EKS-MAM-00287
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00287
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/STKR387.95.0E-116205503299
StatusUnreviewed
Ensembl ProteinENSMMUP00000015715
UniProt AccessionF7H249;
Protein Name
Protein Synonyms/Alias
Gene NameBMPR2
Gene Synonyms/Alias BMPR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000009009ENSMMUP00000011799ENSMMUT00000012585
ENSMMUG00000009009ENSMMUP00000015715ENSMMUT00000016780
OrganismMacaca mulatta
Functional Description
Protein Length1040
Protein Sequence
(FASTA)
MTSSLQRPWR VPWLPWTILL VSTAAASQNQ ERLCAFKDPY QQDLGIGESR ISHENGTILC 60
SKGSTCYGLW EKSKGDINLV KQGKRCWSHI GDPQECHYEE CVVTTTPPSI QNGTYRFCCC 120
STDLCNVNFT ENFPPPDTTP LSPPHSFNRD ETIIIALASV SVLTVLIVAL CFGYRMLTGD 180
RKQGLHSMNM MEAAASEPSL DLDNLKLLEL IGRGRYGAVY KGSLDERPVA VKVFSFANRQ 240
NFINEKNIYR VPLMEHDNIA RFIVGDERVT ADGRMEYLLV MEYYPNGSLC KYLSLHTSDW 300
VSSCRLAHSV TRGLAYLHTE LPRGDHYKPA ISHRDLNSRN VLVKNDGTCV ISDFGLSMRL 360
TGNRLVRPGE EDNAAISEVG TIRYMAPEVL EGAVNLRDCE SALKQVDMYA LGLIYWEIFM 420
RCTDLFPGES IPEYQMAFQT EVGNHPTFED MQVLVSREKQ RPKFPEAWKE NSLAVRSLKE 480
TIEDCWDQDA EARLTAQCAE ERMAELMMIW ERNKSVSPTV NPMTTAMQNE RNLSHNRRVP 540
KIGPYPDYSS SSYIEDSIHH TDSIVKNISS EHSMSSTPLT IGEKNRNSIN YERQQAQARI 600
PSPETSVTSL STNTTTTNTT GLTPSTGMTT ISEMPYPDET NLHATNVAQS IGPTPVCLQL 660
TEEDLETNKL DPKEVDKNLK ESSDENLMEH SLKQFSGPDP LSSTSSSLLY PLIKLAVEAT 720
GQQDFTQAAN GQACLIPDVL PTQIYPLPKQ QNLPKRPTSL PLNTKNSTKE PRLKFGSKHK 780
SNLKQVETGV AKMNTINAAE PHVVTVTMNG VAGRNHSVNS HAATTQYANG TVPSGQTTNI 840
VTHRAQEMLQ NQFIGEDTRL NINSSPDEHE PLLRREQQAG HDEGVLDRLV DRRERPLEGG 900
RTNSNNNNSN PCSEQDVLTQ VVPSTVADPG PSKPRRAQRP NSLDLSATNV LDGSSIQIGE 960
STQDGKSGSG EKIKKRVKTP YSLKRWRPST WVISTESLDC EVNNNGSNRA VHSKSSTAVY 1020
LAEGGTATTM VSKDIGMNCL 1040
Nucleotide Sequence
(FASTA)
ATGACTTCCT CGCTGCAGCG GCCCTGGCGG GTGCCCTGGC TACCATGGAC CATCCTGCTG 60
GTCAGCACTG CGGCCGCTTC GCAGAATCAA GAACGGCTAT GTGCATTTAA AGATCCATAT 120
CAGCAAGACC TTGGGATAGG TGAGAGTAGA ATCTCTCATG AAAATGGGAC AATATTATGC 180
TCAAAAGGTA GCACCTGCTA TGGCCTTTGG GAGAAATCAA AAGGGGACAT AAATCTTGTA 240
AAACAAGGCA AGAGATGTTG GTCTCACATT GGAGATCCCC AAGAGTGTCA CTATGAAGAA 300
TGTGTAGTAA CTACCACTCC TCCCTCAATT CAGAATGGAA CATACCGTTT CTGCTGTTGT 360
AGCACAGATT TATGTAATGT CAACTTTACC GAGAATTTTC CACCTCCTGA CACAACACCA 420
CTCAGTCCAC CTCATTCATT TAACCGAGAT GAGACAATAA TCATTGCTTT GGCATCAGTC 480
TCTGTATTAA CTGTTTTGAT AGTTGCCTTA TGCTTTGGAT ACAGAATGTT GACAGGAGAC 540
CGTAAACAAG GTCTTCACAG TATGAACATG ATGGAGGCAG CAGCATCTGA ACCCTCTCTT 600
GACCTAGATA ATCTGAAACT GTTGGAGCTG ATTGGCCGAG GTCGATATGG AGCAGTATAT 660
AAAGGCTCCT TGGATGAGCG TCCAGTTGCT GTAAAAGTGT TTTCATTTGC AAACCGCCAG 720
AATTTTATCA ACGAAAAGAA CATTTACAGA GTGCCTTTGA TGGAACATGA CAACATTGCC 780
CGCTTTATAG TTGGAGATGA GAGAGTCACT GCAGATGGGC GCATGGAATA TTTGCTTGTG 840
ATGGAGTATT ATCCCAATGG ATCTTTATGC AAGTATTTAA GTCTCCACAC AAGTGACTGG 900
GTAAGCTCTT GCCGTCTTGC TCATTCTGTT ACTAGAGGAC TGGCTTATCT TCACACAGAA 960
TTACCACGAG GAGATCATTA TAAACCTGCA ATTTCCCATC GAGATTTAAA CAGCAGAAAT 1020
GTCCTAGTGA AAAATGATGG AACCTGTGTT ATTAGTGACT TTGGATTGTC CATGAGGCTG 1080
ACTGGAAATA GACTGGTGCG CCCAGGGGAG GAAGATAATG CAGCCATAAG CGAGGTTGGC 1140
ACTATCAGAT ACATGGCACC AGAAGTGCTA GAAGGAGCTG TGAACTTGAG GGACTGTGAA 1200
TCAGCTTTGA AACAAGTAGA CATGTATGCT CTTGGACTAA TCTATTGGGA GATATTTATG 1260
AGATGTACAG ACCTCTTCCC AGGGGAATCC ATACCAGAGT ACCAGATGGC TTTTCAGACA 1320
GAGGTTGGAA ACCATCCCAC CTTCGAGGAT ATGCAGGTTC TTGTGTCTAG GGAAAAACAG 1380
AGACCCAAGT TCCCAGAAGC CTGGAAAGAA AATAGTCTGG CAGTGAGGTC ACTCAAGGAG 1440
ACAATCGAAG ACTGTTGGGA CCAGGATGCA GAGGCTCGGC TTACTGCACA GTGTGCTGAG 1500
GAAAGGATGG CTGAACTTAT GATGATTTGG GAAAGAAACA AATCTGTGAG CCCAACAGTC 1560
AATCCAATGA CTACTGCTAT GCAGAATGAA CGCAACCTGT CACATAATAG GCGTGTGCCA 1620
AAAATTGGTC CTTATCCAGA TTATTCTTCC TCCTCATACA TTGAAGACTC TATCCATCAT 1680
ACCGACAGCA TCGTGAAGAA TATTTCCTCT GAGCATTCTA TGTCCAGCAC ACCTTTGACT 1740
ATAGGGGAAA AAAACCGAAA TTCGATTAAC TATGAACGAC AGCAAGCACA AGCTCGAATA 1800
CCCAGCCCTG AAACAAGTGT CACCAGCCTC TCCACCAACA CAACAACCAC AAACACCACA 1860
GGCCTCACAC CAAGTACTGG CATGACTACT ATATCTGAGA TGCCATACCC AGATGAAACA 1920
AATCTGCATG CCACAAATGT TGCACAGTCA ATTGGGCCAA CCCCTGTCTG CCTACAGCTG 1980
ACAGAAGAAG ACTTGGAGAC CAACAAGCTA GACCCAAAAG AAGTTGATAA GAACCTCAAG 2040
GAAAGCTCTG ATGAGAATCT CATGGAGCAC TCTCTTAAAC AGTTCAGTGG GCCAGACCCA 2100
CTGAGCAGTA CTAGTTCTAG CTTGCTTTAC CCACTCATAA AACTTGCAGT AGAAGCAACT 2160
GGACAGCAGG ACTTCACACA GGCTGCAAAT GGCCAAGCAT GTTTAATTCC TGATGTTCTG 2220
CCTACTCAGA TCTATCCTCT CCCCAAGCAA CAGAACCTTC CCAAGAGACC TACTAGTTTG 2280
CCTTTGAACA CCAAAAATTC AACAAAGGAG CCCCGGCTAA AATTTGGCAG CAAGCACAAA 2340
TCAAACTTGA AACAAGTCGA AACTGGAGTT GCCAAGATGA ATACAATCAA TGCAGCAGAA 2400
CCTCATGTGG TGACAGTCAC CATGAATGGT GTGGCAGGTA GAAACCACAG TGTTAACTCC 2460
CATGCTGCCA CAACCCAATA TGCCAATGGG ACAGTACCAT CTGGCCAAAC AACCAACATA 2520
GTGACACATA GGGCCCAAGA AATGTTGCAG AATCAGTTTA TCGGTGAGGA TACCCGGCTG 2580
AATATTAATT CCAGTCCTGA TGAGCATGAG CCTTTACTGA GACGAGAACA ACAAGCTGGC 2640
CATGATGAAG GTGTTCTGGA TCGTCTTGTG GACAGGAGGG AACGACCACT AGAAGGTGGC 2700
CGAACTAATT CCAATAACAA CAACAGCAAT CCATGTTCAG AACAAGATGT TCTTACACAG 2760
GTTGTTCCAA GCACAGTAGC AGATCCTGGG CCATCAAAGC CCAGAAGAGC ACAGAGGCCT 2820
AATTCTCTGG ATCTTTCAGC CACAAATGTC CTGGATGGCA GCAGTATACA GATAGGTGAG 2880
TCAACACAAG ATGGCAAATC AGGATCAGGT GAAAAGATCA AGAAACGTGT GAAAACTCCC 2940
TATTCTCTTA AGCGGTGGCG CCCCTCCACC TGGGTCATCT CCACTGAATC ACTGGACTGT 3000
GAAGTCAACA ACAATGGCAG TAACAGGGCA GTTCATTCCA AATCCAGCAC TGCTGTTTAC 3060
CTTGCAGAAG GAGGCACTGC CACAACCATG GTGTCTAAAG ATATAGGAAT GAACTGTCTG 3120
TGA 3123
Domain Profile
S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60
         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++ +Ek+iy+++l++h+ni +fi+
Q: 205   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIV  264
         6899********************************************************
S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119
          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++  
Q: 265   GDErVTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG  324
         **9999**************************************************9766
S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175
          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL+++l+ ++ +    +d+aa+s+vGt R
Q: 325   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMRLTGNRLVrpgeEDNAAISEVGTIR  383
         .46***********************************999877787999**********
S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232
         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+++ey+++f+++vg
Q: 384   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESIPEYQMAFQTEVG  443
         *****************99*****************************************
S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291
         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+
Q: 444   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  503
         ***************************9999*************************9987
Domain Sequence
(FASTA)
LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFIN EKNIYRVPLM EHDNIARFIV 60
GDERVTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSVTRGL AYLHTELPRG 120
DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMRLTGNR LVRPGEEDNA AISEVGTIRY 180
MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESIPEY QMAFQTEVGN 240
HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00267
EKS-ANC-00273
EKS-BOT-00285
EKS-CAJ-00291
EKS-CAF-00291
EKS-CAP-00320
EKS-DAR-00625
EKS-DRM-00145
EKS-EQC-00277
EKS-FEC-00271
EKS-GAG-00238
EKS-GAA-00349
EKS-GOG-00284
EKS-HOS-00291
EKS-ICT-00269
EKS-LAC-00296
EKS-LOA-00295
EKS-MEG-00225
EKS-MOD-00280
EKS-MUM-00316
EKS-MUP-00281
EKS-MYL-00287
EKS-NOL-00263
EKS-ORN-00368
EKS-ORA-00247
EKS-ORC-00267
EKS-OTG-00290
EKS-PAT-00269
EKS-PES-00254
EKS-PEM-00153
EKS-POA-00276
EKS-PRC-00027
EKS-PTV-00041
EKS-RAN-00301
EKS-SAH-00267
EKS-SUS-00250
EKS-TAG-00297
EKS-TAR-00369
EKS-TAS-00021
EKS-TEN-00366
EKS-VIP-00019
EKS-XET-00358
EKS-XIM-00360
Gene Ontology
GO:0005901; C:caveola
GO:0009986; C:cell surface
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005024; F:transforming growth factor beta-activated receptor activity
GO:0009952; P:anterior/posterior pattern specification
GO:0060840; P:artery development
GO:0001974; P:blood vessel remodeling
GO:0030509; P:BMP signaling pathway
GO:0009267; P:cellular response to starvation
GO:0048286; P:lung alveolus development
GO:0001946; P:lymphangiogenesis
GO:0060836; P:lymphatic endothelial cell differentiation
GO:0001707; P:mesoderm formation
GO:0030308; P:negative regulation of cell growth
GO:2000279; P:negative regulation of DNA biosynthetic process
GO:0003085; P:negative regulation of systemic arterial blood pressure
GO:0045906; P:negative regulation of vasoconstriction
GO:0030513; P:positive regulation of BMP signaling pathway
GO:0030501; P:positive regulation of bone mineralization
GO:0010595; P:positive regulation of endothelial cell migration
GO:0001938; P:positive regulation of endothelial cell proliferation
GO:0010634; P:positive regulation of epithelial cell migration
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014916; P:regulation of lung blood pressure
GO:0061298; P:retina vasculature development in camera-type eye
GO:0006366; P:transcription from RNA polymerase II promoter
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0060841; P:venous blood vessel development
KEGG
InterPros
IPR000472; Activin_rcpt.
IPR015770; BMPRII.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
Pfam
PF01064; Activin_recp; 1.
PF00069; Pkinase; 1.
SMARTs
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013