EKS-MAM-00241

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00241

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	387.1	5.4E-116	53	304	252

Status

Unreviewed

Ensembl Protein

ENSMMUP00000018564

UniProt Accession

F6TAM5;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000014131	ENSMMUP00000037408	ENSMMUT00000044393
ENSMMUG00000014131	ENSMMUP00000037410	ENSMMUT00000044395
ENSMMUG00000014131	ENSMMUP00000018564	ENSMMUT00000019830
ENSMMUG00000014131	ENSMMUP00000037412	ENSMMUT00000044397

Organism

Macaca mulatta

Functional Description

Protein Length

724

Protein Sequence
(FASTA)

MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI GNYRLLKTIG 60

KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE VRIMKVLNHP NIVKLFEVIE 120

TEKTLYLVME YASGGEVFDY LVAHGRMKEK EARAKFRQIV SAVQYCHQKF IVHRDLKAEN 180

LLLDADMNIK IADFGFSNEF TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL 240

YTLVSGSLPF DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK 300

DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR YNEVMATYLL 360

LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS ANPKQRRFSD QAGPAIPTSN 420

SYSKKTQSNN AENKRPEEDR ESGRKASSTA KVPASPLPGL ERKKTTPTPS TNSVLSTSTN 480

RSRNSPLLER ASLGQASIQN GKDSTAPQRV PVASPSAHNI SSSGGAPDRT NFPRGVSSRS 540

TFHAGQLRQV RDQQNLPYGV TPASPSGHSQ GRRGASGSIF SKFTSKFVRR NLNEPESKDR 600

VETLRPHVEG SGVNDKEKEE FREAKPRSLR FTWSMKTTSS MEPNEMMREI RKVLDANSCQ 660

SELHEKYMLL CMHGTPGHED FVQWEMEVCK LPRLSLNGVR FKRISGTSMA FKNIASKIAN 720

ELKL 724

Nucleotide Sequence
(FASTA)

ATGTCCAGCG CTCGGACCCC CCTACCCACG CTGAACGAGA GGGACACGGA GCAGCCCACC 60

TTGGGACACC TTGACTCCAA GCCCAGCAGT AAGTCCAACA TGATTCGGGG CCGCAACTCA 120

GCCACCTCTG CTGATGAGCA GCCCCACATT GGAAACTACC GGCTCCTCAA GACCATTGGC 180

AAGGGTAACT TTGCCAAGGT GAAGTTGGCC CGACACATCC TGACTGGGAA AGAGGTAGCT 240

GTGAAGATCA TTGACAAGAC TCAACTGAAC TCCTCCAGCC TCCAGAAGCT GTTCCGCGAA 300

GTAAGAATAA TGAAGGTTTT GAATCATCCC AACATAGTTA AATTATTTGA AGTGATTGAG 360

ACTGAGAAAA CGCTCTACCT TGTCATGGAG TACGCTAGTG GCGGAGAGGT ATTTGATTAC 420

CTAGTGGCTC ATGGCAGGAT GAAAGAGAAA GAGGCTCGAG CCAAATTCCG CCAGATAGTG 480

TCTGCTGTAC AGTACTGTCA CCAGAAGTTT ATTGTCCATA GAGACTTAAA GGCAGAAAAC 540

CTGCTCTTGG ACGCTGATAT GAACATCAAG ATTGCAGACT TTGGCTTCAG CAATGAATTC 600

ACCTTTGGGA ACAAGCTGGA CACCTTCTGT GGCAGTCCCC CTTACGCTGC CCCAGAACTC 660

TTCCAGGGCA AAAAATATGA TGGACCCGAG GTGGATGTGT GGAGCCTAGG AGTTATCCTC 720

TATACACTGG TCAGCGGATC CCTGCCTTTT GATGGACAGA ATCTCAAGGA GCTGCGGGAA 780

CGGGTACTGA GGGGAAAATA CCGTATTCCG TTCTACATGT CCACGGACTG TGAAAACTTG 840

CTTAAGAAAT TTCTCATTCT TAATCCCAGC AAGAGAGGCA CTTTAGAGCA AATCATGAAA 900

GATCGATGGA TGAATGTGGG TCACGAAGAT GATGAACTAA AGCCTTATGT GGAGCCACTC 960

CCTGACTACA AGGACCCCCG GCGGACAGAG CTGATGGTGT CCATGGGTTA CACACGGGAA 1020

GAGATCCAGG ACTCGCTGGT GGGCCAGAGA TACAACGAGG TGATGGCCAC CTATCTGCTC 1080

CTGGGCTACA AGAGCTCCGA GCTGGAAGGT GACACCATCA CCCTGAAGCC CCGGCCTTCA 1140

GCTGATCTGA CCAATAGCAG CGCCCCATCC CCATCCCACA AGGTACAGCG CAGCGTGTCG 1200

GCCAATCCCA AGCAGCGGCG CTTCAGCGAC CAGGCTGGTC CTGCCATTCC CACCTCTAAT 1260

TCTTACTCTA AGAAGACTCA GAGTAACAAT GCAGAAAATA AGCGGCCCGA GGAGGACCGG 1320

GAGTCGGGGC GGAAAGCCAG CAGCACAGCC AAGGTGCCTG CCAGCCCCCT GCCCGGCCTG 1380

GAGAGGAAGA AGACCACCCC AACCCCTTCC ACGAACAGCG TCCTCTCCAC CAGCACAAAT 1440

CGAAGCAGGA ATTCCCCACT TTTGGAGCGG GCCAGCCTCG GCCAGGCCTC CATCCAGAAT 1500

GGCAAAGACA GCACAGCCCC CCAACGTGTC CCTGTCGCCT CCCCATCCGC CCACAACATC 1560

AGCAGCAGTG GTGGAGCCCC AGACCGAACT AATTTCCCCC GGGGTGTGTC CAGCCGAAGC 1620

ACCTTCCATG CTGGGCAGCT CCGACAGGTG CGGGACCAGC AGAATTTGCC CTATGGTGTG 1680

ACCCCAGCCT CTCCCTCTGG CCACAGCCAG GGCCGGCGGG GGGCCTCTGG GAGCATCTTC 1740

AGCAAGTTCA CCTCCAAGTT TGTACGCAGG AACCTGAATG AACCTGAAAG CAAAGACCGA 1800

GTGGAGACGC TCAGACCTCA CGTGGAGGGC AGTGGCGTCA ACGACAAAGA AAAGGAAGAA 1860

TTTCGGGAGG CCAAACCCCG CTCCCTCCGC TTCACGTGGA GTATGAAGAC CACGAGCTCC 1920

ATGGAGCCCA ACGAGATGAT GCGGGAGATC CGCAAGGTGC TGGACGCGAA CAGCTGCCAG 1980

AGCGAGCTGC ATGAGAAATA CATGCTGCTG TGCATGCACG GCACGCCGGG CCACGAGGAC 2040

TTCGTGCAGT GGGAGATGGA GGTGTGCAAA CTGCCGCGGC TCTCTCTCAA TGGGGTTCGA 2100

TTTAAGCGGA TATCGGGCAC CTCCATGGCC TTCAAAAACA TTGCCTCCAA AATAGCCAAC 2160

GAGCTGAAGC TTTAA 2175

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 53    YRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNI  112

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 113   VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIV  172

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 173   HRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  232

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 233   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  292

         ************************************************************

S: 241   atieeilkhewl  252

          t+e+i+k++w+

Q: 293   GTLEQIMKDRWM  304

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH ILTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKVLNHPNI 60

VKLFEVIETE KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKFIV 120

HRDLKAENLL LDADMNIKIA DFGFSNEFTF GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GTLEQIMKDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0045180	; C:basal cortex
GO:0016020	; C:membrane
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0030010	; P:establishment of cell polarity
GO:0045197	; P:establishment or maintenance of epithelial cell apical/basal polarity
GO:0007243	; P:intracellular protein kinase cascade
GO:0010976	; P:positive regulation of neuron projection development
GO:0050770	; P:regulation of axonogenesis
GO:0006979	; P:response to oxidative stress

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013