EKS-MAM-00318

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00318

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	348.6	3.9E-104	249	500	252

Status

Unreviewed

Ensembl Protein

ENSMMUP00000015786

UniProt Accession

F7GWI2;

Protein Name

Protein Synonyms/Alias

Serine/threonine-protein kinase PAK 2;

Gene Name

PAK2

Gene Synonyms/Alias

PAK2; EGK_12252;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000012033	ENSMMUP00000015786	ENSMMUT00000016856

Organism

Macaca mulatta

Functional Description

Protein Length

524

Protein Sequence
(FASTA)

MSDNGELEDK PPAPPVRMSS TIFSTGGKDP LSANHSLKPL PSVPEEKKPR HKIISIFSGT 60

EKGSKKKEKE RPEISPPSDF EHTIHVGFDA VTGEFTGMPE QWARLLQTSN ITKLEQKKNP 120

QAVLDVLKFY DSNTVKQKYL SFTPPEKDGF PSGTPALNAK GTETPAVVTE EDDDDEETAP 180

PVIAPRPDHT KSIYTRSVID PVPAPVGDSS VDGGAKSSDK QKKKTKMTDE EIMEKLRTIV 240

SIGDPKKKYT RYEKIGQGAS GTVFTATDVA LGQEVAIKQI NLQKQPKKEL IINEILVMKE 300

LKNPNIVNFL DSYLVGDELF VVMEYLAGGS LTDVVTETCM DEAQIAAVCR ECLQALEFLH 360

ANQVIHRDIK SDNVLLGMEG SVKLTDFGFC AQITPEQSKR STMVGTPYWM APEVVTRKAY 420

GPKVDIWSLG IMAIEMVEGE PPYLNENPLR ALYLIATNGT PELQNPEKLS PIFRDFLNRC 480

LEMDVEKRGS AKELLQHPFL KLAKPLSSLT PLIMAAKEAM KSNR 524

Nucleotide Sequence
(FASTA)

ATGTCTGATA ACGGAGAACT GGAAGACAAG CCCCCAGCAC CTCCTGTGCG AATGAGCAGC 60

ACCATCTTTA GCACTGGAGG CAAAGACCCC TTGTCAGCCA ATCACAGTTT GAAACCTTTG 120

CCCTCTGTTC CGGAGGAGAA GAAGCCCAGG CACAAAATCA TCTCCATATT CTCAGGCACA 180

GAGAAAGGAA GTAAAAAGAA AGAAAAGGAA CGGCCAGAAA TTTCTCCTCC ATCTGATTTT 240

GAACACACCA TCCATGTTGG CTTTGATGCT GTTACTGGAG AATTCACTGG CATGCCAGAA 300

CAGTGGGCTC GATTACTACA GACCTCCAAC ATCACCAAAC TAGAGCAAAA GAAGAATCCT 360

CAGGCTGTGC TGGATGTCCT CAAGTTCTAC GACTCCAACA CAGTGAAGCA GAAGTATCTG 420

AGCTTTACTC CTCCGGAGAA AGATGGCTTC CCTTCTGGAA CACCAGCACT GAACGCCAAG 480

GGAACAGAAA CACCCGCAGT AGTGACAGAG GAAGATGATG ATGATGAAGA GACTGCTCCT 540

CCTGTTATTG CCCCACGACC AGATCATACG AAATCAATTT ACACACGGTC TGTAATTGAC 600

CCCGTTCCTG CACCAGTTGG TGATTCAAGT GTTGATGGTG GTGCCAAGTC TTCAGACAAA 660

CAGAAAAAGA AGACTAAAAT GACAGATGAA GAAATTATGG AGAAATTAAG AACTATTGTG 720

AGCATAGGTG ACCCTAAGAA AAAATATACA AGATATGAAA AAATTGGACA AGGGGCTTCT 780

GGTACAGTTT TCACTGCTAC TGACGTTGCA TTGGGACAGG AGGTTGCTAT CAAACAGATT 840

AATTTACAGA AACAGCCAAA GAAGGAATTG ATCATTAATG AGATTCTGGT GATGAAAGAA 900

TTAAAAAATC CAAACATAGT TAACTTCTTG GACAGTTACC TGGTAGGAGA TGAATTGTTT 960

GTGGTCATGG AATACCTTGC TGGTGGATCG CTCACTGATG TGGTAACAGA AACCTGCATG 1020

GATGAAGCAC AGATTGCTGC TGTATGCAGA GAGTGTCTGC AGGCGTTGGA GTTTTTACAT 1080

GCTAATCAAG TGATCCACAG AGACATCAAA AGCGACAATG TCCTTTTGGG AATGGAAGGA 1140

TCGGTTAAGC TCACTGACTT TGGTTTCTGT GCCCAGATCA CCCCCGAGCA GAGCAAACGC 1200

AGTACCATGG TCGGAACCCC ATACTGGATG GCACCAGAGG TGGTTACACG GAAAGCTTAT 1260

GGCCCCAAAG TCGACATATG GTCTCTGGGT ATCATGGCTA TTGAGATGGT AGAAGGAGAG 1320

CCTCCATACC TCAATGAAAA TCCCTTGAGG GCCTTGTACC TAATAGCAAC TAATGGAACC 1380

CCAGAGCTTC AGAATCCAGA GAAACTTTCC CCAATATTTC GAGATTTCTT AAATCGATGT 1440

TTGGAAATGG ATGTGGAAAA AAGGGGTTCA GCCAAAGAAT TATTACAGCA TCCTTTCTTG 1500

AAACTGGCCA AACCATTATC TAGCTTGACA CCACTGATCA TGGCAGCTAA AGAAGCGATG 1560

AAGAGTAACC GTTAA 1575

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+v++a+++  g+ vaik+inl+kq+k+e++++ei v+k+lk+pniv+

Q: 249   YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN  308

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +l+s+l+ +el++vmeylagGsl+d+v+   ++ ++E qia+++re+l+aLe+lH+++vi

Q: 309   FLDSYLVGDELFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCRECLQALEFLHANQVI  365

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++n+Ll +eg+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 366   HRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  423

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ f++f+++cl+

Q: 424   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEM  483

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR sa+ell+h+Fl

Q: 484   DVEKRGSAKELLQHPFL  500

         ****************7

Domain Sequence
(FASTA)

YTRYEKIGQG ASGTVFTATD VALGQEVAIK QINLQKQPKK ELIINEILVM KELKNPNIVN 60

FLDSYLVGDE LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CRECLQALEF LHANQVIHRD 120

IKSDNVLLGM EGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPIFRDFLN RCLEMDVEKR 240

GSAKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030296	; F:protein tyrosine kinase activator activity
GO:0043066	; P:negative regulation of apoptotic process
GO:2001271	; P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:0018105	; P:peptidyl-serine phosphorylation
GO:2001238	; P:positive regulation of extrinsic apoptotic signaling pathway
GO:0046777	; P:protein autophosphorylation

KEGG

mcc:710314

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013