EKS-MAM-00397
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00397
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl553.41.3E-166567831265
StatusUnreviewed
Ensembl ProteinENSMMUP00000013160
UniProt AccessionF6T7N0;
Protein Name
Protein Synonyms/Alias
Gene NameMERTK
Gene Synonyms/Alias MERTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000010066ENSMMUP00000013160ENSMMUT00000014052
OrganismMacaca mulatta
Functional Description
Protein Length979
Protein Sequence
(FASTA)
AITEAREEAK PYPLFPGPLP GRLQTDHTSL LSLPHTSGYQ PALMFSPTQP GRPYTGNVAI 60
PRVTSAGSKL LPPLAFKHTV GHIILSEHKD VKFNCSISVP NIYQDTTISW WKDGKELLGA 120
HHAITQFYPD DEVTAIIASF SITSVQRSDN GSYICKMKIN NEEIVSDPIY IEVQGLPHFT 180
KQPESMNVTR NTAFNLTCQA VGPPEPVNIF WVQNSSRVNE QPEKSPSVLT VPGLTEMAVF 240
SCEAHNDKGL TVSKGVQINI KAIPSPPTEV SIHNSTAHSI LISWVPGFDG YSPFRNCSVQ 300
VKEVDPLSNG SVMIFNASAS PHMYQIKQLQ ALANYSIGVS CMNEIGWSAV SPWILASTTE 360
GAPSVAPLNV TVLLNESRDN VDIRWMKPLT KRQAGELVGY RISHVWQSAG ISKELLEEVG 420
QNNSRAQISV QVHNATCTVR IAAVTKGGVG PFSDPVKIFI PAHGWVDHAP SSTPAPGNAD 480
PVLIIFGCFC GFILIGLVLY ISLAVRKRVQ ETKFGNAFTE EDSELVVNYI AKKSFCRRAI 540
ELTLHSLGVS EELQNKLEDV VIDRNLLILG KILGEGEFGS VMEGNLKQED GTSQKVAVKT 600
MKLDNFSQRE IEEFLSEAAC MKDFSHPNVI RLLGVCIEMS SQGIPKPMVI LPFMKYGDLH 660
TYLLYSRLET GPKHIPLQTL LKFMMDIALG MEYLSNRNFL HRDLAARNCM LRDDMTVCVA 720
DFGLSKKIYS GDYYRQGRIA KMPVKWIAIE SLADRVYTSK SDVWAFGVTM WEIATRGMTP 780
YPGVQNHEMY DYLLHGHRLK QPEDCLDELY EIMYSCWRTD PLDRPTFSVL RLQLEKLLES 840
LPDVRNQADV IYINTQLLES SEGLAEGSTL APLDLNIDPD SIIASCSPHA AISVVTAEIH 900
DSKPHEGRYI LNGGSEEWED VTSAASAAVT AEKNSVLPGE RLVRNGVPWS HSSTLPLGSS 960
LPDELLFADD SSESSEVLM 979
Nucleotide Sequence
(FASTA)
GCGATCACTG AGGCAAGGGA AGAAGCCAAG CCTTACCCGC TATTCCCAGG ACCTTTGCCA 60
GGGCGCCTGC AAACTGACCA CACATCGTTG TTATCCCTTC CTCACACCAG TGGGTACCAG 120
CCTGCCTTGA TGTTTTCACC AACCCAGCCT GGAAGACCAT ATACAGGAAA TGTAGCCATT 180
CCCCGGGTGA CCTCTGCCGG GTCAAAGCTC CTACCGCCTC TTGCCTTCAA ACATACAGTT 240
GGACACATAA TACTTTCTGA ACATAAAGAT GTCAAATTTA ATTGCTCAAT CAGTGTACCT 300
AATATATACC AGGACACCAC AATTTCTTGG TGGAAAGATG GGAAGGAATT GCTTGGGGCA 360
CATCATGCAA TTACACAGTT TTATCCAGAT GATGAAGTTA CAGCAATAAT CGCTTCCTTC 420
AGCATAACCA GTGTGCAGCG TTCAGACAAT GGGTCGTATA TCTGTAAGAT GAAAATAAAC 480
AATGAAGAGA TCGTGTCTGA TCCCATCTAC ATCGAAGTGC AAGGACTTCC TCACTTTACT 540
AAGCAGCCTG AGAGCATGAA TGTCACCAGA AACACAGCCT TCAACCTCAC CTGTCAGGCT 600
GTGGGCCCGC CTGAGCCTGT CAACATTTTC TGGGTTCAAA ACAGTAGCCG TGTTAACGAA 660
CAGCCTGAAA AATCCCCCTC CGTGCTAACC GTTCCAGGCC TGACAGAGAT GGCGGTCTTC 720
AGTTGTGAGG CCCACAATGA CAAAGGGCTG ACCGTATCCA AGGGAGTGCA GATCAACATC 780
AAAGCAATTC CCTCCCCACC AACTGAAGTC AGCATCCATA ACAGCACTGC ACACAGCATT 840
CTGATCTCCT GGGTCCCTGG TTTTGATGGA TACTCCCCGT TCAGGAATTG CAGCGTTCAG 900
GTCAAGGAAG TTGATCCACT GAGTAATGGC TCAGTCATGA TTTTTAACGC CTCTGCCTCA 960
CCACATATGT ATCAAATCAA GCAGCTGCAA GCCCTGGCTA ATTACAGCAT TGGCGTTTCC 1020
TGCATGAATG AAATAGGCTG GTCGGCAGTG AGCCCTTGGA TTCTAGCCAG CACGACTGAA 1080
GGAGCCCCAT CAGTAGCACC TTTAAACGTC ACTGTGTTGC TGAATGAATC TAGAGATAAT 1140
GTGGACATCA GATGGATGAA GCCTCTGACC AAGCGGCAGG CTGGAGAACT GGTGGGCTAC 1200
CGGATATCCC ATGTGTGGCA GAGTGCAGGG ATTTCCAAAG AGCTCTTGGA GGAAGTTGGC 1260
CAGAATAACA GCCGAGCTCA GATCTCTGTT CAAGTCCACA ATGCTACGTG CACAGTGAGG 1320
ATTGCAGCCG TCACAAAAGG GGGAGTCGGG CCCTTCAGTG ACCCCGTGAA AATATTTATC 1380
CCTGCGCACG GTTGGGTAGA TCATGCCCCC TCTTCAACTC CAGCGCCTGG CAACGCAGAT 1440
CCTGTGCTCA TCATCTTTGG CTGCTTTTGT GGATTTATTT TGATTGGGTT AGTTTTATAC 1500
ATCTCCTTGG CCGTCAGAAA AAGAGTTCAG GAGACAAAGT TTGGGAATGC ATTCACAGAG 1560
GAGGATTCTG AATTAGTGGT AAATTATATA GCAAAGAAGT CCTTCTGTCG GCGAGCCATT 1620
GAACTTACCT TACATAGCTT GGGAGTCAGC GAGGAACTAC AAAATAAACT AGAAGATGTT 1680
GTGATTGACA GGAATCTTCT AATTCTTGGA AAAATTCTGG GTGAAGGAGA GTTTGGGTCT 1740
GTAATGGAAG GAAATCTTAA GCAGGAAGAT GGGACCTCTC AGAAAGTGGC AGTGAAGACC 1800
ATGAAGTTGG ACAACTTTTC ACAGCGGGAG ATCGAGGAGT TTCTCAGTGA GGCAGCGTGC 1860
ATGAAAGATT TCAGCCACCC AAATGTCATT CGACTTCTAG GTGTATGTAT AGAAATGAGC 1920
TCTCAAGGCA TCCCAAAGCC CATGGTAATT TTACCCTTCA TGAAATACGG GGACCTGCAT 1980
ACTTACTTAC TTTATTCCCG ATTGGAGACA GGACCAAAGC ATATTCCTCT GCAGACACTA 2040
CTGAAGTTCA TGATGGATAT TGCCCTGGGA ATGGAGTATC TGAGCAACAG GAATTTTCTT 2100
CATCGAGATT TAGCTGCTCG AAACTGCATG TTGCGAGATG ACATGACTGT CTGTGTTGCG 2160
GACTTCGGCC TCTCTAAGAA GATTTACAGC GGCGATTACT ACCGCCAAGG CCGCATTGCT 2220
AAGATGCCTG TTAAATGGAT CGCCATAGAA AGTCTTGCAG ACCGAGTCTA CACGAGTAAA 2280
AGTGACGTGT GGGCATTTGG CGTGACCATG TGGGAAATAG CTACGCGGGG AATGACTCCC 2340
TATCCCGGGG TCCAGAACCA TGAGATGTAT GACTATCTTC TCCATGGACA CAGGCTGAAG 2400
CAGCCCGAGG ACTGCCTGGA TGAACTGTAT GAAATAATGT ACTCTTGCTG GAGAACCGAT 2460
CCCCTGGACC GCCCCACCTT TTCAGTATTG AGGCTGCAGC TAGAAAAACT CTTAGAAAGT 2520
TTGCCCGACG TTCGGAACCA AGCAGACGTC ATTTACATCA ACACACAGTT GCTGGAGAGC 2580
TCTGAGGGCC TGGCCGAGGG CTCCACGCTT GCTCCACTGG ACTTGAACAT TGACCCTGAC 2640
TCTATAATTG CCTCCTGCAG TCCCCACGCT GCCATCAGCG TGGTCACAGC AGAAATTCAT 2700
GACAGCAAAC CTCATGAAGG ACGGTACATC CTGAATGGGG GCAGTGAGGA ATGGGAAGAT 2760
GTGACTTCTG CCGCCTCTGC TGCAGTCACA GCTGAAAAGA ACAGTGTTTT ACCCGGGGAG 2820
AGACTTGTTA GGAATGGGGT CCCCTGGTCC CACTCGAGCA CGCTGCCCTT GGGAAGCTCA 2880
CTGCCTGATG AACTTTTGTT TGCTGACGAC TCCTCAGAAA GCTCAGAAGT CCTGATGTGA 2940
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         l+lgk+lgegefgsvmeg+lkqedg+++kvavkt+kld+++++eieeflseaacmk+f+h
Q: 567   LILGKILGEGEFGSVMEGNLKQEDGTSQKVAVKTMKLDNFSQREIEEFLSEAACMKDFSH  626
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnvirl+gv++e+s++g +pkp+vilpfmkygdlh++llysrl+++p+++plqtl+kfm+
Q: 627   PNVIRLLGVCIEMSSQG-IPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMM  685
         ****************9.******************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia gmeyls+rnf+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvk
Q: 686   DIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVK  745
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wiaiesladrvytsksdvwafgvtmweiatrg+tpy+gv+n+e+ydyll+g+rlkqpedc
Q: 746   WIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDC  805
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         ldely++my+cw++dp drp+fsvlr
Q: 806   LDELYEIMYSCWRTDPLDRPTFSVLR  831
         *************************9
Domain Sequence
(FASTA)
LILGKILGEG EFGSVMEGNL KQEDGTSQKV AVKTMKLDNF SQREIEEFLS EAACMKDFSH 60
PNVIRLLGVC IEMSSQGIPK PMVILPFMKY GDLHTYLLYS RLETGPKHIP LQTLLKFMMD 120
IALGMEYLSN RNFLHRDLAA RNCMLRDDMT VCVADFGLSK KIYSGDYYRQ GRIAKMPVKW 180
IAIESLADRV YTSKSDVWAF GVTMWEIATR GMTPYPGVQN HEMYDYLLHG HRLKQPEDCL 240
DELYEIMYSC WRTDPLDRPT FSVLR 265
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00370
EKS-ANC-00383
EKS-BOT-00400
EKS-CAJ-00403
EKS-CAF-00399
EKS-CAP-00426
EKS-CIS-00152
EKS-DAR-00776
EKS-EQC-00388
EKS-GAM-00236
EKS-GAG-00337
EKS-GAA-00487
EKS-GOG-00385
EKS-HOS-00401
EKS-ICT-00376
EKS-LAC-00414
EKS-LOA-00404
EKS-MEG-00328
EKS-MOD-00384
EKS-MUM-00430
EKS-MUP-00389
EKS-MYL-00395
EKS-NOL-00363
EKS-ORN-00510
EKS-ORC-00375
EKS-OTG-00400
EKS-PAT-00373
EKS-PES-00354
EKS-POA-00390
EKS-RAN-00412
EKS-TAG-00470
EKS-TAR-00501
EKS-TAS-00047
EKS-TEN-00499
EKS-XET-00510
EKS-XIM-00502
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005615; C:extracellular space
GO:0016021; C:integral to membrane
GO:0016028; C:rhabdomere
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0001779; P:natural killer cell differentiation
GO:0051250; P:negative regulation of lymphocyte activation
GO:0030168; P:platelet activation
GO:0050766; P:positive regulation of phagocytosis
GO:0043491; P:protein kinase B signaling cascade
GO:0060041; P:retina development in camera-type eye
GO:0032940; P:secretion by cell
GO:0007283; P:spermatogenesis
GO:0034446; P:substrate adhesion-dependent cell spreading
GO:0060068; P:vagina development
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 2.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013