EKS-MAM-00163

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00163

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	500.3	1.7E-150	361	618	258

Status

Unreviewed

Ensembl Protein

ENSMMUP00000014211

UniProt Accession

F7G3L7;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000010844	ENSMMUP00000035787	ENSMMUT00000042776
ENSMMUG00000010844	ENSMMUP00000014211	ENSMMUT00000015165
ENSMMUG00000010844	ENSMMUP00000014212	ENSMMUT00000015166

Organism

Macaca mulatta

Functional Description

Protein Length

670

Protein Sequence
(FASTA)

MSELEEDFAK ILMLKEERIK ELEKRLSEKE EEIQELKRKL HKCQSVLPVP STHIGPRTTR 60

AQGISAEPQT YRSFHDLRQA FRKFTKSERS KDLIKEAILD NDFMKNLELS QIQEIVDCMY 120

PVEYGKDSCI IKEGDVGSLV YVMEDGKVEV TKEGVKLCTM GPGKVFGELA ILYNCTRTAT 180

VKTLVNVKLW AIDRQCFQTI MMRTGLIKHT EYMEFLKSVP TFQSLPEEIL SKLADVLEET 240

HYENGEYIIR QGARGDTFFI ISKGTVNVTR EDSPSEDPVF LRTLGKGDWF GEKALQGEDV 300

RTANVIAAEA VTCLVIDRDS FKHLIGGLDD VSNKAYEDAE AKAKYEAEAA FFANLKLSDF 360

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 420

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 480

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 540

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCDNPSE 600

RLGNLKNGVK DIQKHKWFEG FNWEGLRKGT LTPPIIPSVA SPTDTSNFDS FPEDNDEPPP 660

DDNSGWDIDF 670

Nucleotide Sequence
(FASTA)

ATGAGCGAGC TAGAGGAAGA CTTTGCCAAG ATTCTCATGC TCAAGGAGGA GAGGATCAAA 60

GAGCTGGAGA AGCGTCTGTC AGAGAAGGAG GAGGAAATTC AGGAGCTGAA GAGGAAACTC 120

CACAAATGCC AGTCGGTGCT TCCCGTGCCC TCGACCCACA TCGGCCCCCG GACCACCCGG 180

GCGCAGGGCA TCTCGGCCGA GCCGCAGACG TACAGGTCCT TCCACGACCT CCGACAGGCA 240

TTCCGGAAGT TCACCAAGTC CGAAAGGTCC AAGGATCTTA TAAAGGAAGC TATCCTTGAT 300

AATGACTTTA TGAAGAACTT GGAGCTGTCG CAGATCCAGG AGATTGTGGA TTGTATGTAC 360

CCGGTGGAGT ATGGCAAGGA CAGTTGCATC ATCAAAGAAG GAGATGTGGG ATCACTGGTG 420

TATGTCATGG AAGATGGTAA GGTTGAAGTT ACAAAAGAAG GTGTGAAGTT GTGTACCATG 480

GGTCCAGGAA AAGTGTTTGG GGAGTTGGCT ATTCTTTACA ACTGTACCCG GACAGCGACC 540

GTCAAGACTC TTGTAAATGT AAAACTCTGG GCCATTGATC GACAATGTTT TCAAACAATA 600

ATGATGAGGA CAGGACTCAT CAAGCATACC GAGTATATGG AATTTTTAAA AAGTGTTCCA 660

ACATTCCAGA GCCTTCCTGA AGAGATCCTC AGCAAGCTCG CTGATGTCCT TGAAGAGACC 720

CACTATGAAA ATGGAGAATA TATTATCAGG CAAGGTGCAA GAGGGGACAC CTTCTTCATC 780

ATCAGCAAAG GAACGGTAAA TGTCACTCGT GAAGACTCAC CAAGTGAAGA CCCAGTCTTT 840

CTTAGAACTT TAGGAAAAGG AGACTGGTTT GGAGAGAAAG CCTTGCAGGG GGAAGATGTG 900

AGAACAGCAA ATGTAATTGC TGCAGAAGCT GTAACCTGCC TTGTGATTGA CAGAGACTCT 960

TTCAAACATT TGATTGGAGG GCTGGATGAT GTTTCTAATA AAGCATATGA AGATGCAGAA 1020

GCTAAAGCAA AATATGAAGC TGAAGCGGCT TTCTTCGCCA ACCTGAAGCT GTCTGATTTC 1080

AACATCATTG ATACCCTTGG AGTTGGAGGT TTCGGACGAG TAGAACTGGT CCAGTTGAAA 1140

AGTGAAGAAT CCAAAACATT TGCAATGAAG ATTCTCAAGA AACGTCACAT TGTGGACACA 1200

AGACAGCAGG AGCACATCCG CTCAGAGAAG CAGATCATGC AGGGGGCTCA TTCCGATTTC 1260

ATAGTGAGAC TGTACAGAAC ATTTAAGGAC AGCAAATATT TGTATATGTT GATGGAAGCT 1320

TGTCTAGGTG GAGAGCTCTG GACCATTCTC AGGGATAGAG GTTCGTTTGA AGATTCTACA 1380

ACCAGATTTT ACACAGCATG TGTGGTAGAA GCTTTTGCCT ATCTGCATTC CAAAGGAATC 1440

ATTTACAGGG ACCTCAAGCC AGAAAATCTC ATCCTAGATC ACCGAGGTTA TGCCAAACTG 1500

GTTGATTTTG GCTTTGCAAA GAAAATAGGA TTTGGAAAGA AAACATGGAC TTTTTGTGGG 1560

ACTCCAGAGT ATGTAGCCCC AGAGATCATC CTGAACAAAG GCCATGACAT TTCAGCCGAC 1620

TACTGGTCAC TGGGAATCCT AATGTATGAA CTCCTGACTG GCAGCCCACC TTTCTCAGGC 1680

CCAGATCCTA TGAAAACCTA TAACATCATA TTGAGGGGGA TTGACATGAT AGAATTTCCA 1740

AAGAAGATTG CTAAAAATGC TGCTAATTTA ATTAAAAAAC TATGCGACAA TCCATCAGAA 1800

AGATTAGGGA ATTTGAAAAA TGGAGTAAAA GACATTCAAA AGCACAAATG GTTTGAGGGC 1860

TTTAACTGGG AAGGCTTAAG AAAAGGTACC TTGACACCTC CTATAATACC AAGTGTTGCA 1920

TCACCCACAG ATACAAGCAA TTTTGACAGT TTTCCTGAGG ACAACGATGA ACCACCACCT 1980

GATGACAACT CAGGATGGGA CATAGACTTC TAA 2013

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+esk+fa+kilkk+hivdt+qqeh++sek+i++ a+sdf

Q: 361   NIIDTLGVGGFGRVELVQLKSEESKTFAMKILKKRHIVDTRQQEHIRSEKQIMQGAHSDF  420

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 421   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  480

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 481   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  540

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklc dnp+

Q: 541   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLC-DNPS  599

         *******************************************************.79**

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 600   ERLGNLKNGVKDIQKHKWF  618

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEESKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQGAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCDNPSE 240

RLGNLKNGVK DIQKHKWF 258

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005246	; F:calcium channel regulator activity
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity
GO:0016358	; P:dendrite development
GO:0030900	; P:forebrain development
GO:0090331	; P:negative regulation of platelet aggregation
GO:0001764	; P:neuron migration
GO:0043087	; P:regulation of GTPase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013