EKS-MAM-00467

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00467

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	346.4	2.0E-103	20	316	297

Status

Unreviewed

Ensembl Protein

ENSMMUP00000011143

UniProt Accession

F6TGJ6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK6

Gene Synonyms/Alias

MAPK6;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000008503	ENSMMUP00000011143	ENSMMUT00000011883

Organism

Macaca mulatta

Functional Description

Protein Length

721

Protein Sequence
(FASTA)

MAEKFESLMN IHGFDLGSRY MDLKPLGCGG NGLVFSAVDN DCDKRVAIKK IVLTDPQSVK 60

HALREIKIIR RLDHDNIVKV FEILGPSGSQ LTDDVGSLTE LNSVYIVQEY METDLANVLE 120

QGPLLEEHAR LFMYQLLRGL KYIHSANVLH RDLKPANLFI NTEDLVLKIG DFGLARIMDP 180

HYSHKGHLSE GLVTKWYRSP RLLLSPNNYT KAIDMWAAGC IFAEMLTGKT LFAGAHELEQ 240

MQLILESIPV VHEEDRQELL SVIPVYIRND MTEPHKPLTQ LLPGISREAL DFLEQILTFS 300

PMDRLTAEEA LSHPYMSIYS FPMDEPISSH PFHIEDEVDD ILLMDETHSH IYNWERYHDC 360

QFSEHDWPIH NNFDIDEVQL DPRALSDVTD EEEVQVDPRK YLDGDREKYL EDPAFDTSYS 420

TEPCWQYSDH HENKYCDLEC SHTCNYKMRS SSYLDNLVWR ESEVNHYYEP KLIIDLSNWK 480

EQSKEKSDKK GKSKCERNGL VKAQIALEEA SQQLAGKERE KNQGFDFDSF IAGTIQLSSQ 540

HEPTDVVDKL NDLNSSVSQL ELKSLISKSV SQEKQEKGMA NLAQLEALYQ SSWDSQFVSG 600

GEDCFFINQF CEVRKDEQVE KENTYTSYLD KFFSRKEDTE MLETEPVEDG KLGERGHEAG 660

FLNNSGEFLF NKQLESIGIP QFHSPVGSPL KSIQATLTPS AMKSSPQIPH KTYSSILKHL 720

N 721

Nucleotide Sequence
(FASTA)

ATGGCAGAGA AGTTTGAAAG TCTCATGAAC ATTCATGGTT TTGATCTGGG TTCTAGGTAT 60

ATGGACTTAA AACCATTGGG TTGTGGAGGC AATGGCTTGG TTTTTTCTGC TGTAGACAAT 120

GACTGTGACA AAAGAGTAGC CATCAAGAAA ATTGTCCTTA CTGATCCCCA GAGTGTCAAA 180

CATGCTCTAC GTGAAATCAA AATTATTAGA AGACTTGACC ATGATAACAT TGTGAAAGTG 240

TTTGAAATTC TTGGTCCTAG TGGAAGCCAA TTAACAGACG ATGTGGGCTC TCTTACGGAA 300

CTGAACAGTG TTTACATTGT TCAGGAGTAC ATGGAGACAG ACTTGGCTAA TGTGCTGGAG 360

CAGGGCCCTT TACTGGAAGA GCATGCCAGG CTGTTCATGT ATCAGCTGCT ACGGGGGCTC 420

AAGTATATTC ACTCTGCAAA CGTACTGCAC AGAGATCTCA AACCAGCTAA TCTTTTCATT 480

AATACTGAAG ACTTGGTGCT GAAGATAGGT GACTTTGGTC TTGCACGGAT CATGGATCCT 540

CATTATTCCC ATAAGGGTCA TCTTTCTGAA GGATTGGTTA CTAAATGGTA CAGATCTCCA 600

CGTCTTTTAC TTTCTCCTAA TAATTATACT AAAGCCATTG ACATGTGGGC TGCAGGCTGC 660

ATCTTTGCTG AAATGCTGAC TGGTAAAACC CTTTTTGCAG GTGCACATGA ACTTGAACAG 720

ATGCAGCTGA TTTTAGAATC TATTCCTGTT GTACATGAGG AAGATCGTCA GGAGCTTCTC 780

AGTGTAATTC CAGTTTACAT TAGAAATGAC ATGACTGAGC CACACAAACC TTTAACTCAG 840

CTGCTTCCAG GAATTAGTCG AGAAGCACTG GATTTCCTGG AACAAATTTT GACATTTAGT 900

CCCATGGATC GGTTAACAGC AGAAGAAGCT CTCTCCCATC CTTACATGAG CATATATTCT 960

TTTCCAATGG ATGAGCCAAT TTCAAGCCAT CCTTTTCATA TTGAAGATGA AGTTGATGAT 1020

ATTTTGCTTA TGGATGAAAC TCACAGTCAC ATTTATAACT GGGAAAGGTA TCATGATTGT 1080

CAGTTTTCAG AGCATGATTG GCCTATACAT AACAACTTTG ATATTGATGA GGTTCAGCTT 1140

GATCCAAGAG CTCTGTCCGA TGTCACTGAT GAAGAAGAAG TACAAGTTGA TCCCCGAAAA 1200

TATTTGGATG GAGATCGGGA AAAGTATCTA GAGGATCCTG CTTTTGATAC CAGTTACTCT 1260

ACTGAGCCTT GTTGGCAATA CTCAGATCAT CATGAAAACA AATATTGTGA TCTGGAGTGT 1320

AGCCATACTT GTAACTACAA AATGAGGTCG TCATCGTATT TAGATAACTT AGTTTGGAGA 1380

GAAAGTGAAG TTAACCATTA CTATGAACCC AAGCTTATTA TAGATCTTTC CAATTGGAAA 1440

GAACAAAGCA AAGAAAAATC TGATAAGAAA GGCAAATCAA AATGTGAAAG GAATGGATTG 1500

GTTAAAGCCC AGATAGCGCT AGAGGAAGCA TCACAGCAAC TGGCTGGAAA AGAAAGGGAA 1560

AAGAATCAGG GATTTGATTT TGATTCCTTT ATTGCAGGAA CTATTCAACT TAGTTCCCAA 1620

CATGAGCCTA CTGATGTTGT TGATAAATTA AATGACTTGA ATAGCTCAGT GTCCCAACTA 1680

GAATTGAAAA GTTTGATATC AAAGTCAGTA AGCCAGGAAA AACAGGAAAA AGGAATGGCA 1740

AATCTGGCTC AATTAGAAGC CTTGTACCAA TCTTCTTGGG ACAGCCAGTT TGTGAGTGGT 1800

GGGGAGGACT GTTTTTTCAT CAATCAGTTT TGTGAGGTAA GGAAGGATGA ACAAGTTGAG 1860

AAGGAAAACA CTTACACTAG TTACTTGGAC AAGTTCTTTA GCAGGAAAGA AGATACTGAA 1920

ATGCTAGAAA CTGAGCCAGT AGAGGATGGG AAGCTTGGGG AGAGAGGACA TGAGGCAGGA 1980

TTTCTGAACA ACAGTGGGGA GTTCCTCTTC AACAAGCAGC TTGAGTCCAT AGGCATCCCG 2040

CAGTTTCACA GTCCAGTTGG GTCACCACTT AAGTCAATAC AGGCCACATT AACACCTTCT 2100

GCTATGAAAT CTTCCCCTCA AATTCCTCAT AAAACATACA GCAGCATTCT GAAACATCTG 2160

AACTAA 2166

Domain Profile

S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60

         y++lkplg G +g+v+savd+++++rvaikk++  +++ +s+k++lRE+k++++l+h+Ni

Q: 20    YMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIV--LTDPQSVKHALREIKIIRRLDHDNI  77

         7899****************************9..9************************

S: 61    iklldvftpee........eleelkdvYlvtelmetdLkkviksqklsdehiklllyqil  112

         +k+++++ p+         +l+el++vY+v+e+metdL++v+++  l +eh++l++yq+l

Q: 78    VKVFEILGPSGsqltddvgSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLL  137

         *********999999999999***************************************

S: 113   rglkylHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwY  169

         rglky+Hsanv+HrDlKP+Nl++n++   lki dFGlar++d+++++k  l+e ++t+wY

Q: 138   RGLKYIHSANVLHRDLKPANLFINTEDLvLKIGDFGLARIMDPHYSHKghLSEGLVTKWY  197

         ************************876449**************999999**********

S: 170   raPeillslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflk  229

         r+P++lls ++ytka+D+W++GCI+aE+ltgk+lf+g++e++q+++ile ++ ++ee+ +

Q: 198   RSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQ  257

         ************************************************************

S: 230   kieseearnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++ s  +  yi++ +++++k++++l+p  s+eald+le++L+++p++R+++eeaL+hpY+

Q: 258   ELLSV-IPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYM  316

         ****5.*****************************************************7

Domain Sequence
(FASTA)

YMDLKPLGCG GNGLVFSAVD NDCDKRVAIK KIVLTDPQSV KHALREIKII RRLDHDNIVK 60

VFEILGPSGS QLTDDVGSLT ELNSVYIVQE YMETDLANVL EQGPLLEEHA RLFMYQLLRG 120

LKYIHSANVL HRDLKPANLF INTEDLVLKI GDFGLARIMD PHYSHKGHLS EGLVTKWYRS 180

PRLLLSPNNY TKAIDMWAAG CIFAEMLTGK TLFAGAHELE QMQLILESIP VVHEEDRQEL 240

LSVIPVYIRN DMTEPHKPLT QLLPGISREA LDFLEQILTF SPMDRLTAEE ALSHPYM 297

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013