EKS-MAM-00368
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00368
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src442.66.8E-133226476251
StatusUnreviewed
Ensembl ProteinENSMMUP00000018594
UniProt AccessionG7MZD6;
Protein Name
Protein Synonyms/Alias Putative uncharacterized protein;
Gene NameLYN
Gene Synonyms/Alias EGK_18962;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000014149ENSMMUP00000018594ENSMMUT00000019862
OrganismMacaca mulatta
Functional Description
Protein Length491
Protein Sequence
(FASTA)
MGCIKSKGKD SLNDDGVDLK TQPVPESQLL PGQRFQAKDP EEQGDIVVAL YPYDGIHPDD 60
LSFKKGEKMK VLEEHGEWWK AKSLLTKKEG FIPSNYVAKL NTLETEEWFF KDITRKDAER 120
QLLAPGNSAG AFLIRESETL KGSFSLSVRD FDPVHGDVIK HYKIRSLDNG GYYISPRITF 180
PCISDMIKHY QKQPDGLCRR LEKACISPKP QKPWDKDAWE IPRESIKLVK RLGAGQFGEV 240
WMGYYNNSTK VAVKTLKPGT MSVQAFLEEA NLMKTLQHDK LVRLYAVVTR EEPIYIITEY 300
MAKGSLLDFL KSDEGGKVLL PKLIDFSAQI AEGMAYIERK NYIHRDLRAA NVLVSESLMC 360
KIADFGLARV IEDNEYTARE GAKFPIKWTA PEAINFGCFT IKSDVWSFGI LLYEIVTYGK 420
IPYPGRTNAD VMTALSQGYR MPRVENCPDE LYDIMKMCWK EKAEERPTFD YLQSVLDDFY 480
TATEGQYQQQ P 491
Nucleotide Sequence
(FASTA)
ATGGGATGTA TAAAATCAAA AGGGAAAGAC AGCTTGAATG ACGATGGAGT AGATTTGAAG 60
ACTCAACCAG TTCCAGAATC TCAGCTTTTA CCTGGACAGA GGTTTCAAGC TAAAGATCCA 120
GAGGAACAAG GAGACATTGT GGTAGCCTTG TACCCGTATG ATGGCATCCA CCCGGACGAC 180
TTGTCTTTCA AGAAAGGAGA GAAGATGAAA GTCCTGGAGG AGCATGGAGA ATGGTGGAAA 240
GCAAAGTCCC TTTTAACAAA AAAAGAAGGC TTCATCCCCA GCAACTATGT GGCCAAACTC 300
AACACCTTAG AAACAGAAGA GTGGTTTTTC AAGGATATAA CCAGGAAGGA CGCAGAAAGG 360
CAGCTTTTGG CACCAGGAAA TAGTGCTGGA GCTTTCCTTA TTAGAGAAAG TGAAACGTTA 420
AAAGGAAGCT TCTCTCTGTC TGTCAGAGAC TTTGACCCTG TGCATGGGGA TGTTATTAAG 480
CACTACAAAA TTAGAAGTCT GGATAATGGG GGCTATTACA TCTCTCCACG AATCACTTTT 540
CCCTGTATCA GCGACATGAT TAAACATTAC CAAAAGCAGC CAGATGGCTT GTGCAGAAGA 600
TTGGAGAAGG CTTGTATTAG TCCCAAGCCA CAGAAGCCAT GGGATAAAGA TGCCTGGGAG 660
ATCCCCCGGG AGTCCATCAA GTTGGTGAAA AGGCTCGGCG CTGGGCAGTT TGGGGAAGTC 720
TGGATGGGTT ACTATAACAA CAGTACCAAG GTGGCTGTGA AAACCCTGAA GCCGGGCACT 780
ATGTCTGTGC AAGCCTTCCT GGAAGAAGCC AACCTCATGA AGACTCTGCA GCATGATAAG 840
CTCGTGAGGC TGTACGCTGT GGTCACCAGG GAGGAGCCCA TTTACATTAT CACCGAGTAC 900
ATGGCCAAGG GCAGTTTGCT GGATTTCCTG AAGAGCGATG AAGGTGGCAA AGTGCTGCTT 960
CCAAAGCTCA TTGACTTTTC TGCTCAGATT GCAGAGGGAA TGGCGTACAT CGAGCGGAAG 1020
AACTACATTC ACCGGGACCT GCGAGCAGCT AATGTCCTGG TCTCTGAGTC ACTCATGTGC 1080
AAAATTGCAG ATTTTGGCCT TGCTAGAGTA ATTGAAGATA ATGAGTACAC AGCAAGGGAA 1140
GGTGCTAAGT TCCCTATTAA GTGGACGGCT CCAGAAGCAA TCAACTTTGG ATGTTTCACT 1200
ATTAAGTCTG ATGTGTGGTC CTTTGGAATC CTCCTATACG AAATCGTCAC CTATGGGAAA 1260
ATTCCCTACC CAGGGAGAAC TAATGCCGAC GTGATGACCG CCCTGTCCCA GGGCTACAGG 1320
ATGCCCCGTG TGGAGAACTG CCCAGATGAG CTCTATGACA TTATGAAAAT GTGCTGGAAA 1380
GAAAAGGCAG AAGAGAGACC AACATTTGAT TACTTACAGA GCGTCCTGGA TGATTTCTAC 1440
ACAGCCACGG AAGGGCAGTA CCAGCAGCAG CCTTAG 1476
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         +klvk+lG+GqfGevw+g++++s+kvavktlk+gt+s +afleea+++k+l+h+klv+ly
Q: 226   IKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLY  285
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+makGslldflk++eg k+ lpkl+d++aq+aeGmay+e+kn+ihr
Q: 286   AVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHR  345
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+nvlv+esl++k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv
Q: 346   DLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDV  405
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGill+eivt+Gk+PypG tn++v++++++gyr+pr e+cp+ely+++++cwk+++ee
Q: 406   WSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEE  465
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtf++lq+vl
Q: 466   RPTFDYLQSVL  476
         ********986
Domain Sequence
(FASTA)
IKLVKRLGAG QFGEVWMGYY NNSTKVAVKT LKPGTMSVQA FLEEANLMKT LQHDKLVRLY 60
AVVTREEPIY IITEYMAKGS LLDFLKSDEG GKVLLPKLID FSAQIAEGMA YIERKNYIHR 120
DLRAANVLVS ESLMCKIADF GLARVIEDNE YTAREGAKFP IKWTAPEAIN FGCFTIKSDV 180
WSFGILLYEI VTYGKIPYPG RTNADVMTAL SQGYRMPRVE NCPDELYDIM KMCWKEKAEE 240
RPTFDYLQSV L 251
KeywordATP-binding; Kinase; Nucleotide-binding; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00342
EKS-ANC-00358
EKS-BOT-00368
EKS-CAJ-00372
EKS-CAF-00369
EKS-CAP-00401
EKS-DAR-00748
EKS-EQC-00359
EKS-GAM-00222
EKS-GAG-00312
EKS-GAA-00452
EKS-GOG-00359
EKS-HOS-00374
EKS-ICT-00348
EKS-LAC-00384
EKS-LOA-00377
EKS-MOD-00359
EKS-MUM-00400
EKS-MUP-00362
EKS-MYL-00366
EKS-NOL-00336
EKS-ORN-00477
EKS-ORA-00322
EKS-ORC-00346
EKS-ORL-00439
EKS-OTG-00372
EKS-PAT-00348
EKS-PES-00327
EKS-POA-00358
EKS-RAN-00382
EKS-SAH-00338
EKS-SUS-00327
EKS-TAG-00441
EKS-TAS-00040
EKS-TEN-00466
EKS-XET-00488
EKS-XIM-00465
Gene Ontology
GO:0005794; C:Golgi apparatus
GO:0048471; C:perinuclear region of cytoplasm
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0001782; P:B cell homeostasis
GO:0050853; P:B cell receptor signaling pathway
GO:0071300; P:cellular response to retinoic acid
GO:0097028; P:dendritic cell differentiation
GO:0030218; P:erythrocyte differentiation
GO:0002774; P:Fc receptor mediated inhibitory signaling pathway
GO:0002431; P:Fc receptor mediated stimulatory signaling pathway
GO:0035556; P:intracellular signal transduction
GO:0031663; P:lipopolysaccharide-mediated signaling pathway
GO:0030889; P:negative regulation of B cell proliferation
GO:0070373; P:negative regulation of ERK1 and ERK2 cascade
GO:0043407; P:negative regulation of MAP kinase activity
GO:0070667; P:negative regulation of mast cell proliferation
GO:0002762; P:negative regulation of myeloid leukocyte differentiation
GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway
GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway
GO:0031175; P:neuron projection development
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0002576; P:platelet degranulation
GO:0030335; P:positive regulation of cell migration
GO:2000670; P:positive regulation of dendritic cell apoptotic process
GO:0070668; P:positive regulation of mast cell proliferation
GO:0010976; P:positive regulation of neuron projection development
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade
GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein
GO:0002902; P:regulation of B cell apoptotic process
GO:0050855; P:regulation of B cell receptor signaling pathway
GO:0033628; P:regulation of cell adhesion mediated by integrin
GO:0050707; P:regulation of cytokine secretion
GO:0045646; P:regulation of erythrocyte differentiation
GO:0050727; P:regulation of inflammatory response
GO:0043304; P:regulation of mast cell degranulation
GO:0090025; P:regulation of monocyte chemotaxis
GO:0090330; P:regulation of platelet aggregation
GO:0006974; P:response to DNA damage stimulus
GO:0009725; P:response to hormone stimulus
GO:0002513; P:tolerance induction to self antigen
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
mcc:698553;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013