EKS-MAM-00404
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00404
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR575.95.8E-173582910329
StatusUnreviewed
Ensembl ProteinENSMMUP00000015165
UniProt AccessionF7BTH9;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000011556ENSMMUP00000015165ENSMMUT00000016183
ENSMMUG00000011556ENSMMUP00000033873ENSMMUT00000040845
OrganismMacaca mulatta
Functional Description
Protein Length976
Protein Sequence
(FASTA)
MGPGVLLLLL VVTAWHGQGI PVIEPSGPEL VVKPGEMVTL RCVGNGSVEW DGPISPHWTL 60
YSDGPSSVLT TTNATFQNTR TYRCTEPGDP LGGSAAIHLY VKDPARPWNV LAKEVVVFED 120
QDALLPCLLT DPVLEAGVSL VRLRGRPLLR HTNYSFSPWH GFTIHRAKFI QGQDYQCSAL 180
MGSRKVMSIS IRLKVQKVIP GPPALTLVPE ELVRIRGEAA QIVCSASNID VDFDVFLQHN 240
TTKLAIPQRS DFHDNRYQKV LTLSLGQVDF QHAGNYSCVA SNVQGKHSTS MFFRVVESAY 300
LDLSSEQNLI QEVTVGEGLN LKVMVEAYPG LQGFNWTYLG PFSDHQPEPK LANATTKDTY 360
RHTFTLSLPR LKPSEAGRYS FLARNPGGWR ALTFELTLRY PPEVSVIWTS INGSGTLLCA 420
ASGYPQPNVT WLQCAGHTDR CDEAQVLQVW VDPHPEVLSQ EPFQKVTVQS LLTAETLEHN 480
QTYECRAHNS VGSGSWAFIP ISAGARTHPP DEFLFTPVVV ACMSVMALLL LLLLLLLYKY 540
KQKPKYQVRW KIIESYEGNS YTFIDPTQLP YNEKWEFPRN NLQFGKTLGA GAFGKVVEAT 600
AFGLGKEDAV LKVAVKMLKS TAHADEKEAL MSELKIMSHL GQHENIVNLL GACTHGGPVL 660
VITEYCCYGD LLNFLRRKAE AMLGPSLSPG QDPEGGADYK NIHLEKKYVR RDSGFSSQGV 720
DTYVEMRPVS TSSNDSFSEQ DLDKEDGRPL ELWDLLHFSS QVAQGMAFLA SKNCIHRDVA 780
ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK WMAPESIFDC VYTVQSDVWS 840
YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF APKNIYSIMQ ACWALEPTHR 900
PTFQQICSLL QEQAQEDRRE RDYTNLPSSS RSGGSGSGSS SSSSEPEEES SSEHLACCEQ 960
GDIAQPLLQP NNYQFC 976
Nucleotide Sequence
(FASTA)
ATGGGCCCGG GAGTTCTGCT GCTCCTGCTG GTGGTCACAG CTTGGCATGG TCAGGGAATC 60
CCAGTGATAG AGCCCAGTGG CCCTGAGTTG GTCGTGAAGC CGGGAGAAAT GGTGACCCTG 120
CGATGTGTGG GCAATGGCAG TGTGGAATGG GATGGCCCCA TATCACCTCA CTGGACCCTG 180
TACTCTGATG GCCCCAGCAG CGTCCTCACC ACCACCAACG CTACCTTCCA AAACACAAGG 240
ACCTATCGCT GCACTGAGCC TGGAGACCCC CTGGGAGGCA GCGCCGCCAT CCACCTCTAC 300
GTCAAAGATC CTGCCCGGCC CTGGAACGTG CTAGCAAAGG AGGTGGTGGT GTTTGAGGAC 360
CAGGATGCAC TGCTGCCCTG CCTGCTCACA GACCCGGTGC TGGAGGCAGG CGTCTCGCTG 420
GTGCGTCTGC GTGGTCGGCC CCTCCTGCGC CACACCAACT ACTCCTTCTC GCCCTGGCAC 480
GGCTTCACCA TCCACAGGGC CAAATTCATT CAGGGCCAGG ACTATCAATG CAGTGCCCTG 540
ATGGGTAGCA GGAAGGTGAT GTCCATCAGC ATCCGGCTGA AAGTGCAGAA AGTCATCCCA 600
GGGCCCCCAG CCTTGACACT GGTGCCTGAA GAGCTGGTGC GGATTCGAGG GGAGGCTGCC 660
CAGATCGTGT GCTCAGCCAG CAACATTGAC GTTGACTTTG ATGTCTTCCT CCAACACAAC 720
ACCACCAAGC TCGCAATCCC TCAGCGATCT GACTTTCACG ATAACCGTTA CCAAAAAGTC 780
CTGACCCTCA GCCTCGGTCA AGTCGACTTC CAACATGCTG GCAACTACTC CTGCGTGGCC 840
AGCAACGTGC AGGGCAAGCA CTCCACCTCC ATGTTCTTCC GGGTCGTAGA GAGTGCCTAC 900
TTGGACTTGA GCTCTGAGCA GAACCTCATC CAGGAGGTGA CCGTGGGGGA GGGGCTCAAC 960
CTCAAAGTCA TGGTGGAGGC CTACCCAGGC CTGCAAGGTT TTAACTGGAC CTACCTGGGA 1020
CCCTTTTCTG ACCACCAGCC TGAGCCTAAG CTTGCTAATG CTACCACCAA GGACACATAC 1080
AGGCACACCT TCACCCTCTC TCTGCCCCGC CTGAAGCCCT CTGAGGCTGG CCGCTACTCC 1140
TTCCTGGCCA GAAACCCAGG AGGCTGGAGG GCTCTGACGT TTGAGCTCAC CCTTCGATAC 1200
CCCCCAGAGG TAAGTGTCAT ATGGACCTCC ATCAATGGCT CCGGCACCCT TTTGTGTGCT 1260
GCCTCTGGGT ACCCCCAGCC CAACGTGACA TGGCTGCAGT GCGCTGGCCA CACTGATAGG 1320
TGCGATGAGG CCCAAGTGCT GCAGGTCTGG GTCGACCCAC ACCCTGAGGT CCTGAGCCAG 1380
GAGCCCTTCC AGAAGGTGAC CGTGCAGAGC CTGCTGACCG CTGAGACCTT AGAGCACAAC 1440
CAAACCTATG AGTGCAGGGC CCACAACAGC GTGGGGAGTG GCTCCTGGGC CTTCATACCC 1500
ATCTCTGCAG GAGCCCGCAC GCATCCCCCG GATGAGTTCC TCTTCACACC GGTGGTGGTC 1560
GCCTGCATGT CCGTCATGGC CTTGCTGCTG CTGCTGCTCC TGCTGCTATT GTACAAGTAT 1620
AAGCAGAAGC CCAAGTACCA GGTCCGCTGG AAGATCATCG AGAGCTATGA GGGCAACAGT 1680
TATACTTTCA TTGACCCCAC GCAGCTGCCT TACAATGAGA AGTGGGAGTT CCCCCGGAAC 1740
AACCTGCAGT TTGGTAAGAC CCTCGGAGCT GGCGCCTTTG GGAAGGTGGT GGAGGCCACA 1800
GCCTTTGGTC TGGGCAAGGA GGATGCTGTC CTGAAGGTGG CTGTGAAGAT GCTGAAGTCC 1860
ACGGCCCATG CTGATGAGAA AGAGGCCCTC ATGTCTGAGC TGAAGATCAT GAGCCACCTG 1920
GGCCAGCATG AGAACATTGT CAACCTTTTG GGAGCCTGTA CTCATGGAGG CCCTGTACTG 1980
GTCATCACGG AGTACTGTTG CTATGGCGAC CTGCTCAACT TTCTGCGAAG GAAGGCTGAG 2040
GCCATGCTGG GACCCAGCCT GAGCCCTGGC CAGGACCCCG AGGGAGGCGC TGACTATAAG 2100
AACATCCACC TGGAGAAGAA ATATGTCCGC AGGGACAGTG GCTTCTCCAG CCAGGGTGTG 2160
GACACCTATG TGGAGATGAG ACCTGTCTCT ACTTCTTCAA ATGACTCCTT CTCTGAGCAA 2220
GACCTGGACA AGGAGGATGG ACGGCCCCTG GAGCTCTGGG ACCTGCTTCA CTTCTCCAGC 2280
CAAGTAGCCC AGGGCATGGC CTTCCTCGCT TCCAAGAATT GCATCCACCG GGATGTGGCA 2340
GCGCGAAATG TGCTGTTGAC CAATGGGCAT GTGGCCAAGA TTGGGGACTT CGGGCTGGCT 2400
AGGGACATCA TGAATGACTC CAACTACATC GTCAAGGGCA ATGCCCGCCT GCCTGTGAAG 2460
TGGATGGCCC CAGAGAGCAT CTTTGACTGT GTCTACACGG TTCAGAGCGA CGTCTGGTCC 2520
TATGGCATCC TCCTCTGGGA GATCTTCTCA CTTGGGCTGA ATCCCTACCC TGGCATCCTG 2580
GTGAACAGCA AGTTCTATAA ACTGGTGAAG GATGGATACC AAATGGCCCA GCCTGCATTT 2640
GCCCCAAAGA ATATATACAG CATCATGCAG GCCTGCTGGG CCTTGGAGCC CACCCACAGA 2700
CCCACTTTCC AGCAGATCTG CTCCCTCCTT CAGGAGCAAG CCCAAGAGGA CAGGAGAGAG 2760
CGGGACTATA CCAATCTGCC AAGCAGCAGC AGAAGCGGTG GTAGCGGTAG CGGCAGCAGC 2820
AGCAGCAGCA GTGAGCCGGA GGAGGAGAGC TCTAGTGAGC ACCTGGCCTG CTGCGAGCAA 2880
GGGGATATCG CCCAGCCCTT GCTGCAGCCC AACAACTATC AGTTCTGCTG A 2931
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+davlkvavkmlksta+++ekealmselki+shlG
Q: 582   LQFGKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLG  641
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +henivnllGact+gGp++viteyccyGdlln+lrrk+e++l  sl+  +++e  +d+k+
Q: 642   QHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEGGADYKN  701
         ************************************************************
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++r++s +ss++ ++yv++++    vs+s++d++++++            l++e
Q: 702   IhLEKKYVRRDSGFSSQGVDTYVEMRP----VSTSSNDSFSEQD------------LDKE  745
         *999***********************....9999999999988............8899
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++lel+dll+fs+qva+Gm+flasknc+hrd+aarnvllt+G+v+ki+dfGlardim+
Q: 746   DGRPLELWDLLHFSSQVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMN  805
         9***********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsny+vkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+lv+skf
Q: 806   DSNYIVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKF  865
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         ykl+k+Gy+maqpa+a+++iy+imq+cw+ ep++rp+f+q+++ll
Q: 866   YKLVKDGYQMAQPAFAPKNIYSIMQACWALEPTHRPTFQQICSLL  910
         ******************************************996
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDAVL KVAVKMLKST AHADEKEALM SELKIMSHLG 60
QHENIVNLLG ACTHGGPVLV ITEYCCYGDL LNFLRRKAEA MLGPSLSPGQ DPEGGADYKN 120
IHLEKKYVRR DSGFSSQGVD TYVEMRPVST SSNDSFSEQD LDKEDGRPLE LWDLLHFSSQ 180
VAQGMAFLAS KNCIHRDVAA RNVLLTNGHV AKIGDFGLAR DIMNDSNYIV KGNARLPVKW 240
MAPESIFDCV YTVQSDVWSY GILLWEIFSL GLNPYPGILV NSKFYKLVKD GYQMAQPAFA 300
PKNIYSIMQA CWALEPTHRP TFQQICSLL 329
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-POA-00396
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0030316; P:osteoclast differentiation
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
mcc:711512;
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR013151; Immunoglobulin.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF00047; ig; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013