EKS-MAM-00156

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00156

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TLK	615.9	1.4E-185	410	688	279

Status

Unreviewed

Ensembl Protein

ENSMMUP00000014666

UniProt Accession

H9EPW6;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase tousled-like 1 isoform 1;

Gene Name

TLK1

Gene Synonyms/Alias

TLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000011189	ENSMMUP00000014666	ENSMMUT00000015657
ENSMMUG00000011189	ENSMMUP00000014667	ENSMMUT00000015658

Organism

Macaca mulatta

Functional Description

Protein Length

720

Protein Sequence
(FASTA)

GAMDELHSLD PRRQELLEAR FTGVASGSTG STGSCSVGAK ASTNNESSNH SFGSLGSLSD 60

KESETPEKKQ SESSRGRKRK AENQNESSQG KSIGGRGHKI SDYFEYQGGN GSSPVRGIPP 120

AIRSPQNSHS HSTPSSSVRP NSPSPTALAF GDHPIIQPKQ LSFKIIQTDL TMLKLAALES 180

NKIQDLEKKE GRIDDLLRAN CDLRRQIDEQ QKLLEKYKER LNKCISMSKK LLIEKSTQEK 240

LSSREKSMQD RLRLGHFTTV RHGASFTEQW TDGFAFQNLV KQQEWVNQQR EDIERQRKLL 300

AKRKPPTANN SQAPSTNSEP KQRKNKAVNG AENDPFVRPN LPQLLTLAEY HEQEEIFKLR 360

LGHLKKEEAE IQAELERLER VRNLHIRELK RINNEDNSQF KDHPTLNERY LLLHLLGRGG 420

FSEVYKAFDL YEQRYAAVKI HQLNKSWRDE KKENYHKHAC REYRIHKELD HPRIVKLYDY 480

FSLDTDTFCT VLEYCEGNDL DFYLKQHKLM SEKEARSIVM QIVNALRYLN EIKPPIIHYD 540

LKPGNILLVD GTACGEIKIT DFGLSKIMDD DSYGVDGMDL TSQGAGTYWY LPPECFVVGK 600

EPPKISNKVD VWSVGVIFFQ CLYGRKPFGH NQSQQDILQE NTILKATEVQ FPVKPVVSSE 660

AKAFIRRCLA YRKEDRFDVH QLANDPYLLP HMRRSNSSGN LHMAGLTASP TPPSSSIITY 720

Nucleotide Sequence
(FASTA)

GGTGCAATGG ATGAGCTTCA TAGTCTGGAT CCAAGAAGGC AAGAGTTATT GGAAGCTAGA 60

TTTACTGGAG TTGCAAGTGG GAGCACTGGG AGTACGGGCA GTTGCAGTGT TGGAGCTAAA 120

GCCTCAACAA ATAACGAAAG CTCTAATCAC AGTTTTGGAA GCTTGGGATC TTTAAGTGAC 180

AAAGAATCAG AGACACCAGA GAAGAAACAA TCGGAATCAT CCAGGGGAAG AAAGAGAAAA 240

GCAGAAAACC AGAATGAAAG TAGTCAGGGA AAAAGTATTG GGGGACGTGG CCACAAAATT 300

AGCGACTATT TTGAATACCA AGGTGGAAAT GGCTCAAGTC CAGTAAGAGG CATACCTCCT 360

GCAATCCGTT CTCCTCAAAA TTCACATTCA CATTCCACTC CTTCCTCATC TGTTCGACCG 420

AATAGCCCTT CTCCTACTGC ATTAGCATTT GGGGACCACC CTATTATACA ACCAAAGCAG 480

TTATCCTTTA AAATTATTCA GACTGATCTC ACAATGCTGA AATTAGCAGC ATTAGAAAGT 540

AATAAAATCC AGGACCTGGA AAAGAAGGAG GGACGTATAG ATGATTTGCT CAGGGCTAAC 600

TGTGATCTCA GACGGCAAAT AGATGAACAA CAAAAATTAC TTGAAAAATA CAAAGAACGA 660

TTAAATAAGT GCATATCAAT GAGCAAGAAA CTTCTTATTG AAAAGAGTAC ACAAGAAAAA 720

TTGTCAAGCA GAGAGAAGAG TATGCAAGAT CGATTACGCC TCGGGCACTT TACAACAGTT 780

AGACATGGCG CTTCATTTAC TGAACAATGG ACAGATGGCT TTGCATTTCA GAATCTTGTG 840

AAGCAACAAG AATGGGTGAA TCAGCAAAGG GAAGATATTG AAAGGCAAAG GAAACTTCTA 900

GCCAAACGCA AACCTCCCAC AGCTAATAAT TCTCAGGCAC CCTCTACCAA TTCTGAACCA 960

AAACAAAGGA AAAACAAAGC AGTCAATGGA GCAGAGAATG ATCCCTTTGT TAGACCAAAT 1020

TTACCACAAC TGTTGACTTT GGCAGAATAT CATGAACAGG AAGAAATTTT CAAACTTAGA 1080

CTAGGACATC TCAAAAAGGA AGAGGCAGAA ATCCAGGCAG AACTTGAACG TTTGGAAAGA 1140

GTCAGAAATC TTCACATACG TGAGCTGAAA AGAATAAACA ATGAAGATAA TTCACAGTTC 1200

AAAGATCACC CAACATTAAA TGAAAGATAT TTATTACTTC ATCTACTTGG TAGAGGTGGC 1260

TTTAGTGAAG TATATAAGGC TTTTGACCTA TATGAACAAA GATATGCTGC TGTGAAGATA 1320

CATCAGCTTA ATAAAAGCTG GAGAGATGAG AAGAAAGAAA ACTACCACAA ACATGCCTGC 1380

AGAGAGTATA GAATACATAA AGAACTGGAT CACCCCAGAA TAGTTAAACT CTATGATTAT 1440

TTCTCCTTGG ATACAGATAC GTTTTGTACA GTGTTAGAAT ACTGTGAAGG CAATGACTTG 1500

GATTTCTATC TGAAGCAACA CAAGTTAATG TCAGAGAAAG AAGCTAGGTC TATTGTAATG 1560

CAGATTGTAA ATGCACTAAG ATATCTCAAT GAGATCAAAC CCCCTATTAT ACATTATGAT 1620

CTTAAGCCAG GAAACATCCT ACTGGTAGAT GGAACAGCAT GTGGTGAAAT CAAAATCACT 1680

GATTTTGGTC TGTCCAAGAT TATGGATGAT GATAGCTATG GTGTAGATGG AATGGATCTA 1740

ACTTCTCAGG GGGCAGGCAC TTACTGGTAT TTACCTCCTG AGTGTTTTGT AGTTGGAAAA 1800

GAGCCACCAA AGATTTCCAA CAAGGTTGAT GTATGGTCAG TTGGAGTCAT CTTCTTTCAG 1860

TGTCTTTATG GTAGAAAGCC ATTTGGTCAC AATCAGTCTC AACAAGACAT TCTTCAAGAA 1920

AATACAATAT TAAAAGCCAC AGAAGTCCAG TTCCCTGTAA AACCTGTTGT AAGCAGTGAA 1980

GCCAAGGCCT TTATAAGACG CTGTTTGGCA TATCGAAAAG AAGATCGATT TGATGTGCAC 2040

CAGCTGGCAA ATGACCCATA CCTTCTCCCA CACATGAGAA GATCAAATTC TTCAGGAAAC 2100

CTACACATGG CTGGGCTGAC AGCATCCCCT ACGCCCCCTT CTTCAAGCAT AATTACTTAC 2160

TGA 2163

Domain Profile

S: 1     ylllkllgkggfsevykafdlkeqryvavkihqlnkdwkdekkenyvkhalreyrihkel  60

         ylll+llg+ggfsevykafdl+eqry+avkihqlnk+w+dekkeny+kha+reyrihkel

Q: 410   YLLLHLLGRGGFSEVYKAFDLYEQRYAAVKIHQLNKSWRDEKKENYHKHACREYRIHKEL  469

         9***********************************************************

S: 61    dhprivklydllsldtdsfctvleyvegndldfylkqhkllsekearsiimqivsalkyl  120

         dhprivklyd++sldtd+fctvley+egndldfylkqhkl+sekearsi+mqiv+al+yl

Q: 470   DHPRIVKLYDYFSLDTDTFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIVMQIVNALRYL  529

         ************************************************************

S: 121   neikppiihydlkpgnillvegtacgeikitdfglskimdddsydsddgleltsqgagty  180

         neikppiihydlkpgnillv+gtacgeikitdfglskimdddsy++d g++ltsqgagty

Q: 530   NEIKPPIIHYDLKPGNILLVDGTACGEIKITDFGLSKIMDDDSYGVD-GMDLTSQGAGTY  588

         *********************************************99.************

S: 181   wylppecfvvgkeppkisnkvdvwsvgvifyqclygkkpfghnqsqqdileentilkate  240

         wylppecfvvgkeppkisnkvdvwsvgvif+qclyg+kpfghnqsqqdil+entilkate

Q: 589   WYLPPECFVVGKEPPKISNKVDVWSVGVIFFQCLYGRKPFGHNQSQQDILQENTILKATE  648

         ************************************************************

S: 241   vqfpskpvvsseakafirrclayrkedridvqqlakdeyl  280

         vqfp+kpvvsseakafirrclayrkedr+dv+qla+d+yl

Q: 649   VQFPVKPVVSSEAKAFIRRCLAYRKEDRFDVHQLANDPYL  688

         **************************************97

Domain Sequence
(FASTA)

YLLLHLLGRG GFSEVYKAFD LYEQRYAAVK IHQLNKSWRD EKKENYHKHA CREYRIHKEL 60

DHPRIVKLYD YFSLDTDTFC TVLEYCEGND LDFYLKQHKL MSEKEARSIV MQIVNALRYL 120

NEIKPPIIHY DLKPGNILLV DGTACGEIKI TDFGLSKIMD DDSYGVDGMD LTSQGAGTYW 180

YLPPECFVVG KEPPKISNKV DVWSVGVIFF QCLYGRKPFG HNQSQQDILQ ENTILKATEV 240

QFPVKPVVSS EAKAFIRRCL AYRKEDRFDV HQLANDPYL 279

Keyword

ATP-binding; Kinase; Nucleotide-binding; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006886	; P:intracellular protein transport
GO:0035556	; P:intracellular signal transduction
GO:0001672	; P:regulation of chromatin assembly or disassembly

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013