EKS-MAM-00370
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00370
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src430.82.6E-129263512250
StatusUnreviewed
Ensembl ProteinENSMMUP00000018960
UniProt AccessionF7BHF8;
Protein Name
Protein Synonyms/Alias Tyrosine-protein kinase Fgr;
Gene NameFGR
Gene Synonyms/Alias FGR; EGK_00444;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000014434ENSMMUP00000018960ENSMMUT00000020255
OrganismMacaca mulatta
Functional Description
Protein Length529
Protein Sequence
(FASTA)
MGCVYCKKLE PAATAKEDAG LEGDFRSYGA ADHYGPDPTK AQPASSFVHI PNYSNFSSQA 60
INPGFLDGGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK GEKFHILNNT EGDWWEARSL 120
SSGQTGYIPS NYVAPVDSIQ AEEWYFGKIG RKDAERQLLS PGNPQGAFLI RESETTKGAY 180
SLSIRDWDQT RGDHVKHYKI RKLDMGGYYI TTRVQFNSVQ ELVQHYMEVN DGLCNLLTAP 240
CTIMKPQTLG LAKDAWEISR SSITLERRLG TGCFGDVWLG TWNGSTKVAV KTLKPGTMSP 300
KAFLAEAQVM KLLRHDKLVQ LYAVVSEEPI YIVTEFMCHG SLLDFLKNPE GQDLRLPQLV 360
DMAAQVAEGM AYMERMNYIH RDLRAANILV GERLVCKIAD FGLARLIKDD EYNPCQGSKF 420
PIRWTAPEAA LFGRFTIKSD VWSFGILLTE LITKGRIPYP GMSKREVLEQ VEQGYHMPCP 480
PGCPASLYEA MEQTWRLDPE ERPTFEYLQS FLEDYFTSTE PQYQPGDQT 529
Nucleotide Sequence
(FASTA)
ATGGGCTGTG TGTACTGCAA GAAATTGGAG CCGGCGGCCA CGGCCAAAGA GGATGCCGGC 60
CTGGAAGGGG ACTTCAGGAG CTACGGGGCA GCAGACCACT ATGGGCCTGA CCCCACTAAG 120
GCCCAGCCTG CATCATCATT TGTCCACATC CCCAACTACA GCAACTTCTC CTCTCAGGCC 180
ATCAACCCTG GCTTCCTTGA TGGTGGCACC ATCAGGGGTG TGTCAGGGAT TGGAGTGACC 240
CTGTTCATCG CCCTGTATGA CTATGAGGCT CGAACTGAGG ATGACCTCAC CTTCACCAAG 300
GGCGAGAAGT TCCACATCCT GAACAATACT GAAGGTGACT GGTGGGAGGC TCGGTCTCTC 360
AGCTCCGGAC AAACTGGCTA CATTCCCAGC AACTATGTGG CCCCTGTTGA CTCCATCCAG 420
GCTGAAGAGT GGTACTTTGG AAAGATTGGG AGAAAGGATG CAGAGAGGCA GCTGCTCTCA 480
CCAGGCAACC CCCAGGGGGC CTTTCTCATT CGGGAAAGCG AGACCACCAA AGGTGCCTAC 540
TCCCTGTCCA TCCGGGACTG GGATCAGACC AGAGGCGATC ATGTGAAGCA TTACAAGATT 600
CGCAAGCTGG ACATGGGTGG CTACTACATC ACCACGCGGG TTCAGTTCAA CTCGGTGCAG 660
GAGCTGGTGC AGCACTACAT GGAGGTGAAT GACGGGCTGT GCAACCTGCT CACCGCGCCC 720
TGCACCATCA TGAAGCCGCA GACGCTGGGC CTGGCCAAGG ACGCCTGGGA GATCAGCCGC 780
AGCTCCATCA CGCTGGAGCG CCGGCTGGGC ACCGGCTGCT TTGGGGATGT GTGGCTGGGC 840
ACGTGGAACG GCAGCACTAA GGTGGCGGTG AAGACGCTGA AGCCAGGCAC CATGTCCCCG 900
AAGGCCTTCC TGGCGGAGGC GCAGGTCATG AAGCTGCTGC GGCACGACAA GCTGGTGCAG 960
CTGTACGCCG TCGTGTCGGA GGAGCCCATA TACATCGTGA CCGAGTTCAT GTGTCACGGC 1020
AGCTTGCTGG ATTTCCTCAA GAACCCGGAG GGCCAGGATT TGAGGCTGCC CCAGTTGGTG 1080
GACATGGCAG CCCAGGTAGC TGAGGGCATG GCCTACATGG AACGCATGAA CTACATTCAC 1140
CGCGACCTGA GGGCAGCCAA CATCCTGGTC GGGGAGCGGC TGGTGTGCAA GATCGCAGAC 1200
TTCGGCTTGG CCCGTCTCAT CAAGGACGAT GAGTACAACC CCTGCCAAGG GTCCAAGTTC 1260
CCCATCAGGT GGACAGCCCC AGAAGCTGCC CTCTTTGGCA GATTCACCAT CAAGTCAGAT 1320
GTGTGGTCCT TTGGGATCCT GCTCACTGAA CTCATCACCA AGGGCCGAAT CCCCTACCCA 1380
GGCATGAGTA AACGGGAAGT GTTGGAACAG GTGGAGCAGG GCTACCACAT GCCATGCCCT 1440
CCAGGCTGCC CAGCGTCCCT GTATGAGGCC ATGGAACAGA CCTGGCGTCT GGACCCGGAG 1500
GAGAGGCCCA CCTTCGAGTA CCTGCAGTCT TTCCTGGAGG ACTACTTCAC CTCCACCGAA 1560
CCACAGTACC AGCCCGGGGA TCAGACATAG 1590
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         ++l+++lG+G+fG+vwlg+w+gs+kvavktlk+gt+sp+afl+eaq++k lrh+klv+ly
Q: 263   ITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLAEAQVMKLLRHDKLVQLY  322
         5799********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avvse ePiyivte+m +Gslldflk+ eg+ l+lp+lvd+aaqvaeGmay+e++n+ihr
Q: 323   AVVSE-EPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHR  381
         ****9.******************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lvge+lv+k+adfGlarli+ddey++ +g+k+Pi+WtaPea+ +g+ftiksdv
Q: 382   DLRAANILVGERLVCKIADFGLARLIKDDEYNPCQGSKFPIRWTAPEAALFGRFTIKSDV  441
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillte++tkG++PypGm+++evleqve+gy++p+p  cp++lye+++++w+ dpee
Q: 442   WSFGILLTELITKGRIPYPGMSKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEE  501
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe+lq++l
Q: 502   RPTFEYLQSFL  512
         ********986
Domain Sequence
(FASTA)
ITLERRLGTG CFGDVWLGTW NGSTKVAVKT LKPGTMSPKA FLAEAQVMKL LRHDKLVQLY 60
AVVSEEPIYI VTEFMCHGSL LDFLKNPEGQ DLRLPQLVDM AAQVAEGMAY MERMNYIHRD 120
LRAANILVGE RLVCKIADFG LARLIKDDEY NPCQGSKFPI RWTAPEAALF GRFTIKSDVW 180
SFGILLTELI TKGRIPYPGM SKREVLEQVE QGYHMPCPPG CPASLYEAME QTWRLDPEER 240
PTFEYLQSFL 250
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>
EKS-AIM-00344
EKS-BOT-00371
EKS-CAJ-00374
EKS-CAF-00373
EKS-CAP-00403
EKS-EQC-00362
EKS-FEC-00357
EKS-GOG-00361
EKS-HOS-00377
EKS-ICT-00349
EKS-LOA-00379
EKS-MUM-00402
EKS-MUP-00364
EKS-NOL-00341
EKS-ORA-00323
EKS-ORC-00348
EKS-OTG-00373
EKS-PAT-00350
EKS-POA-00360
EKS-RAN-00385
EKS-SAH-00341
Gene Ontology
GO:0015629; C:actin cytoskeleton
GO:0032587; C:ruffle membrane
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0050830; P:defense response to Gram-positive bacterium
GO:0007229; P:integrin-mediated signaling pathway
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0030335; P:positive regulation of cell migration
GO:0050715; P:positive regulation of cytokine secretion
GO:0043306; P:positive regulation of mast cell degranulation
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0045088; P:regulation of innate immune response
GO:0050764; P:regulation of phagocytosis
GO:0045859; P:regulation of protein kinase activity
KEGG
mcc:716296;
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013