EPS-MAM-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-MAM-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	90.0	3.6E-25	57	334	278

Status

Unreviewed

Ensembl Protein

ENSMMUP00000036999

UniProt Accession

F7H8X1;

Protein Name

Protein Synonyms/Alias

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha;

Gene Name

TAB1

Gene Synonyms/Alias

TAB1; EGK_03060;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000012103	ENSMMUP00000015873	ENSMMUT00000016948
ENSMMUG00000012103	ENSMMUP00000036999	ENSMMUT00000043995

Organism

Macaca mulatta

Functional Description

Protein Length

462

Protein Sequence
(FASTA)

MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN 60

NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES 120

IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV 180

ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST 240

RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH 300

GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL 360

LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG 420

AHSASTLDEA TPTLTKEPSC LKTDLTAFPL CQLNLLGSLT PG 462

Nucleotide Sequence
(FASTA)

ATGGCGGCGC AGAGGAGGAG CCTGCTGCAG AGTGAGCAGC AGCCAAGCTG GACAGATGAC 60

CTGCCACTCT GCCACCTCTC TGGGGTTGGC TCAGCCTCCA ACCGCAGCTA CTCTGCTGAT 120

GGCAAGGGCA CTGAGAGCCA CCCGCCAGAG GACAGCTGGC TCAAGTTCAG GAGTGAGAAC 180

AACTGCTTCC TGTATGGGGT CTTCAATGGC TACGATGGCA ACCGGGTGAC CAACTTTGTG 240

GCCCAGCGGC TGTCCGCAGA GCTCCTACTG GGCCAGCTGA ATGCCGAGCA CGCCGAGGCC 300

GACGTGCGGC GCGTGCTGCT GCAGGCCTTC GATGTGGTAG AGAGGAGCTT CCTGGAGTCC 360

ATTGATGATG CCTTGGCTGA GAAGGCAAGC CTCCAGTCGC AACTGCCAGA GGGGGTGCCC 420

CAGCACCAGC TGCCTCCTCA GTATCAGAAG ATCCTTGAGA GACTCAAGAC GCTGGAGAGG 480

GAAATTTCGG GAGGGGCCAT GGCTGTTGTG GCGGTCCTTC TCAACAACAA GCTCTACGTC 540

GCCAATGTCG GTACAAACCG TGCACTTTTA TGTAAATCGA CAGTGGATGG GTTGCAGGTG 600

ACACAGCTGA ACGTGGACCA CACCACAGAG AACGAGGATG AGCTCTTCCG CCTTTCGCAG 660

CTGGGCTTGG ACGCCGGGAA GATCAAGCAG GTGGGGATCA TCTGTGGGCA GGAGAGCACC 720

CGGCGGATCG GGGATTACAA GGTCAAATAT GGCTACACGG ACATTGACCT TCTCAGTGCC 780

GCCAAGTCCA AACCAATCAT CGCAGAGCCA GAAATCCACG GGGCACAGCC ACTGGATGGG 840

GTGACGGGCT TCCTGGTGCT GATGTCAGAG GGGCTGTACA AGGCCCTAGA GGCAGCCCAT 900

GGGCCTGGGC AGGCCAACCA GGAGATTGCT GCAATGATTG ACACTGAGTT TGCCAAGCAG 960

ACCTCCCTGG ACGCCGTGGC CCAGGCCGTG GTGGACCGGG TGAAGCGCAT CCACAGCGAC 1020

ACCTTCGCCA GCGGTGGGGA GCGTGCCAGG TTCTGCCCCC GGCATGAGGA CATGACCCTG 1080

CTGGTGAGGA ACTTTGGCTA CCCACTGGGT GAAATGAGCC AGCCCACACC GAGCCCGGCC 1140

CCAGCTGCAG GGGGACGAGT GTACCCTGTG TCTGTGCCAT ACTCCAGTGC CCAGAGCACC 1200

AGCAAGACCA GCGTGACCCT CTCCCTTGTC ATGCCCTCCC AGGGCCAGAT GGTCAATGGG 1260

GCTCACAGCG CTTCCACCCT GGATGAAGCC ACCCCGACCC TCACCAAGGA GCCATCTTGC 1320

CTGAAAACGG ATTTGACAGC CTTCCCTCTG TGCCAATTAA ACCTGCTGGG GAGCCTGACC 1380

CCAGGGTAG 1389

Domain Profile

S: 29    pekkdrlaffgvyDGhggsevakfcseklheilaeelesseseerkvkkalakaFlstde  88

         +++++   ++gv++G  g++v++f++++l+  l     + e  e++v+++l +aF  +++

Q: 57    RSENN-CFLYGVFNGYDGNRVTNFVAQRLSAELLLGQLNAEHAEADVRRVLLQAFDVVER  115

         44444.589********************976665555599*******************

S: 89    el................................kvleeksldidk..sGstavvalikd  114

          +                                k+le+ ++ +++   G+ avva++ +

Q: 116   SFlesiddalaekaslqsqlpegvpqhqlppqyqKILERLKTLEREisGGAMAVVAVLLN  175

         *******************************99966666666666676999*********

S: 115   sklyvanvGdSravLcrng.k...avelssdHkpsredEleRieeag...gsvilkdgaR  167

         +klyvanvG  ra+Lc++  +   + +l +dH++++edEl R+++ g   g++ +

Q: 176   NKLYVANVGTNRALLCKSTvDglqVTQLNVDHTTENEDELFRLSQLGldaGKIKQVG--I  233

         ****************9663366699*********************9777777665..6

S: 168   vlGvLavsRalGdlylk..............pyvtpePevtshrl.tsedefliLasDGl  212

         ++G  + +R +Gd+++k              + +++ePe++  +  +  + fl+L s Gl

Q: 234   ICG-QESTRRIGDYKVKygytdidllsaaksKPIIAEPEIHGAQPlDGVTGFLVLMSEGL  292

         677.69************************999*******98765155555*********

S: 213   wdvvs........neeavslvrdvlekkeaeqeaakkLvkla  246

         ++ ++        n+e+ +++     k+++++++a+ +v++

Q: 293   YKALEaahgpgqaNQEIAAMIDTEFAKQTSLDAVAQAVVDRV  334

         **9863333333366666666666667888888888877765

Domain Sequence
(FASTA)

RSENNCFLYG VFNGYDGNRV TNFVAQRLSA ELLLGQLNAE HAEADVRRVL LQAFDVVERS 60

FLESIDDALA EKASLQSQLP EGVPQHQLPP QYQKILERLK TLEREISGGA MAVVAVLLNN 120

KLYVANVGTN RALLCKSTVD GLQVTQLNVD HTTENEDELF RLSQLGLDAG KIKQVGIICG 180

QESTRRIGDY KVKYGYTDID LLSAAKSKPI IAEPEIHGAQ PLDGVTGFLV LMSEGLYKAL 240

EAAHGPGQAN QEIAAMIDTE FAKQTSLDAV AQAVVDRV 278

Keyword

Complete proteome; Kinase; Reference proteome; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0019209	; F:kinase activator activity
GO:0016301	; F:kinase activity
GO:0000185	; P:activation of MAPKKK activity
GO:0003007	; P:heart morphogenesis
GO:0001701	; P:in utero embryonic development
GO:0030324	; P:lung development
GO:0007179	; P:transforming growth factor beta receptor signaling pathway

KEGG

mcc:703409

;

InterPros

IPR001932	; PP2C-like.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00332

; PP2Cc; 1.

Prosites

Prints

Created Date

20-Feb-2013