EKS-MAM-00482

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00482

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMK1	337.3	1.1E-100	46	301	256

Status

Unreviewed

Ensembl Protein

ENSMMUP00000015707

UniProt Accession

F7H273;

Protein Name

Protein Synonyms/Alias

Gene Name

CAMK4

Gene Synonyms/Alias

CAMK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000011974	ENSMMUP00000015707	ENSMMUT00000016772

Organism

Macaca mulatta

Functional Description

Protein Length

474

Protein Sequence
(FASTA)

MLKVTVPSCS ASSCSSVTAS AAPGTASLVP DYWIDGSNRD ALSDFFEVES ELGRGATSIV 60

YRCKQKGTQK PYALKVLKKT VDKKIVRTEI GVLLRLSHPN IVSERDLWDS PTTDSYHVLA 120

LKHFLSFCSR IVEKGYYSER DAADAVKQIL EAVAYLHENG IVHRDLKPEN LLYATPAPDA 180

PLKIADFGLS KIVEHQVLMK TVCGTPGYCA PEILRGCAYG PEVDMWSVGI ITYILLCGFE 240

PFYDERGDQF MFRRILNCEY YFISPWWDEV SLNAKDLVRK LIVLDPKKRL TTFQALQHPW 300

VTGKAANFVH MDTAQKKLQE FNARRKLKAA VKAVVASSRL GSASSSHGNI QESHKASRDP 360

SPIQDGNEDM KAIPEGEKIQ SDGAQAAVKG AQAELMKVQA LEKVKGSDIN AEEAPRMVPK 420

AVEDGIKVAD LELEKGLAEE KLKTVEEVAA PREGQGSSAV GFDVPQQDVI LPEY 474

Nucleotide Sequence
(FASTA)

ATGCTCAAAG TCACGGTGCC CTCCTGCTCC GCCTCGTCCT GCTCTTCGGT CACCGCCAGT 60

GCGGCCCCGG GGACCGCGAG CCTCGTCCCG GATTACTGGA TCGACGGCTC CAACAGGGAT 120

GCGCTGAGCG ATTTCTTCGA GGTGGAGTCG GAGCTGGGAC GGGGTGCTAC ATCCATTGTG 180

TACAGATGCA AACAGAAGGG GACCCAGAAG CCTTATGCTC TCAAAGTGTT AAAGAAAACA 240

GTGGACAAAA AAATCGTAAG AACTGAGATA GGAGTTCTTC TTCGCCTCTC ACATCCAAAC 300

ATTGTAAGTG AAAGGGACCT TTGGGATTCT CCCACCACTG ATAGCTACCA TGTACTAGCT 360

CTTAAGCATT TCCTTTCTTT TTGTTCCAGG ATTGTGGAAA AGGGATATTA CAGTGAGCGA 420

GATGCTGCAG ATGCTGTTAA ACAAATCCTG GAGGCAGTCG CTTATCTACA TGAAAATGGA 480

ATTGTCCATC GTGATCTCAA ACCAGAGAAT CTTCTCTATG CAACTCCAGC CCCAGATGCA 540

CCACTCAAAA TCGCTGATTT TGGACTCTCT AAAATTGTGG AACATCAAGT GCTCATGAAG 600

ACAGTATGTG GAACCCCAGG GTACTGCGCA CCTGAAATTC TTAGAGGTTG TGCCTATGGA 660

CCTGAGGTGG ACATGTGGTC TGTAGGAATA ATCACCTACA TCTTACTTTG TGGATTTGAA 720

CCATTCTATG ATGAAAGAGG CGATCAGTTC ATGTTCAGAA GAATTCTGAA TTGTGAATAT 780

TACTTTATCT CCCCCTGGTG GGATGAAGTA TCTCTGAATG CCAAGGACTT GGTCAGAAAA 840

TTAATTGTTT TGGATCCAAA GAAACGGCTG ACTACCTTTC AAGCTCTCCA GCATCCGTGG 900

GTCACAGGTA AAGCAGCCAA TTTTGTACAC ATGGATACCG CTCAAAAGAA GCTTCAAGAA 960

TTCAATGCTC GGCGTAAGCT TAAGGCAGCG GTGAAGGCTG TGGTGGCCTC TTCCCGGCTG 1020

GGAAGTGCCA GCAGCAGCCA TGGCAACATC CAGGAGAGCC ACAAGGCTAG CCGAGACCCT 1080

TCTCCAATCC AAGACGGCAA CGAGGACATG AAAGCTATTC CAGAAGGAGA GAAAATTCAA 1140

AGCGATGGGG CCCAAGCCGC AGTTAAGGGG GCACAGGCTG AGCTGATGAA GGTGCAAGCC 1200

TTAGAGAAAG TTAAAGGTTC AGATATAAAT GCTGAAGAGG CCCCCAGGAT GGTGCCCAAG 1260

GCAGTGGAGG ATGGGATAAA GGTGGCTGAC CTGGAACTAG AGAAGGGCCT AGCAGAGGAG 1320

AAGCTGAAGA CTGTGGAGGA AGTAGCAGCT CCCAGGGAAG GGCAAGGAAG CTCTGCTGTG 1380

GGCTTTGACG TTCCACAGCA AGATGTGATC CTGCCAGAGT ACTAA 1425

Domain Profile

S: 1     yklkeklGeGafsevlkakekktqkavaikvikkkalkgkeesveneiavlkklkhpniv  60

         ++++++lG+Ga+s v+++k+k tqk++a+kv+kk+    +++ v++ei vl +l+hpniv

Q: 46    FEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV---DKKIVRTEIGVLLRLSHPNIV  102

         7899******************************98...89*******************

S: 61    alkdiyesks.klylvlelvtGGelfdrivekgvytekdasevikqvleavkylhelgiv  119

         + +d+++s++   y vl l     +  rivekg+y+e+da++ +kq+leav+ylhe+giv

Q: 103   SERDLWDSPTtDSYHVLALKHFLSFCSRIVEKGYYSERDAADAVKQILEAVAYLHENGIV  162

         *******97526899*********************************************

S: 120   hrdlkPenllylskeedskikiadfGlskleeke.llktacGtvgyvapevlkqkkyskk  178

         hrdlkPenlly++++ d+++kiadfGlsk+ e++ l+kt+cGt+gy+ape+l+ ++y+ +

Q: 163   HRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQvLMKTVCGTPGYCAPEILRGCAYGPE  222

         *****************************9999989************************

S: 179   vdvWsiGvityillcGyppfydekeekl.lekilkgeyefesPyWdeisesakdfikkll  237

         vd+Ws+G+ityillcG++pfyde+ +++ +++il++ey+f sP+Wde+s +akd+++kl+

Q: 223   VDMWSVGIITYILLCGFEPFYDERGDQFmFRRILNCEYYFISPWWDEVSLNAKDLVRKLI  282

         ************************9998789*****************************

S: 238   eldpekrytieqaledpWi  256

          ldp+kr+t+ qal++pW+

Q: 283   VLDPKKRLTTFQALQHPWV  301

         ******************7

Domain Sequence
(FASTA)

FEVESELGRG ATSIVYRCKQ KGTQKPYALK VLKKTVDKKI VRTEIGVLLR LSHPNIVSER 60

DLWDSPTTDS YHVLALKHFL SFCSRIVEKG YYSERDAADA VKQILEAVAY LHENGIVHRD 120

LKPENLLYAT PAPDAPLKIA DFGLSKIVEH QVLMKTVCGT PGYCAPEILR GCAYGPEVDM 180

WSVGIITYIL LCGFEPFYDE RGDQFMFRRI LNCEYYFISP WWDEVSLNAK DLVRKLIVLD 240

PKKRLTTFQA LQHPWV 256

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007616	; P:long-term memory
GO:0043011	; P:myeloid dendritic cell differentiation
GO:0007270	; P:neuron-neuron synaptic transmission
GO:0006913	; P:nucleocytoplasmic transport
GO:0046827	; P:positive regulation of protein export from nucleus
GO:0045893	; P:positive regulation of transcription, DNA-dependent
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013