EKS-MAM-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	331.4	6.9E-99	25	313	289

Status

Unreviewed

Ensembl Protein

ENSMMUP00000015236

UniProt Accession

F6PLJ7;

Protein Name

Protein Synonyms/Alias

Gene Name

NRK

Gene Synonyms/Alias

NRK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000011601	ENSMMUP00000040892	ENSMMUT00000047863
ENSMMUG00000011601	ENSMMUP00000015236	ENSMMUT00000016258

Organism

Macaca mulatta

Functional Description

Protein Length

1583

Protein Sequence
(FASTA)

MAGPGGWRDR EVTDLGHLPD PTGIFSLDKT IGLGTYGRIY LGLHEKTGVF TAVKVMNARK 60

TPLPEIGRRV RVNKYQKSVG WRYSDEEEDL RTELNLLRKY SFHKNIVSFY GAFFKLSPPG 120

QRHQLWMVME LCAAGSVTDV VRMTRNQSLK EDWIAYICRE ILQGLAHLHA HRVIHRDIKG 180

QNVLLTHNAE VKLVDFGVSA QVSRTNGRRN SFIGTPYWMA PEVIDCDEDP RRSYDYRSDV 240

WSVGITAIEM AEGAPPLCNL QPLEALFVIL RESAPTVKSS GWSRKFHNFM EKCTIKNFLF 300

RPTSANMLHH PFVREIKNER HVVESLTRHL TGIIKKRQKK GIPLIFEREE AIKEQYTMRR 360

FRGPSCTHEL LRLPTSSRCR PLRVLHGEPS QPRWLPDREE PQVQALQQLQ GAARVFMPLQ 420

ALDSAPGPLK GQAQAPQRLQ GAARVFMPLQ AQVKAKASKP LQMQIKAPPR LRRAARVLMP 480

LQAQVRAPRL LQVQAQVSKK QQAQTQTSEP QDLDQVPEEF QGQDQVPEQQ RQGQTPEQQQ 540

RHDQVPEQEL EQNQEPEQPE VREQAAEPAQ AETEAEEPES LRVNAQIFLP LLSQDHHVLL 600

PLHLDTQVLI PVEGQTERSP QAQAWTLEPP QAIGSVQALI EGLSKDLLRA PNSNNSKPLG 660

PLQTLMENLS SNRFYSQPEQ AREKKSKVST LRQALAKRLS PKRFRAKSSR RPEELELSDL 720

EARRRRRQRR WEDIFNQHEE ELRQVDKDKE EDESSDNDEV FHSIQAEVQM EPLQPHISNP 780

KKIEVQERSP SVPNNQDHAH HVEFSSSVLQ RSLLEQAQKP IDIRQRSSQN RQNWLAASES 840

SSEEERPVTG RRSQSSPPYS TIDQKLLVDI HVPDGFKVGK ISPPVYLTNE WVGYNALSEI 900

FRNDWLTPAP VVQPPEEDGD YVELYDAGAD TDGDDDDESN DTYEDTYDHT NGNDDLDNQV 960

DQANDVCKDH DDDNNKSVDD NNSYYEAPSC PGASYGRDGS CKQDGYDGSR GKEEAYRGYG 1020

SHRANRSHGG SAASEDNAAT GDQEEHAANI GSERKGSGGD GDKAVIRTSE ESGALGPNGE 1080

ENCSETGGPG LKRAVSQDFE YLQEEPGGGN EASNAIDLGA ALSAPDDESD NKDIPESSTQ 1140

SDFSANHSSP SKGFGKSADA NFASAILYAG FVEVPEESPK QPSEINVNPR YVSPSCKKPL 1200

IHMYEKEFTS EICCGSLWGV NLLLGTRSNL YLMDRSGKAD ITKLIRRRPF RQIQVLEPLN 1260

LLITISGRKN RLRVYHLTWL RNKILNNDPE SKRRQEEMLK TEEACKAIDK LTGCEHFSVL 1320

QHEETTYIAI ALKSSIHLYA WAPKSFDEST AIKVMCIDQS ADSEGDYMSY QAYIRILKIQ 1380

AADPANRMSF LAFWPYLVLY SQVFPTLDHK PVTVDLAIGS EKRLKIFFSS ADGYHIIDAE 1440

SEVMSDVTLP NNPLEIIIPQ NIIILPDCLG IGMMLTFNAE ALSVEANEQL FKKILEMWKD 1500

IPSSIAFECT QRTTGWGQKA IEVRSLQSRV LESELKRRSI KKLRFLCTRG DKLFFTSTLR 1560

NRHSRVYFMT LGKLEELQSN YGV 1583

Nucleotide Sequence
(FASTA)

ATGGCGGGAC CTGGGGGCTG GAGGGACAGG GAGGTCACGG ATCTGGGCCA CTTGCCGGAT 60

CCAACTGGAA TATTCTCACT AGATAAAACC ATTGGCCTTG GTACTTATGG CAGAATCTAC 120

TTGGGACTTC ATGAGAAGAC TGGTGTGTTT ACAGCTGTTA AAGTGATGAA CGCTCGTAAG 180

ACACCTTTAC CTGAAATAGG AAGGCGAGTG AGAGTGAATA AATATCAAAA ATCTGTTGGG 240

TGGAGATACA GCGATGAAGA AGAGGATCTC AGGACTGAAC TCAACCTTCT GAGGAAGTAC 300

TCTTTCCACA AAAACATTGT GTCCTTCTAT GGTGCATTTT TCAAGCTGAG TCCCCCTGGT 360

CAGAGGCACC AACTTTGGAT GGTGATGGAG TTATGTGCAG CAGGTTCGGT CACTGATGTA 420

GTGAGAATGA CCAGAAATCA GAGTTTAAAA GAAGATTGGA TTGCTTATAT CTGCCGAGAA 480

ATCCTTCAGG GCTTAGCTCA CCTTCACGCA CACCGAGTAA TTCACCGGGA CATCAAAGGT 540

CAGAATGTGC TGCTGACTCA TAATGCTGAA GTAAAACTGG TTGATTTTGG AGTGAGTGCC 600

CAGGTGAGCA GAACTAATGG AAGGAGGAAT AGCTTCATTG GGACACCATA CTGGATGGCA 660

CCTGAGGTGA TTGACTGTGA TGAGGACCCA AGACGCTCCT ATGATTACAG AAGTGATGTG 720

TGGTCTGTGG GAATTACTGC CATTGAAATG GCTGAAGGAG CCCCTCCTCT GTGTAACCTT 780

CAACCCTTGG AAGCTCTCTT CGTTATTTTG CGTGAATCTG CTCCCACAGT CAAATCCAGC 840

GGATGGTCCC GTAAGTTCCA CAATTTCATG GAAAAGTGTA CGATAAAAAA TTTCCTGTTT 900

CGTCCTACTT CTGCAAACAT GCTTCATCAC CCATTTGTTC GGGAAATAAA AAATGAACGA 960

CATGTTGTTG AGTCATTAAC GAGGCATCTT ACTGGAATCA TTAAAAAAAG ACAGAAAAAA 1020

GGAATACCTT TGATCTTTGA AAGAGAAGAA GCTATTAAGG AACAGTACAC CATGAGAAGA 1080

TTCAGAGGAC CCTCTTGCAC TCATGAGCTT CTGAGATTGC CAACCAGCAG CAGATGCAGA 1140

CCACTTAGAG TCCTGCATGG AGAACCCTCT CAGCCAAGGT GGCTTCCTGA TCGAGAAGAG 1200

CCACAGGTCC AGGCACTTCA GCAGCTACAG GGAGCAGCCA GGGTATTCAT GCCACTGCAG 1260

GCCCTGGACA GTGCACCTGG GCCTCTAAAG GGGCAGGCTC AGGCACCTCA ACGACTACAA 1320

GGGGCAGCTC GGGTGTTCAT GCCACTACAG GCTCAGGTGA AGGCTAAGGC CTCTAAACCT 1380

CTACAAATGC AGATTAAGGC ACCTCCACGA CTACGGAGGG CAGCCAGGGT GCTCATGCCA 1440

CTACAGGCAC AGGTTAGGGC ACCTAGGCTT TTGCAGGTAC AGGCCCAGGT ATCCAAAAAG 1500

CAGCAGGCCC AGACCCAGAC ATCAGAACCA CAAGATCTGG ACCAAGTACC AGAGGAATTT 1560

CAGGGTCAAG ATCAGGTACC TGAACAACAA AGGCAGGGCC AGACCCCTGA ACAACAGCAG 1620

AGGCACGACC AGGTGCCTGA ACAAGAGCTG GAGCAGAACC AGGAACCTGA ACAGCCAGAG 1680

GTACGGGAAC AGGCTGCTGA GCCTGCACAG GCAGAGACTG AGGCAGAGGA ACCTGAGTCA 1740

TTACGAGTAA ATGCCCAGAT ATTCCTGCCC CTGCTATCAC AGGATCACCA TGTGCTGTTG 1800

CCACTACATT TGGATACTCA GGTGCTCATT CCAGTAGAGG GTCAAACTGA AAGATCACCT 1860

CAGGCACAGG CTTGGACACT AGAACCCCCA CAGGCAATTG GCTCAGTTCA AGCACTGATA 1920

GAGGGACTAT CAAAAGACTT GCTTCGAGCA CCAAACTCAA ATAACTCAAA GCCACTTGGT 1980

CCGTTGCAAA CCCTGATGGA AAATCTGTCA TCAAATAGGT TTTACTCACA ACCAGAACAG 2040

GCACGGGAGA AAAAATCAAA AGTTTCTACT CTGAGGCAAG CACTGGCAAA AAGACTATCA 2100

CCAAAGAGGT TCAGGGCAAA GTCATCACGG AGACCTGAAG AGCTTGAACT CTCAGATTTA 2160

GAAGCCCGCA GGCGAAGGCG CCAACGCAGA TGGGAAGATA TCTTTAATCA GCATGAGGAA 2220

GAATTGAGAC AAGTTGATAA AGACAAAGAA GAAGATGAAT CATCAGACAA TGATGAAGTA 2280

TTTCATTCGA TTCAGGCTGA AGTCCAAATG GAGCCATTGC AGCCACACAT TTCAAATCCT 2340

AAAAAAATTG AGGTTCAAGA GAGATCCCCT TCTGTGCCTA ACAACCAGGA TCATGCACAT 2400

CATGTCGAGT TCTCTTCAAG CGTTCTTCAG CGGTCTCTTT TGGAACAAGC TCAGAAGCCC 2460

ATTGACATCA GACAAAGGAG TTCGCAAAAT CGTCAGAATT GGCTGGCAGC ATCAGAATCT 2520

TCTTCTGAGG AAGAGAGACC TGTGACTGGA AGGAGGTCTC AGTCATCACC ACCTTATTCT 2580

ACTATTGATC AGAAGTTGCT GGTTGACATC CATGTTCCAG ATGGATTTAA AGTAGGAAAA 2640

ATATCACCCC CTGTATACTT GACAAACGAA TGGGTAGGCT ATAATGCACT CTCTGAAATC 2700

TTCCGGAATG ATTGGTTAAC TCCTGCACCT GTCGTTCAGC CACCTGAAGA GGATGGTGAT 2760

TATGTTGAAC TCTATGATGC CGGTGCTGAT ACTGATGGTG ATGATGATGA TGAGTCTAAT 2820

GATACTTATG AAGATACCTA TGATCATACC AATGGCAATG ATGACTTGGA TAACCAGGTT 2880

GATCAGGCTA ATGATGTTTG TAAAGACCAT GATGATGACA ACAATAAGTC TGTTGATGAT 2940

AATAATAGTT ATTATGAGGC ACCTAGTTGT CCAGGGGCAA GCTATGGCAG AGATGGAAGC 3000

TGCAAGCAAG ATGGTTATGA TGGAAGTCGT GGAAAAGAGG AAGCCTACAG AGGCTATGGA 3060

AGCCATAGAG CCAATAGAAG CCATGGAGGA AGTGCAGCCA GTGAGGACAA TGCAGCCACT 3120

GGAGATCAGG AAGAACATGC AGCCAATATA GGCAGTGAAA GAAAAGGCAG TGGGGGTGAT 3180

GGAGATAAGG CAGTCATTCG AACCAGTGAA GAGAGTGGAG CCCTTGGACC CAATGGAGAA 3240

GAAAATTGCT CAGAGACAGG TGGTCCAGGA TTGAAGAGAG CTGTGTCTCA GGACTTTGAA 3300

TATCTACAGG AGGAGCCAGG TGGTGGAAAT GAGGCCTCAA ATGCCATTGA CTTAGGTGCT 3360

GCACTGTCAG CACCTGATGA TGAGAGCGAC AATAAGGACA TACCAGAATC ATCAACACAA 3420

TCAGATTTTT CTGCCAATCA CTCATCTCCT TCCAAAGGTT TTGGGAAGTC TGCTGATGCT 3480

AACTTTGCCA GTGCCATCTT ATATGCTGGA TTTGTAGAAG TACCTGAGGA ATCACCTAAG 3540

CAACCCTCTG AAATCAATGT TAACCCACGC TATGTCTCTC CTTCATGTAA AAAACCACTA 3600

ATCCACATGT ATGAAAAGGA GTTCACTTCT GAGATCTGCT GTGGTTCTTT GTGGGGAGTC 3660

AATTTGCTGT TGGGAACCCG ATCTAATCTA TATCTGATGG ACAGAAGTGG AAAGGCTGAC 3720

ATTACTAAAC TTATAAGGCG AAGACCATTC CGCCAGATTC AAGTCTTAGA GCCACTCAAT 3780

TTGCTGATTA CCATCTCAGG TCGTAAGAAC AGACTTCGGG TGTATCATCT GACCTGGTTG 3840

AGGAACAAGA TTTTGAATAA TGATCCAGAA AGTAAAAGAA GGCAAGAAGA AATGCTGAAG 3900

ACAGAGGAAG CCTGCAAAGC TATTGATAAG TTAACAGGCT GTGAACACTT CAGTGTCCTC 3960

CAACATGAAG AAACAACATA TATTGCAATT GCTTTGAAAT CATCAATTCA CCTTTATGCA 4020

TGGGCACCGA AGTCCTTCGA TGAAAGCACT GCTATTAAAG TGATGTGCAT TGATCAATCA 4080

GCAGACTCTG AAGGAGACTA CATGTCCTAT CAAGCCTATA TACGAATACT GAAAATACAG 4140

GCAGCTGATC CAGCGAACCG AATGTCATTT TTGGCCTTTT GGCCATATTT GGTTTTATAT 4200

TCACAGGTAT TTCCAACACT TGATCATAAG CCAGTGACAG TTGACCTGGC TATTGGTTCT 4260

GAAAAAAGAC TAAAGATTTT CTTCAGCTCA GCAGATGGAT ATCACATCAT TGATGCAGAA 4320

TCTGAGGTTA TGTCTGATGT GACCCTGCCA AATAATCCCC TGGAAATCAT TATACCACAG 4380

AATATCATCA TTTTACCTGA TTGCCTGGGA ATTGGCATGA TGCTCACCTT CAATGCTGAA 4440

GCCCTCTCTG TGGAAGCAAA TGAACAACTC TTCAAGAAGA TCCTTGAAAT GTGGAAAGAC 4500

ATACCATCTT CTATAGCTTT TGAGTGTACA CAGCGAACCA CAGGATGGGG CCAAAAGGCC 4560

ATTGAAGTGC GCTCTTTGCA ATCCAGGGTT CTGGAAAGTG AGCTGAAGCG CAGGTCAATT 4620

AAGAAGCTGA GATTCCTATG CACCCGGGGT GACAAGCTGT TCTTTACCTC TACCCTGCGC 4680

AATCGCCACA GCCGGGTTTA CTTCATGACG CTTGGAAAAC TTGAAGAGCT CCAAAGCAAT 4740

TATGGTGTCT AA 4752

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekq.......................  37

         ++l ++ig G++g++yl+ ++ktg ++a+k++n++k+

Q: 25    FSLDKTIGLGTYGRIYLGLHEKTGVFTAVKVMNARKTplpeigrrvrvnkyqksvgwrys  84

         78999*******************************************************

S: 38    ekleelqkeisvlkklkh.pniveylesflk......eeelwlvmeylagGslsdlvkee  90

         +++e+l++e+++l+k++  +niv+++++f+k      +++lw+vme++a+Gs++d+v+++

Q: 85    DEEEDLRTELNLLRKYSFhKNIVSFYGAFFKlsppgqRHQLWMVMELCAAGSVTDVVRMT  144

         ****************966*****************99**********************

S: 91    lkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeVkLsdfgvaaqlek  150

         ++++lkE++iayi+re+l++L++lH+++viHrdik++n+Llt+++eVkL+dfgv+aq+++

Q: 145   RNQSLKEDWIAYICREILQGLAHLHAHRVIHRDIKGQNVLLTHNAEVKLVDFGVSAQVSR  204

         ************************************************************

S: 151   trkkrktvvgtpywmAPEviaqe...ekgYdekaDiwslGItaielaegepPfkdleplk  207

         t+ +r++++gtpywmAPEvi+++   +++Yd+++D+ws+GItaie+aeg+pP+++l+pl+

Q: 205   TNGRRNSFIGTPYWMAPEVIDCDedpRRSYDYRSDVWSVGITAIEMAEGAPPLCNLQPLE  264

         ***********************99999********************************

S: 208   allkilkneppklkskkkfskefkefvekclqknpekRpsasellkhkFl  257

         al+ il++++p++ks+  +s++f++f+ekc  kn+ +Rp+++++l+h+F+

Q: 265   ALFVILRESAPTVKSS-GWSRKFHNFMEKCTIKNFLFRPTSANMLHHPFV  313

         *************888.********************************7

Domain Sequence
(FASTA)

FSLDKTIGLG TYGRIYLGLH EKTGVFTAVK VMNARKTPLP EIGRRVRVNK YQKSVGWRYS 60

DEEEDLRTEL NLLRKYSFHK NIVSFYGAFF KLSPPGQRHQ LWMVMELCAA GSVTDVVRMT 120

RNQSLKEDWI AYICREILQG LAHLHAHRVI HRDIKGQNVL LTHNAEVKLV DFGVSAQVSR 180

TNGRRNSFIG TPYWMAPEVI DCDEDPRRSY DYRSDVWSVG ITAIEMAEGA PPLCNLQPLE 240

ALFVILRESA PTVKSSGWSR KFHNFMEKCT IKNFLFRPTS ANMLHHPFV 289

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tarsius syrichta"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0007256	; P:activation of JNKK activity
GO:0008285	; P:negative regulation of cell proliferation
GO:0007567	; P:parturition
GO:0060721	; P:regulation of spongiotrophoblast cell proliferation

KEGG

InterPros

IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00780	; CNH; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00036	; CNH; 1.
SM00220	; S_TKc; 1.

Prosites

PS50219	; CNH; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013