EKS-MAM-00401

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00401

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/PDGFR	605.6	5.4E-182	600	958	359

Status

Unreviewed

Ensembl Protein

ENSMMUP00000015166

UniProt Accession

F7BTH1;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

PDGFRB

Gene Synonyms/Alias

PDGFRB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000011557	ENSMMUP00000015166	ENSMMUT00000016184

Organism

Macaca mulatta

Functional Description

Protein Length

1106

Protein Sequence
(FASTA)

MRLPGAMPAL ALKGQLLLLP LLLLLEPQVS QGLVITPPGP ELILNVSSTF VLTCSGSAPV 60

VWERMSQELP QEMAKAQDNT FSSVLTLTNL TGLDTGEYFC TYNDSRGLEP DERKRLYIFV 120

PDPTMGFLPN DAEELFIFLT EITEITIPCR VTDPQLVVTL HEKKGDIALP VPYDHQRGFS 180

GIFEDRSYIC KTTIGDREVD SDAYYVYRLQ VSSINVSVNA VQTVVRQGEN ITLMCIVIGN 240

EVVNFEWMYP RKESGRLVEP VTDFLLDMPY HIRSILHIPS AELEDSGTYT CNVTESVNDH 300

QDEKAINITV VESGYVRLLG EVGALQFAEL HRSRTLQVVF EAYPPPTVLW FKDNRTLGDS 360

SAGEIALSTR NVSETRYVSE LTLVRVKVAE AGHYTMRAFH EDAEVQLSFQ LQINVPVRVL 420

ELSESHPDSG EQTVRCRGRG MPQPNIIWSA CRDLKRCPRE LPPMLLGNSS EEESQLETNV 480

TYWEEEQEFE VVSTLRLQHV DRPLSVRCTL RNAVGQDMQE VIVVPHSLPF KAVVISAILA 540

LVVLTIISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPMQLPYD STWELPRDQL 600

VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 660

HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQHHSDKRRP PSAELYSNAL 720

PVGLPLPSHV SLTGESDGGY MDMSKDESVD YVPMLDMKGD VKYADIESSN YMAPYDNYVP 780

SAPERTCRAT LINESPVLSY MDLVGFSYQV ANGMEFLASK NCVHRDLAAR NVLICEGKLV 840

KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 900

GTPYPELPMN EQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFEIRPP FSQLVLLLER 960

LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RLPGFHGLRS PLDSSSVLYT AVQPNEGDND 1020

YIIPLPDPKP EVADEGPLEG SPSLASSTLN EVNTSSTISC DSPLEPQEEP EPEPQLERQV 1080

EPEPELEQLP DSGCPAPRAE AEDSFL 1106

Nucleotide Sequence
(FASTA)

ATGCGGCTTC CGGGTGCGAT GCCAGCTCTG GCCCTCAAAG GCCAGCTGCT GTTGCTGCCC 60

CTGCTGTTAC TGCTGGAACC GCAGGTCTCT CAGGGCCTGG TCATCACACC CCCGGGGCCA 120

GAGCTTATCC TCAATGTCTC CAGCACCTTT GTTCTGACCT GCTCGGGTTC AGCTCCCGTG 180

GTGTGGGAGC GGATGTCCCA GGAGCTCCCA CAGGAAATGG CCAAGGCCCA GGACAATACC 240

TTCTCCAGTG TGCTGACACT GACCAACCTC ACTGGGCTAG ACACGGGAGA ATACTTTTGC 300

ACCTACAATG ACTCCCGTGG ACTGGAGCCT GATGAGCGGA AACGGCTCTA CATCTTTGTG 360

CCAGATCCCA CCATGGGCTT CCTCCCTAAT GACGCCGAGG AACTATTCAT CTTTCTTACG 420

GAAATAACTG AGATCACCAT TCCATGCCGA GTAACAGACC CACAACTGGT GGTGACACTG 480

CACGAGAAGA AAGGGGACAT TGCACTGCCT GTCCCCTACG ATCACCAGCG TGGCTTTTCT 540

GGTATCTTTG AGGACAGAAG CTACATCTGC AAAACCACCA TTGGGGACAG GGAGGTGGAT 600

TCCGACGCCT ACTATGTCTA CAGACTCCAG GTGTCATCCA TCAACGTCTC CGTGAATGCA 660

GTGCAGACGG TGGTCCGCCA GGGTGAGAAC ATTACCCTCA TGTGCATTGT GATCGGGAAT 720

GAGGTGGTCA ACTTCGAGTG GATGTACCCC CGCAAAGAAA GTGGGCGGCT GGTGGAGCCG 780

GTGACCGACT TCCTCTTGGA TATGCCTTAC CACATCCGCT CCATCCTGCA CATCCCCAGT 840

GCCGAGTTAG AAGACTCGGG GACCTACACC TGCAATGTGA CAGAGAGTGT GAATGACCAT 900

CAGGATGAAA AGGCCATCAA CATCACTGTG GTTGAGAGTG GCTACGTGCG GCTCCTGGGA 960

GAGGTGGGAG CACTACAATT TGCTGAGCTG CACCGGAGCC GGACACTGCA GGTAGTGTTC 1020

GAGGCCTACC CTCCGCCCAC CGTCCTGTGG TTCAAAGACA ACCGCACCTT GGGCGACTCC 1080

AGCGCAGGCG AGATCGCCCT GTCCACGCGC AACGTGTCAG AGACCAGGTA TGTGTCAGAG 1140

CTGACACTCG TTCGGGTGAA GGTGGCAGAG GCTGGCCACT ACACCATGCG GGCCTTCCAT 1200

GAGGACGCTG AGGTCCAGCT CTCCTTCCAG CTACAGATCA ATGTCCCTGT CCGCGTGCTG 1260

GAGCTAAGTG AGAGCCACCC AGACAGCGGG GAACAGACAG TCCGCTGTCG TGGCCGGGGC 1320

ATGCCCCAGC CGAACATCAT CTGGTCTGCC TGCAGAGACC TCAAAAGGTG TCCACGCGAG 1380

CTGCCGCCCA TGCTGCTGGG GAACAGTTCT GAAGAGGAGA GCCAGCTGGA GACGAACGTG 1440

ACATACTGGG AGGAGGAGCA GGAGTTTGAG GTGGTGAGCA CACTGCGTCT GCAGCACGTG 1500

GATCGGCCAC TGTCGGTGCG CTGCACGCTG CGCAACGCTG TGGGCCAGGA CATGCAGGAG 1560

GTCATCGTGG TGCCACACTC TTTGCCCTTC AAGGCAGTGG TGATCTCAGC CATCCTGGCC 1620

CTGGTGGTCC TCACCATCAT CTCCCTTATC ATCCTCATCA TGCTTTGGCA GAAGAAGCCA 1680

CGTTACGAGA TCCGATGGAA GGTGATTGAG TCTGTGAGCT CTGATGGCCA TGAGTACATC 1740

TACGTGGACC CCATGCAGCT GCCCTATGAC TCCACGTGGG AGCTGCCGCG GGACCAGCTT 1800

GTGCTGGGAC GCACCCTCGG CTCTGGGGCC TTTGGGCAGG TGGTGGAGGC CACGGCTCAT 1860

GGCCTGAGCC ATTCTCAGGC CACGATGAAA GTGGCCGTCA AGATGCTTAA ATCCACAGCC 1920

CGCAGCAGTG AGAAGCAAGC CCTCATGTCG GAGCTGAAGA TCATGAGTCA CCTTGGGCCC 1980

CACCTGAACG TGGTCAACCT GTTGGGGGCC TGCACCAAAG GAGGACCCAT CTATATCATC 2040

ACTGAGTACT GCCGCTACGG AGACCTGGTG GACTACCTGC ACCGCAACAA GCACACGTTC 2100

CTGCAGCACC ATTCCGACAA GCGCCGCCCG CCCAGCGCGG AGCTCTACAG CAATGCGCTG 2160

CCCGTTGGGC TCCCCCTGCC CAGCCACGTG TCCCTGACTG GGGAGAGCGA TGGTGGCTAC 2220

ATGGACATGA GCAAGGACGA GTCGGTGGAC TACGTGCCCA TGCTGGACAT GAAAGGAGAT 2280

GTCAAATATG CCGACATCGA GTCCTCCAAC TACATGGCCC CCTACGATAA CTACGTTCCC 2340

TCTGCCCCTG AGAGGACCTG TCGGGCAACT TTAATCAATG AGTCTCCGGT GCTAAGCTAC 2400

ATGGACCTTG TGGGCTTCAG CTACCAGGTG GCCAATGGCA TGGAGTTCCT GGCCTCCAAG 2460

AACTGCGTGC ACCGAGACCT GGCGGCCAGG AACGTGCTCA TCTGCGAGGG CAAGCTGGTC 2520

AAGATCTGTG ACTTTGGCCT GGCTCGAGAC ATCATGCGGG ATTCGAATTA CATCTCCAAA 2580

GGCAGTACCT TTTTGCCTTT GAAGTGGATG GCTCCAGAGA GCATCTTCAA CAGCCTCTAC 2640

ACCACCCTGA GCGACGTGTG GTCCTTCGGG ATCCTGCTCT GGGAGATCTT CACTTTGGGT 2700

GGCACCCCTT ACCCAGAGCT GCCCATGAAT GAGCAGTTCT ACAATGCCAT CAAACGGGGT 2760

TACCGCATGG CCCAGCCTGC CCACGCCTCC GACGAGATCT ATGAGATCAT GCAGAAGTGC 2820

TGGGAAGAGA AGTTTGAGAT TCGGCCCCCT TTCTCCCAGC TGGTGCTGCT TCTCGAGAGA 2880

CTGTTGGGCG AAGGTTACAA AAAGAAGTAC CAGCAGGTGG ATGAGGAGTT TCTGAGGAGT 2940

GACCACCCAG CCATCCTTCG GTCCCAGGCC CGCTTGCCTG GGTTCCATGG CCTCCGATCT 3000

CCCCTGGACA GCAGCTCCGT CCTCTATACC GCCGTGCAGC CCAATGAGGG TGACAACGAC 3060

TATATCATCC CCCTGCCTGA CCCCAAACCC GAGGTTGCTG ACGAGGGCCC ACTGGAGGGT 3120

TCCCCCAGCC TAGCCAGCTC CACCCTGAAT GAAGTCAACA CCTCCTCGAC CATCTCCTGT 3180

GACAGCCCTC TGGAGCCCCA GGAGGAACCA GAGCCAGAGC CCCAGCTTGA GCGCCAGGTG 3240

GAACCAGAGC CAGAGCTGGA ACAGCTGCCG GATTCAGGGT GCCCCGCGCC TCGAGCGGAA 3300

GCAGAGGACA GCTTCCTGTA G 3321

Domain Profile

S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60

         l+lG++lGsGafG+vveata+Gls+s+a++kvavkmlkstarssek+almselki+shlG

Q: 600   LVLGRTLGSGAFGQVVEATAHGLSHSQATMKVAVKMLKSTARSSEKQALMSELKIMSHLG  659

         78**********************************************************

S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120

         +h+n+vnllGactkgGpiy+iteyc+yGdl++yl+r++++fl+++++k++++++el+s+a

Q: 660   PHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFLQHHSDKRRPPSAELYSNA  719

         ************************************************************

S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164

         l+++  l s++sl+ es++ y+d++kd                ++d++ss++++++++++

Q: 720   LPVGLPLPSHVSLTGESDGGYMDMSKDesvdyvpmldmkgdvkYADIESSNYMAPYDNYV  779

         ************************************************************

S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224

          sa er+++a+l++e s vl+++dl+ fsyqva+Gmeflaskncvhrdlaarnvl++eGk

Q: 780   PSAPERTCRATLINE-SPVLSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGK  838

         **************9.9*******************************************

S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284

         +vkicdfGlardim+dsny++kG+++lp+kwmapesif+slyt+ sdvws+Gillweif+

Q: 839   LVKICDFGLARDIMRDSNYISKGSTFLPLKWMAPESIFNSLYTTLSDVWSFGILLWEIFT  898

         ************************************************************

S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344

         lG+tpyp+l+++++fy++ik+Gyrmaqpa+a++eiyeimqkcwe+++e rp+f+qlv ll

Q: 899   LGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLVLLL  958

         ********************************************************9986

Domain Sequence
(FASTA)

LVLGRTLGSG AFGQVVEATA HGLSHSQATM KVAVKMLKST ARSSEKQALM SELKIMSHLG 60

PHLNVVNLLG ACTKGGPIYI ITEYCRYGDL VDYLHRNKHT FLQHHSDKRR PPSAELYSNA 120

LPVGLPLPSH VSLTGESDGG YMDMSKDESV DYVPMLDMKG DVKYADIESS NYMAPYDNYV 180

PSAPERTCRA TLINESPVLS YMDLVGFSYQ VANGMEFLAS KNCVHRDLAA RNVLICEGKL 240

VKICDFGLAR DIMRDSNYIS KGSTFLPLKW MAPESIFNSL YTTLSDVWSF GILLWEIFTL 300

GGTPYPELPM NEQFYNAIKR GYRMAQPAHA SDEIYEIMQK CWEEKFEIRP PFSQLVLLL 359

Keyword

ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005019	; F:platelet-derived growth factor beta-receptor activity
GO:0005021	; F:vascular endothelial growth factor-activated receptor activity
GO:0030325	; P:adrenal gland development
GO:0060326	; P:cell chemotaxis
GO:0001701	; P:in utero embryonic development
GO:0001822	; P:kidney development
GO:0006807	; P:nitrogen compound metabolic process
GO:0018108	; P:peptidyl-tyrosine phosphorylation
GO:0046488	; P:phosphatidylinositol metabolic process
GO:0048015	; P:phosphatidylinositol-mediated signaling
GO:0030335	; P:positive regulation of cell migration
GO:0038091	; P:positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
GO:0043552	; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0010863	; P:positive regulation of phospholipase C activity
GO:0032516	; P:positive regulation of phosphoprotein phosphatase activity
GO:0046777	; P:protein autophosphorylation
GO:0050730	; P:regulation of peptidyl-tyrosine phosphorylation
GO:0048705	; P:skeletal system morphogenesis
GO:0048745	; P:smooth muscle tissue development
GO:0001894	; P:tissue homeostasis
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

mcc:711353

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR013151	; Immunoglobulin.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016243	; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824	; Tyr_kinase_rcpt_3_CS.
IPR009134	; Tyr_kinase_VEGFR_rcpt_N.

Pfam

PF07679	; I-set; 1.
PF00047	; ig; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 2.
SM00408	; IGc2; 1.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00240	; RECEPTOR_TYR_KIN_III; 1.

Prints

PR01832

; VEGFRECEPTOR.

Created Date

20-Feb-2013