EKS-MAM-00485

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00485

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/CCK4	542.1	4.0E-163	666	931	266

Status

Unreviewed

Ensembl Protein

ENSMMUP00000015323

UniProt Accession

F7G3Z5;

Protein Name

Protein Synonyms/Alias

Inactive tyrosine-protein kinase 7 isoform a;

Gene Name

PTK7

Gene Synonyms/Alias

PTK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000011670	ENSMMUP00000015321	ENSMMUT00000016351
ENSMMUG00000011670	ENSMMUP00000033651	ENSMMUT00000040604
ENSMMUG00000011670	ENSMMUP00000015320	ENSMMUT00000016350
ENSMMUG00000011670	ENSMMUP00000015323	ENSMMUT00000016353
ENSMMUG00000011670	ENSMMUP00000033652	ENSMMUT00000040605
ENSMMUG00000011670	ENSMMUP00000015324	ENSMMUT00000016354
ENSMMUG00000011670	ENSMMUP00000015327	ENSMMUT00000016357
ENSMMUG00000011670	ENSMMUP00000033655	ENSMMUT00000040608
ENSMMUG00000011670	ENSMMUP00000033649	ENSMMUT00000040602

Organism

Macaca mulatta

Functional Description

Protein Length

940

Protein Sequence
(FASTA)

MGATRGSLAR PRRLPLLSVL LLPLLGGTQA AIVFIKQPSS QDALQGRRAL LRCEVEAPGL 60

VHVYWLLDGA PVQDTERRFT QGSSLSFAAV DRLQDSGTFQ CVARDDVTGE EARSANASFN 120

IKWIEAGPVV LKHPASEAEI QPQTQVTLRC HIDGHPRPTY QWFRDGTPLS DGQSNNTVSS 180

KERNLTLRPA GPEHSGLYSC CAHNAFGQAC SSQNFTLSIA DESFARVVLA PQDVIVARNE 240

EAMFHCQFSA QPPPNLQWLF EDETPITNRS RPPHLRRATV FANGSLLLTQ VRPRNAGVYR 300

CIGQGQRGPP VILEATLHLA EIEDMPLFEP RVFTAGSEER VTCLPPKGLP EPSVWWEHAG 360

VRLPTHGRVY QKGHELVLAS IAESDAGVYT CHAANLAGQR RQDVNITVAN GSSLPEWVTD 420

NAGTLHFARV TRDDAGNYTC IASNGPQGQI RAHVQLTVAV FITFKVEPER TTVYQGHTAL 480

LQCEAQGDPK PLIQWKGKDR ILDPTKLGPR MHIFQNGSLV IHDVAPEDSG RYTCIAGNSC 540

NIKHTEAPLY VVDKPVPEES EGPGSPPPYK MIQTIGLSVG AAVAYIIAVL GLMFYCKKRC 600

KAKRLQKQPE GEEPEMECLN GGPLQNGQPS AEIQEEVALT SLGSGPTATN KRHSTSDKMH 660

FPRSSLQPIT TLGKSEFGEV FLAKAQGLEE GVAETLVLVK SLQSKDEQQQ LDFRRELEMF 720

GKLNHANVVR LLGLCREAEP HYMVLEYVDL GDLKQFLRIS KSKDEKLKSQ PLSTKQKVAL 780

CTQVALGMEH LSNNRFVHKD LAARNCLVSA QRQVKVSALG LSKDVYNSEY YHFRQAWVPL 840

RWMSPEAILE GDFSTKSDVW AFGVLMWEVF THGEMPHGGQ ADDEVLADLQ AGKARLPQPE 900

GCPSKLFRLM QRCWALSPKD RPSFSEIAST LGDSPVDSKP 940

Nucleotide Sequence
(FASTA)

ATGGGAGCTA CACGGGGATC CCTGGCCAGA CCCCGCCGGT TGCCTCTGCT CAGCGTCCTG 60

CTGCTGCCGC TGCTGGGCGG TACCCAGGCA GCCATCGTCT TCATCAAGCA GCCGTCCTCC 120

CAGGATGCAC TGCAGGGGCG CCGGGCGCTG CTTCGCTGTG AGGTTGAGGC TCCGGGCCTG 180

GTACATGTGT ACTGGCTGCT CGATGGGGCA CCTGTCCAGG ACACAGAACG GCGTTTCACC 240

CAGGGCAGTA GCCTGAGCTT TGCAGCTGTG GACCGGCTGC AGGACTCTGG CACCTTCCAG 300

TGTGTGGCTC GGGATGATGT CACTGGAGAA GAAGCCCGCA GTGCCAATGC CTCCTTCAAC 360

ATCAAATGGA TTGAGGCAGG TCCTGTGGTC CTGAAGCATC CAGCCTCAGA AGCTGAGATC 420

CAGCCACAGA CCCAGGTCAC ACTTCGTTGT CACATTGATG GGCACCCTCG GCCCACCTAC 480

CAATGGTTCC GAGATGGGAC CCCCCTTTCT GATGGTCAGA GCAACAACAC AGTCAGCAGC 540

AAGGAGCGGA ACCTGACGCT CCGGCCAGCT GGTCCTGAGC ATAGTGGGCT CTATTCCTGC 600

TGCGCCCACA ATGCTTTTGG CCAGGCCTGC AGCAGCCAGA ACTTCACCCT GAGCATTGCT 660

GATGAAAGCT TTGCCAGGGT GGTGCTGGCA CCCCAGGACG TGATAGTAGC GAGGAATGAG 720

GAAGCCATGT TCCATTGCCA GTTCTCAGCC CAGCCACCCC CGAACCTGCA GTGGCTCTTT 780

GAGGATGAGA CTCCCATCAC TAACCGCAGT CGCCCCCCAC ACCTTCGCAG AGCCACAGTA 840

TTTGCCAACG GGTCTCTGCT GCTGACCCAG GTCCGGCCAC GCAATGCAGG GGTCTACCGC 900

TGCATCGGCC AGGGGCAGAG GGGCCCACCT GTCATCCTGG AGGCCACACT TCATCTAGCA 960

GAGATTGAAG ACATGCCTCT ATTTGAGCCA CGGGTGTTTA CAGCGGGCAG CGAGGAGCGT 1020

GTTACCTGCC TTCCCCCCAA GGGTCTGCCA GAGCCCAGTG TGTGGTGGGA GCACGCAGGA 1080

GTCCGACTGC CCACCCATGG CAGGGTGTAC CAGAAGGGCC ACGAACTGGT GTTGGCCAGT 1140

ATTGCTGAAA GTGATGCTGG TGTCTACACC TGCCACGCGG CCAACCTGGC TGGTCAGCGG 1200

AGACAGGACG TCAACATCAC TGTGGCCAAT GGGAGCAGCC TTCCAGAGTG GGTGACAGAC 1260

AACGCTGGGA CCCTACATTT TGCCCGGGTG ACTCGAGATG ACGCTGGCAA CTACACTTGC 1320

ATTGCCTCCA ATGGGCCACA GGGCCAGATT CGTGCCCATG TCCAGCTCAC TGTGGCAGTT 1380

TTTATCACCT TCAAAGTAGA GCCAGAGCGC ACGACTGTGT ACCAGGGCCA CACAGCCCTG 1440

CTGCAGTGTG AGGCCCAGGG GGACCCTAAG CCACTGATTC AGTGGAAGGG CAAGGACCGC 1500

ATCCTGGACC CCACCAAGCT GGGACCCAGG ATGCACATCT TCCAGAATGG CTCCCTGGTG 1560

ATCCACGACG TGGCCCCTGA GGACTCAGGC CGCTACACCT GCATTGCAGG CAACAGCTGC 1620

AACATCAAGC ACACGGAGGC CCCCCTCTAT GTCGTGGACA AGCCTGTGCC GGAGGAGTCG 1680

GAGGGCCCTG GCAGCCCTCC CCCCTACAAG ATGATCCAGA CCATTGGGCT GTCGGTGGGT 1740

GCCGCTGTGG CCTACATCAT CGCCGTGCTG GGTCTCATGT TCTACTGCAA GAAGCGCTGC 1800

AAAGCCAAGC GGCTGCAGAA GCAGCCCGAG GGCGAGGAGC CAGAGATGGA ATGCCTCAAC 1860

GGTGGGCCTT TGCAGAACGG GCAGCCCTCA GCAGAGATCC AAGAGGAAGT GGCCTTGACC 1920

AGCTTGGGCT CTGGCCCCAC GGCCACCAAC AAACGCCACA GCACAAGTGA TAAGATGCAC 1980

TTCCCACGGT CCAGCCTGCA GCCTATCACC ACGCTGGGAA AGAGTGAGTT TGGGGAGGTG 2040

TTCCTGGCAA AGGCTCAGGG CTTGGAGGAG GGAGTGGCGG AGACCCTGGT ACTTGTGAAG 2100

AGCCTGCAGA GCAAGGACGA GCAGCAGCAG CTGGACTTCC GGAGGGAGTT GGAGATGTTT 2160

GGGAAGCTGA ACCACGCCAA CGTGGTGCGG CTCCTGGGGC TCTGCCGGGA GGCTGAGCCC 2220

CATTACATGG TGCTGGAATA TGTGGACCTG GGAGACCTCA AGCAGTTCCT GAGGATTTCC 2280

AAGAGCAAGG ATGAAAAATT GAAGTCACAG CCCCTCAGCA CCAAGCAGAA GGTGGCCCTG 2340

TGCACCCAGG TAGCCCTGGG CATGGAGCAC CTGTCCAACA ACCGCTTTGT GCATAAGGAC 2400

TTGGCTGCAC GTAACTGCCT GGTCAGTGCC CAGAGACAAG TGAAGGTGTC TGCTCTGGGC 2460

CTCAGCAAGG ATGTGTACAA CAGTGAGTAC TACCACTTCC GCCAGGCCTG GGTGCCGCTG 2520

CGCTGGATGT CCCCTGAGGC CATCCTGGAG GGTGACTTCT CTACCAAGTC TGATGTCTGG 2580

GCCTTCGGTG TGCTGATGTG GGAAGTGTTT ACACATGGAG AGATGCCCCA TGGTGGGCAG 2640

GCAGATGATG AAGTGCTGGC AGATTTGCAG GCTGGGAAGG CTAGACTTCC TCAGCCCGAG 2700

GGCTGCCCTT CCAAGCTCTT TCGGCTGATG CAGCGCTGCT GGGCCCTCAG CCCCAAGGAC 2760

CGGCCCTCCT TCAGCGAGAT TGCCAGCACC CTGGGAGACA GCCCCGTGGA CAGCAAGCCG 2820

TGA 2823

Domain Profile

S: 1     lqelitlgksefgevflaklkgleegatetlvlvkslqkkdeqaqldfrrelellgklnh  60

         lq+++tlgksefgevflak++gleeg++etlvlvkslq+kdeq+qldfrrele++gklnh

Q: 666   LQPITTLGKSEFGEVFLAKAQGLEEGVAETLVLVKSLQSKDEQQQLDFRRELEMFGKLNH  725

         79**********************************************************

S: 61    anvvrllglcreaephymvleyvdlgdlkqflkiskakdeklksqplstkqkvalasqva  120

         anvvrllglcreaephymvleyvdlgdlkqfl+isk+kdeklksqplstkqkval++qva

Q: 726   ANVVRLLGLCREAEPHYMVLEYVDLGDLKQFLRISKSKDEKLKSQPLSTKQKVALCTQVA  785

         ************************************************************

S: 121   lgmealsrarfvhkdlaarnclisaerqvkvsalalskdvynseyykfrqalvplrwlsp  180

         lgme+ls++rfvhkdlaarncl+sa+rqvkvsal+lskdvynseyy+frqa+vplrw+sp

Q: 786   LGMEHLSNNRFVHKDLAARNCLVSAQRQVKVSALGLSKDVYNSEYYHFRQAWVPLRWMSP  845

         ************************************************************

S: 181   eaileddfstksdvfafgvlvwevftqaelpheeladdevladlqagklrlsqaeatpsk  240

         eaile+dfstksdv+afgvl+wevft++e+ph+++addevladlqagk+rl+q+e++psk

Q: 846   EAILEGDFSTKSDVWAFGVLMWEVFTHGEMPHGGQADDEVLADLQAGKARLPQPEGCPSK  905

         ************************************************************

S: 241   lyrlllrcwasnpkdrpsfselasal  266

         l+rl++rcwa++pkdrpsfse+as+l

Q: 906   LFRLMQRCWALSPKDRPSFSEIASTL  931

         ************************97

Domain Sequence
(FASTA)

LQPITTLGKS EFGEVFLAKA QGLEEGVAET LVLVKSLQSK DEQQQLDFRR ELEMFGKLNH 60

ANVVRLLGLC REAEPHYMVL EYVDLGDLKQ FLRISKSKDE KLKSQPLSTK QKVALCTQVA 120

LGMEHLSNNR FVHKDLAARN CLVSAQRQVK VSALGLSKDV YNSEYYHFRQ AWVPLRWMSP 180

EAILEGDFST KSDVWAFGVL MWEVFTHGEM PHGGQADDEV LADLQAGKAR LPQPEGCPSK 240

LFRLMQRCWA LSPKDRPSFS EIASTL 266

Keyword

Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0003401	; P:axis elongation
GO:0060070	; P:canonical Wnt receptor signaling pathway
GO:0016477	; P:cell migration
GO:0071300	; P:cellular response to retinoic acid
GO:0090103	; P:cochlea morphogenesis
GO:0060026	; P:convergent extension
GO:0045198	; P:establishment of epithelial cell apical/basal polarity
GO:0001736	; P:establishment of planar polarity
GO:0060484	; P:lung-associated mesenchyme development
GO:0001843	; P:neural tube closure
GO:0090179	; P:planar cell polarity pathway involved in neural tube closure
GO:0010976	; P:positive regulation of neuron projection development
GO:0042060	; P:wound healing

KEGG

mcc:699791

;

InterPros

IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR003598	; Ig_sub2.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07679	; I-set; 6.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00409	; IG; 1.
SM00408	; IGc2; 6.
SM00219	; TyrKc; 1.

Prosites

PS50835	; IG_LIKE; 7.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013