EPS-MAM-00025

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00025

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	192.5	2.0E-56	785	1031	247

Status

Unreviewed

Ensembl Protein

ENSMMUP00000015751

UniProt Accession

F7H052;

Protein Name

Protein Synonyms/Alias

PH domain leucine-rich repeat-containing protein phosphatase 2;

Gene Name

PHLPP2

Gene Synonyms/Alias

PHLPP2; EGK_12967;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000012007	ENSMMUP00000015747	ENSMMUT00000016814
ENSMMUG00000012007	ENSMMUP00000015752	ENSMMUT00000016819
ENSMMUG00000012007	ENSMMUP00000015751	ENSMMUT00000016818

Organism

Macaca mulatta

Functional Description

Protein Length

1323

Protein Sequence
(FASTA)

MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADS TTATTTTTTS SSSSSSSSSS 60

DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT ERPLQIVYDY LSRLGFDDLV 120

RIQEEATNPD LGCMIRFYGE KPCHMDHLDR ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC 180

LIVSSVKDCQ TGKMHILPLV GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ 240

RQASKVVSQR ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ 300

LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFRDLPSQ IGNLLNLQTL CLDGNFLTTL 360

PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDKVVMAG NCLEVLNLGV LNRMNHIKHV 420

DLRMNHLKTM VIENLEGNKH ITHVDLRDNR LTDLDLSSLC SLEQLHCERN QLRELTLSGF 480

SLRTLYASSN RLTAVNVYPV PSLLTSLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV 540

PIRILSSLSL RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNLRYLN 600

ASANSLESLP SACTGEESLS MLQLLYLTNN LLTDQCIPVL VGHPHLRILH LANNQLQTFP 660

ASKLNKLEQL EELNLSGNKL KTIPTTIANC KRLHTLVAHS NNISIFPEIL QLPQIQFVDL 720

SCNDLTEILI PEALPATLQD LDLTGNTNLV LEHKTLDIFS HITTLKIDQK PLPTTDSTVT 780

STFWSHGLAE MAGQRNKLCV SALAMDNFAE GVGAVYGMFD GDRNEELPRL LQCTMADVLL 840

EEVQQSTNDT VFMANTFLVS HRKLGMAGQK LGSSALLCYI RPDTADPASS FSLTVANVGT 900

CQAILCRGGK PVPLSKVFSL EQDPEEAQRV KDQKAIITED NKVNGVTCCT RMLGCTYLYP 960

WILPKPHISS TPLTIQDELL ILGNKALWEH LSYTEAVNAV RHVQDPLAAA KKLCTLAQSY 1020

GCQDNVGAMV VYLNIGEEGC TCEMNGLTLP GPVGFASTTS IKDAPKPATP SSSSGIASEF 1080

SSEMSTSEVS SEVGSTASDE HNAGGLDTAL LPRPERRCSL HPTPTSGLFQ RQPSCATFSS 1140

NQSDNGLDSD DDQPVEGVIT NGSKVEVEVD IHCCRGRDLE NSPPLRESSP TPCSEEHARG 1200

SCFGIRRQNS VNSGIVLPMS KDRMELQKSP STSCLYGKKL SNGSIVPLED SLNLIEVATE 1260

VPKRKTGYFA APTQMEPEDQ FVVPRDLEEE VKEQMKQHQD SRLEPEPHEE DRTEPPEEFD 1320

TAL 1323

Nucleotide Sequence
(FASTA)

ATGAAACGCA ATGGGAGCAG AAATTGTTTG AATAGGAGAA GTAGGTTTGG TTCTCGAGAA 60

AGAGACTGGC TAAGAGAAGA TGTAAAGAGA GGCTGTGTTT ACCTTTATGG AGCAGACAGT 120

ACCACTGCCA CTACAACCAC CACCACCTCC TCTTCCTCTT CCTCCTCCTC CTCTTCCTCT 180

GACTTACATC TCGTCCTTTG CACTGTAGAG ACACCAGCAT CAGAAATATG TGCTGGAGAG 240

GGAAGAGAAA GTCTTTATTT ACAGCTTCAT GGAGACCTGG TCAGGAGACT GGAACCTACT 300

GAACGACCTC TTCAGATCGT TTATGATTAC TTATCCAGGC TGGGATTTGA TGATCTTGTG 360

CGCATACAGG AGGAGGCTAC AAATCCTGAC CTCGGCTGTA TGATTCGATT TTATGGTGAA 420

AAACCATGCC ACATGGATCA TTTGGATCGA ATCCTACTGT CTGGCATCTA TAATGTACGC 480

AAGGGAAAGA CCCAGCTGCA TAAGTGGGCT GAGCGCCTAG TTGTCCTCTG TGGTACTTGC 540

CTTATCGTCT CCTCAGTGAA GGACTGTCAA ACTGGAAAGA TGCACATTTT GCCTCTGGTT 600

GGTGGAAAGA TAGAAGAAGT GAAGCGACGG CAGTACTCCC TTGCTTTCAG CTCGGCGGGA 660

GCCCAAGCTC AGACCTATCA TGTCAGCTTC GAGACTTTGG CTGAGTACCA GCGATGGCAA 720

CGGCAAGCAT CCAAGGTGGT GTCTCAGCGA ATCAGTACCG TGGATCTCTC GTGTTACAGC 780

CTCGAGGAGG TTCCTGAGCA TCTCTTCTAT AGTCAAGATA TTACCTACCT CAACTTGCGA 840

CACAACTTCA TGCAGTTAGA AAGACCTGGA GGCCTCGACA CACTCTACAA ATTTTCTCAG 900

CTGAAGGGCC TGAACTTGTC CCATAATAAA CTTGGGTTGT TTCCTATATT ATTATGTGAG 960

ATCTCTACCC TGACTGAGCT CAACCTTTCC TGTAATGGAT TTCGTGACCT ACCAAGTCAA 1020

ATTGGCAATC TGCTAAATCT TCAAACCCTC TGTCTTGATG GCAACTTTCT GACTACTTTA 1080

CCTGAAGAAC TGGGAAATCT ACAACAGCTT TCCTCTTTGG GAATTTCGTT CAACAACTTT 1140

AGTCAAATTC CTGAGGTTTA TGAGAAACTC ACTATGTTAG ATAAAGTGGT TATGGCAGGA 1200

AATTGCCTGG AAGTCCTGAA CTTAGGGGTG CTGAATAGGA TGAACCATAT CAAGCATGTG 1260

GATTTAAGGA TGAACCATTT GAAAACCATG GTTATTGAAA ATCTGGAGGG AAATAAACAC 1320

ATCACCCACG TGGATCTGCG GGACAACCGA CTGACTGACT TGGATCTTAG CTCCTTATGC 1380

AGCTTGGAAC AGCTGCATTG TGAGCGGAAC CAGCTGAGGG AGCTAACACT CAGTGGCTTC 1440

TCCCTTCGGA CCCTCTATGC CAGTTCCAAC AGGCTGACAG CAGTGAACGT CTATCCAGTA 1500

CCCAGCCTGC TCACTTCCTT GGATCTCTCC CGAAACCTGC TAGAGTGTGT CCCTGACTGG 1560

GCCTGTGAAG CGAAGAAGAT AGAAGTATTA GATGTGAGCT ATAATCTTCT CACAGAGGTT 1620

CCCATAAGAA TTCTGAGTAG CTTGAGTCTT AGAAAACTGA TGCTAGGACA CAATCACGTG 1680

CAAAACCTCC CAACACTGGT AGAGCACATC CCCCTCGAGG TGTTGGATCT TCAGCATAAT 1740

GCACTCACGA GGCTGCCAGA CACCCTCTTC TCCAAGGCCT TAAATCTCAG ATACTTGAAT 1800

GCATCTGCAA ATAGTCTGGA GTCTTTACCA TCCGCCTGCA CTGGCGAGGA GAGTTTGAGT 1860

ATGTTGCAGC TGCTTTATCT GACCAACAAT CTCCTGACGG ATCAGTGCAT ACCTGTCCTG 1920

GTGGGGCACC CGCACCTGCG AATCTTGCAC CTTGCAAACA ATCAGTTACA GACCTTTCCT 1980

GCAAGCAAAC TAAATAAATT GGAGCAATTG GAGGAACTGA ACCTAAGTGG CAACAAGCTT 2040

AAAACCATTC CCACAACCAT AGCAAACTGC AAAAGGCTGC ACACCCTTGT TGCACACTCC 2100

AACAACATCA GCATTTTCCC AGAAATACTG CAGTTGCCTC AGATCCAGTT TGTAGACCTA 2160

AGTTGCAATG ACTTGACAGA AATCCTGATT CCAGAGGCTT TGCCTGCTAC ATTACAAGAC 2220

CTTGACCTGA CTGGAAATAC AAATCTGGTT CTGGAACACA AGACACTGGA CATATTTAGC 2280

CATATCACAA CTCTGAAAAT TGATCAGAAA CCTTTGCCAA CCACAGATTC TACAGTTACA 2340

TCAACTTTCT GGAGCCATGG ACTGGCTGAG ATGGCAGGGC AGAGAAATAA GCTGTGTGTC 2400

TCAGCGCTTG CTATGGATAA CTTTGCAGAG GGGGTGGGAG CTGTGTATGG CATGTTTGAT 2460

GGGGACCGAA ATGAGGAGCT CCCACGCCTG CTGCAGTGTA CGATGGCAGA TGTGCTTTTA 2520

GAAGAGGTAC AGCAGTCGAC TAATGACACA GTTTTCATGG CTAACACCTT CTTGGTATCT 2580

CACAGGAAAT TAGGAATGGC TGGCCAGAAG TTGGGCTCCT CCGCTCTCCT GTGCTACATT 2640

CGCCCTGACA CTGCCGATCC AGCAAGTAGC TTTAGCTTGA CTGTAGCCAA TGTTGGCACG 2700

TGTCAAGCAA TCCTGTGCCG AGGTGGGAAG CCAGTGCCCC TCTCTAAAGT CTTCAGCCTG 2760

GAGCAGGACC CAGAGGAGGC GCAAAGGGTG AAGGACCAAA AAGCCATCAT CACAGAGGAC 2820

AACAAAGTGA ATGGGGTAAC CTGCTGTACC CGGATGCTGG GCTGTACATA CCTCTACCCT 2880

TGGATCCTCC CCAAGCCCCA CATATCTTCC ACTCCACTGA CCATTCAAGA TGAGTTGCTG 2940

ATTCTGGGAA ACAAAGCATT GTGGGAACAC TTGTCCTACA CAGAAGCTGT CAATGCTGTA 3000

CGTCATGTAC AAGACCCATT AGCAGCTGCT AAGAAGCTGT GCACGTTAGC ACAGAGCTAT 3060

GGCTGTCAGG ACAACGTAGG GGCGATGGTG GTTTATTTGA ATATTGGTGA GGAAGGCTGC 3120

ACTTGTGAAA TGAATGGGCT CACCCTCCCA GGTCCTGTGG GATTTGCTTC AACCACCAGT 3180

ATCAAGGATG CCCCTAAGCC AGCCACTCCA TCCTCTAGCA GTGGGATTGC CTCTGAGTTC 3240

AGCAGTGAGA TGTCCACCTC AGAGGTGAGC AGTGAAGTGG GGTCCACTGC TTCTGATGAG 3300

CATAATGCTG GGGGCCTGGA CACTGCCTTG CTTCCGAGGC CAGAGCGGCG CTGCAGCCTC 3360

CACCCAACAC CCACCTCTGG GCTGTTTCAG CGCCAGCCTT CTTGTGCTAC CTTCTCCAGT 3420

AACCAGTCTG ACAACGGCCT GGACAGTGAT GATGACCAGC CCGTTGAGGG GGTCATAACC 3480

AACGGCAGCA AGGTAGAGGT AGAAGTAGAC ATCCACTGCT GCAGGGGGAG GGATCTGGAG 3540

AACTCACCCC CTCTCAGAGA GAGTTCTCCT ACCCCGTGTT CTGAGGAACA TGCTAGAGGG 3600

TCGTGTTTTG GGATCCGAAG ACAGAACAGT GTGAATAGTG GCATAGTCCT GCCAATGAGC 3660

AAGGACAGGA TGGAGTTACA GAAGTCTCCC TCCACCTCCT GCCTCTATGG GAAGAAACTC 3720

TCCAATGGCT CTATTGTGCC CCTAGAGGAC AGCCTCAACC TCATTGAAGT GGCCACAGAA 3780

GTGCCCAAGA GGAAAACTGG CTATTTTGCT GCCCCCACTC AGATGGAACC AGAGGATCAG 3840

TTTGTTGTAC CTCGTGACCT GGAAGAAGAA GTGAAGGAAC AAATGAAGCA GCACCAGGAC 3900

AGCCGGCTCG AGCCTGAGCC CCACGAAGAG GATCGGACCG AGCCTCCGGA GGAGTTTGAC 3960

ACAGCACTGT GA 3972

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++++ g+rn+++ ++ +++nf++  +     a++g++DG++++e  + +++++ ++l

Q: 785   SHGLAEMAGQRNKLCVSALAMDNFAEGVG-----AVYGMFDGDRNEELPRLLQCTMADVL  839

         6899*********************9877.....59************************

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikds......  115

          ee++    ++++ + ++a++Fl  +++l       ++ +k Gs+a++++i+++

Q: 840   LEEVQ----QSTNDTVFMANTFLVSHRKL------GMAGQKLGSSALLCYIRPDtadpas  889

         ***99....77888889************......89***************99999***

S: 116   ..klyvanvGdSravLcrngkavelssdHkpsre.dEleRieeaggsvilkdgaRvlGvL  172

           +l+vanvG ++a+Lcr+gk+v+ls+ ++ +++ +E +R++++++ +++++  +v+Gv+

Q: 890   sfSLTVANVGTCQAILCRGGKPVPLSKVFSLEQDpEEAQRVKDQKAIITEDN--KVNGVT  947

         ******************************99866**********9999998..******

S: 173   avsRalGdlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvlekk  232

         +++R+lG++yl+p++ p+P+++s++lt +de liL+ + lw+++s  eav++vr+v +

Q: 948   CCTRMLGCTYLYPWILPKPHISSTPLTIQDELLILGNKALWEHLSYTEAVNAVRHVQD--  1005

         **********************************************************..

S: 233   eaeqeaakkLvklalargskdnvsaivv  260

           + +aakkL++la+++g++dnv a+vv

Q: 1006  --PLAAAKKLCTLAQSYGCQDNVGAMVV  1031

         ..************************97

Domain Sequence
(FASTA)

SHGLAEMAGQ RNKLCVSALA MDNFAEGVGA VYGMFDGDRN EELPRLLQCT MADVLLEEVQ 60

QSTNDTVFMA NTFLVSHRKL GMAGQKLGSS ALLCYIRPDT ADPASSFSLT VANVGTCQAI 120

LCRGGKPVPL SKVFSLEQDP EEAQRVKDQK AIITEDNKVN GVTCCTRMLG CTYLYPWILP 180

KPHISSTPLT IQDELLILGN KALWEHLSYT EAVNAVRHVQ DPLAAAKKLC TLAQSYGCQD 240

NVGAMVV 247

Keyword

Complete proteome; Leucine-rich repeat; Reference proteome; Repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>