EKS-MAM-00147
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00147
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR434.52.2E-130329605277
StatusUnreviewed
Ensembl ProteinENSMMUP00000012567
UniProt AccessionF7A5X3;
Protein Name
Protein Synonyms/Alias
Gene NameFGFR2
Gene Synonyms/Alias FGFR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000009594ENSMMUP00000012571ENSMMUT00000013416
ENSMMUG00000009594ENSMMUP00000012570ENSMMUT00000013415
ENSMMUG00000009594ENSMMUP00000012567ENSMMUT00000013412
ENSMMUG00000009594ENSMMUP00000012569ENSMMUT00000013414
OrganismMacaca mulatta
Functional Description
Protein Length669
Protein Sequence
(FASTA)
GAPYWTNTEK MEKRLHAVPA ANTVKFRCPA GGNPTPTMRW LKNGKEFKQE HRIGGYKVRN 60
QHWSLIMESV VPSDKGNYTC VVENEYGSIN HTYHLDVVER SPHRPILQAG LPANASTVVG 120
GDVEFVCKVY SDAQPHIQWI KHVEKNGSKY GPDGLPYLKV LKHSGINSSN AEVLALFNVT 180
EADAGEYICK VSNYIGQANQ SAWLTVLPKQ QAPGREKEIT ASPDYLEIAI YCIGVFLIAC 240
MVVTVILCRM KNTTKKPDFS SQPAVHKLTK RIPLRRQVSA ESSSSMNSNT PLVRITTRLS 300
STADTPMLAG VSEYELPEDP KWEFPRDKLT LGKPLGEGCF GQVVMAEAVG IDKDKPKEAV 360
TVAVKMLKDD ATEKDLSDLV SEMEMMKMIG KHKNIINLLG ACTQDGENGW ASRSCSQSTP 420
HEHKEGSVPA GLEFLTSSDP STLTSQSVGI TGMSHCTQPH SVSYSILQLC IHRDLAARNV 480
LVTENNVMKI ADFGLARDIN NIDYYKKTTN GRLPVKWMAP EALFDRVYTH QSDVWSFGVL 540
MWEIFTLGGS PYPGIPVEEL FKLLKEGHRM DKPANCTNEL YMMMRDCWHA VPSQRPTFKQ 600
LVEDLDRILT LTTNEEYLDL SQPLEQYSPS YPDTRSSCSS GDDSVFSPDP MPYEPCLPQY 660
PHINGSVKT 669
Nucleotide Sequence
(FASTA)
GGAGCGCCTT ACTGGACCAA CACAGAAAAG ATGGAAAAGC GGCTCCATGC TGTGCCTGCG 60
GCCAACACTG TCAAGTTTCG CTGCCCAGCG GGGGGCAACC CAACACCAAC CATGCGGTGG 120
CTGAAAAACG GGAAGGAGTT TAAGCAGGAG CATCGCATTG GAGGCTACAA GGTACGAAAC 180
CAGCACTGGA GCCTCATTAT GGAAAGCGTG GTCCCATCTG ACAAGGGAAA TTATACCTGT 240
GTGGTGGAGA ATGAATACGG GTCCATCAAT CACACGTACC ACCTGGATGT TGTGGAGCGA 300
TCGCCTCACC GGCCCATCCT CCAAGCCGGA CTGCCGGCAA ATGCCTCCAC AGTGGTTGGA 360
GGAGACGTAG AGTTTGTCTG CAAGGTTTAC AGTGATGCCC AGCCCCACAT CCAGTGGATC 420
AAGCACGTGG AAAAGAACGG CAGTAAATAC GGGCCCGACG GGCTGCCCTA CCTCAAGGTT 480
CTCAAGCACT CGGGGATAAA TAGTTCCAAT GCAGAAGTGC TGGCTCTGTT CAATGTGACC 540
GAGGCGGATG CTGGGGAATA TATATGTAAG GTCTCCAATT ATATAGGGCA GGCCAACCAG 600
TCTGCCTGGC TCACTGTCCT GCCAAAACAG CAAGCTCCTG GAAGAGAAAA GGAGATTACA 660
GCTTCCCCAG ACTACCTGGA GATAGCCATT TACTGCATAG GGGTCTTCTT AATCGCCTGT 720
ATGGTGGTAA CAGTCATCCT GTGCCGAATG AAGAACACGA CCAAGAAGCC AGACTTTAGC 780
AGCCAGCCGG CTGTGCACAA GCTGACCAAG CGCATCCCCC TGCGGAGACA GGTTTCGGCT 840
GAGTCCAGCT CCTCCATGAA CTCCAACACC CCGCTGGTGA GGATAACAAC ACGCCTGTCT 900
TCAACGGCAG ACACCCCCAT GCTGGCAGGG GTCTCTGAGT ATGAACTTCC AGAGGACCCA 960
AAATGGGAAT TTCCAAGAGA TAAGCTGACA CTGGGCAAGC CCCTGGGAGA AGGTTGCTTT 1020
GGGCAAGTGG TCATGGCGGA AGCAGTGGGA ATCGACAAAG ACAAGCCCAA GGAGGCGGTC 1080
ACCGTGGCCG TGAAGATGTT GAAAGATGAT GCCACAGAGA AAGACCTTTC TGATCTGGTG 1140
TCAGAGATGG AGATGATGAA GATGATTGGG AAACACAAAA ATATCATAAA TCTTCTTGGA 1200
GCTTGCACAC AGGATGGTGA AAACGGTTGG GCTTCTAGAT CCTGCTCCCA GAGCACCCCC 1260
CATGAACACA AAGAAGGGTC TGTGCCCGCT GGTCTTGAAT TCCTGACCTC AAGTGATCCG 1320
TCCACCTTGA CCTCCCAAAG TGTTGGTATT ACAGGCATGA GCCACTGCAC CCAGCCGCAC 1380
TCTGTTTCTT ATAGTATACT GCAACTGTGT ATTCATCGAG ATTTAGCAGC CAGAAATGTT 1440
TTGGTAACAG AAAACAATGT GATGAAAATA GCAGACTTTG GACTCGCCAG AGATATCAAC 1500
AATATAGACT ATTACAAAAA GACCACCAAT GGTCGACTTC CAGTCAAGTG GATGGCTCCA 1560
GAAGCCCTGT TTGATAGAGT ATACACTCAT CAGAGTGATG TCTGGTCCTT CGGGGTGTTA 1620
ATGTGGGAGA TCTTCACTTT AGGGGGCTCG CCCTACCCAG GGATTCCCGT GGAGGAACTT 1680
TTTAAGCTGC TGAAGGAAGG ACACAGGATG GATAAACCAG CCAACTGCAC CAACGAACTG 1740
TACATGATGA TGAGGGACTG TTGGCATGCG GTGCCCTCCC AGAGACCAAC GTTCAAGCAG 1800
TTGGTAGAAG ACTTGGATCG AATTCTCACT CTCACAACCA ATGAGGAATA CTTGGACCTC 1860
AGCCAACCTC TCGAACAGTA TTCACCTAGT TACCCTGACA CAAGAAGTTC TTGTTCTTCA 1920
GGAGATGATT CTGTTTTTTC TCCAGACCCC ATGCCTTACG AACCATGCCT TCCTCAGTAT 1980
CCACACATAA ATGGCAGTGT TAAAACATGA 2010
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv+aea+g+dkdk+k++vtvavkmlk+dat+kdl+dlvseme++k+
Q: 329   LTLGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKM  388
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeask..dkskaseeql  118
         iGkhkniinllGactq+G        +++   +e+ +   p g e  +  d+s  +++++
Q: 389   IGKHKNIINLLGACTQDGENGWASRSCSQSTPHEHKEGSVPAGLEFLTssDPSTLTSQSV  448
         ********************999********************9965444999999999*
S: 119   tekdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyyk  178
         +   + +++    + + y   + cihrdlaarnvlvte+nv+kiadfGlard+++idyyk
Q: 449   GITGMSHCTQ--PHSVSYSILQLCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYK  506
         *999999986..577899999***************************************
S: 179   kttnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllke  238
         kttnGrlpvkwmapealfdrvyt+qsdvwsfGvl+wei+tlGgspypgi+veelfkllke
Q: 507   KTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKE  566
         ************************************************************
S: 239   Ghrmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         Ghrm+kpa+ct+ely++mr+cwha++s+rptfkqlvedl
Q: 567   GHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  605
         *************************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVMAEA VGIDKDKPKE AVTVAVKMLK DDATEKDLSD LVSEMEMMKM 60
IGKHKNIINL LGACTQDGEN GWASRSCSQS TPHEHKEGSV PAGLEFLTSS DPSTLTSQSV 120
GITGMSHCTQ PHSVSYSILQ LCIHRDLAAR NVLVTENNVM KIADFGLARD INNIDYYKKT 180
TNGRLPVKWM APEALFDRVY THQSDVWSFG VLMWEIFTLG GSPYPGIPVE ELFKLLKEGH 240
RMDKPANCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00139
EKS-ANC-00140
EKS-BOT-00148
EKS-CAJ-00155
EKS-CAF-00154
EKS-CAP-00147
EKS-EQC-00145
EKS-FEC-00140
EKS-GAG-00125
EKS-GOG-00147
EKS-HOS-00152
EKS-ICT-00144
EKS-LOA-00149
EKS-MOD-00147
EKS-MUM-00151
EKS-MUP-00151
EKS-NOL-00141
EKS-ORC-00138
EKS-OTG-00152
EKS-PAT-00137
EKS-PES-00132
EKS-POA-00143
EKS-PTV-00139
EKS-RAN-00145
EKS-SAH-00142
EKS-TAG-00176
Gene Ontology
GO:0005938; C:cell cortex
GO:0009986; C:cell surface
GO:0031012; C:extracellular matrix
GO:0005887; C:integral to plasma membrane
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0001525; P:angiogenesis
GO:0007409; P:axonogenesis
GO:0030282; P:bone mineralization
GO:0060349; P:bone morphogenesis
GO:0060667; P:branch elongation involved in salivary gland morphogenesis
GO:0060670; P:branching involved in labyrinthine layer morphogenesis
GO:0048755; P:branching morphogenesis of a nerve
GO:0060449; P:bud elongation involved in lung branching
GO:0045165; P:cell fate commitment
GO:0048557; P:embryonic digestive tract morphogenesis
GO:0009880; P:embryonic pattern specification
GO:0061031; P:endodermal digestive tract morphogenesis
GO:0060664; P:epithelial cell proliferation involved in salivary gland morphogenesis
GO:0060595; P:fibroblast growth factor receptor signaling pathway involved in mammary gland specification
GO:0031069; P:hair follicle morphogenesis
GO:0032808; P:lacrimal gland development
GO:0060601; P:lateral sprouting from an epithelium
GO:0070307; P:lens fiber cell development
GO:0060174; P:limb bud formation
GO:0048286; P:lung alveolus development
GO:0060463; P:lung lobe morphogenesis
GO:0060484; P:lung-associated mesenchyme development
GO:0060615; P:mammary gland bud formation
GO:0003149; P:membranous septum morphogenesis
GO:0060915; P:mesenchymal cell differentiation involved in lung development
GO:0060916; P:mesenchymal cell proliferation involved in lung development
GO:0030901; P:midbrain development
GO:0035264; P:multicellular organism growth
GO:0008285; P:negative regulation of cell proliferation
GO:0045839; P:negative regulation of mitosis
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0007528; P:neuromuscular junction development
GO:0042476; P:odontogenesis
GO:0035265; P:organ growth
GO:0030916; P:otic vesicle formation
GO:0003148; P:outflow tract septum morphogenesis
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0051781; P:positive regulation of cell division
GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010518; P:positive regulation of phospholipase activity
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0009791; P:post-embryonic development
GO:0060527; P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523; P:prostate epithelial cord elongation
GO:0046777; P:protein autophosphorylation
GO:0060687; P:regulation of branching involved in prostate gland morphogenesis
GO:0010453; P:regulation of cell fate commitment
GO:0040036; P:regulation of fibroblast growth factor receptor signaling pathway
GO:0040014; P:regulation of multicellular organism growth
GO:0051150; P:regulation of smooth muscle cell differentiation
GO:0008589; P:regulation of smoothened signaling pathway
GO:0060529; P:squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:0048489; P:synaptic vesicle transport
GO:0001657; P:ureteric bud development
GO:0055010; P:ventricular cardiac muscle tissue morphogenesis
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013