EKS-MAM-00052
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00052
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TKL/RAF356.91.4E-106310566257
StatusUnreviewed
Ensembl ProteinENSMMUP00000014981
UniProt AccessionF6VS08;
Protein Name
Protein Synonyms/Alias
Gene NameARAF
Gene Synonyms/Alias ARAF;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000011418ENSMMUP00000014981ENSMMUT00000015986
OrganismMacaca mulatta
Functional Description
Protein Length605
Protein Sequence
(FASTA)
MEPPRGPPAN GAEPSRAVGT VKVYLPNKQR TVVTVRDGMS VYDSLDKALK VRGLNQDCCV 60
VYRLIKGRKT VTAWDTAIAP LDGEELIVEV LEDVPLTMHN FVRKTFFSLA FCDFCLKFLF 120
HGFRCQTCGY KFHQHCSSKV PTVCVDMSTN RQQFYHSVQD LSGGSRQHEA PSNRPLNELL 180
TPQGPRPHTQ HCDPEHFPFP APANAPLQRI RSTSTPNVHM VSTTAPMDSN LIQLTGQSFS 240
TDAASSRGGG DGTPRGSPSP ASVSSGRKSP HSKSPAEQRE RKSLADDKKK VKNLGYRDSG 300
YYWEVPPSEV QLLKRIGTGS FGTVFRGRWH GDVAVKVLKV SQPTAEQAQA FKNEMQVLRK 360
TRHVNILLFM GFMTRPGFAI ITQWCEGSSL YHHLHVADTR FDMVQLIDVA RQTAQGMDWC 420
DIKGLLWSLT LADIFLHEGL TVKIGDFGLA TVKTRWSGAQ PLEQPSGSVL WMAAEVIRMQ 480
DPNPYSFQSD VYAYGVVLYE LMTGSLPYSH IGCRDQIIFM VGRGYLSPDL SKISSNCPKA 540
MRRLLSDCLK FQREERPLFP QILATIELLQ RSLPKIERSA SEPSLHRTQA DELPACLLSA 600
ARLVP 605
Nucleotide Sequence
(FASTA)
ATGGAGCCAC CACGGGGCCC CCCTGCCAAT GGGGCCGAGC CGTCCCGGGC AGTGGGCACC 60
GTCAAAGTGT ACCTGCCCAA CAAGCAACGC ACGGTGGTGA CTGTCCGGGA TGGCATGAGT 120
GTCTACGACT CTCTAGACAA GGCCCTGAAG GTGCGGGGTC TAAATCAGGA CTGCTGTGTG 180
GTCTACCGAC TCATCAAGGG ACGAAAGACA GTCACTGCCT GGGACACAGC CATTGCTCCC 240
CTGGATGGCG AGGAGCTCAT TGTCGAGGTC CTTGAAGATG TCCCGCTGAC CATGCACAAT 300
TTTGTACGGA AGACCTTCTT CAGCCTGGCA TTCTGTGACT TCTGCCTTAA GTTTCTGTTC 360
CATGGCTTCC GTTGCCAAAC CTGTGGCTAC AAGTTCCACC AGCATTGTTC CTCCAAGGTC 420
CCCACAGTCT GTGTTGACAT GAGTACCAAC CGCCAACAGT TCTACCACAG TGTCCAGGAT 480
TTGTCCGGAG GCTCCAGACA ACATGAGGCT CCCTCGAACC GCCCCCTGAA TGAGTTGCTA 540
ACCCCCCAGG GTCCCAGGCC TCACACTCAG CACTGTGACC CGGAGCACTT CCCCTTCCCT 600
GCCCCGGCCA ACGCCCCCCT GCAGCGCATC CGCTCCACAT CCACTCCCAA CGTCCATATG 660
GTCAGCACCA CGGCCCCCAT GGACTCCAAC CTCATCCAGC TCACTGGCCA GAGTTTCAGC 720
ACTGATGCTG CCAGTAGTAG AGGAGGTGGT GATGGAACCC CCCGGGGGAG CCCCAGCCCA 780
GCCAGCGTGT CCTCGGGGAG GAAGTCCCCA CATTCCAAGT CACCAGCAGA GCAGCGTGAG 840
CGGAAGTCTT TGGCCGATGA CAAGAAGAAA GTGAAGAACC TGGGGTACCG GGACTCAGGC 900
TATTACTGGG AAGTACCACC CAGTGAGGTG CAGCTGCTGA AGAGGATCGG GACGGGCTCG 960
TTTGGCACCG TGTTTCGAGG GCGGTGGCAT GGCGATGTGG CTGTGAAGGT GCTCAAGGTG 1020
TCCCAGCCCA CAGCTGAGCA GGCCCAAGCT TTCAAGAATG AGATGCAGGT GCTCAGGAAG 1080
ACGCGACATG TCAACATCTT GCTGTTTATG GGCTTCATGA CCCGGCCGGG ATTCGCCATC 1140
ATCACACAGT GGTGTGAAGG CTCCAGCCTC TACCATCACC TGCATGTGGC CGACACGCGC 1200
TTCGACATGG TCCAGCTCAT CGACGTGGCC CGGCAGACTG CCCAGGGCAT GGATTGGTGT 1260
GATATTAAGG GGCTCCTGTG GTCCTTGACC CTGGCGGACA TCTTCCTACA TGAGGGGCTC 1320
ACGGTGAAGA TCGGTGACTT TGGCTTGGCC ACAGTGAAGA CTCGATGGAG CGGGGCCCAG 1380
CCCTTGGAGC AGCCCTCAGG CTCTGTGCTG TGGATGGCAG CTGAGGTGAT CCGTATGCAG 1440
GACCCGAACC CCTACAGCTT CCAGTCAGAT GTCTATGCCT ACGGGGTTGT GCTCTACGAG 1500
CTCATGACTG GCTCACTGCC TTACAGCCAC ATTGGCTGCC GTGACCAGAT TATCTTTATG 1560
GTGGGCCGTG GCTATCTGTC CCCGGACCTC AGCAAAATCT CTAGCAACTG CCCCAAGGCC 1620
ATGCGGCGCC TGCTGTCTGA CTGCCTCAAG TTCCAGCGGG AGGAACGGCC CCTCTTCCCC 1680
CAGATCCTGG CCACAATTGA GCTGCTGCAA CGGTCACTCC CCAAGATTGA GCGGAGTGCC 1740
TCGGAACCCT CCTTGCACCG CACCCAGGCT GATGAGTTGC CTGCCTGCCT ACTCAGCGCA 1800
GCCCGCCTTG TGCCTTAG 1818
Domain Profile
S: 1     velaekiGsGrfGtvyrgkwhGdvavkllnveelseeqleaFkkevaaykktRhenivLF  60
         v+l ++iG+G+fGtv+rg+whGdvavk+l+v+++++eq++aFk+e+++++ktRh+ni+LF
Q: 310   VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLF  369
         67899*******************************************************
S: 61    mGyvskpelaivtslckgssLykllheqetkldlaklidiarqiaqgmdYLhakkilhkD  120
         mG++++p +ai+t++c+gssLy++lh+++t++d+++lid+arq+aqgmd+   k++l   
Q: 370   MGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDWCDIKGLLW-S  428
         *******************************************************997.6
S: 121   lksknilleeglkvvitDFgllsvkrllsgrrekqleipkgwilylapeviralsidleq  180
         l   +i+l+egl+v+i+DFgl++vk+++sg  ++ le+p+g++l++a+evir+      q
Q: 429   LTLADIFLHEGLTVKIGDFGLATVKTRWSG--AQPLEQPSGSVLWMAAEVIRM------Q  480
         999***************************..9********************......*
S: 181   delpfskesDvyafGivlyellarelpyke.esadqilfavgrG.lkpdlskvksklpke  238
         d +p+s++sDvya+G+vlyel++++lpy++  ++dqi+f+vgrG l+pdlsk++s++pk+
Q: 481   DPNPYSFQSDVYAYGVVLYELMTGSLPYSHiGCRDQIIFMVGRGyLSPDLSKISSNCPKA  540
         ************************************************************
S: 239   lkellleClkfekeeRPlftqilkkl  264
         +++ll++Clkf++eeRPlf+qil+++
Q: 541   MRRLLSDCLKFQREERPLFPQILATI  566
         **********************9875
Domain Sequence
(FASTA)
VQLLKRIGTG SFGTVFRGRW HGDVAVKVLK VSQPTAEQAQ AFKNEMQVLR KTRHVNILLF 60
MGFMTRPGFA IITQWCEGSS LYHHLHVADT RFDMVQLIDV ARQTAQGMDW CDIKGLLWSL 120
TLADIFLHEG LTVKIGDFGL ATVKTRWSGA QPLEQPSGSV LWMAAEVIRM QDPNPYSFQS 180
DVYAYGVVLY ELMTGSLPYS HIGCRDQIIF MVGRGYLSPD LSKISSNCPK AMRRLLSDCL 240
KFQREERPLF PQILATI 257
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00045
EKS-BOT-00052
EKS-CAJ-00052
EKS-CAF-00053
EKS-CAP-00052
EKS-DAR-00067
EKS-EQC-00051
EKS-FEC-00050
EKS-GAM-00023
EKS-GAA-00070
EKS-GOG-00051
EKS-HOS-00053
EKS-ICT-00049
EKS-LAC-00056
EKS-LOA-00052
EKS-MAE-00026
EKS-MUM-00053
EKS-MUP-00054
EKS-MYL-00054
EKS-NOL-00052
EKS-ORC-00048
EKS-OTG-00055
EKS-POA-00049
EKS-SAH-00049
EKS-SUS-00043
EKS-TAR-00072
EKS-TEN-00076
EKS-TUT-00052
EKS-XIM-00069
Gene Ontology
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0046872; F:metal ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005057; F:receptor signaling protein activity
GO:0035556; P:intracellular signal transduction
GO:0043066; P:negative regulation of apoptotic process
GO:0033138; P:positive regulation of peptidyl-serine phosphorylation
KEGG
InterPros
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR003116; Raf-like_ras-bd.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
Pfam
PF00130; C1_1; 1.
PF07714; Pkinase_Tyr; 1.
PF02196; RBD; 1.
SMARTs
SM00109; C1; 1.
SM00455; RBD; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50898; RBD; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013