EKS-MAM-00331

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00331

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	319.9	2.2E-95	21	287	267

Status

Unreviewed

Ensembl Protein

ENSMMUP00000016040

UniProt Accession

F6VF32;

Protein Name

Protein Synonyms/Alias

Gene Name

MYO3A

Gene Synonyms/Alias

MYO3A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000012229	ENSMMUP00000016040	ENSMMUT00000017127

Organism

Macaca mulatta

Functional Description

Protein Length

1630

Protein Sequence
(FASTA)

MFPLIGKTII FDNFPDPSDT WEITETIGKG TYGKVFKVLN KKNGQKAAVK ILDPVHDIDE 60

EIEAEYNILK ALSDHRNVVR FYGIYFKKDK VNGDKLWLVL ELCNGGSVTD LVKGFLKRGE 120

RMSEPLIAYI LHEALMGLQH LHNHKTIHRD VKGNNILLTA EGGVKLVDFG VSAQLTSTRH 180

RRNTSVGTPF WMAPEVIACE QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF 240

KIPRNPPPKL RQPELWSAEF NDFISKCLTK DYEKRPTVSD LLQHKFITQI EGKDVMLQKQ 300

LMEFIGIHQC MGGTEKARHE RIHTKKGNFN WSLISNPKDV DDLATLEVLD ENTVSEQLEK 360

CYSRDQIYIY VGDILIALNP FQSLDLYSTK HSKLYIGSKR TASPPHIFAM ADLGYQSMIT 420

YNSDQCIVIS GESGAGKTES AHLLVQQLTV LGKANNRTLQ EKILQVNNLV EAFGNACTII 480

NDNSSRFGKY LEMKFTSSGA VVGAQISEYL LEKSRVIHQA IGEKNFHIFY YIYAGLAEKK 540

KLAHYKLPEN KPPRYLQNDH LRTVQDIMNN SFYKSQYELI EQCFKVIGFT MEQLGSIYSI 600

LAAILNVGNI EFSSVASEHQ IDKSHISNHT ALENCASLLC IQADELQEAL TSHCVVTRGE 660

TIIRPNTVEK ATDVRDAMAK TLYGRLFSWI VNCINSLLKH DSSPSGNGDE LSIGILDIFG 720

FENFKKNSFE QLCINIANEQ IQYYYNQHVF AWEQVILSLL QNEYLNEDVD ARVIEYEDNR 780

PLLNMFLQKP MGLLSLLDEE SRFPKATDQT LIEKFEGNLK SQYFWRPKRL ELSFGIHHYA 840

GKVLYNASGF LAKNRDTLPT DIVLLLRSSD NSVIRQLVNH PLTKTGNLPH SKTQNVINYQ 900

MRTSEKLINL AKGDTGEATR HARETTNMKT QTVASYFRYS LMDLLSKMVV GQPHFVRCIK 960

PNNERQARKY DKEKVLLQLR YTGILETARI RRLGFSHRIL FANFIKRYHV LCYKSSEQPP 1020

MSPDTCATIL EKAGLDNWAL GKTKVFLKYY HVEQLNLMRK EAIDKLILIQ ACVRAFLCSR 1080

RYQKIQEKRK ESAIIIQSAA RGHLVRKQRK EIVNVKNTAV TTIQTSDQEF DYQKNFENTR 1140

ESFVKKQAEN AISANERFIS APNNKGSVSV VKTSTFKPEE ETTNAVESNN RQYQTPKKMN 1200

NVYEEEVKQE FYLVGPEVSP KQKSIKDLEE NSKLTKVEKE EAMIQSYCQR YTEERNCEES 1260

KAAYLERKAI SERPSYPVPW LAENETSFKT ILEPTLSQRS VYQNANSTKK EKKTSVVTQS 1320

APICSQEGGG SHLRHETVKE RQAEPVTQAQ EEEDKAAVFI QSKYRGYKRR QQVRKDKMSS 1380

FKHQRIVTTP TEVARNTQNL YSYPTKHEKT NNIKMKDNKD SKATSEREAW DLAIFSKQIS 1440

KLSEEYFILQ KKLNEMILSQ QLKPLYLGVL HHKPINRGVS SQQCLSGISK GEEPKILRPP 1500

RRPRKPKTLN NPEDSTYYYL LHKSIQEDKR RPRKDSQGKL LDLEDFYYKE FLPSRSGPKE 1560

HSPSLRERRP QQELQNQCIK ANERCWAAES PEEEEEEEKK EEERGAAANP YDFRRLLRKT 1620

SQRRRLVQQS 1630

Nucleotide Sequence
(FASTA)

ATGTTTCCAT TAATTGGAAA AACAATCATC TTTGATAACT TTCCTGATCC TTCTGATACG 60

TGGGAAATCA CTGAGACAAT TGGCAAAGGA ACTTATGGGA AAGTTTTTAA AGTATTGAAT 120

AAGAAAAATG GCCAAAAAGC AGCAGTCAAA ATTCTTGATC CAGTTCACGA TATTGATGAA 180

GAGATTGAAG CAGAGTATAA CATCTTAAAA GCACTTTCTG ATCACCGTAA TGTGGTCAGA 240

TTCTATGGGA TATACTTTAA GAAGGATAAA GTAAATGGAG ACAAGCTGTG GTTGGTTCTT 300

GAGCTGTGCA ATGGAGGATC AGTGACTGAC CTTGTGAAAG GATTTCTGAA GAGGGGTGAA 360

AGAATGAGTG AGCCTCTAAT TGCCTATATT TTACATGAAG CACTAATGGG ACTTCAACAT 420

TTGCATAACC ACAAAACTAT CCACAGAGAT GTGAAAGGAA ATAACATCCT ATTGACTGCT 480

GAAGGTGGAG TGAAACTAGT AGATTTTGGT GTGTCTGCAC AGCTTACCAG TACCCGGCAC 540

CGTCGGAACA CATCCGTAGG AACACCGTTT TGGATGGCTC CTGAGGTGAT TGCGTGTGAA 600

CAGCAATTGG ATACCACTTA TGATGCCAGA TGTGACACTT GGTCCCTGGG TATAACGGCC 660

ATTGAGTTGG GTGATGGAGA TCCTCCACTA GCTGACCTGC ATCCCATGAG AGCACTCTTC 720

AAAATACCAA GGAATCCACC CCCAAAACTA AGGCAGCCTG AGCTATGGTC AGCAGAATTC 780

AATGACTTCA TAAGCAAGTG CTTGACTAAA GATTATGAAA AGCGTCCAAC AGTGTCAGAT 840

CTTTTACAAC ATAAATTCAT TACTCAAATT GAGGGCAAAG ATGTGATGTT ACAAAAACAA 900

TTAATGGAAT TCATTGGCAT CCATCAATGC ATGGGAGGCA CAGAAAAGGC CAGACATGAA 960

CGTATTCACA CCAAGAAAGG GAACTTCAAC TGGTCTCTAA TATCCAATCC GAAGGATGTA 1020

GATGATTTAG CAACCCTAGA AGTTTTGGAT GAGAATACAG TCTCAGAGCA ACTTGAGAAG 1080

TGTTATTCCA GAGATCAGAT CTATATCTAT GTGGGAGACA TACTCATTGC TCTTAACCCT 1140

TTTCAGAGTC TGGATCTTTA CTCCACAAAG CATTCCAAAC TATATATTGG ATCAAAGAGA 1200

ACTGCCAGTC CTCCTCACAT TTTTGCAATG GCTGACTTAG GATATCAATC TATGATAACA 1260

TATAATTCAG ATCAGTGCAT TGTTATTTCT GGAGAAAGTG GTGCTGGAAA GACAGAAAGT 1320

GCTCATCTTT TAGTTCAGCA GCTGACAGTG CTTGGAAAGG CTAATAACAG AACCTTGCAA 1380

GAGAAGATTT TACAAGTAAA CAATTTGGTA GAAGCCTTTG GCAATGCCTG CACTATTATA 1440

AATGACAATT CTAGCCGATT TGGAAAATAC TTAGAAATGA AATTCACCTC TTCTGGAGCT 1500

GTAGTGGGAG CACAGATTTC TGAATATCTC CTGGAAAAAT CCCGAGTTAT CCACCAAGCT 1560

ATTGGAGAAA AAAATTTTCA TATTTTTTAC TACATTTATG CTGGTTTGGC TGAAAAGAAG 1620

AAACTAGCCC ATTACAAACT GCCTGAAAAT AAGCCTCCCA GGTACCTACA AAATGACCAC 1680

CTCAGAACAG TACAAGACAT CATGAATAAT AGTTTCTATA AATCCCAGTA TGAATTAATT 1740

GAGCAATGTT TCAAAGTCAT AGGTTTTACA ATGGAGCAAC TTGGAAGCAT ATACAGTATA 1800

CTGGCTGCAA TCTTGAATGT TGGCAACATT GAATTTTCTT CTGTGGCATC TGAACACCAG 1860

ATTGACAAGA GCCACATTTC TAATCATACA GCCCTGGAGA ACTGTGCTTC TTTGCTTTGT 1920

ATTCAGGCAG ATGAGCTACA AGAAGCTCTC ACCTCCCACT GTGTGGTCAC TAGAGGAGAA 1980

ACAATTATAC GACCCAATAC TGTAGAAAAA GCTACCGATG TCAGGGATGC CATGGCTAAA 2040

ACCTTATATG GACGTCTCTT TAGTTGGATA GTCAACTGCA TTAACAGTTT GTTGAAGCAT 2100

GACTCATCAC CAAGTGGGAA TGGTGATGAG CTGAGCATTG GCATTCTTGA TATATTTGGC 2160

TTTGAAAATT TCAAAAAAAA TTCCTTTGAG CAGCTGTGCA TTAACATTGC AAATGAACAA 2220

ATTCAGTATT ATTATAATCA ACATGTGTTT GCATGGGAAC AGGTAATTTT GTCTTTGTTA 2280

CAAAATGAAT ACCTAAATGA AGATGTGGAT GCTAGAGTTA TTGAATATGA GGATAACCGG 2340

CCCCTCTTAA ATATGTTTCT GCAAAAGCCA ATGGGTTTAC TTTCCCTACT TGATGAAGAA 2400

AGTAGATTTC CCAAGGCCAC TGACCAGACT CTTATAGAAA AATTTGAAGG TAACCTGAAA 2460

TCACAGTACT TCTGGAGACC CAAAAGATTG GAACTTAGTT TTGGAATTCA CCATTATGCA 2520

GGAAAGGTCC TCTATAATGC AAGTGGATTC TTAGCCAAAA ACAGAGACAC TCTTCCAACT 2580

GATATTGTGC TACTTTTGAG GTCATCTGAC AACAGTGTAA TTAGGCAACT AGTCAACCAC 2640

CCTCTGACCA AAACAGGTAA TCTACCACAT TCTAAAACTC AAAACGTTAT AAACTATCAA 2700

ATGAGGACTT CAGAAAAATT AATCAACCTG GCAAAGGGCG ACACTGGAGA AGCCACGCGT 2760

CATGCCAGAG AGACAACCAA CATGAAAACA CAAACAGTTG CATCATATTT TAGATATTCC 2820

CTGATGGATT TGTTGTCTAA AATGGTGGTG GGCCAACCTC ATTTCGTCCG TTGCATCAAA 2880

CCAAATAATG AGCGTCAGGC AAGAAAATAT GACAAAGAGA AAGTTCTGCT GCAGCTTCGG 2940

TACACAGGAA TTCTGGAAAC AGCAAGAATT CGAAGGCTAG GATTCTCCCA TCGGATACTT 3000

TTTGCTAATT TTATAAAGCG GTACCACGTT CTCTGCTACA AGTCGAGCGA GCAGCCCCCC 3060

ATGAGCCCTG ACACCTGTGC CACCATTTTG GAAAAAGCTG GTCTCGATAA CTGGGCTCTT 3120

GGAAAAACAA AAGTGTTCCT TAAATATTAT CACGTGGAAC AGTTAAATCT AATGCGAAAG 3180

GAAGCTATTG ACAAGCTTAT TTTGATTCAA GCTTGTGTCA GAGCATTCTT GTGTTCAAGA 3240

AGATACCAAA AAATACAGGA GAAAAGGAAG GAAAGCGCTA TAATAATACA GTCAGCTGCA 3300

AGAGGACACC TTGTCAGGAA ACAAAGAAAA GAAATTGTTA ACGTGAAAAA CACGGCAGTA 3360

ACAACCATTC AGACTTCTGA TCAGGAATTC GACTACCAGA AAAACTTTGA AAATACAAGG 3420

GAATCTTTCG TGAAGAAACA AGCAGAAAAT GCAATCTCTG CTAATGAAAG ATTCATTTCA 3480

GCTCCAAATA ATAAAGGAAG TGTATCTGTA GTGAAGACTT CCACTTTCAA ACCTGAAGAG 3540

GAAACCACCA ATGCTGTGGA GAGTAACAAC AGACAGTATC AGACTCCAAA AAAAATGAAT 3600

AATGTGTATG AAGAAGAGGT TAAGCAAGAA TTCTACCTTG TAGGGCCAGA AGTAAGCCCC 3660

AAACAGAAGT CTATCAAAGA CCTGGAAGAG AACAGCAAGC TAACGAAAGT AGAGAAAGAG 3720

GAAGCTATGA TCCAGAGTTA CTGTCAGAGG TACACAGAGG AGAGGAATTG TGAAGAGTCA 3780

AAAGCAGCAT ATCTAGAAAG GAAGGCCATA TCGGAAAGGC CAAGCTACCC AGTGCCTTGG 3840

TTAGCTGAAA ATGAGACTTC CTTTAAAACA ATTTTGGAAC CTACACTTAG CCAAAGGTCA 3900

GTTTATCAAA ATGCAAATAG CACCAAAAAA GAAAAGAAGA CATCTGTAGT TACCCAGAGT 3960

GCACCAATAT GCAGCCAGGA GGGAGGTGGA AGCCATCTGA GGCATGAGAC AGTCAAAGAG 4020

AGGCAAGCTG AACCGGTGAC ACAGGCCCAG GAGGAAGAAG ATAAAGCAGC GGTATTCATT 4080

CAGAGCAAAT ACCGGGGTTA CAAGAGAAGG CAGCAGGTGA GGAAGGACAA GATGTCTTCT 4140

TTTAAGCATC AGAGGATTGT CACAACACCA ACAGAAGTAG CAAGAAACAC TCAGAATTTG 4200

TATTCCTATC CCACAAAACA TGAGAAAACC AATAATATCA AGATGAAGGA TAACAAAGAC 4260

TCGAAAGCAA CCTCAGAAAG AGAAGCATGG GATTTGGCAA TTTTTTCAAA ACAGATATCA 4320

AAGTTATCTG AAGAATATTT CATTCTGCAG AAAAAATTGA ATGAAATGAT TTTGTCACAG 4380

CAACTGAAGC CACTTTATCT GGGTGTCTTG CACCATAAGC CAATTAATAG AGGAGTTTCT 4440

TCTCAGCAGT GCCTCTCAGG TATCTCTAAA GGAGAGGAGC CAAAAATATT GAGACCCCCA 4500

AGACGACCCC GGAAACCCAA AACATTAAAT AACCCTGAAG ACTCCACATA CTATTATCTA 4560

CTACATAAGT CAATCCAAGA AGACAAACGA AGACCAAGGA AAGACAGTCA GGGAAAATTA 4620

TTAGATTTGG AAGATTTCTA TTATAAGGAA TTTTTGCCCA GTCGTTCTGG ACCAAAGGAA 4680

CATAGCCCTA GTTTAAGAGA ACGAAGACCA CAGCAAGAAC TCCAGAATCA ATGTATTAAG 4740

GCTAATGAAA GGTGCTGGGC GGCGGAGAGC CCCGAGGAGG AGGAGGAAGA GGAGAAGAAG 4800

GAGGAGGAGA GAGGGGCAGC AGCCAACCCC TACGACTTCA GGAGGCTCCT GCGCAAAACC 4860

TCCCAGCGCC GGCGCCTAGT CCAGCAGTCC TAA 4893

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkh.pniv  59

         +e++e+igkG++gkv++  +kk+g+++a+k+++  + +  ee++ e+++lk l++ +n+v

Q: 21    WEITETIGKGTYGKVFKVLNKKNGQKAAVKILDPVH-DIDEEIEAEYNILKALSDhRNVV  79

         7999*****************************998.9999**********98755****

S: 60    eylesflk.....eeelwlvmeylagGslsdlvk..eelkselkEeqiayilrevlkaLe  112

         +++++++k      ++lwlv+e+++gGs++dlvk   ++ ++++E  iayil+e+l +L+

Q: 80    RFYGIYFKkdkvnGDKLWLVLELCNGGSVTDLVKgfLKRGERMSEPLIAYILHEALMGLQ  139

         ********99998899******************7778889*******************

S: 113   ylHskkviHrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaq  172

         +lH++k+iHrd+k++niLlt eg VkL+dfgv+aql++tr++r+t vgtp+wmAPEvia+

Q: 140   HLHNHKTIHRDVKGNNILLTAEGGVKLVDFGVSAQLTSTRHRRNTSVGTPFWMAPEVIAC  199

         ************************************************************

S: 173   e...ekgYdekaDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfske  229

         e   +++Yd+++D wslGItaiel +g+pP++dl+p++al+ki++n+ppkl++++ +s e

Q: 200   EqqlDTTYDARCDTWSLGITAIELGDGDPPLADLHPMRALFKIPRNPPPKLRQPELWSAE  259

         9888899*****************************************************

S: 230   fkefvekclqknpekRpsasellkhkFl  257

         f++f++kcl+k++ekRp++s+ll+hkF+

Q: 260   FNDFISKCLTKDYEKRPTVSDLLQHKFI  287

         ***************************7

Domain Sequence
(FASTA)

WEITETIGKG TYGKVFKVLN KKNGQKAAVK ILDPVHDIDE EIEAEYNILK ALSDHRNVVR 60

FYGIYFKKDK VNGDKLWLVL ELCNGGSVTD LVKGFLKRGE RMSEPLIAYI LHEALMGLQH 120

LHNHKTIHRD VKGNNILLTA EGGVKLVDFG VSAQLTSTRH RRNTSVGTPF WMAPEVIACE 180

QQLDTTYDAR CDTWSLGITA IELGDGDPPL ADLHPMRALF KIPRNPPPKL RQPELWSAEF 240

NDFISKCLTK DYEKRPTVSD LLQHKFI 267

Keyword

ATP-binding; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031941	; C:filamentous actin
GO:0030175	; C:filopodium
GO:0016459	; C:myosin complex
GO:0030898	; F:actin-dependent ATPase activity
GO:0043531	; F:ADP binding
GO:0005524	; F:ATP binding
GO:0060002	; F:plus-end directed microfilament motor activity
GO:0004672	; F:protein kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007605	; P:sensory perception of sound

KEGG

InterPros

IPR000048	; IQ_motif_EF-hand-BS.
IPR011009	; Kinase-like_dom.
IPR001609	; Myosin_head_motor_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00612	; IQ; 2.
PF00063	; Myosin_head; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00015	; IQ; 3.
SM00242	; MYSc; 1.
SM00220	; S_TKc; 1.

Prosites

PS50096	; IQ; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00193

; MYOSINHEAVY.

Created Date

20-Feb-2013