EKS-MAM-00451

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00451

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	491.1	1.2E-147	9	269	261

Status

Unreviewed

Ensembl Protein

ENSMMUP00000037008

UniProt Accession

F7HF84;

Protein Name

Protein Synonyms/Alias

Casein kinase I isoform epsilon;

Gene Name

CSNK1E

Gene Synonyms/Alias

CSNK1E; EGK_03040;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000010122	ENSMMUP00000037009	ENSMMUT00000044005
ENSMMUG00000010122	ENSMMUP00000024099	ENSMMUT00000025760
ENSMMUG00000010122	ENSMMUP00000037008	ENSMMUT00000044004
ENSMMUG00000010122	ENSMMUP00000013233	ENSMMUT00000014130

Organism

Macaca mulatta

Functional Description

Protein Length

343

Protein Sequence
(FASTA)

MELRVGNKYR LGRKIGSGSF GDIYLGANIA SGEEVAIKLE CVKTKHPQLH IESKFYKMMQ 60

GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH 120

SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA 180

SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL 240

CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFARSTS 300

PSTAAALTAF LESLLSQALK LEAGQRCPQP YPLPITDSLP QPP 343

Nucleotide Sequence
(FASTA)

ATGGAGCTAC GCGTGGGGAA CAAGTACCGC CTGGGACGGA AGATTGGGAG CGGGTCCTTC 60

GGAGATATCT ACCTGGGTGC CAACATCGCC TCTGGTGAGG AAGTCGCCAT CAAGCTGGAG 120

TGTGTGAAGA CGAAGCACCC CCAGCTGCAC ATTGAGAGCA AGTTCTACAA GATGATGCAG 180

GGCGGTGTGG GGATCCCTTC CATCAAGTGG TGCGGAGCTG AGGGTGACTA CAACGTGATG 240

GTCATGGAGC TGCTGGGGCC CAGCCTCGAG GACCTGTTCA ACTTCTGTTC CCGCAAGTTC 300

AGCCTCAAGA CGGTGCTGCT CCTGGCCGAC CAGATGATCA GCCGCATCGA GTATATCCAC 360

TCCAAGAACT TCATCCACCG GGACGTCAAG CCCGACAACT TCCTCATGGG GCTGGGGAAG 420

AAGGGCAACC TGGTCTACAT CATCGACTTC GGCCTGGCCA AGAAGTACCG GGACGCCCGC 480

ACCCACCAGC ACATTCCCTA CCGGGAAAAC AAGAACCTGA CCGGCACAGC TCGCTACGCT 540

TCCATCAACA CGCACCTGGG CATTGAGCAA AGCCGTCGAG ATGACCTGGA GAGCCTGGGC 600

TACGTGCTCA TGTACTTCAA CCTGGGCTCC CTGCCCTGGC AGGGACTCAA AGCAGCCACC 660

AAGCGCCAGA AGTATGAGCG GATCAGCGAG AAGAAGATGT CAACACCCAT TGAGGTCCTC 720

TGCAAAGGCT ATCCCTCCGA ATTCTCAACA TACCTCAACT TCTGCCGCTC CCTGCGGTTT 780

GACGACAAGC CCGACTACTC TTACCTACGT CAGCTCTTCC GCAACCTCTT CCACCGGCAG 840

GGCTTCTCCT ATGACTACGT CTTCGACTGG AACATGCTGA AATTCGCCAG GAGCACCTCT 900

CCATCCACTG CTGCTGCTCT GACCGCCTTC CTGGAGTCCC TCTTGAGTCA GGCCCTGAAG 960

TTAGAAGCTG GGCAGAGGTG CCCACAGCCT TATCCTTTGC CAATCACTGA CTCATTGCCA 1020

CAGCCACCGT AG 1032

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         yr+++kiGsGsfGdiylg+n+asgeevaikle++k+k+pql++es++yk++qggvgiP++

Q: 9     YRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSI  68

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +++g+e++ynv+v++llGpsledlf++c+rkfslktvllladq+isriey+hsk++i+rd

Q: 69    KWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRD  128

         ************************************************************

S: 121   ikPdnfllgigrkgkkvylidfGlakkyrdaktkkhipyreeksltGtaryasinthlgk  180

         +kPdnfl+g+g+kg+ vy+idfGlakkyrda+t++hipyre+k+ltGtaryasinthlg+

Q: 129   VKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGI  188

         ************************************************************

S: 181   eqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegfPeef  240

         eqsrrddleslgyvl+yf+ gslPWqglkaatk+qkye+isekk+st+ievlc+g+P+ef

Q: 189   EQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEF  248

         ************************************************************

S: 241   atylkyvrklkfeekPdyeyl  261

         +tyl+++r+l+f++kPdy+yl

Q: 249   STYLNFCRSLRFDDKPDYSYL  269

         *******************97

Domain Sequence
(FASTA)

YRLGRKIGSG SFGDIYLGAN IASGEEVAIK LECVKTKHPQ LHIESKFYKM MQGGVGIPSI 60

KWCGAEGDYN VMVMELLGPS LEDLFNFCSR KFSLKTVLLL ADQMISRIEY IHSKNFIHRD 120

VKPDNFLMGL GKKGNLVYII DFGLAKKYRD ARTHQHIPYR ENKNLTGTAR YASINTHLGI 180

EQSRRDDLES LGYVLMYFNL GSLPWQGLKA ATKRQKYERI SEKKMSTPIE VLCKGYPSEF 240

STYLNFCRSL RFDDKPDYSY L 261

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0030529	; C:ribonucleoprotein complex
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0034613	; P:cellular protein localization
GO:0030178	; P:negative regulation of Wnt receptor signaling pathway
GO:0090263	; P:positive regulation of canonical Wnt receptor signaling pathway
GO:0032436	; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG

mcc:700565

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013