EKS-MAM-00344
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00344
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PEK406.79.2E-122442926485
StatusUnreviewed
Ensembl ProteinENSMMUP00000036348
UniProt AccessionF7H8D0;
Protein Name
Protein Synonyms/Alias
Gene NameEIF2AK3
Gene Synonyms/Alias EIF2AK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000009254ENSMMUP00000036348ENSMMUT00000043349
ENSMMUG00000009254ENSMMUP00000012122ENSMMUT00000012933
OrganismMacaca mulatta
Functional Description
Protein Length965
Protein Sequence
(FASTA)
MIIPSLDGAL FQWDRDRESM ETVPFTVESL LESSYKFGDD VVLVGGKSLT TYGLSACSGK 60
VRYICSALGC RQWDSDEMEQ EEDILLVQRT QKTVRAVGPR SGNEKWNFSV GHFELRYIPD 120
METRAGFIES TFKPNENTEE SKIISDVEEQ EAAIMDIVIK VSVADWKVMA FSKKGGHLEW 180
EYQFCTPIAS AWLLKDGKVI PISLFDDTSY TSNDDVLEDE EDIVEAARGA TENSVYLGMY 240
RGQLYLQSSV RISEKFPTSP KALESVNNEN AIIPLPTIKW KPLIHSPSRT PVLVGSDEFD 300
KCLSNDKFSH EEYSNGALSI LQYPYDNGYY LPYYKRERNK RSTQITVRFL DNPNYNKNIR 360
KKDPVLLLHW WKEIVATILF CIIATTFIVR RLFHPHPHRQ RKESETQCQT ENKYDSVSGE 420
ANDSNWNDIK NSGYVSRYLT DFEPIQCLGR GGFGVVFEAK NKVDDCNYAI KRIRLPNREL 480
AREKVMREVK ALAKLEHPGI VRYFNAWLEA PPEKWQEKMD EIWLKDASTD WPLSSPSPMD 540
APSVKIRRMD PFSTKEHVEI IAPSPERSRS FSVGISCDQT SSSESQFSPL EFSGMDHEDI 600
SESVDAAYNL QDSCLTDCDV EDGTMDGNDE GHSFELCPSE ASPYVRSRER TSSSIVFEDS 660
GCDNASSKEE PKTNRLHIGN HCANKLTAFK PTSSKSSSEA TLSISPPRPT TLSLDLTKNT 720
TEKLQPSSPK VYLYIQMQLC RKENLKDWMN GRCTIEERER SMCLHIFLQI AEAVEFLHSK 780
GLMHRDLKPS NIFFTMDDVV KVGDFGLVTA MDQDEEEQTV LTPMPAYARH TGQVGTKLYM 840
SPEQIHGNSY SHKVDIFSLG LILFEILYPF STQMERVRTL TDVRNLKFPP LFTQKYPCEY 900
MMVQDMLSPS PMERPEATNI IENAVFEDLD FPGKTVLRQR SRSLSSSGTK HSRQSNNSHS 960
PLPSN 965
Nucleotide Sequence
(FASTA)
ATGATTATTC CTTCCCTGGA TGGAGCCCTC TTCCAGTGGG ACCGAGACCG TGAGAGCATG 60
GAAACAGTTC CTTTCACAGT TGAATCACTT CTCGAATCTT CTTATAAATT TGGAGATGAT 120
GTTGTTTTGG TTGGAGGAAA ATCTCTCACT ACATATGGAC TCAGTGCATG TAGTGGAAAG 180
GTGAGGTATA TCTGTTCAGC TCTGGGTTGT CGCCAATGGG ATAGTGATGA AATGGAACAA 240
GAGGAAGACA TCCTGCTTGT ACAGCGTACC CAAAAAACTG TTAGAGCTGT CGGACCTCGC 300
AGTGGCAATG AGAAGTGGAA TTTCAGTGTT GGCCACTTTG AACTTCGGTA TATTCCAGAC 360
ATGGAAACGA GAGCCGGATT TATTGAAAGC ACCTTTAAGC CCAATGAGAA CACAGAAGAG 420
TCTAAAATTA TTTCAGATGT GGAAGAACAG GAAGCTGCCA TAATGGACAT AGTGATAAAG 480
GTTTCGGTTG CTGACTGGAA AGTTATGGCA TTCAGTAAGA AGGGAGGACA TCTGGAATGG 540
GAGTACCAGT TTTGTACTCC AATTGCATCT GCCTGGTTAC TTAAGGATGG GAAAGTCATT 600
CCCATCAGTC TTTTTGATGA TACAAGTTAT ACATCTAATG ATGATGTTTT AGAAGATGAA 660
GAAGACATTG TAGAAGCTGC CAGAGGAGCC ACAGAAAACA GTGTTTACTT GGGAATGTAT 720
AGAGGCCAGC TTTATCTGCA GTCATCAGTC AGAATTTCGG AAAAGTTTCC TACAAGTCCC 780
AAGGCTTTGG AATCTGTCAA TAATGAAAAC GCAATTATTC CTTTGCCAAC AATCAAATGG 840
AAACCCTTAA TTCATTCTCC TTCCAGAACT CCTGTCTTGG TAGGATCTGA TGAATTTGAC 900
AAATGTCTTA GTAATGATAA GTTTTCTCAT GAAGAATATA GTAATGGCGC ACTTTCAATC 960
TTGCAGTATC CATATGATAA TGGTTATTAT CTACCGTACT ACAAGAGGGA AAGGAACAAA 1020
CGAAGCACAC AGATTACAGT CAGATTCCTC GACAACCCAA ATTACAACAA GAATATCCGC 1080
AAAAAGGATC CTGTTCTCCT CTTACACTGG TGGAAAGAAA TAGTTGCAAC GATTTTGTTT 1140
TGTATCATAG CAACAACGTT TATTGTGCGC AGGCTTTTCC ACCCTCATCC TCACAGGCAA 1200
AGGAAGGAGT CTGAAACTCA GTGTCAAACT GAAAATAAAT ATGATTCTGT AAGTGGTGAA 1260
GCCAATGACA GTAACTGGAA TGACATAAAA AACTCTGGAT ATGTATCACG ATATCTAACT 1320
GATTTTGAGC CAATTCAGTG CCTGGGACGT GGTGGCTTTG GAGTTGTTTT TGAAGCTAAA 1380
AACAAAGTAG ATGACTGCAA TTATGCTATC AAGAGGATCC GTCTGCCCAA TAGGGAATTG 1440
GCTCGGGAAA AGGTAATGCG AGAAGTTAAA GCCTTAGCCA AGCTTGAACA CCCAGGCATT 1500
GTTAGATATT TCAATGCCTG GCTCGAAGCA CCACCAGAGA AGTGGCAAGA AAAGATGGAT 1560
GAAATTTGGC TGAAAGATGC AAGCACAGAC TGGCCACTCA GCTCTCCTAG CCCAATGGAT 1620
GCACCATCAG TTAAAATACG CAGAATGGAT CCTTTCTCTA CAAAAGAACA TGTTGAAATC 1680
ATAGCTCCTT CACCAGAAAG AAGCAGGTCT TTTTCAGTAG GGATTTCCTG TGACCAGACA 1740
AGTTCATCTG AGAGCCAGTT CTCACCACTG GAATTCTCAG GAATGGACCA TGAGGACATC 1800
AGTGAGTCAG TGGATGCAGC ATACAACCTC CAGGACAGCT GCCTTACAGA CTGTGATGTG 1860
GAAGATGGTA CTATGGATGG CAATGATGAG GGGCACTCCT TTGAACTTTG TCCTTCTGAA 1920
GCTTCTCCTT ATGTAAGGTC AAGGGAGAGA ACTTCCTCTT CGATAGTATT TGAAGATTCT 1980
GGCTGTGATA ATGCTTCCAG TAAAGAAGAG CCCAAAACTA ATCGATTGCA TATTGGCAAC 2040
CATTGTGCAA ATAAACTAAC TGCTTTCAAG CCCACCAGTA GCAAATCTTC TTCTGAAGCT 2100
ACATTATCTA TTTCTCCTCC AAGACCAACC ACTTTAAGTT TAGATCTCAC TAAAAACACC 2160
ACAGAAAAAC TCCAGCCCAG TTCCCCAAAG GTGTATCTTT ACATTCAAAT GCAGCTGTGC 2220
AGAAAAGAAA ACCTCAAAGA CTGGATGAAT GGACGATGTA CCATAGAGGA GAGAGAGAGG 2280
AGCATGTGTC TGCACATCTT CCTGCAGATC GCAGAGGCAG TGGAGTTTCT TCACAGTAAA 2340
GGACTGATGC ACAGGGACCT CAAGCCATCC AACATATTCT TTACAATGGA TGATGTGGTC 2400
AAGGTTGGAG ACTTTGGGTT AGTGACTGCA ATGGACCAGG ATGAGGAAGA GCAGACGGTT 2460
CTGACCCCAA TGCCAGCTTA TGCCAGACAC ACAGGACAAG TAGGGACCAA ACTGTATATG 2520
AGCCCAGAGC AGATTCATGG AAACAGCTAT TCTCATAAAG TGGACATCTT TTCTTTAGGC 2580
CTGATTCTAT TTGAAATACT GTACCCATTC AGCACTCAGA TGGAGAGAGT CAGGACCTTA 2640
ACTGATGTAA GAAATCTCAA ATTTCCACCA TTATTTACTC AGAAATATCC TTGTGAGTAT 2700
ATGATGGTTC AAGACATGCT CTCTCCATCC CCCATGGAAC GACCTGAAGC TACAAACATC 2760
ATTGAAAATG CTGTGTTTGA GGACTTGGAC TTTCCAGGAA AAACAGTGCT CAGACAGAGG 2820
TCTCGCTCCT TGAGTTCATC GGGAACAAAA CATTCAAGAC AGTCCAACAA CTCCCATAGC 2880
CCTTTGCCAA GCAATTAG 2898
Domain Profile
S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakkelekverevkaLaklehpniv  60
         fe i++lG+GgfgvV++aknk+d+++yaikri+l++++ ++ekv+revkaLaklehp+iv
Q: 442   FEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIV  501
         799*********************************************************
S: 61    rYfaawleekeesl..............................................  74
         rYf+awle ++e++                                              
Q: 502   RYFNAWLEAPPEKWqekmdeiwlkdastdwplsspspmdapsvkirrmdpfstkehveii  561
         ************************************************************
S: 75    ............................................................  74
                                                                     
Q: 562   apspersrsfsvgiscdqtsssesqfsplefsgmdhedisesvdaaynlqdscltdcdve  621
         ************************************************************
S: 75    ..td.sseveaeaeleesesseesdtk.................................  98
           t+ ++++ +++el++se+s++++++                                 
Q: 622   dgTMdGNDEGHSFELCPSEASPYVRSRertsssivfedsgcdnasskeepktnrlhignh  681
         **66699******************999********************************
S: 99    ..................................................llyiqmelce  108
                                                           +lyiqm+lc+
Q: 682   cankltafkptsskssseatlsispprpttlsldltkntteklqpsspkvYLYIQMQLCR  741
         ************************************************************
S: 109   ketLkdwiderkllesrselvm.rlfkqllegleylHskgliHrdLkpsniFldsddqvK  167
         ke+Lkdw++ r+++e+r++ ++ ++f q++e++e+lHskgl+HrdLkpsniF+++dd vK
Q: 742   KENLKDWMNGRCTIEERERSMClHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVK  801
         ************************************************************
S: 168   igDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvDifsLGl  227
         +gDFgL+ta++++++e+++ ++++++a+htgqvgtklymsPeq+++++Y++kvDifsLGl
Q: 802   VGDFGLVTAMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGL  861
         ************************************************************
S: 228   ilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRpsasell  287
         ilfe+lypfst+merv+tlt++r++k+p  f++k+p+e++++q++ls +p+eRp+a++++
Q: 862   ILFEILYPFSTQMERVRTLTDVRNLKFPPLFTQKYPCEYMMVQDMLSPSPMERPEATNII  921
         ************************************************************
S: 288   ksell  292
         +++++
Q: 922   ENAVF  926
         *9875
Domain Sequence
(FASTA)
FEPIQCLGRG GFGVVFEAKN KVDDCNYAIK RIRLPNRELA REKVMREVKA LAKLEHPGIV 60
RYFNAWLEAP PEKWQEKMDE IWLKDASTDW PLSSPSPMDA PSVKIRRMDP FSTKEHVEII 120
APSPERSRSF SVGISCDQTS SSESQFSPLE FSGMDHEDIS ESVDAAYNLQ DSCLTDCDVE 180
DGTMDGNDEG HSFELCPSEA SPYVRSRERT SSSIVFEDSG CDNASSKEEP KTNRLHIGNH 240
CANKLTAFKP TSSKSSSEAT LSISPPRPTT LSLDLTKNTT EKLQPSSPKV YLYIQMQLCR 300
KENLKDWMNG RCTIEERERS MCLHIFLQIA EAVEFLHSKG LMHRDLKPSN IFFTMDDVVK 360
VGDFGLVTAM DQDEEEQTVL TPMPAYARHT GQVGTKLYMS PEQIHGNSYS HKVDIFSLGL 420
ILFEILYPFS TQMERVRTLT DVRNLKFPPL FTQKYPCEYM MVQDMLSPSP MERPEATNII 480
ENAVF 485
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00317
EKS-ANC-00330
EKS-BOT-00338
EKS-CAE-00275
EKS-CAJ-00347
EKS-CAF-00346
EKS-CAP-00372
EKS-CII-00189
EKS-CIS-00091
EKS-DAR-00702
EKS-DRM-00166
EKS-EQC-00330
EKS-FEC-00329
EKS-GAM-00208
EKS-GAG-00285
EKS-GAA-00421
EKS-GOG-00335
EKS-HOS-00345
EKS-ICT-00322
EKS-LAC-00353
EKS-LOA-00350
EKS-MEG-00279
EKS-MOD-00334
EKS-MUM-00373
EKS-MUP-00333
EKS-MYL-00337
EKS-NOL-00309
EKS-ORN-00442
EKS-ORA-00297
EKS-ORC-00317
EKS-ORL-00409
EKS-OTG-00343
EKS-PAT-00321
EKS-PES-00298
EKS-PEM-00179
EKS-POA-00331
EKS-PTV-00079
EKS-RAN-00353
EKS-SAH-00317
EKS-SUS-00302
EKS-TAG-00414
EKS-TAR-00445
EKS-TAS-00033
EKS-TEN-00441
EKS-TUT-00088
EKS-VIP-00041
EKS-XET-00434
EKS-XIM-00430
EKS-SAC-00083
EKS-SCP-00084
Gene Ontology
GO:0005789; C:endoplasmic reticulum membrane
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0030282; P:bone mineralization
GO:0019722; P:calcium-mediated signaling
GO:0002063; P:chondrocyte development
GO:0031018; P:endocrine pancreas development
GO:0007029; P:endoplasmic reticulum organization
GO:0030968; P:endoplasmic reticulum unfolded protein response
GO:0006983; P:ER overload response
GO:0045444; P:fat cell differentiation
GO:0030073; P:insulin secretion
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0007595; P:lactation
GO:0031642; P:negative regulation of myelination
GO:0017148; P:negative regulation of translation
GO:0032092; P:positive regulation of protein binding
GO:0009967; P:positive regulation of signal transduction
GO:0046777; P:protein autophosphorylation
GO:0051260; P:protein homooligomerization
GO:0019217; P:regulation of fatty acid metabolic process
GO:0032933; P:SREBP signaling pathway
GO:0006412; P:translation
GO:0006926; P:virus-infected cell apoptotic process
KEGG
mcc:699575;
InterPros
IPR011009; Kinase-like_dom.
IPR018391; PQQ_beta_propeller_repeat.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011047; Quinonprotein_ADH-like.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
SM00564; PQQ; 3.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013