EPS-MAM-00026

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00026

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	191.3	4.7E-56	235	488	254

Status

Unreviewed

Ensembl Protein

ENSMMUP00000011987

UniProt Accession

F7HQ96;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000009139	ENSMMUP00000011987	ENSMMUT00000012784
ENSMMUG00000009139	ENSMMUP00000034765	ENSMMUT00000041752

Organism

Macaca mulatta

Functional Description

Protein Length

757

Protein Sequence
(FASTA)

MAGCIPEEKT YRRFLELFLG EFRGPCGGGE PEPEPEPEPE PEPESEPEPE PELVEAEAAE 60

ASVEEPGEEA ATVAASEEGD QEQDPEPEEE AAVAAVEGEL GLQAPATSPG YSLQAPPPGH 120

PDQTPLPPSP AELLSDLQQE EEEGKEPCLC YVSIYTHNCP SFLAAALARA TSDEVLQSDL 180

SAHYIPKETD GTEGTVEIET VKLARSVFSK LHEICCSWVK DFPLRRRPQL YYETSIHAIK 240

NMRRKMEDKH VCIPDFNMLF NLEDQEEQAY FAVFDGHGGV DAAIYASIHL HVNLVRQEMF 300

PHDPAEALCR AFRVTDERFV QKAARESLRC GTTGVVTFIR GNMLHVAWVG DSQVMLVRKG 360

QAVELMKPHK PDREDEKQRI EALGGCVVWF GAWRVNGSLS VSRAIGDAEH KPYICGDADS 420

ASTVLDGTED YLILACDGFY DTVNPDEAVK VVSDHLKENN GDSSMVAHKL VASARDAGSS 480

DNITVIVVFL RDMNKAVNVS EESDWTENSF QGGQEDGGDD KENHGECKRP WPQHQCSAPA 540

DLGYDGRVDS FTDRTSLSPG SQINVLEDPG YLDLTQIEAS KPHSAQFLPP VEMFGPGAPK 600

KANLINELMM EKKSVQSSLP EWSGAGEFPA AFNLGSTGEQ IYRMERLSLV CSGLENEQFK 660

FPGNRVSRLS HLRHHYSKKW HRFRFNPKFY SFLSAQEPSH KIGTSLSSLT GSGKRNRIRS 720

SLPWRQNSWK GYSENMRKLR KTHDIPCPDL PWSYKIE 757

Nucleotide Sequence
(FASTA)

ATGGCCGGCT GCATCCCTGA GGAGAAAACT TACCGGCGCT TCCTGGAGCT ATTCCTGGGC 60

GAGTTTCGCG GACCGTGCGG CGGCGGCGAG CCGGAGCCGG AACCCGAACC CGAACCCGAA 120

CCCGAACCCG AGTCCGAGCC TGAGCCCGAA CCTGAACTGG TAGAAGCTGA GGCGGCCGAG 180

GCTTCGGTAG AGGAACCCGG GGAGGAGGCG GCCACGGTAG CCGCGTCGGA AGAGGGGGAC 240

CAGGAGCAAG ACCCGGAGCC CGAGGAGGAA GCGGCGGTGG CGGCGGTTGA GGGTGAGCTG 300

GGACTACAGG CGCCCGCCAC CTCGCCCGGC TACTCACTGC AAGCTCCGCC TCCTGGGCAT 360

CCTGACCAAA CTCCTCTCCC ACCATCCCCA GCTGAACTCC TCTCTGACTT ACAGCAGGAG 420

GAGGAGGAAG GGAAGGAGCC ATGTCTGTGT TATGTATCAA TATATACCCA TAATTGCCCT 480

TCCTTTTTGG CTGCTGCTTT AGCCAGAGCC ACATCGGATG AAGTCCTTCA GAGTGATCTT 540

TCTGCACATT ATATCCCAAA GGAAACGGAT GGCACAGAAG GGACTGTGGA GATTGAGACA 600

GTGAAATTGG CCCGTTCTGT CTTCAGCAAA CTACACGAGA TTTGCTGCAG CTGGGTGAAA 660

GACTTCCCCC TCCGCAGGAG ACCCCAGCTT TATTATGAGA CATCAATCCA TGCCATCAAA 720

AACATGCGCA GGAAAATGGA GGACAAACAT GTCTGCATTC CTGACTTTAA TATGCTCTTC 780

AACCTAGAGG ACCAGGAAGA ACAAGCTTAC TTTGCAGTGT TTGATGGCCA TGGGGGAGTA 840

GATGCTGCTA TTTATGCCTC CATTCACCTC CACGTTAACT TAGTCCGCCA GGAGATGTTC 900

CCCCATGATC CTGCTGAGGC CCTGTGCAGG GCCTTCCGGG TCACTGATGA GCGGTTTGTG 960

CAGAAAGCAG CCAGGGAGAG CTTAAGATGT GGGACCACAG GAGTGGTGAC TTTCATCAGA 1020

GGCAACATGC TACATGTGGC CTGGGTGGGT GATTCCCAGG TTATGCTTGT GAGAAAGGGT 1080

CAAGCTGTTG AACTAATGAA GCCACACAAA CCAGACAGAG AGGATGAAAA GCAGCGAATT 1140

GAGGCCCTTG GAGGTTGCGT AGTCTGGTTT GGTGCCTGGA GGGTGAATGG AAGTCTGTCA 1200

GTCTCCAGAG CTATTGGAGA TGCTGAACAT AAGCCATATA TCTGTGGGGA TGCAGATTCT 1260

GCCTCCACTG TTCTGGATGG GACCGAAGAC TACCTCATTC TGGCCTGTGA TGGCTTCTAT 1320

GACACCGTGA ACCCTGATGA GGCAGTGAAA GTTGTGTCCG ACCACCTGAA AGAGAATAAC 1380

GGAGACAGCA GCATGGTTGC CCACAAGTTA GTGGCATCAG CTCGTGATGC TGGGTCAAGT 1440

GATAACATCA CGGTTATTGT GGTATTCCTG AGGGACATGA ACAAAGCTGT AAATGTTAGT 1500

GAGGAATCAG ATTGGACAGA GAACTCTTTT CAAGGAGGGC AAGAAGATGG TGGGGATGAT 1560

AAGGAGAATC ATGGAGAGTG CAAACGCCCT TGGCCTCAGC ACCAGTGCTC AGCACCAGCC 1620

GATCTAGGCT ATGATGGGCG TGTGGATTCA TTCACTGATA GAACTAGTCT GAGCCCAGGG 1680

TCCCAAATCA ACGTGCTGGA AGACCCAGGC TACCTAGATC TCACACAAAT AGAAGCAAGC 1740

AAACCTCACA GTGCCCAGTT TTTGCCACCA GTTGAAATGT TTGGTCCTGG TGCACCAAAG 1800

AAAGCCAATC TTATTAATGA GTTAATGATG GAGAAAAAAT CAGTTCAGTC ATCATTGCCT 1860

GAATGGAGTG GTGCTGGAGA GTTTCCCGCT GCTTTCAATT TGGGTTCAAC AGGGGAGCAG 1920

ATATACAGAA TGGAGCGCTT GTCTCTTGTC TGTTCAGGGT TGGAAAATGA ACAGTTCAAA 1980

TTCCCGGGAA ACAGAGTTTC TAGATTGTCT CATTTACGCC ACCACTACTC AAAGAAGTGG 2040

CACAGATTCA GGTTTAATCC AAAGTTTTAT TCATTTCTCT CTGCTCAAGA GCCTTCCCAC 2100

AAAATAGGCA CTAGCCTGTC CTCACTTACT GGAAGTGGGA AGAGAAATAG GATAAGAAGT 2160

TCTCTGCCAT GGAGGCAAAA TAGTTGGAAA GGGTACAGTG AAAACATGAG GAAGCTCAGA 2220

AAGACTCATG ATATTCCATG CCCAGATCTT CCTTGGAGCT ATAAAATAGA GTAA 2274

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  l

Q: 235   SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNL  294

         567899**************99766555544459************************99

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

          ++         +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 295   VRQEM----FPHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  348

         99955....6788888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         vGdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 349   VGDSQVMLVRKGQAVELMKPHKPDREDEKQRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  407

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+  +++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 408   AEHKPYICGDADSASTVLDGTEDYLILACDGFYDTVNPDEAVKVVSDHLKeNNGDSSMVA  467

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 468   HKLVASARDAGSSDNITVIVV  488

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNL 60

VRQEMFPHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWVGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKQRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGTEDYLIL ACDGFYDTVN PDEAVKVVSD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013