EKS-MAM-00017

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00017

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	516.5	2.2E-155	963	1230	268

Status

Unreviewed

Ensembl Protein

ENSMMUP00000016307

UniProt Accession

F7DJH4;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

INSRR

Gene Synonyms/Alias

INSRR;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000012422	ENSMMUP00000038680	ENSMMUT00000045640
ENSMMUG00000012422	ENSMMUP00000016307	ENSMMUT00000017413

Organism

Macaca mulatta

Functional Description

Protein Length

1285

Protein Sequence
(FASTA)

MAVPSLWPWG ACLPVIFLSL GFGLDTVEVC PSLDIRSEVA ELRRLENCSV VEGHLQILLM 60

FTATGEDFRG LSFPRLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGTRLF LGYALVIFEM 120

PHLRDVGLPA LGAVLRGAVR VEKNQELCHL STIDWGLLQP APGANHIVGN KLGEECADVC 180

PGVLGAAGES CAKTTFSGHT DYRCWTSSHC QRETAGSHGA GWSQDGMAQY FQCHCFLIRT 240

HPMRQVRKQR EKLNNQCGIR QLRAAGECRE GGGHPGSSEG LRRPKLVQGS GYLLAPASIF 300

CHKCEGLCPK ECKVGTKTID SIQAAQDLVG CTHVEGSLIL NLRQGYNLEP QLQHSLGLVE 360

TITGFLKIKH SFALVSLGFF KNLKLIRGDA MVDGNYTLYV LDNQNLQQLG SWVAAGLTIP 420

VGKIYFAFNP RLCLEHIYRL EEVTGTRGRQ NKAEINPRTN GDRAACQTRT LRFVSNVTEA 480

DRILLRWERY EPLEARDLLS FIVYYKESPF QNATEHVGPD ACGTQSWNLL DVELPLSRTQ 540

EPGVTLASLK PWTQYAVFVR AITLTTDEDS PHQGAQSPIV YLRTLPAAPT VPQDVISTSN 600

SSSHLLVRWK PPTQRNGNLT YYLVLWQRLA EDGDLYLNDY CHRGLRLPTS NNDPRFDRED 660

GDPEAEMESG CCPCQHPPPG QVLPPLEAQE ASFQKKFENF LHNAITIPKS PWKVTSINKS 720

PQRDSGRHRR ATGPLRLGDN SSDFEIQEDK VPRERAVLSG LRHFTEYRID IHACNHAAHT 780

VGCSAATFVF ARTMPHREAD GIPGKVAWEA SSKNSVLLRW LEPPDPNGLI LKYEIKYRRL 840

GEEATVLCVS RLRYAKFGGV HLALLPPGNY SARVRATSLA GNGSWTDSVA FYILGPEEED 900

AGGLHVLLTA TPVGLMLLIV LAALGFFYGK KRNRTLYASV NPEYFSASDM YIPDEWEVPR 960

EQISIIRELG QGSFGMVYEG LARGLEAGEE STPVALKTVN ELASPRERIE FLKEASVMKA 1020

FKCHHVVRLL GVVSQGQPTL VIMELMTHGD LKSHLRSLRP EAENNPGLPQ PALGEMIQMA 1080

GEIADGMAYL AANKFVHRDL AARNCMVSQD FTVKIGDFGM TRDVYETDYY RKGGKGLLPV 1140

RWMAPESLKD GIFTTHSDVW SFGVVLWEIV TLAEQPYQGL SNEQVLKFVM DGGVLEELEG 1200

CPLQLQELMS RCWQPNPRLR PSFTHILDSI QEELRPSFRL LSFYYSSECQ GARGSLPPTD 1260

AEPDSSPTPR GASSDCSPQN GGPGH 1285

Nucleotide Sequence
(FASTA)

ATGGCAGTGC CTAGTCTGTG GCCCTGGGGA GCATGCCTGC CTGTGATCTT CCTCTCGTTG 60

GGATTTGGCC TGGATACAGT AGAGGTGTGT CCGAGCCTGG ACATTCGCTC TGAGGTGGCA 120

GAGCTTCGTC GACTGGAGAA CTGCAGCGTG GTGGAGGGCC ACCTGCAGAT CCTGCTCATG 180

TTCACAGCCA CCGGGGAGGA CTTCCGCGGC CTCAGCTTCC CTCGCCTCAC CCAGGTCACC 240

GACTACCTGC TGCTCTTCCG TGTCTACGGA CTGGAGAGCC TGCGCGACCT CTTCCCCAAC 300

CTAGCAGTCA TCCGCGGGAC GCGCCTCTTC CTGGGCTACG CACTGGTCAT CTTTGAGATG 360

CCGCATCTGC GTGACGTGGG ACTACCTGCG CTTGGGGCCG TGCTGCGTGG GGCTGTGCGT 420

GTGGAGAAGA ACCAGGAACT CTGCCACCTC TCCACCATTG ACTGGGGACT GCTGCAGCCA 480

GCACCTGGTG CCAACCACAT TGTGGGCAAC AAGCTGGGCG AGGAGTGTGC TGACGTGTGC 540

CCTGGTGTGC TGGGTGCTGC TGGCGAATCC TGTGCCAAGA CCACCTTCAG CGGGCACACT 600

GACTACAGAT GCTGGACCTC CAGCCACTGC CAGAGAGAAA CAGCAGGGTC ACATGGGGCT 660

GGGTGGTCAC AGGATGGTAT GGCTCAGTAC TTTCAGTGCC ACTGTTTTTT AATCCGCACT 720

CATCCTATGA GGCAGGTAAG GAAACAAAGG GAAAAGTTAA ATAACCAATG TGGCATAAGA 780

CAGCTAAGGG CAGCAGGTGA GTGTAGGGAG GGTGGGGGGC ACCCTGGGAG CAGTGAGGGC 840

CTGAGGAGGC CCAAACTGGT CCAAGGCTCA GGATATCTGC TTGCTCCTGC TAGCATATTC 900

TGCCACAAGT GCGAGGGGCT GTGCCCTAAA GAGTGCAAGG TAGGCACCAA GACCATCGAC 960

TCCATCCAGG CGGCACAGGA TCTGGTGGGC TGCACGCATG TGGAGGGAAG CCTCATCCTC 1020

AACCTTCGCC AGGGCTACAA CCTGGAGCCG CAGCTGCAGC ACAGCCTGGG GCTGGTAGAA 1080

ACCATTACTG GCTTCCTCAA AATCAAGCAC TCCTTTGCCC TCGTGTCCCT GGGCTTTTTC 1140

AAGAACCTCA AACTAATCCG GGGAGACGCC ATGGTGGACG GGAACTACAC TCTCTACGTG 1200

CTGGACAACC AGAACCTACA GCAGCTAGGG TCCTGGGTGG CCGCGGGGCT CACCATTCCC 1260

GTGGGCAAGA TCTACTTCGC CTTCAACCCG CGCCTCTGCT TGGAGCACAT CTACCGACTG 1320

GAGGAGGTGA CCGGCACACG AGGTCGGCAG AACAAGGCTG AGATCAACCC CCGCACCAAC 1380

GGAGACCGCG CCGCCTGCCA GACTCGCACC CTGCGCTTCG TGTCCAACGT GACGGAGGCA 1440

GACCGCATCC TGCTACGCTG GGAGCGCTAC GAGCCACTGG AGGCCCGCGA CCTGCTCAGC 1500

TTCATCGTGT ACTACAAGGA GTCCCCATTC CAGAATGCCA CAGAGCACGT GGGTCCAGAT 1560

GCTTGTGGAA CCCAGAGCTG GAACCTGCTG GATGTGGAGC TGCCCCTAAG CCGCACCCAG 1620

GAGCCAGGGG TGACCCTAGC CTCCCTCAAG CCTTGGACAC AGTACGCAGT GTTTGTGCGG 1680

GCCATAACGC TAACCACTGA TGAGGACAGC CCCCATCAAG GAGCCCAGAG TCCCATCGTC 1740

TACCTCCGAA CGCTGCCTGC AGCTCCCACG GTGCCCCAGG ACGTCATCTC CACGTCCAAC 1800

TCCTCCTCCC ACCTCCTGGT GCGCTGGAAG CCACCCACCC AGCGCAACGG GAACCTCACC 1860

TACTACCTGG TGCTGTGGCA GCGGCTGGCA GAGGACGGCG ACCTCTACCT CAATGACTAC 1920

TGCCACCGCG GCTTGCGGCT GCCCACCAGC AACAATGACC CGCGCTTCGA CCGCGAAGAC 1980

GGAGATCCTG AGGCAGAGAT GGAGTCCGGC TGCTGCCCTT GCCAGCACCC ACCTCCTGGT 2040

CAGGTTCTGC CCCCGCTGGA GGCGCAAGAG GCCTCGTTCC AAAAGAAGTT TGAAAACTTT 2100

CTACACAACG CGATCACCAT CCCCAAATCC CCTTGGAAGG TGACGTCCAT CAACAAGAGC 2160

CCCCAAAGGG ACTCCGGGCG GCACCGCCGG GCAACTGGGC CCCTCCGGCT GGGGGACAAC 2220

AGCTCGGATT TCGAGATCCA GGAGGACAAG GTACCCCGTG AGCGAGCGGT GCTGAGCGGC 2280

CTGCGCCACT TCACGGAATA CCGAATCGAC ATCCATGCCT GCAACCACGC GGCGCACACC 2340

GTGGGCTGCA GCGCCGCCAC CTTCGTCTTT GCGCGCACCA TGCCCCACAG AGAGGCTGAT 2400

GGTATTCCAG GAAAGGTGGC CTGGGAGGCC TCCAGCAAGA ACAGTGTCCT CCTGCGCTGG 2460

CTCGAGCCAC CAGACCCCAA CGGACTCATC CTCAAGTACG AAATCAAGTA CCGCCGCTTG 2520

GGAGAGGAGG CCACAGTGCT TTGTGTGTCC CGTCTTCGAT ATGCGAAGTT TGGGGGAGTC 2580

CACCTGGCCC TGCTGCCCCC TGGAAACTAC TCTGCCAGGG TTAGGGCAAC CTCACTGGCT 2640

GGCAATGGCT CTTGGACAGA CAGTGTTGCC TTCTACATCC TTGGCCCAGA GGAGGAGGAT 2700

GCTGGGGGGC TGCATGTCCT CCTCACTGCC ACCCCTGTGG GGCTCATGCT GCTCATCGTT 2760

CTTGCTGCCC TTGGTTTCTT CTACGGCAAG AAGAGAAACA GAACCCTGTA TGCTTCTGTG 2820

AATCCGGAGT ACTTCAGCGC CTCTGATATG TACATCCCTG ATGAGTGGGA GGTGCCTCGG 2880

GAGCAGATCT CGATAATCCG GGAACTGGGC CAGGGCTCTT TTGGGATGGT ATATGAGGGC 2940

CTGGCACGAG GACTTGAGGC TGGAGAGGAG TCCACACCCG TGGCCCTGAA GACAGTGAAT 3000

GAGCTGGCCA GCCCACGGGA ACGCATTGAG TTCCTCAAGG AAGCTTCTGT CATGAAAGCC 3060

TTCAAGTGTC ACCATGTGGT GCGTCTCTTG GGTGTGGTGT CTCAGGGCCA GCCAACTCTG 3120

GTCATCATGG AGTTAATGAC CCATGGGGAC CTCAAGAGCC ATCTTCGATC TTTGCGGCCT 3180

GAGGCAGAGA ACAACCCTGG GCTCCCACAG CCAGCATTGG GGGAAATGAT CCAGATGGCT 3240

GGTGAGATTG CAGACGGCAT GGCCTACCTT GCTGCCAACA AGTTTGTGCA CCGAGATCTA 3300

GCAGCCCGCA ACTGCATGGT GTCCCAGGAT TTCACCGTCA AGATCGGGGA CTTCGGGATG 3360

ACTCGAGACG TGTATGAGAC AGACTATTAC CGCAAGGGTG GGAAGGGGCT GCTGCCCGTG 3420

CGCTGGATGG CCCCTGAGTC CCTCAAAGAT GGGATCTTCA CCACCCACTC GGATGTCTGG 3480

TCCTTCGGTG TGGTACTCTG GGAGATTGTG ACCCTGGCTG AACAACCCTA CCAGGGCCTG 3540

TCCAATGAGC AGGTGCTCAA GTTCGTCATG GATGGCGGGG TCCTGGAGGA GCTGGAGGGC 3600

TGTCCCCTTC AGCTGCAGGA GCTGATGAGC CGCTGCTGGC AGCCGAACCC ACGCCTGCGC 3660

CCATCTTTCA CGCACATTCT GGACAGCATA CAGGAGGAGC TTCGGCCCTC CTTCCGCCTC 3720

CTCTCCTTCT ACTACAGCTC GGAGTGCCAG GGGGCCCGGG GCTCCCTGCC TCCCACCGAT 3780

GCAGAACCTG ACTCCTCACC CACCCCAAGA GGGGCTTCAT CAGACTGCAG CCCTCAAAAT 3840

GGGGGTCCAG GGCACTGA 3858

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i+++relGqGsfGmvyeG+a+++++gee+t+va+ktvne as rerieflkeasvmk+fk

Q: 963   ISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRERIEFLKEASVMKAFK  1022

         6799********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslrpe+en+++l++pal+++iqma+e

Q: 1023  CHHVVRLLGVVSQGQPTLVIMELMTHGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGE  1082

         ************************************************************

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmv++d+tvkiGdfGmtrd+yetdyyrkggkgllpvrw

Q: 1083  IADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRW  1142

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         m+peslkdG+ft++sdvwsfGvvlweivtlaeqpyqGlsneqvlkfv+dggvle++e cp

Q: 1143  MAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCP  1202

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

          +l+elm++cwq np+lrpsf++i++++

Q: 1203  LQLQELMSRCWQPNPRLRPSFTHILDSI  1230

         ************************9976

Domain Sequence
(FASTA)

ISIIRELGQG SFGMVYEGLA RGLEAGEEST PVALKTVNEL ASPRERIEFL KEASVMKAFK 60

CHHVVRLLGV VSQGQPTLVI MELMTHGDLK SHLRSLRPEA ENNPGLPQPA LGEMIQMAGE 120

IADGMAYLAA NKFVHRDLAA RNCMVSQDFT VKIGDFGMTR DVYETDYYRK GGKGLLPVRW 180

MAPESLKDGI FTTHSDVWSF GVVLWEIVTL AEQPYQGLSN EQVLKFVMDG GVLEELEGCP 240

LQLQELMSRC WQPNPRLRPS FTHILDSI 268

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0071469	; P:cellular response to alkalinity
GO:0030238	; P:male sex determination
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00041	; fn3; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013