EKS-MAM-00391

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00391

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE11	325.3	6.3E-97	1076	1340	265

Status

Unreviewed

Ensembl Protein

ENSMMUP00000034679

UniProt Accession

F7EB20;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP3K1

Gene Synonyms/Alias

MAP3K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000012387	ENSMMUP00000034679	ENSMMUT00000041654
ENSMMUG00000012387	ENSMMUP00000016267	ENSMMUT00000017371

Organism

Macaca mulatta

Functional Description

Protein Length

1345

Protein Sequence
(FASTA)

MENKETLKGL HKMDDRPEER MIREKLKATC MPAWKHEWLE RRNRRGPVVV KPIPVKGDGS 60

EMNHLAAESP GEAQASMASP ASKGRRSPSP GNSPSGRTVK SESPGVRRKR VSPVPFQSGR 120

ITPPRRAPSP DGFSPYSPEE TNRRVNKVMR ARLYLLQQIG PNSFLIGGDS PDNKYRVFIG 180

PQNCSCGRGT FCIHLLFVML RVFQLEPSDP MLWRKTLKNF EVESLFQKYH SRRSSRIKAP 240

SRNTIQKFVS RMSNSHTLSS SSTSTSSSEN SIKDEEEQMC PICLLGMLDE ESLTVCEDGC 300

RNKLHHHCMS IWAEECRRNR EPLICPLCRS KWRSHDFYSH ELSSPVDSPS SLRAAQQQTV 360

QQQPLAGSQR RNQESNFNLT HYGTQQIPPA YKDLAEPWIQ VFGMELVGCL FSRNWNVREM 420

ALRRLSHDVS GALLLANGES TGNSGGSSGS SPSGGAASGS SQTSISGDVV EACCNVLSMV 480

CADPVYKVYV AALKTLRAML VYTPCHSLAE RIKLQRLLRP VVDTILVKCA DANSRTSQLS 540

ISTLLELCKG QAGELAVGRE ILKAGSIGIG GVDYVLNCIL GNQTESNNWQ ELLGRLCLID 600

RLLLEFPAEF YPHIVSTDVS QAEPVEIRYK KLLSLLTFAL QSIDNSHSMV GKLSRRIYLS 660

SARMVTTVPH VFSKLLEMLS VSSSTHFTRM RRRLMAIADE VEIAEAIQLG VEDTLDGQQD 720

SFLQASVPSD YPETTEKSSP ECTIHLEKTG KGLCATKLSA SSEDISERLA SISVGPSSST 780

TTEQPKPMVQ TKGRPHSQCL NSSPLSPHSQ LMFPALSSPS SSAPSVPAGT ATDVSKHRLQ 840

GFVPCKIPSA SPQTQRKFSL QFHRNCPENR DSDKLSPVFT QSRPLPSSNI HRPKPSRPTP 900

GNTSKQGDPS KNSMTLDLNS SSKCDDNFGC SSSSSNAVIP SDETVFTPVE EKCRLDVNTE 960

LNSSIEDLLE ASMPSSDTTV TFKSEVAVLS PEKAENDDTY KDDVNHNQKC KEKMEAEEEE 1020

ALAIAMAMSA SQDALPIVPQ LQVENGEDII IIQQDTPETL PGHTKAKQPY REDTEWLKGQ 1080

QIGLGAFSSC YQAQDVGTGT LMAVKQVTYV RNTSSEQEEV VEALREEIRM MSHLNHPNII 1140

RMLGATCEKS NYNLFIEWMA GGSVAHLLSK YGAFKESVVI NYTEQLLRGL SYLHENQIIH 1200

RDVKGANLLI DSTGQRLRIA DFGAAARLAS KGTGAGEFQG QLLGTIAFMA PEVLRGQQYG 1260

RSCDVWSVGC AIIEMACAKP PWNAEKHSNH LALIFKIASA TTAPSIPSHL SPGLRDVALR 1320

CLELQPQDRP PSRELLKHPV FRTTW 1345

Nucleotide Sequence
(FASTA)

ATGGAGAATA AAGAAACTCT CAAAGGGTTG CACAAGATGG ACGATCGTCC AGAGGAACGA 60

ATGATCAGGG AGAAACTGAA GGCAACCTGT ATGCCAGCGT GGAAGCACGA ATGGTTGGAA 120

AGGAGAAATA GGCGAGGGCC TGTGGTGGTA AAACCAATCC CAGTTAAAGG AGATGGATCT 180

GAAATGAATC ACTTGGCAGC TGAGTCTCCA GGAGAGGCCC AGGCGAGTAT GGCTTCACCA 240

GCTTCCAAAG GCCGACGCAG TCCTTCTCCT GGCAACTCCC CATCAGGTCG CACAGTGAAA 300

TCAGAATCTC CAGGAGTAAG GAGAAAAAGA GTTTCCCCAG TGCCTTTTCA GAGTGGCAGA 360

ATCACACCAC CCCGAAGAGC CCCTTCACCA GATGGCTTCT CACCATATAG CCCTGAGGAA 420

ACAAATCGCC GTGTTAACAA AGTGATGCGG GCCAGACTGT ACTTATTGCA GCAGATAGGG 480

CCCAACTCTT TCCTGATTGG AGGAGACAGC CCAGACAATA AATACCGGGT GTTTATTGGG 540

CCTCAGAACT GCAGCTGTGG ACGTGGAACA TTCTGTATTC ATCTGCTGTT TGTAATGCTC 600

CGGGTGTTTC AACTAGAACC TTCAGACCCA ATGTTATGGA GAAAAACTTT AAAGAATTTT 660

GAGGTTGAGA GTTTGTTCCA GAAATATCAC AGTAGGCGTA GCTCAAGGAT CAAAGCTCCA 720

TCTCGTAACA CCATCCAGAA GTTTGTTTCA CGCATGTCAA ATTCTCATAC ATTGTCATCA 780

TCTAGTACTT CTACATCTAG TTCAGAAAAC AGTATAAAGG ATGAAGAGGA GCAGATGTGT 840

CCTATTTGCT TATTGGGCAT GCTTGATGAA GAAAGTCTTA CAGTGTGTGA AGACGGCTGC 900

AGGAACAAGC TGCACCACCA CTGCATGTCA ATTTGGGCAG AAGAGTGTAG AAGAAATAGA 960

GAACCTTTAA TATGTCCCCT TTGTAGATCT AAGTGGAGGT CTCATGATTT CTACAGCCAC 1020

GAATTGTCAA GTCCTGTGGA TTCCCCTTCT TCCCTCAGAG CTGCACAGCA GCAGACCGTA 1080

CAGCAGCAGC CTTTGGCTGG ATCACAAAGA AGGAATCAAG AGAGCAATTT TAACCTTACT 1140

CATTATGGAA CTCAGCAAAT CCCTCCTGCT TACAAAGATT TAGCTGAGCC ATGGATTCAG 1200

GTATTTGGAA TGGAACTCGT TGGCTGCTTA TTTTCTAGAA ACTGGAATGT GAGAGAGATG 1260

GCCCTCAGGC GTCTTTCCCA TGATGTCAGT GGGGCCCTGC TGTTGGCAAA TGGGGAGAGC 1320

ACTGGAAATT CCGGGGGCAG CAGTGGAAGC AGCCCGAGTG GGGGAGCTGC CAGTGGGTCT 1380

TCCCAGACGA GTATCTCAGG AGATGTGGTG GAGGCATGCT GCAACGTTCT GTCAATGGTC 1440

TGTGCTGACC CTGTCTACAA AGTGTATGTT GCTGCTTTAA AAACATTGAG AGCCATGCTG 1500

GTATATACTC CTTGTCACAG TTTAGCGGAA AGAATCAAAC TTCAGAGACT TCTCCGGCCA 1560

GTTGTAGACA CCATCCTAGT CAAATGTGCA GATGCCAATA GCCGCACAAG TCAGCTGTCC 1620

ATATCAACAC TGTTGGAACT GTGCAAAGGC CAAGCAGGAG AGTTGGCAGT TGGCAGAGAA 1680

ATACTTAAAG CTGGATCCAT TGGTATTGGT GGTGTTGATT ATGTCTTAAA TTGTATTCTT 1740

GGAAACCAAA CTGAATCAAA CAATTGGCAA GAACTTCTTG GCCGCCTTTG TCTTATAGAT 1800

AGACTGTTGT TGGAATTTCC TGCTGAATTT TATCCTCATA TTGTCAGTAC TGATGTTTCA 1860

CAAGCTGAGC CTGTTGAAAT CAGGTATAAG AAGCTGCTGT CCCTCTTAAC CTTTGCTTTG 1920

CAGTCCATTG ATAATTCCCA CTCAATGGTT GGCAAACTTT CCAGAAGGAT CTACTTGAGT 1980

TCTGCAAGAA TGGTTACTAC AGTGCCCCAT GTGTTTTCAA AACTGTTAGA AATGCTGAGT 2040

GTTTCCAGTT CCACTCACTT CACCAGGATG CGTCGCCGTT TGATGGCTAT TGCAGATGAG 2100

GTGGAAATTG CTGAAGCCAT CCAGTTGGGC GTAGAAGACA CTTTGGATGG TCAACAGGAC 2160

AGCTTTTTGC AGGCATCTGT TCCCAGTGAC TATCCGGAAA CCACAGAGAA GAGTTCCCCT 2220

GAGTGCACAA TCCATTTAGA GAAAACTGGA AAAGGATTAT GTGCTACAAA ATTGAGTGCC 2280

AGTTCAGAGG ACATTTCTGA GAGACTGGCC AGCATTTCAG TAGGACCTTC TAGTTCAACA 2340

ACAACAGAGC AACCAAAGCC AATGGTTCAA ACAAAAGGCA GGCCCCATAG TCAGTGTTTG 2400

AACTCCTCTC CTTTATCTCC TCATTCCCAA TTAATGTTTC CAGCCTTGTC AAGCCCTTCT 2460

TCTTCGGCCC CATCTGTACC AGCTGGCACT GCAACAGATG TCTCTAAGCA TAGACTTCAG 2520

GGATTCGTTC CCTGCAAAAT ACCTTCTGCA TCTCCTCAAA CACAGCGCAA GTTTTCTCTA 2580

CAATTCCACA GAAACTGTCC TGAAAACAGA GACTCAGATA AACTTTCCCC AGTCTTTACT 2640

CAGTCAAGAC CCTTGCCCTC CAGTAATATA CACAGGCCAA AGCCATCTCG ACCTACCCCA 2700

GGTAATACAA GTAAACAGGG AGATCCCTCA AAAAATAGCA TGACACTTGA TCTGAACAGT 2760

AGTTCCAAAT GTGATGACAA CTTTGGCTGT AGCAGCAGTA GTAGTAATGC TGTTATACCC 2820

AGTGATGAGA CGGTGTTCAC CCCAGTAGAG GAGAAATGCA GATTAGATGT CAATACAGAG 2880

CTCAACTCCA GTATTGAGGA CCTTCTTGAA GCATCTATGC CTTCAAGTGA TACAACAGTC 2940

ACTTTCAAGT CAGAAGTTGC TGTCCTCTCT CCTGAAAAGG CTGAAAATGA TGATACCTAC 3000

AAAGATGATG TGAATCATAA TCAAAAGTGC AAAGAAAAGA TGGAAGCTGA AGAAGAAGAA 3060

GCTTTAGCAA TTGCCATGGC AATGTCAGCG TCTCAGGATG CCCTCCCCAT AGTTCCTCAG 3120

CTGCAGGTTG AAAATGGAGA AGATATCATC ATTATTCAAC AGGATACACC AGAGACTCTA 3180

CCGGGACATA CCAAAGCAAA ACAACCGTAT AGAGAAGATA CTGAATGGCT GAAAGGTCAA 3240

CAGATAGGCC TTGGAGCATT TTCTTCTTGT TATCAGGCTC AAGATGTGGG AACTGGAACT 3300

TTAATGGCTG TTAAACAGGT GACTTATGTC AGAAACACAT CATCTGAGCA AGAAGAAGTA 3360

GTAGAAGCAT TAAGAGAAGA GATAAGAATG ATGAGCCATC TGAATCATCC AAACATCATT 3420

AGGATGTTGG GAGCCACGTG TGAGAAGAGC AATTACAATC TCTTCATTGA ATGGATGGCA 3480

GGGGGATCTG TGGCTCATTT GCTGAGTAAA TATGGAGCTT TCAAAGAATC AGTAGTTATT 3540

AACTACACTG AACAATTACT TCGTGGCCTT TCGTATCTCC ATGAAAACCA AATCATTCAC 3600

AGAGATGTCA AAGGTGCCAA TTTGCTAATT GACAGCACTG GTCAGAGACT AAGAATTGCA 3660

GATTTTGGAG CTGCAGCCAG GTTGGCATCA AAAGGAACTG GTGCAGGAGA GTTTCAGGGA 3720

CAATTACTGG GGACAATTGC ATTTATGGCA CCTGAGGTAC TAAGAGGTCA ACAGTATGGA 3780

AGGAGCTGTG ATGTATGGAG TGTTGGCTGT GCTATTATAG AAATGGCTTG TGCAAAACCA 3840

CCATGGAATG CAGAAAAACA CTCCAATCAT CTTGCTTTGA TATTTAAGAT TGCTAGTGCA 3900

ACGACTGCTC CATCGATCCC TTCACATTTG TCTCCCGGCT TACGAGATGT GGCTCTTCGT 3960

TGTTTAGAAC TTCAACCTCA GGACAGGCCT CCATCAAGAG AGCTACTAAA GCATCCAGTC 4020

TTTCGTACTA CGTGGTAG 4038

Domain Profile

S: 1     wqkrevigkGsfgsvyaaldvdtgellavKeveikpekksekk.evkalkeEikllkelk  59

         w k+++ig G+f+s+y+a+dv tg+l+avK+v++ ++++se++ +v+al+eEi+++++l+

Q: 1076  WLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVTYVRNTSSEQEeVVEALREEIRMMSHLN  1135

         899*******************************999998887699**************

S: 60    HenivkyyGveveeeelkiflEyvegGslssllekygkleesvikkytkqileglayLHe  119

         H+ni++++G+++e++++++f+E+++gGs+++ll+kyg+++esv+ +yt+q+l+gl+yLHe

Q: 1136  HPNIIRMLGATCEKSNYNLFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHE  1195

         ************************************************************

S: 120   kkivHRDiKgaNillds.sgvvklsDFGaskrlaelntkaae.lesltGtlaymaPEvik  177

         ++i+HRD+KgaN+l+ds  + ++++DFGa++rla++ t a+e + +l Gt+a+maPEv++

Q: 1196  NQIIHRDVKGANLLIDStGQRLRIADFGAAARLASKGTGAGEfQGQLLGTIAFMAPEVLR  1255

         *****************7789******************9996779*************9

S: 178   kkekgygrkaDiWslgcvviemltgkrPfa..eldeelaimfkvgakktkPeipeklsee  235

         ++  +ygr++D+Ws+gc++iem+++k+P++  +++++la++fk+++++t+P+ip++ls+

Q: 1256  GQ--QYGRSCDVWSVGCAIIEMACAKPPWNaeKHSNHLALIFKIASATTAPSIPSHLSPG  1313

         98..8************************87678899***********************

S: 236   gkdflekcleldpkkrpsaeeLLkhef  262

          +d+  +clel+p++rp ++eLLkh++

Q: 1314  LRDVALRCLELQPQDRPPSRELLKHPV  1340

         *************************86

Domain Sequence
(FASTA)

WLKGQQIGLG AFSSCYQAQD VGTGTLMAVK QVTYVRNTSS EQEEVVEALR EEIRMMSHLN 60

HPNIIRMLGA TCEKSNYNLF IEWMAGGSVA HLLSKYGAFK ESVVINYTEQ LLRGLSYLHE 120

NQIIHRDVKG ANLLIDSTGQ RLRIADFGAA ARLASKGTGA GEFQGQLLGT IAFMAPEVLR 180

GQQYGRSCDV WSVGCAIIEM ACAKPPWNAE KHSNHLALIF KIASATTAPS IPSHLSPGLR 240

DVALRCLELQ PQDRPPSREL LKHPV 265

Keyword

ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding; Reference proteome; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Vicugna pacos"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0008545	; F:JUN kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0008270	; F:zinc ion binding
GO:0008637	; P:apoptotic mitochondrial changes
GO:0043010	; P:camera-type eye development
GO:0071260	; P:cellular response to mechanical stimulus
GO:0030838	; P:positive regulation of actin filament polymerization
GO:0030334	; P:regulation of cell migration
GO:0007179	; P:transforming growth factor beta receptor signaling pathway
GO:0042060	; P:wound healing

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR001841	; Znf_RING.
IPR013083	; Znf_RING/FYVE/PHD.
IPR007527	; Znf_SWIM.

Pfam

PF00069	; Pkinase; 1.
PF04434	; SWIM; 1.

SMARTs

SM00184	; RING; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50089	; ZF_RING_2; 1.
PS50966	; ZF_SWIM; 1.

Prints

Created Date

20-Feb-2013