EKS-MAM-00377

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00377

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	344.8	5.3E-103	129	402	274

Status

Unreviewed

Ensembl Protein

ENSMMUP00000012093

UniProt Accession

F7HHI3;

Protein Name

Protein Synonyms/Alias

Mitogen-activated protein kinase kinase kinase MLK4;

Gene Name

KIAA1804

Gene Synonyms/Alias

KIAA1804;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000009226	ENSMMUP00000012093	ENSMMUT00000012899

Organism

Macaca mulatta

Functional Description

Protein Length

1040

Protein Sequence
(FASTA)

MALPGAECAA DTPVSSARGA PGGSASSSST SSGGSASAGA GLWAALYDYE ARGEDELSLR 60

RGQLVEVLSQ DAAVSGDEGW WAGQVQRRLG IFPANYVAPC RPAASPAPPP APPPPRPSSP 120

VHVAFERLEL KELIGAGGFG QVYRATWQGQ EVAVKAARRD PEQDAAAAAE SVRREARLFA 180

MLRHPNIIEL RGVCLQQPHL CLVLEFARGG ALNRALAAAN AAPDPRAPGP RRARRIPPHV 240

LVNWAVQIAR GMLYLHEEAF VPILHRDLKS SNILLLEKIE HDDICNKTLK ITDFGLAREW 300

HRTTKMSAAG TYAWMAPEVI KSSLFSKGSD IWSYGVLLWE LLTGEVPYRG IDGLAVAYGV 360

AVNKLTLPIP STCPEPFAKL MKECWEQDPH IRPSFALILE QLTAIEGAVM TEMPQESFHS 420

MQDDWKLEIQ QMFDELRTKE KELRSREEEL TRAALQQKSQ EELLKRREQQ LAEREIDVLE 480

RELNILIFQL NQEKPKVKKR KGKFKRSRLK LKDGHRISLP SDFQHKITVQ ASPNLDKRRS 540

LNSSSSSPPS SPTMMPRLRA IQLTSDESNK TWGRNTVFRQ EEFEDVKRNF KKKGCTWGPN 600

SIQMKERADC KERIRPLSDG NSPWSTILIK NQKPMPLASL FVDQPGSCEE PKLSPDGLEH 660

RKPKQIKLPS QAYIDLPLGK DAQRENPSEA ESWEEAASAN AATVSTEVTP MNNLSRSPQR 720

KKTELALYGC TVLLASVALG LDLRELHKAQ AAEEPLPKEE KKKREGIFQR ASKSRRSASP 780

PTRLPPTGRE ASSPLSLPRT SALGILSTPS LSTKCLLQID SEDPLGGGTP VTCDSEMLTP 840

DFSPTAPGSS REPALMPRLD TTRSVSGNLP TSFLEQTCGN VPYWASSKDR PSHHRRTMSD 900

GNPTPTGAAI ISITGASALP LCPSPAPHSH LPREVSPKKH STVHIVPQPR PASLRSRSDL 960

PQAHPQAAVS QLAQAACVVG RPGPHPTQFL ATKERTKSHV PSLLDADVEG QSRDYTVPLC 1020

RMRSKTSRPS IYELEKEFLS 1040

Nucleotide Sequence
(FASTA)

ATGGCTTTGC CGGGCGCAGA GTGCGCGGCC GACACCCCGG TGTCCTCGGC CCGGGGAGCC 60

CCAGGCGGCT CAGCGTCCTC GTCGTCCACC TCCTCGGGAG GCTCGGCCTC GGCTGGCGCG 120

GGGCTGTGGG CCGCTCTCTA TGACTACGAG GCTCGCGGCG AGGACGAGCT GAGCCTGCGG 180

CGCGGCCAGC TGGTGGAGGT GCTGTCGCAG GACGCCGCCG TGTCGGGCGA CGAGGGCTGG 240

TGGGCAGGCC AGGTGCAGCG GCGCCTCGGC ATCTTCCCCG CCAACTACGT GGCTCCCTGC 300

CGCCCGGCAG CCAGCCCCGC GCCGCCGCCT GCGCCGCCGC CCCCGCGGCC CAGCTCCCCG 360

GTGCACGTCG CCTTCGAGCG GCTGGAGCTG AAGGAGCTCA TCGGCGCGGG GGGCTTCGGG 420

CAGGTGTACC GCGCCACCTG GCAGGGCCAA GAGGTGGCGG TGAAGGCGGC GCGCCGGGAC 480

CCGGAGCAGG ACGCTGCGGC GGCAGCCGAG AGCGTGCGGC GCGAGGCTCG GCTCTTCGCC 540

ATGCTGCGGC ACCCAAACAT CATCGAGCTG CGCGGCGTGT GCCTGCAGCA GCCGCACCTC 600

TGCCTGGTGC TGGAGTTCGC CCGCGGCGGA GCGCTCAACC GTGCCCTGGC CGCTGCCAAC 660

GCCGCCCCGG ACCCGCGCGC GCCCGGCCCC CGCCGCGCGC GCCGCATCCC TCCGCACGTG 720

CTGGTCAACT GGGCCGTGCA GATAGCGCGG GGCATGCTTT ACCTGCACGA AGAGGCCTTC 780

GTGCCCATCT TGCACCGGGA CCTCAAGTCC AGCAACATTT TGCTACTTGA GAAGATAGAG 840

CATGATGACA TCTGCAATAA AACATTGAAG ATTACAGATT TTGGGTTGGC GAGGGAATGG 900

CACAGGACGA CCAAAATGAG CGCAGCAGGC ACCTATGCCT GGATGGCCCC TGAAGTGATC 960

AAGTCTTCCT TGTTTTCTAA GGGAAGTGAC ATCTGGAGCT ATGGAGTGCT GCTGTGGGAA 1020

CTGCTCACGG GAGAAGTGCC CTATCGGGGC ATTGATGGCC TCGCGGTGGC TTATGGGGTA 1080

GCAGTCAATA AACTCACTTT GCCCATTCCA TCCACCTGCC CTGAGCCATT TGCCAAGCTC 1140

ATGAAAGAAT GCTGGGAACA AGACCCTCAT ATTCGTCCGT CATTTGCCTT AATTCTTGAA 1200

CAGCTGACTG CTATTGAAGG GGCAGTGATG ACTGAAATGC CTCAAGAATC TTTTCATTCC 1260

ATGCAAGATG ACTGGAAACT AGAAATTCAG CAAATGTTTG ATGAGTTGAG AACAAAGGAA 1320

AAGGAGCTGC GATCCCGGGA AGAGGAGCTG ACTCGGGCGG CTCTGCAGCA GAAGTCTCAG 1380

GAGGAGCTGC TAAAGCGGCG GGAGCAGCAG CTGGCAGAGC GCGAGATCGA CGTGCTGGAG 1440

CGGGAACTTA ACATTCTGAT ATTCCAGCTG AACCAGGAGA AGCCCAAAGT GAAGAAGAGG 1500

AAGGGGAAGT TTAAGAGAAG TCGTTTAAAG CTCAAAGATG GACATCGAAT CAGTTTACCT 1560

TCAGATTTCC AGCACAAGAT AACCGTGCAG GCCTCTCCCA ACTTGGACAA ACGGCGGAGC 1620

CTGAACAGCA GCAGTTCCAG TCCCCCGAGC AGTCCTACAA TGATGCCCCG GCTCCGAGCC 1680

ATACAGTTGA CTTCAGATGA AAGCAATAAA ACTTGGGGAA GGAACACAGT CTTTCGACAA 1740

GAAGAATTTG AGGACGTAAA AAGGAATTTT AAGAAAAAAG GTTGTACCTG GGGACCAAAT 1800

TCCATTCAAA TGAAAGAAAG AGCAGATTGC AAAGAAAGGA TAAGACCTCT CTCCGATGGC 1860

AACAGTCCTT GGTCAACTAT CTTAATAAAA AATCAGAAAC CCATGCCCTT GGCTTCATTG 1920

TTTGTGGACC AGCCAGGGTC CTGTGAAGAG CCAAAACTTT CCCCTGATGG ATTAGAACAC 1980

AGAAAACCGA AGCAAATAAA ATTGCCCAGT CAGGCCTACA TTGATCTACC TCTTGGGAAA 2040

GATGCTCAGA GAGAGAATCC TTCAGAAGCT GAAAGCTGGG AGGAGGCAGC CTCTGCGAAT 2100

GCTGCCACAG TCTCCACTGA GGTGACTCCT ATGAATAATC TGAGTAGATC CCCCCAGAGA 2160

AAGAAAACGG AGTTGGCTCT GTATGGGTGC ACCGTCCTGC TGGCATCAGT GGCTCTGGGA 2220

CTGGACCTCA GAGAGCTTCA TAAAGCACAG GCTGCTGAAG AACCATTGCC CAAGGAAGAG 2280

AAGAAGAAAC GAGAGGGAAT CTTCCAGCGG GCTTCCAAGT CCCGCAGAAG CGCCAGTCCT 2340

CCCACAAGGC TGCCGCCCAC TGGTAGGGAA GCCAGCAGCC CACTGTCCCT GCCACGGACG 2400

AGTGCCCTGG GCATCCTCTC CACGCCGTCT CTCTCCACAA AGTGCCTGCT GCAGATAGAC 2460

AGTGAAGATC CACTGGGGGG CGGTACACCT GTCACTTGCG ACTCTGAGAT GCTCACTCCG 2520

GATTTTTCTC CCACTGCTCC AGGAAGTAGT CGTGAGCCAG CCCTCATGCC AAGACTTGAC 2580

ACTACTCGTA GTGTGTCAGG AAACTTGCCC ACTTCCTTCC TAGAGCAGAC ATGTGGGAAT 2640

GTACCTTACT GGGCTTCTTC AAAAGATAGA CCATCACATC ACAGACGGAC CATGTCTGAT 2700

GGGAATCCGA CCCCAACTGG TGCAGCTATT ATCTCAATCA CTGGAGCCTC TGCACTGCCA 2760

CTGTGCCCCT CACCTGCTCC TCACAGTCAC CTGCCAAGGG AGGTCTCACC CAAGAAGCAC 2820

AGCACTGTCC ATATCGTGCC TCAGCCTCGC CCTGCCTCCC TGAGAAGCCG CTCAGATCTG 2880

CCTCAGGCTC ACCCACAGGC AGCAGTGTCT CAGCTGGCAC AGGCTGCCTG TGTAGTGGGT 2940

CGCCCAGGAC CACATCCCAC CCAGTTCCTT GCTACCAAGG AGAGGACTAA ATCCCATGTG 3000

CCTTCATTAC TGGATGCTGA CGTGGAAGGT CAGAGCAGGG ACTACACTGT GCCTCTGTGC 3060

AGAATGAGGA GCAAAACCAG CCGGCCATCT ATATATGAAC TGGAGAAAGA ATTCCTGTCT 3120

TAA 3123

Domain Profile

S: 2     eleeligsgafgkvykakwrkkevavKklreeaee..kekleklereakllsklshpnii  59

         el+elig+g fg+vy+a+w+++evavK++r++ e+  ++++e+++rea+l+++l+hpnii

Q: 129   ELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQdaAAAAESVRREARLFAMLRHPNII  188

         689*******************************9888899*******************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhe............kskreidlevlvswalqi  107

         el+Gvcl++p+l+lv+e+++gg+L+++l++            ++ r+i+++vlv+wa+qi

Q: 189   ELRGVCLQQPHLCLVLEFARGGALNRALAAanaapdprapgpRRARRIPPHVLVNWAVQI  248

         *****************************999**********9*****************

S: 108   ArGmaYLhseapkkiihrdLksknvLl.......seekktlkicdFGtarelskstkmsa  160

         ArGm YLh+ea ++i+hrdLks+n+Ll       +  +ktlki+dFG are++++tkmsa

Q: 249   ARGMLYLHEEAFVPILHRDLKSSNILLlekiehdDICNKTLKITDFGLAREWHRTTKMSA  308

         *******************************999999***********************

S: 161   agtlawmaPEvlkeekvseksDvwSygvvLWelltrevPykdlselaiaykvalkglrlp  220

         agt+awmaPEv+k++ +s+ sD+wSygv+LWellt+evPy++++ la+ay+va+++l+lp

Q: 309   AGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLP  368

         ************************************************************

S: 221   ipsscpeklkkLmkecwnedpekRpsfseivksl  254

         ips+cpe+++kLmkecw++dp+ Rpsf+ i+++l

Q: 369   IPSTCPEPFAKLMKECWEQDPHIRPSFALILEQL  402

         ******************************9986

Domain Sequence
(FASTA)

ELKELIGAGG FGQVYRATWQ GQEVAVKAAR RDPEQDAAAA AESVRREARL FAMLRHPNII 60

ELRGVCLQQP HLCLVLEFAR GGALNRALAA ANAAPDPRAP GPRRARRIPP HVLVNWAVQI 120

ARGMLYLHEE AFVPILHRDL KSSNILLLEK IEHDDICNKT LKITDFGLAR EWHRTTKMSA 180

AGTYAWMAPE VIKSSLFSKG SDIWSYGVLL WELLTGEVPY RGIDGLAVAY GVAVNKLTLP 240

IPSTCPEPFA KLMKECWEQD PHIRPSFALI LEQL 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0000186	; P:activation of MAPKK activity
GO:0000165	; P:MAPK cascade

KEGG

mcc:712755

;

InterPros

IPR011009	; Kinase-like_dom.
IPR016231	; MAPKKK9/10/11.
IPR015785	; MAPKKK9/10/11-like.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001452	; SH3_domain.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50002	; SH3; 1.

Prints

PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013