EPS-MAM-00014

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00014

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/aDSP	68.6	9.1E-19	158	310	153

Status

Unreviewed

Ensembl Protein

ENSMMUP00000013946

UniProt Accession

F7BCU8;

Protein Name

Protein Synonyms/Alias

Gene Name

EPM2A

Gene Synonyms/Alias

EPM2A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000010643	ENSMMUP00000013946	ENSMMUT00000014887

Organism

Macaca mulatta

Functional Description

Protein Length

331

Protein Sequence
(FASTA)

MRFRFGVVVP PAVAGARPEL LVVGSRPELG RWEPRGAVRL RPAGTAVGAG ALALQEPGLW 60

LGEVELAVEK AAQDGAEPGR VDTFWYKFLK REPGGELSWE GNGPHHDRCC TYNENNLVDG 120

VYCLPIGHWI EATGHTNEMK HTTDFYFNIA GHQAMHYSRI LPNIWLGSCP RQVEHVTIKL 180

KRELGITAVM NFQTEWDIVQ NSSGCNRYPE PMTPDTMIKL YREEGLAYIW MPTPDMSTEG 240

RVQMLPQAVC LLHALLEKGH IVYVHCNAGV GRSTAAVCGW FQYVMGWNLR KVQYFLMAKR 300

PAVYIDEEAL ARAQEDFFQK FGKVRSSVCS L 331

Nucleotide Sequence
(FASTA)

ATGCGCTTCC GCTTCGGGGT GGTGGTGCCG CCCGCCGTGG CAGGCGCCCG GCCAGAGCTG 60

CTGGTGGTGG GGTCGCGGCC CGAGCTGGGA CGTTGGGAGC CGCGCGGGGC CGTACGCCTG 120

AGGCCGGCAG GCACTGCGGT GGGCGCCGGG GCGCTGGCGC TGCAGGAGCC GGGCCTGTGG 180

CTCGGGGAGG TGGAGCTGGC GGTCGAGAAG GCGGCGCAGG ACGGGGCGGA GCCGGGCCGC 240

GTGGACACGT TCTGGTACAA GTTCCTGAAG CGGGAGCCGG GAGGAGAGCT CTCCTGGGAA 300

GGCAATGGAC CTCATCATGA CCGTTGCTGT ACTTACAATG AAAACAACTT GGTGGATGGT 360

GTGTATTGTC TCCCAATAGG ACACTGGATT GAGGCCACTG GGCACACCAA TGAAATGAAG 420

CACACAACAG ACTTCTATTT TAATATTGCA GGCCACCAAG CCATGCATTA TTCAAGAATT 480

CTACCAAATA TCTGGCTGGG TAGCTGCCCT CGTCAAGTGG AACACGTAAC CATCAAACTG 540

AAGCGTGAAC TGGGGATTAC AGCTGTAATG AATTTCCAGA CTGAATGGGA TATTGTACAG 600

AATTCCTCAG GCTGTAACCG CTACCCAGAA CCCATGACTC CAGACACTAT GATTAAACTA 660

TATAGGGAAG AAGGCTTGGC CTACATCTGG ATGCCAACAC CAGATATGAG CACCGAAGGT 720

CGAGTGCAGA TGCTGCCCCA GGCAGTGTGC TTGCTGCATG CGCTGCTGGA GAAGGGACAC 780

ATCGTGTATG TGCACTGCAA CGCTGGGGTG GGCCGCTCCA CCGCGGCTGT CTGCGGCTGG 840

TTCCAGTACG TGATGGGCTG GAATCTGAGG AAGGTGCAGT ATTTCCTCAT GGCCAAGAGG 900

CCAGCTGTCT ACATTGATGA AGAGGCTTTG GCCCGTGCAC AAGAAGATTT TTTCCAGAAA 960

TTTGGGAAGG TTCGTTCTTC TGTGTGTAGT CTGTAG 996

Domain Profile

S: 3     teilpglylgdqataldrreLs...klgitvvinaslsvikvq...........viPe..  46

         ++ilp+++lg+    +++++++   +lgit v+n  ++   vq            +P+

Q: 158   SRILPNIWLGSCPRQVEHVTIKlkrELGITAVMNFQTEWDIVQnssgcnrypepMTPDtm  217

         799********9999999876422368999999977654333311111111222356522

S: 47    ..ylikkgityknipvdDsdvtdllqyfdeaaefideakekggkvlvHCaaGvsRSatlv  104

           +++++g  y  +p  D  ++  +q++++a+++++   ekg+ v+vHC+aGv+RS++ v

Q: 218   ikLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAV  277

         22456799****************************************************

S: 105   laYLmkveglslsdAieavkrkrpsiepnegfl  137

         +++  +v+g++l+++   +++krp+++ +e+ l

Q: 278   CGWFQYVMGWNLRKVQYFLMAKRPAVYIDEEAL  310

         ****************************99976

Domain Sequence
(FASTA)

SRILPNIWLG SCPRQVEHVT IKLKRELGIT AVMNFQTEWD IVQNSSGCNR YPEPMTPDTM 60

IKLYREEGLA YIWMPTPDMS TEGRVQMLPQ AVCLLHALLE KGHIVYVHCN AGVGRSTAAV 120

CGWFQYVMGW NLRKVQYFLM AKRPAVYIDE EAL 153

Keyword

Complete proteome; Hydrolase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005844	; C:polysome
GO:0004725	; F:protein tyrosine phosphatase activity
GO:0008138	; F:protein tyrosine/serine/threonine phosphatase activity
GO:2001070	; F:starch binding
GO:0007610	; P:behavior
GO:0007399	; P:nervous system development

KEGG

mcc:699361

;

InterPros

IPR013784	; Carb-bd-like_fold.
IPR002044	; CBM_fam20.
IPR000340	; Dual-sp_phosphatase_cat-dom.
IPR020422	; Dual-sp_phosphatase_subgr_cat.
IPR024950	; DUSP.
IPR013783	; Ig-like_fold.
IPR000387	; Tyr/Dual-specificity_Pase.
IPR016130	; Tyr_Pase_AS.

Pfam

PF00686	; CBM_20; 1.
PF00782	; DSPc; 1.

SMARTs

SM01065

; CBM_2; 1.

Prosites

PS51166	; CBM20; 1.
PS00383	; TYR_PHOSPHATASE_1; 1.
PS50056	; TYR_PHOSPHATASE_2; 1.
PS50054	; TYR_PHOSPHATASE_DUAL; 1.

Prints

Created Date

20-Feb-2013