EKS-MAM-00464
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00464
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK405.22.4E-12155347293
StatusUnreviewed
Ensembl ProteinENSMMUP00000011191
UniProt AccessionF6WBZ5;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK7
Gene Synonyms/Alias MAPK7;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000008536ENSMMUP00000011194ENSMMUT00000011935
ENSMMUG00000008536ENSMMUP00000011193ENSMMUT00000011934
ENSMMUG00000008536ENSMMUP00000011191ENSMMUT00000011932
OrganismMacaca mulatta
Functional Description
Protein Length816
Protein Sequence
(FASTA)
MAEPLKEEDG EDGSAEPPGP VKAEPAHTAA SVAAKNLALL KARSFDVTFD VGDEYEIIET 60
IGNGAYGVVS SARRRLTGQQ VAIKKIPNAF DVVTNAKRTL RELKILKHFK HDNIIAIKDI 120
LRPTVPYGEF KSVYVVLDLM ESDLHQIIHS SQPLTLEHVR YFLYQLLRGL KYMHSAQVIH 180
RDLKPSNLLV NENCELKIGD FGMARGLCTS PAEHQYFMTE YVATRWYRAP ELMLSLHEYT 240
QAIDLWSVGC IFGEMLARRQ LFPGKNYVHQ LQLIMMVLGT PSPAVIQAVG AERVRAYIQS 300
LPPRQPVPWE TVYPGADRQA LSLLGRMLRF EPSARISAAA ALRHPFLAKY HDPDDEPDCA 360
PPFDFAFDRE ALTRERIKEA IVAEIEDFHA RREGIRQQIR FQPSLQPVAS EPGCPDVEMP 420
SPWAPSGDCA MESPPPAPPP CPGPGPDTID LTLQPPPPAS EPAPPKKEGA ISDNTKAALK 480
AALLKSLRSR LRDGPSAPLE ASEPRKPVTA QERQREREEK RRRRQERAKE REKRRQERER 540
KERGAGASGG PSTDPLAGLV LSDNDRSLLE RWTRMARPPA PAPTSVPAPA PVPTPTPAQP 600
ASPPPGPVAQ PTGPQPQPQP VGSTSGPVPQ PACPPPGPAA HPTGPPRPIP VPAPPQIATS 660
TSLLAPQSLV PPPGLPGSNT PGVLPYFPPG LPPTDAGGAP QSSMSESPDV NLVTQQLSKS 720
QVEDPLPPVF SGTPKGSGAG YGVGFDLEEF LNQSFDMGVA DGPQDGQSDS ASLSASLLAD 780
WLEGHGMNPA DIESLQREIQ MDSPMLLADL PDLQDP 816
Nucleotide Sequence
(FASTA)
ATGGCCGAGC CCCTGAAGGA GGAAGACGGC GAGGACGGCT CTGCGGAACC CCCCGGGCCC 60
GTGAAGGCCG AACCCGCCCA CACCGCTGCC TCTGTAGCGG CCAAGAACCT GGCCCTGCTT 120
AAAGCCCGCT CCTTCGATGT GACCTTTGAC GTGGGCGACG AGTACGAGAT CATCGAGACC 180
ATAGGCAACG GGGCCTACGG AGTGGTGTCC TCCGCCCGCC GCCGTCTCAC CGGCCAGCAG 240
GTGGCCATCA AGAAGATCCC TAATGCTTTT GATGTGGTGA CCAATGCCAA GCGAACCCTC 300
AGGGAGCTGA AGATCCTCAA GCACTTTAAG CACGACAACA TCATCGCCAT CAAGGACATC 360
CTGAGGCCCA CTGTGCCCTA TGGCGAATTC AAATCTGTCT ACGTGGTCCT GGACCTGATG 420
GAAAGTGACC TGCACCAGAT CATCCACTCC TCACAGCCCC TCACACTGGA ACACGTGCGC 480
TACTTCCTGT ACCAACTGCT GCGGGGCCTG AAGTACATGC ACTCGGCTCA GGTCATCCAC 540
CGTGACCTCA AGCCCTCCAA CCTATTGGTG AATGAGAACT GTGAGCTCAA GATTGGTGAC 600
TTTGGTATGG CTCGTGGCCT GTGCACCTCG CCCGCTGAAC ATCAGTACTT CATGACCGAG 660
TATGTGGCCA CGCGCTGGTA CCGTGCCCCT GAGCTCATGC TCTCTTTGCA TGAGTATACA 720
CAGGCTATTG ACCTTTGGTC TGTGGGCTGC ATCTTTGGTG AGATGCTGGC CCGGCGCCAG 780
CTCTTCCCGG GCAAAAACTA TGTACACCAG CTACAGCTCA TCATGATGGT GCTGGGTACC 840
CCATCACCAG CCGTGATTCA GGCTGTGGGG GCTGAGAGGG TGCGGGCCTA TATCCAGAGC 900
TTGCCACCAC GCCAGCCTGT GCCCTGGGAG ACAGTGTACC CAGGTGCCGA CCGTCAGGCC 960
CTATCACTCC TGGGTCGCAT GCTGCGTTTT GAGCCCAGCG CCCGCATCTC AGCAGCTGCT 1020
GCCCTTCGCC ACCCTTTCCT GGCCAAGTAC CATGATCCTG ATGATGAGCC TGACTGTGCC 1080
CCGCCCTTTG ACTTTGCCTT TGATCGTGAA GCCCTCACTC GGGAGCGCAT TAAGGAGGCC 1140
ATCGTGGCTG AGATTGAGGA CTTCCATGCA AGGCGCGAGG GCATCCGCCA GCAGATCCGC 1200
TTCCAGCCTT CTCTCCAGCC TGTGGCTAGT GAACCTGGCT GTCCAGATGT TGAAATGCCC 1260
AGTCCCTGGG CTCCCAGTGG GGACTGTGCC ATGGAGTCTC CCCCACCAGC CCCACCACCG 1320
TGCCCTGGCC CTGGACCTGA CACCATTGAT CTGACCCTGC AGCCACCCCC ACCAGCCAGT 1380
GAGCCTGCCC CACCGAAGAA AGAGGGTGCC ATCTCAGACA ACACTAAGGC TGCCCTTAAA 1440
GCTGCCCTGC TCAAGTCTTT GAGAAGCCGG CTCAGAGATG GCCCCAGCGC ACCCCTGGAG 1500
GCTTCTGAGC CTCGGAAGCC GGTGACAGCC CAGGAGCGCC AGCGGGAGCG GGAGGAGAAG 1560
CGGCGGCGGC GGCAAGAGCG AGCCAAGGAG CGGGAGAAAC GGCGGCAGGA GCGGGAGCGA 1620
AAGGAACGGG GGGCCGGGGC CTCTGGGGGC CCCTCCACTG ACCCTTTGGC TGGACTAGTG 1680
CTCAGCGACA ATGACAGAAG CCTTTTGGAA CGCTGGACTC GAATGGCCCG ACCCCCAGCC 1740
CCAGCCCCGA CCTCTGTGCC AGCCCCTGCC CCAGTGCCAA CGCCAACCCC AGCCCAACCT 1800
GCCAGTCCTC CTCCTGGCCC TGTAGCCCAG CCCACTGGCC CACAACCACA ACCACAACCT 1860
GTGGGCTCCA CATCTGGCCC TGTACCCCAG CCTGCCTGCC CACCCCCTGG CCCTGCAGCC 1920
CACCCCACCG GCCCTCCTAG GCCCATCCCT GTCCCTGCGC CACCCCAGAT TGCCACCTCT 1980
ACCAGCCTCC TGGCTCCCCA GTCACTTGTG CCACCCCCTG GGTTGCCTGG CTCCAACACC 2040
CCAGGAGTTT TGCCTTACTT CCCACCTGGC CTGCCACCTA CAGACGCCGG GGGAGCCCCT 2100
CAGTCTTCCA TGTCAGAGTC ACCTGATGTC AACCTAGTGA CCCAGCAGCT ATCTAAGTCA 2160
CAGGTGGAGG ACCCCCTGCC CCCTGTGTTC TCAGGCACAC CAAAGGGCAG TGGGGCTGGC 2220
TACGGTGTTG GCTTTGACCT GGAGGAATTC TTAAACCAGT CTTTCGACAT GGGCGTGGCT 2280
GATGGGCCAC AGGATGGCCA GTCAGATTCA GCCTCACTCT CAGCCTCCCT GCTTGCTGAC 2340
TGGCTCGAAG GCCATGGCAT GAACCCTGCC GATATTGAGT CCCTGCAGCG TGAGATCCAG 2400
ATGGACTCCC CAATGCTGCT GGCTGACCTG CCTGACCTCC AGGACCCCTG A 2451
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         ye ++++g+Gaygvv sa ++ t+++vaikk+ ++f+  t+akrtlRElk+lk++kh+Ni
Q: 55    YEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNI  114
         77899*******************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglkylH  119
         i + d+++p+  + e+k+vY+v +lme+dL+++i+s+  l+ eh++++lyq+lrglky+H
Q: 115   IAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSqPLTLEHVRYFLYQLLRGLKYMH  174
         ***********************************9889*********************
S: 120   sanviHrDlKPsNllvnedcelkildFGlarsadkekekk...lteyvatrwYraPeill  176
         sa+viHrDlKPsNllvne+celki dFG+ar   ++  ++   +teyvatrwYraPe++l
Q: 175   SAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHqyfMTEYVATRWYRAPELML  234
         *******************************955444333489*****************
S: 177   slkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseea  236
         sl+eyt+a+D+WsvGCI++E+l++++lfpgk++++ql++i+ vlgtps  +++++  e++
Q: 235   SLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERV  294
         ************************************************************
S: 237   rnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289
         r+yi+slp+++  ++e+++p a+++al Ll ++L ++p+ Ris++ aL+hp+l
Q: 295   RAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFL  347
         ***************************************************97
Domain Sequence
(FASTA)
YEIIETIGNG AYGVVSSARR RLTGQQVAIK KIPNAFDVVT NAKRTLRELK ILKHFKHDNI 60
IAIKDILRPT VPYGEFKSVY VVLDLMESDL HQIIHSSQPL TLEHVRYFLY QLLRGLKYMH 120
SAQVIHRDLK PSNLLVNENC ELKIGDFGMA RGLCTSPAEH QYFMTEYVAT RWYRAPELML 180
SLHEYTQAID LWSVGCIFGE MLARRQLFPG KNYVHQLQLI MMVLGTPSPA VIQAVGAERV 240
RAYIQSLPPR QPVPWETVYP GADRQALSLL GRMLRFEPSA RISAAAALRH PFL 293
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>
EKS-ANC-00453
EKS-BOT-00468
EKS-CAJ-00473
EKS-CAF-00467
EKS-CAP-00499
EKS-CII-00261
EKS-CIS-00221
EKS-DAR-00877
EKS-ECT-00063
EKS-EQC-00456
EKS-FEC-00444
EKS-GAA-00566
EKS-GOG-00457
EKS-HOS-00475
EKS-ICT-00443
EKS-LAC-00474
EKS-LOA-00472
EKS-MIM-00085
EKS-MOD-00459
EKS-MUM-00499
EKS-MUP-00457
EKS-MYL-00459
EKS-NOL-00424
EKS-ORN-00592
EKS-ORC-00442
EKS-ORL-00535
EKS-OTG-00473
EKS-PES-00412
EKS-PTV-00166
EKS-RAN-00480
EKS-SAH-00436
EKS-TAR-00580
EKS-TEN-00580
EKS-XET-00615
EKS-XIM-00581
EKS-SAC-00102
Gene Ontology
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0004707; F:MAP kinase activity
GO:0006915; P:apoptotic process
GO:0071560; P:cellular response to transforming growth factor beta stimulus
GO:0000165; P:MAPK cascade
GO:0043066; P:negative regulation of apoptotic process
GO:0034115; P:negative regulation of heterotypic cell-cell adhesion
GO:0051534; P:negative regulation of NFAT protein import into nucleus
GO:0060761; P:negative regulation of response to cytokine stimulus
GO:0018105; P:peptidyl-serine phosphorylation
GO:0051247; P:positive regulation of protein metabolic process
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0045765; P:regulation of angiogenesis
KEGG
mcc:702837;
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013