EKS-MAM-00010
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00010
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph430.62.7E-129629881253
StatusUnreviewed
Ensembl ProteinENSMMUP00000016603
UniProt AccessionF7EBG2;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA1
Gene Synonyms/Alias EPHA1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000012638ENSMMUP00000016603ENSMMUT00000017729
OrganismMacaca mulatta
Functional Description
Protein Length978
Protein Sequence
(FASTA)
MERRWPLGLG LVLLLCTPLP PGARTKEVTL MDTSKAQGEL GWLLDPPKDG WSERQQILNG 60
TPLYMYQDCP VQGRRDTDHW LRSNWIYRGE EASRVHVELQ FTLRDCKSFP GGAGPLGCKE 120
TFNLLYMESD QDVGIQLRRP LFQKVTTVAA DQSFTIRDLA SGSMKLNVER CSLGHLTRRG 180
LYLAFHNPGA CVALVSVRVF YQRCPETLNG LAQFPDTLPG PAGLVEVAGT CLPHAQASPS 240
PRPSGAPRMH CSPDGEWLVP VGRCHCEPGY EEGGSGKGCV ACPSGSYRMD MDTPHCLTCP 300
QHSTAESEGA TICTCESGHY RAPGEGPQVA CTRPPSAPQN LSSSASGTQL SLRWEPPADM 360
GGRQDVRYSV RCSQCQGTVQ DGGPCQPCGV GVHFSPGARG LTTSAVHVSG LEPYANYTFN 420
VEAQNGVSGL GSSGHASTSV SISMGHAEPL SGLSLRLVKK EPRQLELTWA GSRPRSPGGN 480
LSYELHVLNQ DEERYQMVLE PRVLLTELQP DTTYIVRVRM LTPLGPGPFS PDHEFRTSPP 540
VSRGLSGGEI IAVIFGLLLG AALLLGILVF RSRRAQRQRQ QRQRDRATDV DREDKLWLKP 600
YVDLQAYEDP AQGALDFTRE LDPAWLMGDT VIGEGEFGEV YRGTLRLPSQ DCKTVAIKTL 660
KDTSPGGQWW NFLREATIMG QFSHPHILHL EGVITKRKPI MIITEFMENG ALDAFLREQE 720
DQLVPGQLVA MLQGIASGMN YLSNHNYVHR DLAARNILVN QDLCCKVSDF GLTRLLDDFD 780
GTYETQGGKI PIRWTAPEAI AHRIFTTASD VWSFGIVMWE VLSFGDKPYG EMSNQEVMKS 840
IEDGYRLPPP VDCPAPLYEL MKNCWAYDRA RRPHFQKLQA HLEQVLANPH SLRTIANFDP 900
RVTLRLPSLS GSDGIPYRSV SEWLESIRMK RYILHFHSAG LDTMECVLEL TAEDLTQMGI 960
TLPGHQKRIL CSIQGFKD 978
Nucleotide Sequence
(FASTA)
ATGGAGCGGC GCTGGCCCCT GGGGCTCGGG CTGGTGCTGC TGCTCTGCAC CCCGCTGCCC 60
CCGGGGGCGC GCACCAAGGA AGTTACTCTG ATGGACACAA GCAAGGCACA GGGAGAGCTG 120
GGCTGGCTGC TGGATCCCCC AAAAGATGGG TGGAGTGAAC GGCAACAGAT ACTGAATGGG 180
ACACCCCTGT ACATGTACCA GGACTGCCCA GTGCAAGGAC GCAGAGACAC TGACCACTGG 240
CTTCGCTCCA ACTGGATCTA CCGCGGGGAG GAGGCTTCCC GGGTCCACGT GGAGCTGCAG 300
TTCACCTTGC GGGACTGCAA GAGTTTCCCT GGGGGAGCCG GGCCTCTGGG CTGCAAGGAG 360
ACCTTCAACC TTCTGTACAT GGAGAGTGAC CAGGATGTGG GCATTCAGCT CCGACGGCCC 420
TTGTTCCAGA AGGTAACCAC GGTGGCCGCA GACCAGAGCT TTACCATTCG AGACCTCGCA 480
TCTGGCTCCA TGAAGCTGAA TGTGGAGCGC TGCTCCCTGG GCCACCTGAC CCGCCGTGGC 540
CTCTACCTCG CTTTCCACAA CCCAGGTGCC TGTGTGGCCC TGGTGTCTGT CCGGGTCTTC 600
TACCAGCGCT GTCCTGAGAC CCTGAATGGC TTGGCCCAGT TCCCTGACAC TCTGCCTGGC 660
CCCGCTGGGT TGGTGGAAGT GGCAGGGACC TGCTTGCCCC ACGCGCAGGC CAGCCCCAGC 720
CCCAGGCCCT CAGGTGCACC CCGCATGCAC TGCAGCCCTG ATGGCGAGTG GCTGGTGCCT 780
GTAGGACGGT GCCACTGTGA GCCTGGCTAT GAGGAAGGTG GCAGTGGCAA GGGATGTGTT 840
GCCTGCCCTA GCGGCTCCTA CCGGATGGAC ATGGACACAC CCCATTGTCT CACGTGCCCC 900
CAGCACAGCA CGGCTGAGTC TGAGGGGGCC ACCATCTGTA CCTGTGAGAG CGGCCATTAC 960
AGAGCTCCCG GGGAGGGCCC CCAGGTGGCA TGCACACGTC CCCCTTCAGC CCCCCAAAAC 1020
CTGAGCTCCT CGGCATCAGG GACTCAGCTC TCCCTGCGTT GGGAACCCCC AGCAGATATG 1080
GGGGGACGCC AGGATGTCAG ATACAGTGTG AGGTGTTCCC AGTGTCAGGG CACAGTGCAG 1140
GACGGGGGGC CCTGCCAGCC CTGTGGGGTA GGCGTGCACT TCTCGCCAGG GGCCCGGGGG 1200
CTCACCACAT CTGCAGTGCA TGTCAGTGGC CTTGAACCTT ACGCCAACTA CACCTTTAAC 1260
GTGGAAGCCC AAAATGGAGT GTCAGGGCTG GGCAGCTCTG GCCATGCCAG CACCTCAGTC 1320
AGCATCAGCA TGGGGCATGC AGAGCCACTG TCGGGCCTGT CTCTGAGACT GGTGAAGAAA 1380
GAACCGAGGC AACTTGAGCT GACCTGGGCG GGGTCCCGGC CCCGAAGCCC TGGGGGGAAC 1440
CTGAGCTATG AGCTGCACGT GCTGAACCAG GATGAAGAAC GGTACCAAAT GGTTCTAGAA 1500
CCCAGGGTCT TGCTGACAGA GCTGCAGCCC GACACCACAT ACATCGTCAG AGTCCGAATG 1560
CTGACCCCAC TGGGTCCTGG CCCTTTCTCC CCTGATCATG AGTTTCGGAC CAGCCCACCA 1620
GTGTCCAGGG GCCTGTCTGG AGGAGAGATC ATAGCTGTCA TCTTTGGGCT GCTGCTTGGT 1680
GCAGCCTTGC TGCTGGGGAT TCTCGTTTTC CGGTCCAGGA GAGCCCAGCG GCAGAGGCAG 1740
CAGAGGCAGC GTGACCGCGC CACCGATGTG GATCGAGAGG ACAAGCTGTG GCTGAAGCCC 1800
TATGTGGACC TCCAGGCATA CGAGGACCCT GCACAGGGAG CCTTGGACTT TACCCGGGAG 1860
CTCGATCCAG CGTGGCTGAT GGGGGACACT GTCATAGGAG AAGGAGAGTT TGGGGAAGTC 1920
TATCGAGGGA CCCTGAGGCT CCCCAGCCAA GACTGCAAGA CTGTGGCCAT TAAGACCTTA 1980
AAAGACACAT CCCCAGGTGG CCAGTGGTGG AACTTCCTTC GAGAGGCAAC TATCATGGGC 2040
CAGTTTAGCC ACCCGCACAT TCTGCATCTG GAAGGCGTCA TCACAAAGAG AAAGCCGATC 2100
ATGATCATCA CAGAATTTAT GGAGAATGGA GCCCTGGATG CTTTCCTGAG GGAGCAGGAG 2160
GACCAGCTGG TCCCTGGGCA GCTAGTGGCC ATGCTGCAGG GCATAGCATC TGGCATGAAC 2220
TACCTCAGTA ATCACAATTA TGTCCACCGG GACCTGGCTG CCAGGAACAT CTTAGTGAAT 2280
CAAGACCTGT GCTGCAAGGT GTCTGACTTT GGCCTGACTC GCCTCCTGGA TGACTTTGAT 2340
GGCACATATG AAACTCAGGG AGGAAAGATC CCTATCCGGT GGACAGCCCC CGAAGCCATT 2400
GCCCATAGGA TCTTCACCAC GGCCAGCGAT GTGTGGAGCT TTGGGATTGT GATGTGGGAG 2460
GTGCTGAGCT TTGGGGACAA GCCTTATGGG GAGATGAGCA ATCAGGAGGT TATGAAGAGC 2520
ATTGAGGATG GGTACCGGTT GCCCCCTCCT GTGGACTGCC CTGCGCCTCT GTATGAGCTC 2580
ATGAAGAACT GCTGGGCATA TGACCGTGCC CGCCGGCCAC ACTTCCAGAA GCTTCAGGCA 2640
CATCTGGAGC AAGTGCTTGC CAACCCCCAC TCCCTGCGGA CCATTGCCAA CTTTGACCCC 2700
AGGGTGACTC TTCGACTGCC CAGCCTGAGC GGCTCAGATG GGATCCCGTA TCGAAGCGTC 2760
TCTGAGTGGC TCGAGTCCAT ACGCATGAAA CGCTACATCC TGCACTTCCA CTCGGCTGGG 2820
CTGGACACCA TGGAGTGTGT GCTGGAGCTG ACCGCTGAGG ACCTGACGCA GATGGGAATC 2880
ACACTGCCCG GGCACCAGAA GCGCATTCTT TGCAGTATTC AGGGATTCAA GGACTGA 2937
Domain Profile
S: 4     ekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhpnii  63
         ++viG+GefGev++G+l+lp++   +vaiktlk++s   q+++fl+ea+i+Gqf+hp+i+
Q: 629   DTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHIL  688
         78******************999999**********************************
S: 64    rleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdmgyv  123
         +leGv+tk+kp+mi+te+mengald+flr++++q++  qlv+ml+Giasgm+yls+++yv
Q: 689   HLEGVITKRKPIMIITEFMENGALDAFLREQEDQLVPGQLVAMLQGIASGMNYLSNHNYV  748
         ************************************************************
S: 124   hrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrkfts  183
         hrdlaarnilvn++l+ckvsdfGl+r l dd + +y+t+ggkipirwtapeaia+r ft+
Q: 749   HRDLAARNILVNQDLCCKVSDFGLTRLL-DDFDGTYETQGGKIPIRWTAPEAIAHRIFTT  807
         **************************98.7889***************************
S: 184   asdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldcwqk  243
         asdvws+Giv+wevls+G++py +msnq+v+k+ie+gyrlppp+dcpa ly+lm++cw  
Q: 808   ASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAY  867
         ************************************************************
S: 244   draerpkfeqivsi  257
         dra+rp+f++++++
Q: 868   DRARRPHFQKLQAH  881
         **********9986
Domain Sequence
(FASTA)
DTVIGEGEFG EVYRGTLRLP SQDCKTVAIK TLKDTSPGGQ WWNFLREATI MGQFSHPHIL 60
HLEGVITKRK PIMIITEFME NGALDAFLRE QEDQLVPGQL VAMLQGIASG MNYLSNHNYV 120
HRDLAARNIL VNQDLCCKVS DFGLTRLLDD FDGTYETQGG KIPIRWTAPE AIAHRIFTTA 180
SDVWSFGIVM WEVLSFGDKP YGEMSNQEVM KSIEDGYRLP PPVDCPAPLY ELMKNCWAYD 240
RARRPHFQKL QAH 253
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>
EKS-AIM-00011
EKS-ANC-00010
EKS-BOT-00011
EKS-CAJ-00011
EKS-CAF-00012
EKS-CAP-00009
EKS-EQC-00012
EKS-FEC-00009
EKS-GAG-00011
EKS-GOG-00012
EKS-HOS-00012
EKS-ICT-00011
EKS-LAC-00015
EKS-LOA-00012
EKS-MEG-00010
EKS-MOD-00011
EKS-MUM-00012
EKS-MUP-00012
EKS-MYL-00013
EKS-NOL-00011
EKS-OCP-00003
EKS-ORC-00011
EKS-OTG-00012
EKS-PAT-00010
EKS-PES-00009
EKS-POA-00009
EKS-RAN-00011
EKS-SAH-00009
EKS-SUS-00009
EKS-TAG-00011
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004672; F:protein kinase activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0032862; P:activation of Rho GTPase activity
GO:0030336; P:negative regulation of cell migration
GO:0006469; P:negative regulation of protein kinase activity
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0045766; P:positive regulation of angiogenesis
GO:0030335; P:positive regulation of cell migration
GO:0008284; P:positive regulation of cell proliferation
GO:0001954; P:positive regulation of cell-matrix adhesion
GO:0051496; P:positive regulation of stress fiber assembly
GO:0046777; P:protein autophosphorylation
GO:0032314; P:regulation of Rac GTPase activity
GO:0034446; P:substrate adhesion-dependent cell spreading
KEGG
mcc:706295;
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013