EKS-MAM-00105
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00105
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec476.04.2E-143363613251
StatusUnreviewed
Ensembl ProteinENSMMUP00000014407
UniProt AccessionF7GS57;
Protein Name
Protein Synonyms/Alias Tyrosine-protein kinase ITK/TSK;
Gene NameITK
Gene Synonyms/Alias ITK; EGK_17070;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000010995ENSMMUP00000014407ENSMMUT00000015377
OrganismMacaca mulatta
Functional Description
Protein Length620
Protein Sequence
(FASTA)
MNNFILLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKASLAY FEDRHGKKRT LKGSIELSRI 60
KCVEIVKSDI SIPCHYKYPF QVMHDNYLLY VFAPDRESRQ RWVLALKEET RNNNSLVPKY 120
HPNFWMDGKW RCCSQLEKLA AGCAQYDPTK NASKKPLPPT PEDNRRPLWE PEETVVIALY 180
DYQTNDPQEL ALRRNEEYCL LDSSEIHWWR VQDRNGHEGY VPSSYLVEKS PNNLETYEWY 240
NKSISRDKAE KLLWDTGKEG AFMVRDSRTP GTYTVSVFTK AVVSENNPCI KHYHIKETND 300
NPKRYYVAEK FVFDSIPLLI NYHQHNGGGL VTRLRYPVCF GRQKAPVTAG LRYGKWVIDP 360
SELTFVQEIG SGQFGLVHLG YWLNKDKVAI KTIREGAMSE EDFIEEAEVM MKLSHPKLVQ 420
LYGVCLEQAP ICLVFEFMEH GCLSDYLRSQ RGLFAAETLL GMCLDVCEGM AYLEEACVIH 480
RDLAARNCLV GENQVIKVSD FGMTRFVLDD QYTSSTGTKF PVKWASPEVF SFSRYSSKSD 540
VWSFGVLMWE VFSEGKIPYE NRSNSEVVED ISTGFRLYKP RLASTHVYQI MNHCWKERPE 600
DRPAFSRLLR QLAEIAESGL 620
Nucleotide Sequence
(FASTA)
ATGAACAACT TTATCCTCCT GGAAGAACAG CTCATCAAGA AATCCCAACA AAAGAGAAGA 60
ACTTCTCCCT CGAACTTTAA AGTCCGCTTC TTTGTGTTAA CCAAAGCCAG CCTGGCATAC 120
TTTGAGGATC GTCATGGGAA GAAGCGCACG CTGAAGGGGT CCATTGAGCT GTCCCGAATC 180
AAATGTGTCG AGATTGTGAA AAGTGACATC AGCATCCCAT GCCACTATAA ATACCCGTTT 240
CAGGTCATGC ATGACAACTA CCTCCTGTAT GTGTTTGCTC CAGATCGTGA GAGCCGGCAG 300
CGCTGGGTGC TGGCCCTTAA AGAAGAAACG AGGAATAATA ACAGTCTGGT GCCTAAATAT 360
CATCCTAATT TCTGGATGGA TGGGAAGTGG AGGTGCTGTT CTCAGCTGGA GAAGCTTGCA 420
GCAGGCTGTG CCCAATATGA TCCAACCAAG AACGCTTCAA AGAAGCCTCT TCCTCCTACT 480
CCTGAAGACA ACAGGCGACC ACTTTGGGAA CCTGAAGAAA CTGTGGTCAT TGCCTTGTAT 540
GACTACCAAA CCAATGATCC TCAGGAACTC GCACTGCGGC GCAATGAAGA GTACTGCCTG 600
CTGGACAGTT CTGAGATTCA CTGGTGGAGA GTCCAGGACA GGAATGGGCA TGAAGGATAT 660
GTACCAAGCA GTTATCTGGT GGAAAAATCT CCAAATAATC TGGAAACCTA TGAGTGGTAC 720
AATAAGAGTA TCAGCCGAGA CAAAGCTGAA AAACTTCTTT GGGACACAGG CAAAGAAGGA 780
GCCTTCATGG TAAGAGATTC CAGGACTCCG GGAACATACA CCGTGTCTGT TTTCACCAAG 840
GCTGTTGTGA GTGAGAACAA CCCCTGTATA AAGCACTATC ACATCAAGGA AACAAATGAC 900
AATCCTAAGC GATACTATGT GGCTGAAAAG TTTGTGTTCG ATTCCATCCC TCTTCTCATC 960
AACTATCACC AACATAATGG AGGAGGCCTG GTGACTCGAC TCCGGTATCC AGTGTGTTTT 1020
GGGAGGCAGA AAGCTCCAGT TACAGCAGGA CTGAGATACG GGAAATGGGT GATTGATCCC 1080
TCAGAGCTCA CTTTTGTACA AGAGATTGGC AGTGGGCAGT TTGGGTTGGT GCATCTGGGC 1140
TACTGGCTCA ACAAGGACAA GGTGGCTATC AAAACCATTC GGGAAGGGGC TATGTCAGAA 1200
GAAGACTTCA TAGAGGAGGC TGAAGTCATG ATGAAACTGT CTCATCCCAA ACTGGTCCAG 1260
CTGTATGGGG TGTGCCTGGA GCAGGCCCCC ATCTGCCTGG TGTTTGAGTT CATGGAGCAC 1320
GGCTGCCTGT CAGATTATCT ACGCAGCCAG CGGGGACTTT TTGCGGCAGA GACCCTGCTG 1380
GGCATGTGTC TGGACGTGTG TGAGGGCATG GCCTACCTGG AAGAGGCATG TGTCATCCAC 1440
AGAGACTTGG CTGCCCGAAA TTGTTTGGTG GGAGAAAATC AAGTCATCAA GGTGTCCGAC 1500
TTTGGGATGA CAAGGTTTGT TCTTGATGAT CAGTACACCA GTTCCACAGG CACCAAATTC 1560
CCGGTGAAGT GGGCATCCCC AGAAGTTTTC TCTTTCAGTC GCTATAGCAG CAAATCGGAT 1620
GTGTGGTCAT TTGGTGTGCT GATGTGGGAA GTTTTCAGTG AAGGCAAAAT CCCGTATGAA 1680
AACCGGAGCA ACTCAGAGGT GGTGGAAGAT ATCAGCACTG GATTTCGGTT GTACAAGCCC 1740
CGGCTGGCCT CCACACATGT CTACCAGATT ATGAATCACT GCTGGAAAGA GAGACCAGAA 1800
GATCGGCCAG CCTTCTCCAG ACTGCTGCGT CAACTGGCTG AAATTGCAGA ATCGGGACTT 1860
TAG 1863
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt+++e+gsgqfg+v+lg+w +k++vaik+i+egamseedfieea+vmmklshpklvqly
Q: 363   LTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQLY  422
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvcl+q+pi++v+e++e+gcl++ylr++++ +++e+ll mc dvcegm+yle++++ihrd
Q: 423   GVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEEACVIHRD  482
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++v+kvsdfg++r+vlddqy+ss+g+kfpvkw++pev+s+s+yssksdvw
Q: 483   LAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVW  542
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye++snsevve++s+g+rly+p+las++vy++m++cwke+pe+r
Q: 543   SFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDR  602
         ************************************************************
S: 241   ptfkellsale  251
         p+f++ll++l+
Q: 603   PAFSRLLRQLA  613
         ********996
Domain Sequence
(FASTA)
LTFVQEIGSG QFGLVHLGYW LNKDKVAIKT IREGAMSEED FIEEAEVMMK LSHPKLVQLY 60
GVCLEQAPIC LVFEFMEHGC LSDYLRSQRG LFAAETLLGM CLDVCEGMAY LEEACVIHRD 120
LAARNCLVGE NQVIKVSDFG MTRFVLDDQY TSSTGTKFPV KWASPEVFSF SRYSSKSDVW 180
SFGVLMWEVF SEGKIPYENR SNSEVVEDIS TGFRLYKPRL ASTHVYQIMN HCWKERPEDR 240
PAFSRLLRQL A 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543; F:phospholipid binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0032609; P:interferon-gamma production
GO:0032633; P:interleukin-4 production
GO:0035556; P:intracellular signal transduction
GO:0001865; P:NK T cell differentiation
GO:0050852; P:T cell receptor signaling pathway
KEGG
mcc:715471;
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013