EKS-MAM-00328
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00328
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20323.71.6E-9630280251
StatusUnreviewed
Ensembl ProteinENSMMUP00000017358
UniProt AccessionF6XFA0;
Protein Name
Protein Synonyms/Alias Serine/threonine-protein kinase 4 37kDa subunit;
Gene NameSTK4
Gene Synonyms/Alias STK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000013212ENSMMUP00000017358ENSMMUT00000018534
OrganismMacaca mulatta
Functional Description
Protein Length486
Protein Sequence
(FASTA)
METVQLRNPP RRQLKKLDED SLTKQPEEVF DVLEKLGEGS YGSVYKAIHK ETGQIVAIKQ 60
VPVESDLQEI IKEISIMQQC DSPHVVKYYG SYFKNTDLWI VMEYCGAGSV SDIIRLRNKT 120
LTEDEIATIL QSTLKGLEYL HFMRKIHRDI KAGNILLNTE GHAKLADFGV AGQLTDTMAK 180
RNTVIGTPFW MAPEVIQEIG YNCVADIWSL GITAIEMAEG KPPYADIHPM RALWLTPVIP 240
ALWEAEVDGS PEVRNFVKQC LVKSPEQRAT ATQLLQHPFV KSAKGVSILR DLINEAMDVK 300
LKRQESQQRE VDQDDEENSE EDEMDSGTMV RAVGDEMGTV RVASTMTDGA NTMIEHDDTL 360
PSQLGTMVIN TEDEEEEGTM KRRDETMQPA KPSFLEYFEQ KEKENQINSF GKSVPGPLKN 420
SSDWKIPQDG DYEFLKSWTV EDLQKRLLAL DPMMEQEIEE IRQKYQSKRQ PILDAIEAKK 480
RRQQNF 486
Nucleotide Sequence
(FASTA)
ATGGAGACGG TACAGCTGAG GAACCCGCCG CGCCGGCAGC TGAAAAAGTT GGATGAAGAT 60
AGTTTAACCA AACAACCAGA AGAAGTATTT GATGTCTTAG AGAAACTTGG AGAAGGGTCC 120
TATGGCAGCG TATACAAAGC TATTCATAAA GAGACAGGTC AGATTGTTGC TATTAAGCAA 180
GTTCCTGTGG AATCAGACCT GCAGGAGATA ATCAAAGAAA TCTCTATAAT GCAGCAATGT 240
GACAGCCCTC ATGTAGTCAA ATATTATGGC AGTTATTTTA AGAACACGGA CTTATGGATC 300
GTTATGGAGT ACTGTGGGGC TGGTTCTGTA TCTGATATCA TTCGATTACG AAATAAAACG 360
TTAACAGAAG ATGAAATAGC TACAATATTA CAATCAACTC TTAAGGGACT TGAATACCTT 420
CATTTTATGA GAAAAATACA CCGAGATATC AAGGCAGGAA ATATTTTGCT AAATACAGAA 480
GGACACGCAA AACTTGCAGA TTTTGGGGTA GCAGGTCAAC TTACAGATAC CATGGCCAAG 540
CGGAATACAG TGATAGGAAC ACCATTTTGG ATGGCTCCAG AAGTGATTCA GGAAATTGGA 600
TACAACTGTG TAGCAGATAT CTGGTCCCTG GGAATAACTG CCATAGAAAT GGCTGAAGGA 660
AAGCCCCCTT ATGCTGATAT CCATCCAATG AGGGCGTTGT GGCTCACACC TGTAATCCCA 720
GCACTTTGGG AGGCTGAGGT GGATGGATCA CCTGAGGTCA GGAATTTTGT GAAACAGTGT 780
CTTGTAAAGA GTCCTGAGCA GAGAGCCACA GCCACTCAGC TCTTGCAGCA CCCATTTGTC 840
AAGAGTGCCA AAGGAGTGTC AATACTGCGA GACTTAATTA ATGAAGCCAT GGATGTGAAA 900
CTGAAACGCC AGGAATCCCA GCAGCGGGAA GTGGACCAGG ACGATGAAGA AAACTCAGAA 960
GAGGATGAAA TGGATTCTGG CACAATGGTT CGAGCAGTGG GTGATGAGAT GGGCACTGTC 1020
CGAGTAGCCA GCACCATGAC TGATGGAGCC AATACTATGA TTGAGCACGA TGACACGTTG 1080
CCATCACAGC TGGGCACCAT GGTGATCAAT ACAGAGGATG AGGAAGAGGA AGGAACTATG 1140
AAAAGAAGGG ATGAGACCAT GCAGCCTGCA AAACCATCTT TTCTTGAATA TTTTGAACAA 1200
AAAGAAAAGG AAAACCAGAT CAACAGCTTT GGCAAGAGTG TACCTGGTCC ACTGAAAAAT 1260
TCTTCAGATT GGAAAATACC ACAGGATGGA GACTACGAGT TTCTTAAGAG TTGGACAGTG 1320
GAGGACCTTC AGAAGAGGCT CTTGGCCCTG GACCCCATGA TGGAGCAGGA GATTGAAGAG 1380
ATCCGGCAGA AGTACCAGTC CAAGCGGCAG CCCATCCTGG ATGCCATTGA GGCTAAGAAG 1440
AGACGGCAAC AAAACTTTTG A 1461
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +++le++g+G++g+vy+a +k+tg++vaik++ +e+  +l+e++keis+++++++p++v+
Q: 30    FDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVK  87
         7899*******************************7..9*********************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s++k+++lw+vmey+ +Gs+sd+++  ++++l+E++ia+il+++lk+LeylH +++i
Q: 88    YYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEDEIATILQSTLKGLEYLHFMRKI  146
         ****************************.99*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180
         Hrdika+niLl++eg+ kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gY++ 
Q: 147   HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ--EIGYNCV  204
         ***************************************************..9******
S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppkl.kskkkfskefkefvekclq  239
         aDiwslGItaie+aeg+pP++d++p++al +++    p l + + + s+e+++fv++cl 
Q: 205   ADIWSLGITAIEMAEGKPPYADIHPMRALWLTPV--IPALwEAEVDGSPEVRNFVKQCLV  262
         ****************************998775..56663555689*************
S: 240   knpekRpsasellkhkFl  257
         k+pe+R++a++ll+h+F+
Q: 263   KSPEQRATATQLLQHPFV  280
         *****************7
Domain Sequence
(FASTA)
FDVLEKLGEG SYGSVYKAIH KETGQIVAIK QVPVESDLQE IIKEISIMQQ CDSPHVVKYY 60
GSYFKNTDLW IVMEYCGAGS VSDIIRLRNK TLTEDEIATI LQSTLKGLEY LHFMRKIHRD 120
IKAGNILLNT EGHAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIQEI GYNCVADIWS 180
LGITAIEMAE GKPPYADIHP MRALWLTPVI PALWEAEVDG SPEVRNFVKQ CLVKSPEQRA 240
TATQLLQHPF V 251
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00294
EKS-ANC-00306
EKS-BOT-00313
EKS-CAJ-00321
EKS-CAF-00316
EKS-CAP-00348
EKS-EQC-00306
EKS-FEC-00300
EKS-GAG-00267
EKS-GAA-00393
EKS-GOG-00309
EKS-HOS-00321
EKS-ICT-00294
EKS-LAC-00325
EKS-LOA-00325
EKS-MEG-00256
EKS-MOD-00310
EKS-MUM-00346
EKS-MUP-00308
EKS-MYL-00313
EKS-NOL-00288
EKS-ORN-00415
EKS-ORC-00297
EKS-ORL-00377
EKS-OTG-00323
EKS-PAT-00297
EKS-PES-00280
EKS-POA-00303
EKS-RAN-00329
EKS-SAH-00293
EKS-SOA-00034
EKS-TAG-00330
EKS-TUT-00072
EKS-XET-00388
EKS-XIM-00408
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0043539; F:protein serine/threonine kinase activator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0060706; P:cell differentiation involved in embryonic placenta development
GO:0000902; P:cell morphogenesis
GO:0007417; P:central nervous system development
GO:0003157; P:endocardium development
GO:0035329; P:hippo signaling cascade
GO:0006917; P:induction of apoptosis
GO:0007243; P:intracellular protein kinase cascade
GO:0030216; P:keratinocyte differentiation
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0046621; P:negative regulation of organ growth
GO:0001841; P:neural tube formation
GO:0001569; P:patterning of blood vessels
GO:0018105; P:peptidyl-serine phosphorylation
GO:0060215; P:primitive hemopoiesis
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011524; SARAH.
IPR024205; SARAH_domain.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF11629; Mst1_SARAH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50951; SARAH; 1.
Prints
Created Date20-Feb-2013