIELAPR EKIVILLCGR NHHVHLYPWS SLDGAEGSFD 1320

IKLPETKGCQ LMATATLKRN SGTCLFVAVK RLILCYEIQR TKPFHRKFNE IVAPGSVQCL 1380

AVLRDRLCVG YPSGFCLLSI QGDGQPLNLV NPNDPSLAFL SQQSFDALCA VELESEEYLL 1440

CFSHMGLYVD PQGRRARAQE FMWPAAPVAC SCSPTHVTVY SEYGVDVFDV RTMEWVQTIG 1500

LRRIRPLNSE GTLNLLNCEP PRLIYFKSKF SGAVLNVPDT SDNSKKQMLR TRSKRRFVFK 1560

VPEEERLQQR REMLRDPELR SKMISNPTNF NHVAHMGPGD GMQVLMDLPL SAVPPSQEER 1620

PGPAPTNLAR QPPSRNKPYI SWPSSGTEEV AVVFTLPSSC SQPDSDSTKH STPSNSSNPS 1680

GPPSPNSPHR SQLPLEGLEQ PACDT 1705

Nucleotide Sequence
(FASTA)

ATGTCGGCCA AGGTGCGGCT CAAGAAGCTG GAGCAGCTGC TCCTGGACGG GCCCTGGCGC 60

AACGAGAGCG CCCTGAGCGT GGAGACGCTG CTTGACGTGC TCGTCTGCCT GTACACCGAG 120

TGCAGCCACT CGGCCCTGCG CCGCGACAAG TACGTGGCCG AGTTCCTCGA GTGGGCTAAA 180

CCATTTACAC AGCTGGTGAA AGAAATGCAG CTTCATCGAG AAGACTTTGA AATAATTAAA 240

GTAATTGGAA GAGGTGCTTT TGGTGAGGTT GCTGTTGTCA AAATGAAGAA TACTGAACGA 300

ATTTATGCAA TGAAAATCCT CAACAAGTGG GAGATGCTGA AAAGAGCAGA GACCGCGTGC 360

TTCCGAGAGG AGCGCGATGT GCTGGTGAAC GGCGACTGCC AGTGGATCAC CGCGCTGCAC 420

TACGCCTTTC AGGACGAGAA CCACCTGTAC TTAGTCATGG ATTACTATGT GGGTGGTGAT 480

TTACTGACCC TGCTCAGCAA ATTTGAAGAC AAGCTTCCAG AAGATATGGC GAGGTTCTAC 540

ATTGGTGAAA TGGTGCTGGC CATTGACTCC ATCCATCAGC TTCATTACGT GCACAGAGAC 600

ATTAAACCTG ACAATGTCCT TTTGGACGTG AATGGTCATA TCCGCCTGGC TGACTTTGGA 660

TCATGTTTGA AGATGAATGA TGATGGAACT GTGCAGTCCT CCGTGGCCGT GGGCACCCCT 720

GACTACATCT CGCCGGAGAT CCTGCAGGCG ATGGAGGACG GCATGGGCAA ATACGGGCCT 780

GAGTGTGACT GGTGGTCTCT GGGGGTCTGC ATGTATGAGA TGCTCTATGG AGAAACGCCG 840

TTTTATGCGG AGTCACTCGT GGAGACCTAC GGGAAGATCA TGAACCATGA AGAGCGATTC 900

CAGTTCCCGT CCCATGTCAC GGATGTTTCT GAAGAAGCGA AGGACCTCAT CCAGAGACTG 960

ATCTGCAGTA GAGAGCGCCG GCTGGGGCAG AATGGAATAG AGGATTTCAA AAAGCATGCG 1020

TTTTTTGAAG GTCTGAATTG GGAAAATATA CGAAACCTAG AAGCACCTTA CATTCCCGAC 1080

GTGAGCAGTC CCTCTGACAC ATCCAACTTT GACGTGGACG ACGATGTGCT GAGAAACACG 1140

GAAATATTAC CTCCTGGTTC TCACACAGGC TTTTCTGGAT TACATTTGCC ATTCATTGGT 1200

TTTACATTCA CAACAGAAAG CTGTTTTTCT GATCGAGGCT CTCTGAAGAG CATAATGCAG 1260

TCCAACACAT TAACCAAAGA TGAGGATGTG CAGCGGGACC TGGAGCACAG CCTGCAGATG 1320

GAAGCTTACG AGAGGAGGAT TCGGAGGCTG GAACAGGAGA AGCTGGAGCT GAGCAGGAAG 1380

CTGCAAGAGT CCACCCAGAC CGTGCAGTCC CTCCACGGCT CATCTCGGGC CCTCAGCAAT 1440

TCAAACCGAG ATAAAGAAAT CAAGAAGCTA AATGAAGAAA TCGAACGCTT GAAGAATAAA 1500

ATAGCAGATT CAAACAGGCT CGAGCGACAG CTTGAGGACA CAGTGGCGCT TCGCCAGGAG 1560

CGTGAGGACT CCACGCAGCG GCTGCGGGGG CTGGAGAAGC AGCACCGCGT GGTCCGGCAG 1620

GAGAAGGAGG AGCTGCACAA GCAACTGGTT GAAGCCTCGG AGCGGTTGAA ATCCCAGGCC 1680

AAGGAACTCA AAGATGCCCA TCAGCAGCGA AAGCTGGCCC TGCAGGAATT CTCGGAGCTG 1740

AATGAGCGCA TGGCAGAGCT CCGTGCCCAG AAGCAGAAGG TGTCCCGGCA GCTGCGGGAC 1800

AAGGAGGAAG AGATGGAGGT GGCCACGCAG AAGGTGGACG CCATGCGGCA GGAGATGCGG 1860

AGAGCCGAGA AGCTCAGGAA AGAGCTGGAA GCTCAGCTTG ATGATGCTGT TGCTGAGGCC 1920

TCCAAGGAGC GCAAGCTTCG TGAGCACAGT GAGAACTTCT GCAAGCAAAT GGAAAGCGAG 1980

CTGGAGGCCC TCAAGATGAA GCAAGGAGGC CGGGGAGCAG GTGCCACTTT AGAGCACCAG 2040

CAAGAGATTT CCAAAATCAA ATCCGAGCTG GAGAAGAAAG TCTTATTTTA TGAAGAGGAA 2100

TTGGTCAGAC GTGAGGCCTC CCATGTGCTC GAAGTGAAAA ATGTGAAGAA GGAGGTGCAT 2160

GATTCAGAAA GCCACCAGCT GGCCCTGCAG AAAGAAATCT TGATGTTAAA AGATAAGTTA 2220

GAAAAGTCAA GGAGAGAACG GCATAACGAG ATGGAGGAGG CGGTAGGTAC AGTAAAAGAT 2280

AAATACGAAC GAGAAAGAGC AATGCTATTT GATGAAAACA AGAAGCTAAC CGCTGAAAAT 2340

GAAAAGCTCT GTTCCTTTGT GGATAAACTC ACAGCTCAAA ATAGACAGCT GGAGGATGAG 2400

CTGCAGGATC TGGCAGCCAA GAAGGAGTCG GTGGCCCACT GGGAAGCTCA GATTGCGGAA 2460

ATCATTCAGT GGGTCAGCGA CGAGAAAGAT GCCCGGGGCT ACCTTCAAGC TCTTGCTTCC 2520

AAGATGACCG AAGAGCTCGA GGCTTTGAGG AGTTCTAGTC TGGGGTCAAG AACACTGGAT 2580

CCACTGTGGA AGGTGCGCCG CAGCCAGAAG CTGGACATGT CCGCGCGGCT GGAGCTGCAG 2640

TCGGCCCTGG AGGCGGAGAT CCGGGCCAAG CAGCTTGTCC AGGAGGAGCT GAGGAAGGTC 2700

AAGGATGCCA ACCTCACCTT GGAAAGCAAA CTAAAGGACT CTGAAGCCAA AAACAGAGAA 2760

TTATTAGAAG AAATGGAAAT TTTGAAGAAA AAGATGGAAG AAAAATTCAG AGCAGATACT 2820

GGGCTCAAAC TTCCAGATTT TCAGGATTCC ATTTTTGAGT ATTTCAACAC TGCACCCCTT 2880

GCACATGACC TGACATTTAG AACCAGCTCA GCTAGTGAGC AAGAAACACA AGCTCCGAAG 2940

CCAGAAACGT CCCCGTCGAT GTCTGTGGCT GCATCAGAGC AACAGGAGGA CATGGCTCGG 3000

CCCCCGCAGA GGCCATCCGC TGTGCCGTTG CCCACCACGC AGGCCCTGGC TCTGGCTGGA 3060

CCGAAGCCGA AAGCTCACCA GTTCAGCATC AAGTCCTTCT CCAGCCCTAC TCAGTGCAGC 3120

CACTGCACCT CCCTGATGGT TGGGCTGATC CGGCAGGGCT ACGCCTGCGA GGTGTGTTCT 3180

TTTGCTTGCC ACGTGTCCTG CAAAGACAGC GCCCCCCAGG TGTGCCCAAT ACCTCCTGAG 3240

CAGTCCAAGA GGCCTCTGGG CGTGGATGTG CAGCGAGGCA TCGGAACAGC CTACAAAGGC 3300

CATGTCAAGG TCCCAAAGCC CACGGGGGTG AAGAAGGGAT GGCAGCGTGC ATATGCAGTC 3360

GTCTGTGACT GCAAGCTCTT CCTGTATGAT CTGCCTGAAG GAAAATCCAC CCAGCCTGGT 3420

GTCATTGCGA GCCAAGTCTT GGATCTCAGG TCTGTTGAGG TGGACACATC AGCCCCCGTT 3480

GCTCCTGGGG TGCGTGGCTC CAGCAGGGCC GTGGCAGCTG TGTGCAGCTT TGGTGTGACG 3540

GCCTCTCTCT TAGGTGCACC TTCTAAGACC AGCTCGCTGC TCATTCTGAC AGAAAATGAG 3600

AATGAAAAGA GGAAGTGGGT TGGGATTCTA GAAGGACTCC AGTCCATCCT TCATAAAAAC 3660

CGGCTGAGGA ATCAGGTCGT GCATGTTCCC TTGGAAGCCT ACGACAGCTC GCTGCCTCTC 3720

ATCAAGGCCG TCCTAACAGC TGCCATCGTG GATGCAGACA GGATTGCAGT CGGCCTAGAA 3780

GAAGGGCTCT ATGTCATAGA GGTCACCCGA GATGTGATCG TCCGTGCCGC TGACTGTAAG 3840

AAGGTGCACC AGATCGAGCT TGCTCCCAGA GAGAAGATCG TAATCCTCCT CTGTGGCCGG 3900

AACCACCATG TGCACCTCTA TCCATGGTCA TCCCTTGATG GAGCGGAAGG CAGTTTTGAC 3960

ATCAAGCTTC CGGAAACCAA AGGCTGCCAG CTCATGGCCA CGGCCACACT CAAGAGGAAC 4020

TCTGGCACCT GCCTGTTTGT GGCCGTGAAA CGGCTGATCC TTTGCTATGA GATCCAGAGA 4080

ACGAAGCCAT TCCACAGAAA GTTCAATGAG ATTGTGGCTC CCGGCAGCGT GCAGTGCCTG 4140

GCGGTGCTCA GGGACAGGCT CTGTGTGGGC TACCCCTCGG GGTTCTGCCT GCTGAGCATC 4200

CAGGGGGACG GGCAGCCTCT AAACCTGGTA AATCCCAATG ACCCCTCGCT TGCGTTCCTC 4260

TCACAACAGT CTTTTGATGC CCTTTGTGCT GTGGAGCTCG AAAGCGAGGA GTACCTGCTT 4320

TGCTTCAGCC ACATGGGACT GTACGTGGAC CCGCAAGGCC GGAGGGCACG CGCGCAGGAG 4380

TTCATGTGGC CTGCGGCTCC TGTCGCCTGT AGTTGCAGCC CCACCCACGT CACGGTGTAC 4440

AGCGAGTATG GCGTGGACGT CTTTGATGTG CGCACCATGG AGTGGGTGCA GACCATCGGC 4500

CTGCGCAGGA TAAGGCCCCT GAACTCTGAG GGCACCCTGA ACCTCCTCAA CTGTGAGCCT 4560

CCACGCTTGA TCTACTTCAA GAGCAAGTTC TCGGGAGCGG TTCTCAACGT GCCGGACACC 4620

TCCGACAACA GCAAGAAGCA GATGCTGCGC ACCAGGAGCA AAAGGCGGTT CGTCTTCAAG 4680

GTCCCGGAGG AAGAGAGACT GCAGCAGAGG CGAGAGATGC TTAGAGACCC AGAATTGAGA 4740

TCCAAAATGA TATCCAACCC AACCAACTTC AACCACGTGG CTCACATGGG CCCAGGCGAC 4800

GGCATGCAGG TGCTCATGGA CCTGCCTCTG AGTGCTGTGC CCCCCTCCCA GGAGGAAAGG 4860

CCGGGCCCCG CTCCCACCAA CCTGGCTCGC CAGCCTCCGT CCCGGAACAA GCCCTACATC 4920

TCGTGGCCCT CATCAGGTAC GGAGGAAGTG GCAGTGGTGT TCACCCTGCC CTCTTCCTGT 4980

TCACAGCCTG ATTCGGACTC CACCAAACAC TCAACTCCAT CGAACAGCTC CAACCCCAGC 5040

GGCCCACCGA GCCCCAACTC CCCCCACAGG AGCCAGCTCC CCCTCGAAGG CCTGGAGCAG 5100

CCGGCCTGTG ACACCTGA 5118

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         fei+kviGrGafgevavv++k+te++yamkil+k+e+lkrae+a+freerdvlv++d++w

Q: 76    FEIIKVIGRGAFGEVAVVKMKNTERIYAMKILNKWEMLKRAETACFREERDVLVNGDCQW  135

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde++lylvm+y+vGGdlltllsk+edklpe++arfy+ e+vla+ds+h+l+

Q: 136   ITALHYAFQDENHLYLVMDYYVGGDLLTLLSKFEDKLPEDMARFYIGEMVLAIDSIHQLH  195

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdn+lld++Ghi+ladfGsclk+n+dgtv+ssvavGtpdyispe+l+a+e+g+

Q: 196   YVHRDIKPDNVLLDVNGHIRLADFGSCLKMNDDGTVQSSVAVGTPDYISPEILQAMEDGM  255

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nh+e+++fp+++ +vseeakd

Q: 256   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHEERFQFPSHVtDVSEEAKD  315

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+kkh+ff

Q: 316   LIQRLICSRERRLGQNGIEDFKKHAFF  342

         **************************9

Domain Sequence
(FASTA)

FEIIKVIGRG AFGEVAVVKM KNTERIYAMK ILNKWEMLKR AETACFREER DVLVNGDCQW 60

ITALHYAFQD ENHLYLVMDY YVGGDLLTLL SKFEDKLPED MARFYIGEMV LAIDSIHQLH 120

YVHRDIKPDN VLLDVNGHIR LADFGSCLKM NDDGTVQSSV AVGTPDYISP EILQAMEDGM 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HEERFQFPSH VTDVSEEAKD 240

LIQRLICSRE RRLGQNGIED FKKHAFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0046872	; F:metal ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013