EKS-MAM-00030
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00030
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Jak346.32.3E-103592868277
StatusUnreviewed
Ensembl ProteinENSMMUP00000014406
UniProt AccessionF7GS58;
Protein NameTyrosine-protein kinase
Protein Synonyms/Alias
Gene NameJAK3
Gene Synonyms/Alias JAK3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000010996ENSMMUP00000031753ENSMMUT00000038665
ENSMMUG00000010996ENSMMUP00000014406ENSMMUT00000015376
OrganismMacaca mulatta
Functional Description
Protein Length897
Protein Sequence
(FASTA)
RHSLMAKYIM DLERLDPAGA AETFHVSLPG VPGGQDGLGL LRVAGDGGIA WTQGEQEVLQ 60
PFCDFPEIVD ISIKQAPRVG PAGEHRLVTV TRTDNQILEA EFPGLPEALS FVALVDGYFR 120
LTTDSQHFFC KEVAPPRLLE EVAEQCHGPI TLDFAINKLK TGGSRPGSYV LRRSPQDFDS 180
FLLTVCVQTP LGPDYKGCLI RRSPTGSFFL VGLSRSHSSL RELLAACWDG GLHVDGVTVT 240
LTSCCIPRPK EKSNLIVVQR GRSPPTSSLV QPQSQCQLSQ MIFHKIPADS LEWHENLGHG 300
SFTKIYRGCR HEVVDGESRK TEVLLKVMDA KHKNCMESFL EAASLMSQVS YRHLVLLHGV 360
CMAGDSTMVQ EFVHLGAIDT YLRKRGHLVP ASWKLQVVKQ LAYALNYLED KGLPHGNVSA 420
RKVLLAREGT DGSPPFIKLS DPGVSPAVLS LEMLTDRIPW VAPECLRKAQ TLSLEADKWG 480
FGATVWEVFS GVTMPISALD PAKKLQFYED RQQLPAPKWT ELALLIQQCM AYEPVQRPSF 540
RAVIRDLNSL ISSDYELLSD PTPGALAPRD GLWNGAQLYA CQDPTIFEER HLKYISQLGK 600
GNFGSVELCR YDPLGDNTGA LVAVKQLQHS GPDQQRDFQR EIQILKALHS DFIVKYRGVS 660
YGPGEPGRQS LRLVMEYLPS GCLRDFLQRH RARLDASRLL LYSSQICKGM EYLGSRRCVH 720
RDLAARNILV ESEAHVKIAD FGLAKLLPLD KDYYVVREPG QSPIFWYAPE SLSDNIFSRQ 780
SDVWSFGVVL YELFTYCDKS CSPSAEFLRM MGCERDVPAL CRLLELLEEG QRLPAPPACP 840
AEVHELMKLC WAPSPQDRPS FSTLGPQLDM LWSGSRGCET HAFTAHPEGK PHSLSFL 897
Nucleotide Sequence
(FASTA)
CGGCACTCGC TCATGGCCAA GTACATTATG GATCTGGAGC GGCTGGATCC GGCTGGGGCC 60
GCCGAGACCT TCCACGTGAG CCTCCCTGGG GTCCCTGGTG GCCAGGACGG GCTGGGGCTG 120
CTCCGCGTGG CTGGTGACGG AGGAATCGCC TGGACCCAGG GAGAACAGGA GGTCCTCCAG 180
CCCTTCTGCG ACTTTCCAGA AATCGTAGAC ATTAGCATCA AGCAGGCCCC GCGCGTTGGC 240
CCGGCCGGGG AGCACCGCCT GGTCACTGTC ACCAGGACAG ACAACCAGAT TTTGGAGGCC 300
GAGTTCCCGG GGCTGCCCGA GGCTCTGTCT TTCGTGGCGC TCGTGGACGG CTACTTCCGG 360
CTGACCACAG ACTCCCAGCA CTTCTTCTGC AAGGAGGTGG CACCGCCGAG GCTGCTGGAG 420
GAGGTGGCAG AGCAGTGCCA CGGCCCCATC ACTCTGGACT TTGCCATAAA CAAGCTTAAG 480
ACTGGGGGCT CACGTCCTGG CTCCTATGTT CTCCGCCGCA GCCCCCAGGA CTTTGACAGC 540
TTCCTCCTCA CTGTCTGTGT ACAGACCCCC CTTGGTCCTG ATTATAAGGG TTGCCTCATT 600
CGGCGCAGCC CCACAGGGAG CTTCTTTCTG GTTGGCCTCA GCCGATCCCA CAGCAGTCTT 660
CGAGAGCTCC TGGCAGCCTG CTGGGATGGG GGGCTGCACG TAGATGGGGT CACAGTGACC 720
CTCACCTCCT GCTGTATCCC CAGACCCAAA GAAAAGTCCA ACTTGATCGT GGTCCAGAGA 780
GGTCGCAGCC CACCCACGTC CTCCCTGGTT CAGCCCCAAT CCCAATGCCA GCTGAGTCAG 840
ATGATATTTC ACAAGATCCC CGCTGACAGC CTAGAGTGGC ATGAGAACCT GGGCCATGGA 900
TCCTTCACCA AGATTTACCG GGGCTGTCGC CACGAGGTGG TGGATGGGGA ATCCCGAAAG 960
ACAGAGGTGC TGCTAAAAGT GATGGATGCT AAGCACAAGA ACTGCATGGA GTCATTCCTG 1020
GAAGCAGCGA GCTTGATGAG CCAAGTGTCG TACCGGCATC TCGTGCTGCT CCACGGCGTG 1080
TGCATGGCTG GAGACAGCAC CATGGTGCAA GAATTTGTAC ACCTGGGGGC GATAGACACG 1140
TATCTGCGAA AACGTGGCCA CCTGGTGCCA GCCAGCTGGA AGCTGCAGGT GGTCAAACAG 1200
CTGGCCTACG CCCTCAACTA TCTGGAGGAC AAAGGCCTCC CCCATGGCAA TGTCTCCGCC 1260
CGGAAGGTGC TCCTGGCTCG GGAGGGCACT GATGGGAGCC CGCCCTTCAT CAAGCTAAGT 1320
GACCCTGGGG TCAGCCCCGC TGTGTTAAGC CTGGAGATGC TCACCGACAG GATCCCCTGG 1380
GTGGCTCCCG AGTGTCTTCG GAAGGCCCAG ACACTTAGCT TGGAAGCTGA CAAGTGGGGC 1440
TTCGGCGCCA CGGTCTGGGA GGTGTTTAGT GGCGTCACCA TGCCCATCAG CGCCCTGGAT 1500
CCTGCTAAGA AACTCCAATT TTATGAGGAC CGGCAGCAGC TGCCAGCCCC CAAGTGGACA 1560
GAGCTGGCCC TGCTAATTCA ACAGTGCATG GCCTATGAGC CAGTCCAGAG GCCCTCCTTC 1620
CGAGCCGTCA TTCGTGACCT CAACAGCCTC ATCTCTTCAG ACTATGAGCT CCTCTCAGAC 1680
CCCACACCTG GTGCCCTGGC ACCTCGTGAT GGGCTGTGGA ATGGTGCCCA GCTCTATGCC 1740
TGCCAAGACC CCACGATCTT CGAGGAGAGA CACCTCAAGT ACATCTCACA GCTGGGCAAG 1800
GGCAACTTTG GCAGCGTGGA GCTGTGCCGC TATGACCCGC TAGGCGACAA CACAGGTGCC 1860
CTGGTGGCCG TGAAACAGCT GCAGCACAGC GGGCCAGACC AGCAGAGGGA CTTCCAGCGG 1920
GAGATTCAGA TCCTCAAAGC ACTGCACAGT GATTTCATTG TCAAGTATCG TGGTGTCAGC 1980
TACGGCCCGG GTGAGCCAGG CCGCCAGAGC CTGCGGCTGG TCATGGAGTA CCTGCCCAGC 2040
GGCTGCTTGC GCGACTTCCT GCAGCGGCAC CGCGCGCGCC TGGATGCCAG CCGCCTCCTG 2100
CTCTACTCCT CGCAGATCTG CAAGGGCATG GAGTACCTGG GCTCCCGCCG CTGCGTGCAC 2160
CGCGACCTGG CCGCCCGAAA TATCCTGGTG GAGAGCGAGG CACACGTCAA GATCGCTGAC 2220
TTCGGCCTAG CTAAGCTGCT GCCGCTTGAC AAAGACTACT ACGTGGTCCG CGAGCCGGGC 2280
CAGAGCCCCA TTTTCTGGTA TGCCCCCGAA TCCCTCTCGG ACAACATCTT CTCTCGCCAG 2340
TCAGACGTAT GGAGCTTCGG GGTCGTCCTG TACGAGCTCT TCACCTACTG CGACAAAAGC 2400
TGCAGCCCCT CGGCCGAGTT TCTGCGGATG ATGGGATGTG AGCGGGATGT CCCCGCCCTC 2460
TGCCGCCTCC TGGAACTGCT GGAGGAGGGC CAGAGGCTGC CGGCGCCTCC TGCCTGCCCT 2520
GCTGAGGTTC ACGAGCTCAT GAAGCTGTGC TGGGCCCCTA GCCCACAGGA CCGCCCATCA 2580
TTCAGCACCC TGGGCCCCCA GCTGGACATG CTATGGAGCG GAAGCCGGGG GTGTGAGACT 2640
CACGCCTTCA CTGCTCACCC AGAGGGCAAA CCACACTCCC TGTCCTTTTT ATAG 2694
Domain Profile
S: 1     lkqiesLgkgtftkvfevredaegdsteeevalkvLkesgedisrdfkreaeilsqlshe  60
         lk+i++Lgkg+f++v+++r+d+ gd+t++ va+k+L++sg+d++rdf+re++il++l+++
Q: 592   LKYISQLGKGNFGSVELCRYDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSD  651
         799*********************************************************
S: 61    hivklkgvcvaegen.....rlVmeyvesGsLdiyLrkkkealslsslldvakqlakame  115
         +ivk++gv++ +ge      rlVmey++sG+L+++L++++++l++s+ll +++q++k+me
Q: 652   FIVKYRGVSYGPGEPgrqslRLVMEYLPSGCLRDFLQRHRARLDASRLLLYSSQICKGME  711
         ********999887666799****************************************
S: 116   YLedkklvhrdvaarnvLveresnegtppfvklsdpglakavnqd.eYylvreerdsrip  174
         YL+++++vhrd+aarn+Lve+e++      vk++d+glak+++ d +Yy+vre+++s+i+
Q: 712   YLGSRRCVHRDLAARNILVESEAH------VKIADFGLAKLLPLDkDYYVVREPGQSPIF  765
         ************************......******************************
S: 175   wlapeclseaknlstasdvWsFgvtlyellt.cskgesp....lrsesle.......rkl  222
         w+ape+ls++  +s++sdvWsFgv+lyel+t c+k++sp    lr++++e       r+l
Q: 766   WYAPESLSDNI-FSRQSDVWSFGVVLYELFTyCDKSCSPsaefLRMMGCErdvpalcRLL  824
         ***********.************************************************
S: 223   elleekerlpkpk.cpaelaelmtnclsyepsqrpsFrailedl  265
         ellee++rlp+p+ cpae++elm+ c++ +p++rpsF+++  +l
Q: 825   ELLEEGQRLPAPPaCPAEVHELMKLCWAPSPQDRPSFSTLGPQL  868
         ***************************************98776
Domain Sequence
(FASTA)
LKYISQLGKG NFGSVELCRY DPLGDNTGAL VAVKQLQHSG PDQQRDFQRE IQILKALHSD 60
FIVKYRGVSY GPGEPGRQSL RLVMEYLPSG CLRDFLQRHR ARLDASRLLL YSSQICKGME 120
YLGSRRCVHR DLAARNILVE SEAHVKIADF GLAKLLPLDK DYYVVREPGQ SPIFWYAPES 180
LSDNIFSRQS DVWSFGVVLY ELFTYCDKSC SPSAEFLRMM GCERDVPALC RLLELLEEGQ 240
RLPAPPACPA EVHELMKLCW APSPQDRPSF STLGPQL 277
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; SH2 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>
EKS-AIM-00027
EKS-BOT-00033
EKS-CAF-00032
EKS-CAP-00034
EKS-EQC-00030
EKS-FEC-00029
EKS-GOG-00029
EKS-HOS-00030
EKS-ICT-00030
EKS-LOA-00032
EKS-MOD-00032
EKS-MUM-00033
EKS-MUP-00033
EKS-MYL-00033
EKS-NOL-00031
EKS-OTG-00032
EKS-PAT-00027
EKS-POA-00030
EKS-PTV-00031
EKS-RAN-00034
EKS-SAH-00030
EKS-SUS-00027
Gene Ontology
GO:0005856; C:cytoskeleton
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0030183; P:B cell differentiation
GO:0007167; P:enzyme linked receptor protein signaling pathway
GO:0035771; P:interleukin-4-mediated signaling pathway
GO:0007243; P:intracellular protein kinase cascade
GO:0002731; P:negative regulation of dendritic cell cytokine production
GO:0045221; P:negative regulation of FasL biosynthetic process
GO:0032693; P:negative regulation of interleukin-10 production
GO:0032695; P:negative regulation of interleukin-12 production
GO:0045626; P:negative regulation of T-helper 1 cell differentiation
GO:0070244; P:negative regulation of thymocyte apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter
GO:0043029; P:T cell homeostasis
KEGG
InterPros
IPR000299; FERM_domain.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
IPR020775; Tyr_kinase_non-rcpt_Jak3.
Pfam
PF07714; Pkinase_Tyr; 2.
SMARTs
SM00252; SH2; 1.
SM00219; TyrKc; 2.
Prosites
PS50057; FERM_3; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 2.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR01823; JANUSKINASE.
PR01826; JANUSKINASE3.
PR00109; TYRKINASE.
Created Date20-Feb-2013