EKS-MAM-00286

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00286

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	396.1	1.5E-118	244	537	294

Status

Unreviewed

Ensembl Protein

ENSMMUP00000013111

UniProt Accession

F6Q193;

Protein Name

Protein Synonyms/Alias

Gene Name

TGFBR2

Gene Synonyms/Alias

TGFBR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000010031	ENSMMUP00000013113	ENSMMUT00000014004
ENSMMUG00000010031	ENSMMUP00000038325	ENSMMUT00000045300
ENSMMUG00000010031	ENSMMUP00000013111	ENSMMUT00000014002

Organism

Macaca mulatta

Functional Description

Protein Length

567

Protein Sequence
(FASTA)

MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SVNNDMMVTD NNGAVKFPQL CKFCDVRFST 60

CDNQKSCLSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK 120

CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPDL LLVIFQVTGI SLLPPLGVAI 180

SVIIIFYCYR VNRQQKLSSS WEAGKPRKLM DFSEHCAIIL EDDRSDISST CANNINHNTE 240

LLPIELDTLV GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDINLK 300

HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL GSSLARGIAH 360

LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPTLSV DDLANSGQVG 420

TARYMAPEVL ESRMNLENVE SFKQTDVYSM ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE 480

HPCVESMKDN VLRDRGRPEI PSFWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE 540

LEHLDRLSGR SCSEEKIPED GSLNTTK 567

Nucleotide Sequence
(FASTA)

ATGGGTCGGG GGCTGCTCAG GGGCCTGTGG CCGCTGCACA TCGTCCTGTG GACGCGTATC 60

GCCAGCACGA TCCCACCGCA CGTTCAGAAG TCGGTTAACA ATGACATGAT GGTCACTGAC 120

AACAATGGTG CAGTCAAGTT TCCACAACTG TGTAAATTTT GTGATGTGAG ATTTTCCACC 180

TGTGACAACC AGAAATCCTG CCTGAGCAAC TGCAGCATCA CCTCCATCTG TGAAAAGCCA 240

CAGGAAGTCT GTGTGGCTGT ATGGAGAAAG AATGACGAGA ACATAACACT AGAGACAGTT 300

TGCCATGATC CCAAGCTCCC CTACCATGAC TTTATTCTGG AAGATGCTGC TTCTCCAAAG 360

TGCATTATGA AGGAAAAAAA AAAGCCTGGT GAGACTTTCT TCATGTGTTC CTGTAGCTCT 420

GATGAGTGCA ATGACAACAT CATCTTCTCA GAAGAATACA ACACCAGCAA TCCTGACTTG 480

TTGCTAGTCA TATTTCAAGT GACAGGCATC AGCCTCCTGC CACCACTGGG AGTTGCCATA 540

TCTGTCATCA TCATCTTCTA CTGCTACCGC GTTAACCGGC AGCAGAAGCT GAGCTCATCC 600

TGGGAAGCTG GCAAGCCACG GAAGCTCATG GACTTCAGCG AGCACTGTGC CATCATCCTG 660

GAAGACGACC GCTCCGACAT CAGCTCCACA TGCGCCAACA ACATCAACCA CAACACAGAG 720

CTGCTGCCTA TTGAACTGGA CACCCTGGTG GGGAAAGGTC GCTTTGCTGA GGTCTATAAG 780

GCCAAGCTGA AGCAGAACAC TTCAGAGCAG TTTGAGACAG TGGCAGTCAA GATCTTTCCC 840

TATGAGGAGT ATGCCTCTTG GAAGACGGAG AAGGACATCT TCTCAGACAT CAACCTGAAG 900

CATGAGAACA TACTCCAGTT CCTGACAGCT GAGGAGCGCA AGACGGAGTT GGGGAAACAG 960

TACTGGCTGA TCACTGCCTT CCATGCCAAG GGCAACCTAC AGGAGTACCT GACGCGGCAT 1020

GTCATCAGCT GGGAGGACCT GCGCAAACTG GGCAGCTCCC TCGCCCGGGG CATTGCCCAC 1080

CTCCACAGTG ATCACACTCC GTGCGGGAGG CCCAAGATGC CCATCGTGCA CAGGGACCTC 1140

AAGAGCTCCA ATATCCTCGT GAAGAACGAC CTGACCTGCT GCCTGTGTGA CTTTGGGCTT 1200

TCCCTGCGTC TGGACCCTAC TCTGTCTGTG GATGACCTGG CTAACAGCGG GCAGGTGGGA 1260

ACTGCAAGAT ACATGGCTCC AGAAGTCCTA GAATCCAGGA TGAATTTGGA GAATGTAGAG 1320

TCCTTTAAGC AGACCGATGT CTACTCCATG GCTCTGGTGC TCTGGGAAAT GACATCGCGC 1380

TGTAATGCGG TGGGAGAAGT AAAAGATTAT GAGCCTCCAT TTGGTTCCAA GGTGCGGGAG 1440

CACCCCTGTG TTGAAAGCAT GAAGGACAAC GTGTTGAGAG ATCGAGGACG ACCAGAAATT 1500

CCCAGCTTCT GGCTCAACCA CCAGGGCATC CAGATGGTGT GTGAGACGTT GACTGAGTGC 1560

TGGGACCACG ACCCAGAGGC CCGCCTCACA GCCCAGTGTG TGGCAGAACG CTTCAGTGAG 1620

CTGGAGCACC TGGACAGGCT CTCGGGGAGG AGCTGCTCCG AGGAGAAGAT TCCTGAAGAC 1680

GGCTCCCTAA ACACTACCAA ATAG 1704

Domain Profile

S: 1     lklleligkGrygeVwkaklrg......eevAvKifstedeaswkrEkeiyqtvllrhen  54

         ++l +l+gkGr++eV+kakl++      e+vAvKif++e+ aswk+Ek+i++ ++l+hen

Q: 244   IELDTLVGKGRFAEVYKAKLKQntseqfETVAVKIFPYEEYASWKTEKDIFSDINLKHEN  303

         678899***************99999999*******************************

S: 55    ilqfiaadkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHe  114

         ilqf++a+++++++ ++++l+t++h kg+L++yL+r+++++e+l +l +sla+G+ahLH+

Q: 304   ILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHS  363

         ************************************************************

S: 115   eivgtkgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtk  174

         + ++ +g+ K+ i+HRDlks Nilvk+dltcc++D+GL+l+l+ + ++ dla++ qvGt

Q: 364   D-HTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTA  422

         *.8999******************************************************

S: 175   RYmaPEvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsd  234

         RYmaPEvle+++nl+++e+fk++DvYs++LvlWE++sRc++  +ev++y++pf ++v+++

Q: 423   RYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNA-VGEVKDYEPPFGSKVREH  481

         *****************************************.999***************

S: 235   PsleemkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkr  290

         P++e+mk+ v++++ rP+ip+ w +++ +++++++l+ecWd+dpeaRlta++v++r

Q: 482   PCVESMKDNVLRDRGRPEIPSFWLNHQGIQMVCETLTECWDHDPEARLTAQCVAER  537

         *****************************************************987

Domain Sequence
(FASTA)

IELDTLVGKG RFAEVYKAKL KQNTSEQFET VAVKIFPYEE YASWKTEKDI FSDINLKHEN 60

ILQFLTAEER KTELGKQYWL ITAFHAKGNL QEYLTRHVIS WEDLRKLGSS LARGIAHLHS 120

DHTPCGRPKM PIVHRDLKSS NILVKNDLTC CLCDFGLSLR LDPTLSVDDL ANSGQVGTAR 180

YMAPEVLESR MNLENVESFK QTDVYSMALV LWEMTSRCNA VGEVKDYEPP FGSKVREHPC 240

VESMKDNVLR DRGRPEIPSF WLNHQGIQMV CETLTECWDH DPEARLTAQC VAER 294

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009897	; C:external side of plasma membrane
GO:0016021	; C:integral to membrane
GO:0043235	; C:receptor complex
GO:0005524	; F:ATP binding
GO:0005539	; F:glycosaminoglycan binding
GO:0046872	; F:metal ion binding
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005026	; F:transforming growth factor beta receptor activity, type II
GO:0032147	; P:activation of protein kinase activity
GO:0006915	; P:apoptotic process
GO:0007420	; P:brain development
GO:0060434	; P:bronchus morphogenesis
GO:0051216	; P:cartilage development
GO:0048701	; P:embryonic cranial skeleton morphogenesis
GO:0035162	; P:embryonic hemopoiesis
GO:0007369	; P:gastrulation
GO:0007507	; P:heart development
GO:0001701	; P:in utero embryonic development
GO:0002088	; P:lens development in camera-type eye
GO:0060463	; P:lung lobe morphogenesis
GO:0060443	; P:mammary gland morphogenesis
GO:0043011	; P:myeloid dendritic cell differentiation
GO:0060021	; P:palate development
GO:0060389	; P:pathway-restricted SMAD protein phosphorylation
GO:0001569	; P:patterning of blood vessels
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0002663	; P:positive regulation of B cell tolerance induction
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0002053	; P:positive regulation of mesenchymal cell proliferation
GO:0051138	; P:positive regulation of NK T cell differentiation
GO:2000379	; P:positive regulation of reactive oxygen species metabolic process
GO:0002666	; P:positive regulation of T cell tolerance induction
GO:0002651	; P:positive regulation of tolerance induction to self antigen
GO:0070723	; P:response to cholesterol
GO:0042493	; P:response to drug
GO:0023014	; P:signal transduction by phosphorylation
GO:0007224	; P:smoothened signaling pathway
GO:0060440	; P:trachea formation
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0001570	; P:vasculogenesis

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017194	; Transform_growth_fac-b_typ-2.
IPR015013	; Transforming_GF_b_rcpt_2_ecto.

Pfam

PF08917	; ecTbetaR2; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013