EKS-MAM-00304

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00304

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Alk	509.0	4.7E-153	1116	1384	269

Status

Unreviewed

Ensembl Protein

ENSMMUP00000013440

UniProt Accession

F6PVR5;

Protein Name

Protein Synonyms/Alias

Gene Name

ALK

Gene Synonyms/Alias

ALK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000010265	ENSMMUP00000013440	ENSMMUT00000014350

Organism

Macaca mulatta

Functional Description

Protein Length

1619

Protein Sequence
(FASTA)

MGTIGLLWLL PLLLSTAALG SGTGTGQRTG SPAAGPPLQP REPLSYSRLQ RKSLAVDFVV 60

PSLFRVYARD LLLPPSPSEL KAGRPEARGS LALDCAPLLR LLGPAPGVSW TAGSPTPAEA 120

RTLSRVLKGG SVRKLRRAKQ LVLELGEEAI LEGCVGPPGE AAVGLLQFNL SELFSWWIRQ 180

GEGRLRIRLM PEKKASEVGR EGRLSAAIRA SQPRLLFQIF GTGHSSLESP TNIPSPSPDY 240

FTWNLTWIMK DSFPFLSHRS RYGLECSFDF PCELEYSPPL HDLRNQSWSW RRVPSEEASQ 300

MDLLDGPEAE RSKEMPRGSF LLLNTSADSK HTILSPWMRS SSEHCTLAVS VHRHLQPSGR 360

YIAQLLPHNE AAREILLMPT PGKHGWTVLQ GRIGRPDNPF RVALEYISSG NRSLSAVDFF 420

ALKNCSEGTS PGSKMALQSS FTCWNGTVLQ LGQACDFHQD CAQGEDESQI CRKLPVGFYC 480

NFEDGFCGWT QGTLSPHTPQ WQVRTLNDAR FQDHQDHALL LSTTDASTSE SATVTSATFP 540

APIKSSPWEL RMSWLIRGVL RGNVSLVLVE NKTGKEQGRM VWHVAAYEGL SLWQWTVLPL 600

LDVSDRFWLQ MVAWWGQGSR AIVAFDNISI SLDCYLTISG EDKILQNTAP KSRNLFERNP 660

NKELKPGENS PRQTPIFDPT VHWLFTTCGA SGPHGPTQAQ CNNAYQNSNL SVEVGSEGPL 720

KGIQIWKVPA TDTYSISGYG AAGGKGGKNT MMRSHGVSVL GIFNLEKDDT LYILVGQQGE 780

DACPSTNQLI QKVCIGENNV IEEEIRVNRS VHEWAGGGGG GGGATYVFKM KDGVPVPLII 840

AAGGGGRAYG AKTDAFHPER LENNSSVLGL NGNSGAAGGG GGWNDNTSLL WAGKSLLEGA 900

TGGHSCPQAM KKWGWETRGG FGGGGGGCSS GGGGGGYIGG NAASNNDPEM DGEDGVSFIS 960

PLGILYTPAL KVMEGHGEVN IKHYLNCSHC EVDECHMDTE SHKVICFCDH GTVLAEDGVS 1020

CIVSPTPEPH LPLSLILSVV TSALVAALVL AFSGIMIVYR RKHQELQAMQ MELQSPEYKL 1080

SKLRTSTIMT DYNPNYCFAG KTSSISDLKE VPRKNITLIR GLGHGAFGEV YEGQVSQPPP 1140

PPHFPFSAQT LPEVCSEQDE LDFLMEALII SKFNHQNIVR CIGVSLQALP RFILLELMAG 1200

GDLKSFLRET RPRPSQPSSL AMLDLLHVAR DIACGCQYLE ENHFIHRDIA ARNCLLTCPG 1260

PGRVAKIGDF GMARDIYRAS YYRKGGCAML PVKWMPPEAF MEGIFTSKTD TWSFGVLLWE 1320

IFSLGYMPYP SKSNQEVLEF VTSGGRMDPP KNCPGPVYRI MTQCWQHQPE DRPNFAIILE 1380

RIEYCTQDPD VINTALPIEY GPLVEEEEKV PVRPKDPEGV PPLLVSQQAK RGEERSPAAP 1440

PPVPTTSSGK AAKKPTAAEV SVRVPRGPAV EGGHVNMAFS QSNPPSELHK VQGSRNKPTS 1500

LWNPTYGSWF TEKPTKKNNP LAKKEPHERG NLGLEGSCTV PPNVATGRLP GASLLLEPSS 1560

LTANMKEVPL FRLRHFPCGN VNYGYQQQGL PLEAATAPGA GHYEDTILKS KNSMNQPGP 1619

Nucleotide Sequence
(FASTA)

ATGGGAACCA TCGGGCTCCT GTGGCTGCTG CCGCTGCTGC TTTCCACTGC AGCTTTGGGC 60

TCTGGGACGG GGACCGGCCA GCGCACGGGA TCCCCAGCTG CGGGGCCGCC GCTGCAGCCC 120

CGGGAGCCGC TCAGCTACTC TCGCCTGCAG AGGAAGAGTC TGGCAGTGGA CTTCGTAGTG 180

CCCTCACTCT TCCGTGTCTA TGCCCGGGAC CTGCTGCTGC CGCCATCCCC CTCGGAGCTA 240

AAGGCTGGCA GGCCCGAGGC GCGCGGCTCG CTCGCTCTGG ACTGCGCCCC GCTGCTCAGG 300

TTGCTGGGGC CGGCGCCTGG GGTCTCCTGG ACAGCCGGCT CACCCACCCC GGCAGAGGCC 360

CGGACGCTGT CCAGGGTGCT GAAGGGCGGC TCGGTGCGCA AGCTCCGGCG TGCCAAGCAG 420

CTGGTGCTGG AGCTGGGCGA GGAGGCGATC TTGGAGGGTT GCGTCGGGCC CCCTGGGGAG 480

GCGGCTGTGG GGCTGCTCCA GTTCAACCTC AGCGAGCTGT TCAGTTGGTG GATTCGCCAG 540

GGCGAAGGGC GACTGAGGAT CCGCCTGATG CCCGAGAAGA AGGCGTCGGA AGTGGGCAGA 600

GAGGGAAGGC TGTCTGCGGC AATCCGCGCC TCCCAGCCCC GCCTTCTCTT CCAGATCTTC 660

GGGACTGGTC ATAGCTCCTT GGAGTCACCA ACAAACATAC CTTCTCCTTC TCCTGATTAT 720

TTTACATGGA ATCTCACCTG GATAATGAAA GACTCCTTCC CTTTCCTGTC TCATCGCAGC 780

CGATATGGTC TGGAGTGCAG CTTTGACTTC CCCTGTGAGC TGGAATATTC CCCTCCACTG 840

CACGACCTCA GGAACCAGAG CTGGTCCTGG CGCCGTGTTC CCTCCGAGGA GGCCTCCCAG 900

ATGGACTTGC TGGATGGGCC TGAGGCAGAG CGTTCTAAGG AGATGCCCAG AGGGTCCTTT 960

CTCCTCCTCA ACACCTCAGC TGACTCCAAG CACACCATCC TAAGTCCGTG GATGAGGAGC 1020

AGCAGTGAGC ACTGTACGCT GGCCGTCTCA GTGCACAGGC ACCTGCAGCC CTCTGGAAGG 1080

TACATTGCCC AGCTGCTGCC CCACAACGAG GCTGCAAGAG AGATCCTCCT GATGCCCACC 1140

CCAGGGAAGC ATGGTTGGAC AGTGCTCCAG GGAAGAATCG GGCGCCCAGA CAACCCCTTT 1200

CGAGTGGCCC TGGAATACAT CTCCAGTGGA AACCGCAGCT TGTCTGCAGT GGACTTCTTT 1260

GCCCTGAAGA ACTGCAGTGA AGGAACATCC CCAGGCTCCA AGATGGCCCT GCAGAGCTCC 1320

TTCACTTGTT GGAATGGGAC AGTCCTCCAG CTTGGGCAGG CCTGTGACTT CCACCAGGAC 1380

TGCGCCCAGG GAGAAGACGA GAGCCAGATA TGCCGGAAAC TCCCTGTGGG TTTTTACTGC 1440

AACTTCGAAG ATGGCTTCTG TGGCTGGACC CAAGGCACAC TCTCACCTCA CACTCCTCAG 1500

TGGCAGGTCA GGACTCTAAA CGATGCCCGG TTCCAGGACC ACCAAGACCA TGCTCTATTG 1560

CTCAGTACCA CTGATGCCTC CACTTCAGAA AGTGCTACAG TGACCAGTGC TACGTTTCCC 1620

GCACCGATCA AGAGCTCTCC ATGGGAACTC CGAATGTCCT GGCTCATTCG TGGAGTCCTG 1680

AGGGGAAACG TGTCCTTGGT GCTAGTGGAG AACAAAACTG GGAAGGAGCA AGGCAGGATG 1740

GTCTGGCATG TCGCCGCCTA TGAAGGCTTG AGCCTGTGGC AGTGGACGGT GTTGCCTCTC 1800

CTCGACGTGT CTGACAGGTT CTGGCTGCAG ATGGTTGCAT GGTGGGGACA AGGATCCAGA 1860

GCCATCGTGG CTTTTGACAA TATTTCCATC AGCCTGGACT GCTACCTCAC CATTAGTGGA 1920

GAGGACAAGA TCCTACAGAA TACAGCACCC AAATCAAGAA ACCTGTTTGA GAGAAACCCA 1980

AACAAGGAGC TGAAACCCGG GGAAAATTCA CCACGACAGA CGCCCATCTT TGACCCTACA 2040

GTTCATTGGC TGTTCACCAC ATGTGGGGCC AGCGGACCCC ATGGTCCCAC CCAGGCGCAG 2100

TGCAACAACG CCTACCAGAA CTCCAACCTG AGCGTGGAGG TGGGAAGCGA GGGCCCCCTG 2160

AAGGGCATCC AGATCTGGAA GGTGCCAGCC ACCGACACCT ACAGCATCTC GGGCTACGGA 2220

GCTGCTGGCG GGAAAGGCGG GAAGAACACC ATGATGCGGT CCCACGGCGT GTCTGTGCTG 2280

GGCATCTTCA ACCTGGAGAA AGACGACACG CTGTACATCC TGGTTGGGCA GCAGGGAGAG 2340

GACGCCTGCC CCAGTACAAA CCAGTTAATC CAGAAAGTCT GCATTGGAGA GAACAATGTG 2400

ATAGAAGAAG AAATCCGTGT GAACAGAAGC GTGCATGAGT GGGCAGGAGG AGGAGGAGGA 2460

GGGGGTGGAG CCACCTACGT ATTTAAGATG AAGGATGGAG TGCCGGTGCC CCTGATCATT 2520

GCAGCCGGAG GTGGCGGCAG GGCCTATGGG GCCAAGACAG ACGCGTTCCA CCCAGAGAGA 2580

CTGGAGAATA ACTCCTCGGT TCTAGGGCTG AACGGCAATT CCGGAGCCGC AGGTGGTGGA 2640

GGTGGCTGGA ATGATAACAC TTCCTTGCTC TGGGCCGGAA AATCTTTGCT GGAGGGTGCC 2700

ACCGGAGGAC ATTCCTGCCC CCAGGCCATG AAGAAGTGGG GGTGGGAGAC AAGAGGGGGT 2760

TTCGGAGGGG GTGGAGGGGG GTGCTCCTCA GGTGGAGGAG GCGGAGGATA TATAGGCGGC 2820

AATGCAGCCT CAAACAATGA CCCCGAAATG GATGGGGAAG ATGGGGTTTC CTTCATCAGT 2880

CCACTGGGCA TCCTGTACAC CCCAGCTTTA AAAGTGATGG AAGGCCATGG GGAAGTGAAT 2940

ATTAAGCATT ATCTAAACTG CAGTCACTGT GAGGTAGACG AATGTCACAT GGACACTGAA 3000

AGCCACAAGG TCATCTGCTT CTGTGACCAC GGGACAGTGC TGGCAGAGGA TGGCGTCTCC 3060

TGCATTGTGT CGCCCACCCC GGAGCCGCAC CTGCCACTCT CACTGATCCT CTCCGTGGTG 3120

ACCTCTGCCC TCGTGGCTGC CCTGGTCCTG GCTTTCTCCG GCATCATGAT TGTGTACCGC 3180

CGGAAGCACC AGGAGCTGCA AGCCATGCAG ATGGAGCTGC AGAGCCCTGA GTACAAGCTG 3240

AGTAAGCTCC GCACCTCAAC CATCATGACC GACTACAACC CCAACTACTG CTTTGCTGGC 3300

AAGACCTCCT CCATCAGTGA CCTGAAGGAG GTGCCGCGGA AAAACATCAC CCTCATTCGG 3360

GGTCTGGGCC ATGGCGCCTT TGGGGAGGTG TATGAAGGCC AGGTCTCACA GCCTCCTCCT 3420

CCTCCCCACT TCCCCTTCTC TGCCCAGACG CTGCCTGAGG TGTGCTCAGA ACAGGACGAA 3480

CTGGATTTCC TCATGGAAGC CCTGATCATC AGCAAATTCA ACCACCAGAA CATCGTTCGC 3540

TGCATCGGGG TGAGCCTGCA GGCCCTGCCC CGGTTCATCC TACTGGAGCT CATGGCAGGA 3600

GGAGACCTCA AGTCCTTCCT CCGAGAGACC CGCCCTCGCC CGAGCCAGCC CTCCTCCCTG 3660

GCCATGCTGG ACCTTCTGCA TGTGGCTCGG GACATTGCCT GTGGCTGTCA GTATTTGGAG 3720

GAAAACCACT TCATCCACCG AGACATTGCT GCCAGAAACT GCCTCTTGAC CTGTCCAGGC 3780

CCTGGAAGAG TGGCCAAGAT TGGAGACTTC GGGATGGCCC GAGACATCTA CAGGGCAAGC 3840

TACTACAGAA AGGGAGGCTG TGCGATGCTG CCAGTTAAGT GGATGCCCCC AGAGGCCTTC 3900

ATGGAAGGAA TATTCACCTC TAAAACAGAC ACATGGTCCT TTGGAGTGCT GCTGTGGGAA 3960

ATCTTTTCTC TCGGATATAT GCCATATCCC AGCAAAAGCA ACCAGGAAGT TCTGGAGTTC 4020

GTCACCAGTG GAGGCCGGAT GGACCCACCC AAGAACTGCC CTGGGCCTGT ATACCGGATA 4080

ATGACTCAGT GCTGGCAACA TCAGCCTGAA GACAGGCCCA ACTTTGCCAT CATTTTGGAG 4140

AGGATTGAAT ACTGCACCCA GGACCCAGAT GTAATCAACA CTGCTTTGCC GATAGAATAC 4200

GGTCCACTTG TAGAAGAGGA AGAGAAAGTA CCCGTGAGGC CCAAGGACCC TGAGGGGGTT 4260

CCTCCTCTCC TGGTCTCTCA ACAGGCGAAA CGGGGGGAGG AGCGCAGCCC AGCTGCCCCA 4320

CCACCTGTGC CTACCACCTC CTCTGGCAAG GCTGCAAAGA AACCCACAGC TGCAGAGGTC 4380

TCTGTTCGAG TCCCTAGAGG GCCGGCCGTG GAAGGGGGAC ACGTGAATAT GGCATTCTCT 4440

CAGTCCAACC CCCCTTCGGA GTTGCACAAG GTCCAGGGAT CCAGAAACAA GCCCACCAGC 4500

TTGTGGAACC CAACGTACGG CTCCTGGTTT ACAGAGAAAC CCACCAAAAA GAATAATCCT 4560

CTAGCAAAGA AGGAGCCACA TGAGAGGGGT AACCTGGGGC TGGAGGGAAG CTGTACTGTC 4620

CCACCTAACG TTGCAACTGG GAGACTTCCG GGGGCCTCAC TGCTCCTAGA GCCCTCTTCG 4680

CTGACTGCCA ACATGAAGGA GGTACCTCTG TTCAGGCTAC GTCACTTCCC TTGTGGGAAT 4740

GTCAATTACG GCTACCAGCA ACAGGGCTTG CCCTTAGAAG CCGCTACTGC CCCCGGAGCT 4800

GGTCATTACG AGGACACCAT TCTGAAAAGC AAGAATAGCA TGAACCAGCC TGGGCCCTGA 4860

Domain Profile

S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60

         i+l+r+lG+GafGevyeg+vs+ p  + ++  + +tlpe++seqdeldfl+ealiiskfn

Q: 1116  ITLIRGLGHGAFGEVYEGQVSQ-PPPPPHFPFSAQTLPEVCSEQDELDFLMEALIISKFN  1174

         799******************9.888999*******************************

S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120

         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+q+sslam dll+va+d+a+

Q: 1175  HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIAC  1234

         ************************************************************

S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180

         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkw

Q: 1235  GCQYLEENHFIHRDIAARNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  1294

         ************************************************************

S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240

         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p

Q: 1295  MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTSGGRMDPPKNCP  1354

         ************************************************************

S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270

         g+vyrimt+cw+h+pedrp+f++iler+++

Q: 1355  GPVYRIMTQCWQHQPEDRPNFAIILERIEY  1384

         ***************************986

Domain Sequence
(FASTA)

ITLIRGLGHG AFGEVYEGQV SQPPPPPHFP FSAQTLPEVC SEQDELDFLM EALIISKFNH 60

QNIVRCIGVS LQALPRFILL ELMAGGDLKS FLRETRPRPS QPSSLAMLDL LHVARDIACG 120

CQYLEENHFI HRDIAARNCL LTCPGPGRVA KIGDFGMARD IYRASYYRKG GCAMLPVKWM 180

PPEAFMEGIF TSKTDTWSFG VLLWEIFSLG YMPYPSKSNQ EVLEFVTSGG RMDPPKNCPG 240

PVYRIMTQCW QHQPEDRPNF AIILERIEY 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187	; P:activation of MAPK activity
GO:0048666	; P:neuron development
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR026830	; ALK.
IPR008985	; ConA-like_lec_gl_sf.
IPR011009	; Kinase-like_dom.
IPR002172	; LDrepeatLR_classA_rpt.
IPR000998	; MAM_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00629	; MAM; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00192	; LDLa; 1.
SM00219	; TyrKc; 1.

Prosites

PS50060	; MAM_2; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013