EKS-MAM-00011

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00011

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Eph	403.3	5.6E-121	364	622	259

Status

Unreviewed

Ensembl Protein

ENSMMUP00000018841

UniProt Accession

F7CTI9;

Protein Name

Protein Synonyms/Alias

Gene Name

EPHA10

Gene Synonyms/Alias

EPHA10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000014342	ENSMMUP00000018836	ENSMMUT00000020124
ENSMMUG00000014342	ENSMMUP00000018841	ENSMMUT00000020129

Organism

Macaca mulatta

Functional Description

Protein Length

730

Protein Sequence
(FASTA)

ACPPGFYKVS PRRPLCSPCP EHSRALENAS TFCTPHPSHC RSSIPPPPPS CIPPRPPSAP 60

RDLQYSLSRS PLALRLRWLP PADSGGRSDV TYSLLCLRCG REGPAGACEP CGPRVAFVPR 120

QAGLREQAAT LLHLRPGARY TVRVAALNGV SGPAPAAGAT YAQVTVSTGP GAPWEEDEIR 180

RERVEPQSVS LSWREPIPAG APGANGTEYE IRYYEKGQSE QTYSMVKTGA PTVTVTNLKP 240

ATRYVFQIRA ASPGPSWEAQ SFNPSIEVQT PGEAASGSRD QSPAVVVTVV TISALLVLGS 300

VMSVLAIWRR PCSYGKGGGD AHDEEELYFH FKVPTRRTFL DPQSCGDPLQ AVHLFAKELD 360

AKSVTLERRL GAGKLGRFGE LCCGCLQLPG RQELPVAVHT LRDSASDSQR LGFLAEALTL 420

GQFDHSHIVR LEGVVTRGST LMIVTEYMSH GALDGFLRRH EGQLVAGQLM GLLPGLASAM 480

KYLSEMGYVH RGLAARRVLV SSDLVCKISG FGRGPRDRAE AVYTTMSGRS PALWAAPETL 540

QFGHFSSASD VWSFGIVMWE VMAFGERPYW DMSGQDVIKA VEDGFRLPPP RNCPTPLHRL 600

MLDCWQKDPG ERPRFSQIHS ILSKMVQDPE PPNCAPTTCP RPPTPLADRA FSTFPSFGSV 660

GAWLEALDLC RYKDSFAAAG YGSLEAVAEM TAQDLVSLGI SSAEHREALL SGISALQARV 720

LQLQGQGVQV 730

Nucleotide Sequence
(FASTA)

GCCTGTCCCC CAGGGTTTTA CAAGGTGTCC CCGCGGCGGC CCCTCTGCTC ACCGTGCCCA 60

GAGCACAGCC GGGCCCTGGA AAACGCCTCC ACCTTCTGCA CCCCTCACCC CTCCCATTGC 120

CGCTCATCCA TCCCTCCCCC GCCCCCCTCG TGCATTCCGC CCCGGCCGCC GTCGGCGCCG 180

CGGGACCTGC AGTACAGCCT GAGCCGCTCG CCGCTGGCGC TGCGACTGCG CTGGCTGCCG 240

CCGGCCGACT CGGGAGGCCG CTCGGACGTC ACCTACTCGC TGCTGTGCCT GCGCTGCGGC 300

CGCGAGGGCC CGGCGGGCGC GTGCGAGCCG TGCGGGCCGC GCGTGGCCTT CGTACCGCGC 360

CAGGCCGGGC TGCGGGAGCA AGCCGCCACG CTGCTGCACC TGCGGCCCGG AGCGCGCTAC 420

ACTGTGCGCG TGGCCGCACT CAACGGCGTC TCGGGCCCGG CGCCCGCCGC GGGAGCCACC 480

TACGCGCAGG TCACCGTCTC CACCGGGCCC GGGGCGCCCT GGGAGGAGGA TGAGATCCGC 540

AGGGAACGAG TGGAACCCCA GAGCGTGTCC CTGTCGTGGC GGGAGCCCAT CCCTGCCGGA 600

GCCCCTGGGG CCAATGGCAC GGAGTACGAG ATCCGATACT ACGAGAAGGG TCAGAGTGAG 660

CAGACTTACT CCATGGTGAA GACAGGGGCG CCCACAGTCA CTGTCACCAA CCTGAAGCCA 720

GCTACCCGCT ACGTCTTTCA GATCCGGGCT GCTTCCCCGG GGCCATCCTG GGAGGCCCAG 780

AGCTTTAACC CCAGCATTGA AGTGCAGACC CCGGGGGAGG CTGCCTCAGG GTCCAGGGAC 840

CAGAGCCCCG CTGTTGTCGT CACCGTAGTG ACCATCTCAG CCCTCCTCGT CCTGGGCTCC 900

GTGATGAGTG TGCTGGCCAT TTGGAGGAGG CCCTGCAGCT ATGGTAAAGG AGGAGGGGAC 960

GCCCATGATG AAGAGGAGCT GTATTTCCAC TTCAAAGTCC CAACACGTCG CACATTCCTG 1020

GACCCCCAGA GCTGTGGGGA CCCACTGCAG GCTGTGCATC TGTTTGCCAA GGAACTGGAT 1080

GCGAAAAGCG TCACGCTGGA GAGGAGGCTT GGAGCAGGCA AGCTGGGGCG GTTTGGGGAG 1140

CTGTGCTGTG GCTGCCTGCA GCTCCCCGGT CGCCAGGAGC TGCCCGTAGC CGTGCACACG 1200

CTGAGGGACA GCGCCTCCGA CTCACAGAGG CTTGGCTTCC TGGCGGAGGC CCTCACTCTG 1260

GGCCAGTTTG ACCATAGCCA CATCGTGCGG CTGGAGGGTG TTGTCACCCG AGGAAGCACC 1320

TTGATGATTG TCACCGAGTA CATGAGCCAT GGGGCCCTGG ACGGCTTCCT CAGGCGGCAC 1380

GAGGGGCAGC TGGTGGCTGG GCAACTGATG GGGTTGCTGC CTGGGCTGGC ATCAGCCATG 1440

AAGTATCTGT CAGAGATGGG CTACGTTCAC CGGGGCCTGG CAGCTCGCCG TGTGCTGGTC 1500

AGCAGCGACC TTGTCTGCAA GATCTCTGGC TTCGGGCGGG GCCCCCGGGA CCGAGCAGAG 1560

GCTGTCTACA CCACTATGAG TGGCCGGAGC CCGGCGCTGT GGGCCGCCCC TGAGACGCTT 1620

CAGTTTGGCC ACTTCAGCTC CGCCAGTGAT GTATGGAGCT TTGGCATCGT CATGTGGGAG 1680

GTGATGGCCT TTGGGGAGCG GCCTTACTGG GACATGTCTG GCCAAGACGT GATCAAGGCT 1740

GTGGAGGATG GCTTCCGGCT GCCACCTCCC AGGAACTGTC CTACCCCACT GCACCGACTA 1800

ATGCTCGACT GCTGGCAGAA GGACCCAGGT GAGCGGCCCA GGTTCTCCCA GATCCACAGC 1860

ATCCTGAGCA AGATGGTGCA GGACCCAGAG CCCCCCAACT GTGCCCCGAC TACCTGTCCC 1920

AGGCCTCCCA CCCCACTAGC GGACCGTGCC TTCTCCACCT TCCCCTCCTT TGGCTCTGTG 1980

GGCGCGTGGC TGGAGGCCCT GGACCTGTGC CGCTACAAGG ACAGCTTCGC AGCTGCTGGC 2040

TACGGGAGCC TGGAGGCCGT GGCCGAGATG ACCGCCCAGG ACCTGGTGAG CCTAGGCATC 2100

TCTTCAGCTG AACATCGAGA GGCCCTCCTC AGCGGGATCA GCGCCCTGCA GGCACGAGTG 2160

CTCCAGCTGC AGGGCCAGGG GGTGCAGGTG TGA 2193

Domain Profile

S: 1     vkiekviGaG...efGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqf  57

         v++e+ +GaG   +fGe+c+G+l+lpg++e++va++tl+++++++qr  fl+ea +lGqf

Q: 364   VTLERRLGAGklgRFGELCCGCLQLPGRQELPVAVHTLRDSASDSQRLGFLAEALTLGQF  423

         567888888633379*********************************************

S: 58    dhpniirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkyl  117

         dh++i+rleGvvt+++++mivteym++gald flr+++gq+++ ql+g+l G+as+mkyl

Q: 424   DHSHIVRLEGVVTRGSTLMIVTEYMSHGALDGFLRRHEGQLVAGQLMGLLPGLASAMKYL  483

         ************************************************************

S: 118   sdmgyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaia  177

         s+mgyvhr laar++lv+s+lvck+s fG+++   d +ea+ytt++g++p  w+ape+++

Q: 484   SEMGYVHRGLAARRVLVSSDLVCKISGFGRGPR--DRAEAVYTTMSGRSPALWAAPETLQ  541

         *******************************99..888**********************

S: 178   yrkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlm  237

         +++f+sasdvws+Giv+wev+++Gerpywdms qdvika+e+g+rlppp++cp+ l++lm

Q: 542   FGHFSSASDVWSFGIVMWEVMAFGERPYWDMSGQDVIKAVEDGFRLPPPRNCPTPLHRLM  601

         ************************************************************

S: 238   ldcwqkdraerpkfeqivsil  258

         ldcwqkd  erp+f+qi+sil

Q: 602   LDCWQKDPGERPRFSQIHSIL  622

         ******************985

Domain Sequence
(FASTA)

VTLERRLGAG KLGRFGELCC GCLQLPGRQE LPVAVHTLRD SASDSQRLGF LAEALTLGQF 60

DHSHIVRLEG VVTRGSTLMI VTEYMSHGAL DGFLRRHEGQ LVAGQLMGLL PGLASAMKYL 120

SEMGYVHRGL AARRVLVSSD LVCKISGFGR GPRDRAEAVY TTMSGRSPAL WAAPETLQFG 180

HFSSASDVWS FGIVMWEVMA FGERPYWDMS GQDVIKAVED GFRLPPPRNC PTPLHRLMLD 240

CWQKDPGERP RFSQIHSIL 259

Keyword

ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005005	; F:transmembrane-ephrin receptor activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00060	; FN3; 2.
SM00454	; SAM; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013