EKS-MAM-00001
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00001
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph520.41.0E-156621878258
StatusUnreviewed
Ensembl ProteinENSMMUP00000016238
UniProt AccessionG7N911;
Protein Name
Protein Synonyms/Alias Ephrin type-A receptor 4;
Gene NameEPHA4
Gene Synonyms/Alias EPHA4; EGK_04837;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000012364ENSMMUP00000016238ENSMMUT00000017337
OrganismMacaca mulatta
Functional Description
Protein Length949
Protein Sequence
(FASTA)
MAGIFYFALF SCLFGICDAV TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 60
DEKNTPIRTY QVCNVMEPSQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE 120
TFNLYYYESD NDKERFIREN QFVKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG 180
FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK 240
DVPKMYCGAD GEWLVPIGNC LCNAGHEERS GECQACKIGY YKALSTDATC AKCPPHSYSV 300
WEGATSCTCD RGFFRADNDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQNTGGRQDI 360
SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKTTKVSI TDLLAHTNYT FEIWAVNGVS 420
KYNPSPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE 480
KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII 540
GDGANSTVLL VSVSGSVVLV VILIAAFVIS RRRSKYSKAK QEADEEKHLN QGVRTYVDPF 600
TYEDPNQAVR EFAKEIDASC IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT 660
DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV 720
IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT 780
TRGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG 840
YRLPPPMDCP IALHQLMLDC WQKERSDRPK FGQIVNMLDK LIRNPNSLKR TGTESSRPNT 900
ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD NFTAAGYTTL EAVVHVNQE 949
Nucleotide Sequence
(FASTA)
ATGGCTGGGA TTTTCTATTT CGCCCTCTTT TCGTGTCTCT TCGGGATTTG CGACGCTGTC 60
ACCGGTTCCA GGGTGTACCC CGCGAATGAA GTTACCTTAC TGGATTCCAG ATCTGTTCAG 120
GGAGAACTTG GGTGGATAGC AAGCCCTCTG GAAGGAGGGT GGGAGGAAGT GAGTATCATG 180
GATGAAAAAA ATACACCAAT CCGAACCTAC CAAGTGTGCA ATGTGATGGA ACCCAGCCAG 240
AATAACTGGC TACGAACTGA TTGGATCACC CGAGAAGGGG CTCAGAGGGT ATATATTGAG 300
ATTAAATTCA CCTTGAGGGA CTGCAACAGT CTTCCGGGCG TCATGGGGAC TTGCAAGGAG 360
ACGTTTAACC TGTACTACTA TGAATCAGAC AACGACAAAG AGCGTTTCAT CAGAGAGAAC 420
CAGTTTGTCA AAATTGACAC CATTGCTGCT GATGAGAGCT TCACCCAAGT GGACATTGGT 480
GACAGAATCA TGAAGCTGAA CACCGAGATC CGGGATGTAG GGCCATTAAG CAAAAAGGGG 540
TTTTACCTGG CTTTTCAGGA TGTGGGGGCC TGCATCGCCC TGGTATCAGT CCGTGTGTTC 600
TATAAAAAGT GTCCACTCAC AGTCCGCAAT CTGGCCCAGT TTCCCGACAC CATCACAGGG 660
GCTGATACGT CTTCCCTGGT GGAAGTTCGA GGCTCCTGTG TCAACAACTC AGAAGAGAAG 720
GATGTGCCAA AAATGTACTG TGGGGCAGAT GGTGAATGGC TGGTACCCAT TGGCAACTGT 780
CTATGCAACG CTGGGCATGA GGAGCGGAGC GGAGAATGCC AAGCTTGCAA AATTGGATAT 840
TACAAGGCTC TCTCCACGGA TGCCACCTGT GCCAAGTGCC CACCCCACAG CTACTCTGTC 900
TGGGAAGGAG CCACCTCGTG CACCTGTGAC CGAGGCTTTT TCAGAGCTGA CAATGATGCT 960
GCCTCCATGC CCTGCACCCG TCCACCATCT GCTCCCCTGA ACTTGATTTC GAATGTCAAC 1020
GAGACATCTG TGAACTTGGA ATGGAGTAGC CCTCAGAATA CAGGTGGCCG CCAGGACATT 1080
TCCTACAATG TGGTATGCAA GAAATGTGGA GCTGGTGACC CCAGCAAGTG CCGACCCTGT 1140
GGAAGTGGGG TCCACTATAC CCCACAGCAG AATGGCTTGA AGACCACCAA AGTCTCCATC 1200
ACCGACCTCC TAGCTCATAC CAATTACACC TTTGAAATCT GGGCTGTGAA TGGAGTGTCC 1260
AAATATAACC CTAGCCCAGA CCAATCAGTT TCCGTCACTG TGACAACCAA CCAAGCAGCA 1320
CCATCATCCA TTGCTTTGGT CCAGGCTAAA GAAGTCACAA GATACAGTGT GGCACTGGCT 1380
TGGTTGGAAC CAGATCGGCC CAATGGTGTA ATCCTGGAAT ACGAAGTCAA GTATTATGAG 1440
AAGGATCAGA ATGAGCGAAG CTATCGTATA GTTCGGACAG CTGCCAGGAA CACAGATATC 1500
AAAGGCCTGA ACCCTCTCAC TTCCTATGTT TTCCACGTGC GAGCCAGGAC AGCAGCTGGC 1560
TATGGAGACT TCAGTGAGCC CTTGGAGGTC ACAACCAACA CAGTGCCTTC CCGGATCATT 1620
GGAGATGGGG CCAACTCCAC AGTCCTTCTG GTCTCTGTCT CAGGCAGTGT GGTGCTGGTG 1680
GTAATTCTCA TTGCAGCTTT TGTCATCAGC CGGAGACGGA GTAAATACAG TAAAGCCAAA 1740
CAAGAAGCGG ATGAAGAGAA ACATTTGAAT CAAGGTGTGA GAACATATGT GGACCCCTTT 1800
ACGTACGAAG ATCCCAACCA AGCAGTTCGA GAATTTGCCA AAGAAATTGA CGCATCCTGC 1860
ATTAAGATTG AAAAAGTTAT AGGAGTTGGT GAATTTGGTG AGGTATGCAG CGGGCGTCTC 1920
AAAGTGCCTG GCAAGAGAGA GATCTGTGTG GCTATCAAGA CGCTGAAAGC TGGTTATACA 1980
GACAAACAGA GGAGAGACTT CCTGAGCGAG GCCAGCATCA TGGGACAGTT TGACCATCCG 2040
AACATCATTC ACTTGGAAGG CGTGGTCACT AAATGTAAAC CAGTAATGAT CATAACAGAG 2100
TACATGGAGA ATGGCTCCTT GGATGCATTC CTCAGGAAAA ATGATGGCAG ATTTACAGTC 2160
ATTCAGCTGG TGGGCATGCT TCGTGGCATT GGGTCTGGGA TGAAGTATTT ATCTGATATG 2220
AGCTATGTGC ATCGTGATCT GGCCGCACGG AACATCCTGG TGAACAGCAA CTTGGTCTGC 2280
AAAGTGTCTG ATTTTGGCAT GTCCCGAGTG CTTGAGGATG ATCCGGAAGC AGCTTACACT 2340
ACCAGGGGTG GCAAGATTCC TATCCGGTGG ACTGCGCCAG AAGCAATTGC CTATCGTAAA 2400
TTCACATCAG CAAGTGATGT ATGGAGCTAT GGAATCGTTA TGTGGGAAGT GATGTCGTAC 2460
GGGGAGAGGC CCTACTGGGA TATGTCCAAT CAAGATGTGA TTAAAGCCAT TGAGGAAGGC 2520
TATCGGTTAC CCCCTCCAAT GGACTGCCCC ATTGCACTCC ACCAGCTGAT GCTAGACTGC 2580
TGGCAGAAGG AGAGAAGCGA CAGGCCTAAA TTTGGGCAGA TTGTCAACAT GTTGGACAAA 2640
CTCATCCGCA ACCCCAACAG CTTGAAGAGG ACAGGGACGG AGAGCTCCAG ACCTAACACT 2700
GCCTTGTTGG ATCCAAGCTC CCCTGAATTC TCTGCTGTGG TATCAGTGGG CGATTGGCTC 2760
CAGGCCATTA AAATGGACCG GTATAAGGAT AACTTCACAG CTGCCGGTTA TACCACACTA 2820
GAGGCTGTGG TGCACGTGAA CCAGGAGTAA 2850
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         +kiekviG GefGevcsGrlk+pgkrei+vaiktlkag+t+kqrrdflseasi+Gqfdhp
Q: 621   IKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHP  680
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtk+kpvmi+teymeng+ld+flrk+dg+ftviqlvgmlrGi+sgmkylsdm
Q: 681   NIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDM  740
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         +yvhrdlaarnilvnsnlvckvsdfG+srvledd+eaaytt+ggkipirwtapeaiayrk
Q: 741   SYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRK  800
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpywdmsnqdvikaieegyrlpppmdcp al+qlmldc
Q: 801   FTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDC  860
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqk+r++rpkf qiv++l
Q: 861   WQKERSDRPKFGQIVNML  878
         ***************985
Domain Sequence
(FASTA)
IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT DKQRRDFLSE ASIMGQFDHP 60
NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV IQLVGMLRGI GSGMKYLSDM 120
SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAYRK 180
FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG YRLPPPMDCP IALHQLMLDC 240
WQKERSDRPK FGQIVNML 258
KeywordATP-binding; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00001
EKS-ANC-00001
EKS-BOT-00001
EKS-CAF-00001
EKS-CAP-00001
EKS-CIS-00002
EKS-DAR-00001
EKS-EQC-00001
EKS-FEC-00001
EKS-GAG-00001
EKS-GAA-00001
EKS-GOG-00001
EKS-HOS-00002
EKS-ICT-00001
EKS-LAC-00002
EKS-LOA-00001
EKS-MEG-00001
EKS-MOD-00001
EKS-MUM-00001
EKS-MUP-00001
EKS-MYL-00001
EKS-NOL-00001
EKS-ORN-00001
EKS-ORA-00001
EKS-ORC-00001
EKS-ORL-00001
EKS-OTG-00005
EKS-PAT-00001
EKS-PES-00001
EKS-POA-00001
EKS-PRC-00001
EKS-PTV-00001
EKS-RAN-00001
EKS-SAH-00001
EKS-TAG-00001
EKS-TAR-00001
EKS-TAS-00001
EKS-TEN-00006
EKS-XET-00002
EKS-XIM-00001
Gene Ontology
GO:0030424; C:axon
GO:0030425; C:dendrite
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0007628; P:adult walking behavior
GO:0021957; P:corticospinal tract morphogenesis
GO:0097156; P:fasciculation of motor neuron axon
GO:0097155; P:fasciculation of sensory neuron axon
GO:0008045; P:motor neuron axon guidance
GO:0048681; P:negative regulation of axon regeneration
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0043507; P:positive regulation of JUN kinase activity
GO:2001108; P:positive regulation of Rho guanyl-nucleotide exchange factor activity
GO:0046777; P:protein autophosphorylation
GO:0048710; P:regulation of astrocyte differentiation
GO:0061001; P:regulation of dendritic spine morphogenesis
GO:0032314; P:regulation of Rac GTPase activity
GO:0032317; P:regulation of Rap GTPase activity
KEGG
mcc:704857;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR011510; SAM_2.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF07647; SAM_2; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013