EKS-MAM-00140

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00140

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/CDC7	555.1	7.6E-167	58	569	512

Status

Unreviewed

Ensembl Protein

ENSMMUP00000014420

UniProt Accession

F7GQW8;

Protein Name

Protein Synonyms/Alias

Cell division cycle 7-related protein kinase;

Gene Name

CDC7

Gene Synonyms/Alias

CDC7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000011010	ENSMMUP00000014420	ENSMMUT00000015393
ENSMMUG00000011010	ENSMMUP00000039759	ENSMMUT00000046731

Organism

Macaca mulatta

Functional Description

Protein Length

574

Protein Sequence
(FASTA)

MEASLGIQMD EPMAFSPQRD RSQAEGSLKK NEQNFKLAGV KKDIEKLYEA VPQLGNVFKI 60

KDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPVR IAAELQCLTV AGGQDNVMGV 120

KYCFRKNDHV VIAMPYLEHE SFLDILNSLS FQEVREYMFN LFKALKRIHQ FGIVHRDVKP 180

SNFLYNRRLK KYALVDFGLA QGTHDTKIEL LKFVQSEAQQ ERCSQNKSHI ITGNKIPLSG 240

PVPKELDQQS TTKASVKRPY TNAQIQIKQG KDGKEGSVGL SVQRSVFGER NFNIHSSISH 300

ESPAVKLMKQ SKTVDVLSRK LATKKKTISA KVMNSGVMRK TASSCPTSLT CDCYATDKVC 360

SICLSRRQQV APRAGTPGFR APEVLTKCPN QTTAIDMWSA GVIFLSLLSG RYPFYKASDD 420

LTALAQIMTI RGSRETIQAA KTFGKSILCS KEVPAQDLRK LCERLRGMDS NTPKLTSDIQ 480

GPASHQPTVS EKTDHKASRL IQTPPGQYSG NSFKKGDSNS CGCCFDEYTT NLEGWNEVPD 540

EAYDLLDKLL DLNPASRITA EEALLHPFFK DMSL 574

Nucleotide Sequence
(FASTA)

ATGGAGGCGT CTTTGGGGAT TCAAATGGAT GAGCCAATGG CTTTTTCTCC CCAGCGTGAC 60

CGGTCTCAGG CTGAAGGCTC TCTAAAAAAA AACGAGCAGA ATTTTAAACT TGCAGGTGTT 120

AAAAAAGATA TTGAGAAGCT TTATGAAGCT GTACCACAGC TTGGGAATGT GTTTAAGATT 180

AAGGACAAAA TTGGAGAAGG CACTTTCAGC TCTGTTTATT TGGCCACAGC ACAGTTACAA 240

GTAGGACCTG AAGAGAAAAT TGCTCTAAAA CACTTGATTC CAACAAGTCA TCCTGTAAGA 300

ATTGCAGCTG AACTTCAGTG CCTAACAGTG GCTGGGGGGC AAGATAATGT CATGGGAGTT 360

AAATACTGCT TTAGGAAGAA TGATCATGTA GTTATTGCTA TGCCGTATCT GGAGCATGAG 420

TCGTTTTTGG ACATTTTGAA TTCTCTTTCC TTTCAAGAAG TACGGGAATA TATGTTTAAT 480

CTGTTCAAAG CTTTGAAACG CATCCATCAG TTTGGTATTG TTCACCGTGA TGTTAAGCCC 540

AGCAATTTTT TATATAATAG GCGCTTGAAA AAGTATGCCT TGGTAGACTT TGGTTTGGCC 600

CAAGGAACCC ATGACACGAA AATAGAGCTT CTCAAATTTG TCCAGTCTGA AGCTCAGCAG 660

GAAAGGTGTT CACAAAACAA ATCCCACATA ATCACAGGAA ACAAGATTCC ATTGAGTGGC 720

CCAGTACCTA AGGAGCTGGA TCAGCAGTCC ACCACAAAAG CTTCTGTTAA AAGACCCTAC 780

ACAAATGCAC AAATTCAGAT TAAACAAGGA AAAGATGGAA AGGAGGGATC TGTAGGCCTT 840

TCTGTCCAGC GCTCTGTTTT TGGAGAAAGA AATTTCAATA TACACAGCTC CATTTCACAT 900

GAGAGCCCTG CAGTGAAACT CATGAAGCAG TCAAAGACTG TGGATGTACT GTCTAGAAAG 960

TTAGCAACAA AAAAGAAGAC TATTTCTGCA AAAGTTATGA ATAGTGGTGT AATGAGGAAA 1020

ACTGCCAGTT CTTGCCCAAC TAGCCTGACC TGTGACTGCT ATGCAACAGA TAAAGTTTGT 1080

AGTATTTGCC TTTCAAGGCG TCAGCAGGTT GCCCCTAGGG CAGGTACACC AGGATTCAGA 1140

GCACCAGAAG TCTTGACAAA GTGCCCCAAT CAAACTACAG CAATTGACAT GTGGTCTGCA 1200

GGTGTCATAT TTCTTTCTTT GCTTAGTGGA CGATACCCAT TTTATAAAGC AAGTGATGAT 1260

TTAACTGCTT TGGCCCAAAT TATGACAATT CGGGGATCCA GAGAAACTAT CCAAGCTGCT 1320

AAAACTTTTG GGAAATCAAT ATTATGTAGC AAAGAAGTTC CAGCACAAGA CTTGAGAAAA 1380

CTCTGTGAGA GACTCAGGGG TATGGATTCT AACACTCCCA AGTTAACAAG TGATATACAA 1440

GGACCTGCTT CTCATCAACC AACTGTTTCA GAGAAGACTG ACCATAAAGC TTCTCGCCTC 1500

ATACAAACAC CTCCAGGACA ATACTCAGGG AATTCATTTA AAAAGGGGGA TAGTAATAGC 1560

TGTGGGTGTT GTTTTGATGA GTATACTACC AATTTAGAAG GCTGGAATGA GGTACCTGAT 1620

GAAGCTTATG ACCTGCTTGA TAAGCTTCTA GATCTAAATC CAGCTTCAAG AATAACAGCA 1680

GAAGAAGCTT TGCTGCATCC ATTTTTTAAA GATATGAGCT TGTGA 1725

Domain Profile

S: 1     fkikdkiGeGtfssvylataqleegleekialkhliptshPeriaaeLelltvlgGqenv  60

         fkikdkiGeGtfssvylataql++g+eekialkhliptshP riaaeL++ltv+gGq+nv

Q: 58    FKIKDKIGEGTFSSVYLATAQLQVGPEEKIALKHLIPTSHPVRIAAELQCLTVAGGQDNV  117

         9***********************************************************

S: 61    vglkecfrkndsvvivlpylehesfldllrslsfqevreYlrnLlvalkrvhkfgivhrD  120

         +g+k+cfrknd+vvi++pylehesfld+l+slsfqevreY++nL++alkr+h+fgivhrD

Q: 118   MGVKYCFRKNDHVVIAMPYLEHESFLDILNSLSFQEVREYMFNLFKALKRIHQFGIVHRD  177

         ************************************************************

S: 121   vkpsnfLynrrlkkfaLvDfGLaq..............seaqkeecsrn..........l  156

         vkpsnfLynrrlkk+aLvDfGLaq              seaq+e+cs+n          +

Q: 178   VKPSNFLYNRRLKKYALVDFGLAQgthdtkiellkfvqSEAQQERCSQNkshiitgnkiP  237

         ***********************************************************9

S: 157   lsaavekevd..................................................  166

         ls++v+ke+d

Q: 238   LSGPVPKELDqqsttkasvkrpytnaqiqikqgkdgkegsvglsvqrsvfgernfnihss  297

         ************************************************************

S: 167   ....................................................tcdcygtd  174

                                                             tcdcy+td

Q: 298   ishespavklmkqsktvdvlsrklatkkktisakvmnsgvmrktasscptslTCDCYATD  357

         ************************************************************

S: 175   kvcsvclsrrqqvanraGtpGfraPevLlkipdqttaiDiwsaGvilLsllsgryPffka  234

         kvcs+clsrrqqva+raGtpGfraPevL+k+p+qttaiD+wsaGvi+LsllsgryPf+ka

Q: 358   KVCSICLSRRQQVAPRAGTPGFRAPEVLTKCPNQTTAIDMWSAGVIFLSLLSGRYPFYKA  417

         ************************************************************

S: 235   sddlealaeivtilGsreiikaakafgksvllskevp.......................  271

         sddl+ala+i+ti+Gsre+i+aak+fgks+l+skevp

Q: 418   SDDLTALAQIMTIRGSRETIQAAKTFGKSILCSKEVPaqdlrklcerlrgmdsntpklts  477

         ************************************************************

S: 272   .......................................dsdsye...............  277

                                                ds+s+

Q: 478   diqgpashqptvsektdhkasrliqtppgqysgnsfkkgDSNSCGccfdeyttnlegwne  537

         *****************************9999999999555555667777777888899

S: 278   .PdeaydlldkllelnPakritaeealkhpff  308

          Pdeaydlldkll+lnPa+ritaeeal+hpff

Q: 538   vPDEAYDLLDKLLDLNPASRITAEEALLHPFF  569

         9******************************8

Domain Sequence
(FASTA)

FKIKDKIGEG TFSSVYLATA QLQVGPEEKI ALKHLIPTSH PVRIAAELQC LTVAGGQDNV 60

MGVKYCFRKN DHVVIAMPYL EHESFLDILN SLSFQEVREY MFNLFKALKR IHQFGIVHRD 120

VKPSNFLYNR RLKKYALVDF GLAQGTHDTK IELLKFVQSE AQQERCSQNK SHIITGNKIP 180

LSGPVPKELD QQSTTKASVK RPYTNAQIQI KQGKDGKEGS VGLSVQRSVF GERNFNIHSS 240

ISHESPAVKL MKQSKTVDVL SRKLATKKKT ISAKVMNSGV MRKTASSCPT SLTCDCYATD 300

KVCSICLSRR QQVAPRAGTP GFRAPEVLTK CPNQTTAIDM WSAGVIFLSL LSGRYPFYKA 360

SDDLTALAQI MTIRGSRETI QAAKTFGKSI LCSKEVPAQD LRKLCERLRG MDSNTPKLTS 420

DIQGPASHQP TVSEKTDHKA SRLIQTPPGQ YSGNSFKKGD SNSCGCCFDE YTTNLEGWNE 480

VPDEAYDLLD KLLDLNPASR ITAEEALLHP FF 512

Keyword

ATP-binding; Cell cycle; Cell division; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0051301	; P:cell division
GO:0008284	; P:positive regulation of cell proliferation
GO:0033261	; P:regulation of S phase

KEGG

mcc:704730

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013