EKS-MAM-00041

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00041

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/VRK	369.4	1.5E-110	124	390	267

Status

Unreviewed

Ensembl Protein

ENSMMUP00000031512

UniProt Accession

F7G6L3;

Protein Name

Protein Synonyms/Alias

Gene Name

VRK3

Gene Synonyms/Alias

VRK3; EGK_10917;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000010837	ENSMMUP00000031512	ENSMMUT00000038411
ENSMMUG00000010837	ENSMMUP00000014200	ENSMMUT00000015154

Organism

Macaca mulatta

Functional Description

Protein Length

432

Protein Sequence
(FASTA)

MISFCPDCGK SIQAAFKFCP YCGNSLPTEE EHVGSETSVS SHVSSFRGSG SRPPTPKSSP 60

QKTRKSPQKT SCSPQKTKQS PQKTSCSPQT LKRSPQTLKR SRVTTSLEAL PTGTVLTDKS 120

GRQWKLKFLQ TRDDQGILYE AAPTSALAYD SELQKQKFSL KLDAKDGRLF NEQNFFQRAA 180

KPLQVNKWKK LYSTPQLAVP TCMGFGVHQD KYRFLVLPSL GRSLQSALDV SPEHVLSERS 240

VLQVACRLLD ALEFLHENEY VHGNVTAENI FVDPEDRSQV TLAGYGFAFR YCPSGKHVAY 300

VEGSRSPHEG DLEFISMDLH KGCGPSRRSD LQSLGYCMLK WLYGFLPWTN CLPNTEDIMK 360

QKQKFTDKPG PFVGPCGHWI RPSETLQNYL KVVMALKYEE KPPYAVLRNN LEALLQDLRV 420

SPYDPIGLPM VP 432

Nucleotide Sequence
(FASTA)

ATGATCTCCT TCTGTCCAGA CTGTGGCAAA AGTATCCAAG CGGCATTCAA GTTCTGCCCC 60

TACTGTGGAA ATTCTCTGCC CACAGAGGAG GAGCATGTGG GGTCCGAAAC CTCTGTCAGT 120

TCACATGTGT CATCCTTCCG AGGCTCCGGG AGCAGACCCC CAACCCCCAA AAGCAGCCCT 180

CAGAAGACCA GGAAGAGCCC TCAGAAGACC AGCTGCAGCC CTCAGAAGAC CAAGCAGAGC 240

CCTCAGAAGA CCAGCTGCAG CCCTCAGACG CTGAAGCGGA GCCCTCAGAC GCTGAAGCGG 300

AGCCGGGTGA CCACCTCACT TGAAGCTTTG CCCACAGGGA CAGTGCTGAC AGACAAGAGT 360

GGGCGACAGT GGAAGCTGAA GTTCCTCCAG ACCAGGGACG ACCAGGGCAT TCTCTATGAA 420

GCTGCACCCA CCTCCGCCCT CGCCTATGAC TCAGAACTCC AGAAGCAAAA GTTCTCGCTC 480

AAACTGGATG CCAAGGATGG GCGCTTGTTC AATGAGCAGA ACTTCTTCCA GCGGGCCGCC 540

AAGCCTCTGC AAGTCAACAA GTGGAAGAAG CTGTACTCGA CCCCGCAACT GGCCGTCCCT 600

ACCTGCATGG GTTTCGGTGT TCACCAGGAC AAATACAGGT TCTTGGTGTT ACCCAGCCTG 660

GGGAGGAGCC TTCAGTCGGC CCTGGATGTC AGCCCAGAGC ATGTGCTGTC AGAGAGGTCT 720

GTGCTGCAGG TGGCCTGCCG GCTGCTGGAT GCCCTGGAGT TCCTCCATGA GAATGAGTAT 780

GTTCATGGAA ATGTGACAGC TGAAAATATC TTTGTGGATC CAGAGGACCG GAGTCAGGTG 840

ACCTTGGCAG GCTATGGCTT CGCCTTCCGC TATTGCCCGA GTGGCAAACA TGTGGCCTAC 900

GTGGAAGGCA GCAGGAGCCC TCACGAGGGG GACCTTGAGT TCATTAGCAT GGACCTGCAC 960

AAGGGATGCG GGCCCTCCCG CCGCAGCGAC CTCCAGAGCC TGGGCTACTG CATGCTGAAG 1020

TGGCTCTACG GGTTTCTGCC ATGGACAAAC TGCCTTCCTA ACACTGAGGA CATCATGAAG 1080

CAAAAACAGA AGTTTACTGA TAAGCCGGGG CCCTTTGTGG GACCCTGCGG TCATTGGATC 1140

AGACCCTCAG AGACCCTGCA GAATTACCTG AAGGTGGTGA TGGCCCTCAA GTACGAGGAG 1200

AAGCCGCCCT ACGCCGTGCT GAGGAACAAC CTAGAAGCTC TGCTGCAGGA TCTGCGTGTG 1260

TCCCCATATG ACCCCATTGG CCTCCCGATG GTGCCCTAG 1299

Domain Profile

S: 1     wklgkkigkggfGeiyla.....ltckkeekdaklvvkvepkenGpLfvelkfyqraakk  55

         wkl+  ++++++G++y+a     l+ ++e +++k+++k+++k+ G+Lf+e++f+qraak+

Q: 124   WKLKFLQTRDDQGILYEAaptsaLAYDSELQKQKFSLKLDAKD-GRLFNEQNFFQRAAKP  182

         99***************98877667788999***********9.****************

S: 56    eqikkwkkkkklkllgiPtliasGlhefegekyRflvlprlgrdLqklleqngkr.lsek  114

          q++kwkk ++++ l++Pt++++G+h+   +kyRflvlp+lgr+Lq++l+ ++++ lse+

Q: 183   LQVNKWKKLYSTPQLAVPTCMGFGVHQ---DKYRFLVLPSLGRSLQSALDVSPEHvLSER  239

         ***************************...*************************99***

S: 115   tvlqlavrlldvleylHeneYvHgdikAanllleeeeasqvyLvdyGlayrycpegkhke  174

         +vlq+a+rlld+le+lHeneYvHg+++A+n+++++e+ sqv+L++yG+a+rycp+gkh++

Q: 240   SVLQVACRLLDALEFLHENEYVHGNVTAENIFVDPEDRSQVTLAGYGFAFRYCPSGKHVA  299

         ************************************************************

S: 175   ykedkrraHdGtleftslDaHkGvapsrRsDleiLgYcllkWltgkLPWeallkdpekvq  234

         y+e++r++H+G+lef+s+D+HkG++psrRsDl++LgYc+lkWl+g+LPW+++l+++e+++

Q: 300   YVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSLGYCMLKWLYGFLPWTNCLPNTEDIM  359

         ************************************************************

S: 235   kakekfldelpellkkllkkkssseelakyl  265

         k+k+kf d+++ ++  + ++ ++se+l++yl

Q: 360   KQKQKFTDKPGPFVGPCGHWIRPSETLQNYL  390

         ******************************7

Domain Sequence
(FASTA)

WKLKFLQTRD DQGILYEAAP TSALAYDSEL QKQKFSLKLD AKDGRLFNEQ NFFQRAAKPL 60

QVNKWKKLYS TPQLAVPTCM GFGVHQDKYR FLVLPSLGRS LQSALDVSPE HVLSERSVLQ 120

VACRLLDALE FLHENEYVHG NVTAENIFVD PEDRSQVTLA GYGFAFRYCP SGKHVAYVEG 180

SRSPHEGDLE FISMDLHKGC GPSRRSDLQS LGYCMLKWLY GFLPWTNCLP NTEDIMKQKQ 240

KFTDKPGPFV GPCGHWIRPS ETLQNYL 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0070373	; P:negative regulation of ERK1 and ERK2 cascade
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity

KEGG

mcc:719158

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS50011

; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013