EKS-MAM-00003
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-MAM-00003
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph517.67.4E-156676933258
StatusUnreviewed
Ensembl ProteinENSMMUP00000018999
UniProt AccessionF7GJT5;
Protein Name
Protein Synonyms/Alias
Gene NameEPHA5
Gene Synonyms/Alias EPHA5;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSMMUG00000014468ENSMMUP00000018999ENSMMUT00000020298
ENSMMUG00000014468ENSMMUP00000019000ENSMMUT00000020299
OrganismMacaca mulatta
Functional Description
Protein Length1004
Protein Sequence
(FASTA)
MRGSGPRGAG RRRPPGGGGD TPITPASLAG CYSAPRRAPL WTCLLLCAAL RTLLASPSNE 60
VNLLDSRTVM GDLGWIAFPK NGWEEIGEVD ENYAPIHTYQ VCKVMEQNQN NWLLTSWISN 120
EGASRIFIEL KFTLRDCNSL PGGLGTCKET FNMYYFESDD QNGRNIKENQ YIKIDTIAAD 180
ESFTELDLGD RVMKLNTEVR DVGPLSKKGF YLAFQDVGAC IALVSVRVYY KKCPSVVRHL 240
AVFPDTITGA DSSQLLEVSG SCVNHSVTDE PPKMHCSAEG EWLVPIGKCM CKAGYEEKNG 300
TCQVCRPGFF KASPHIQSCG KCPPHSYTHE EASTSCVCEK DYFRRESDPP TMACTRPPSA 360
PRNAISNINE TSVFLEWIPP ADTGGRKDVS YYIACKKCNS HAGVCEECGG HVRYLPRQSG 420
LKNTSVMMVD LLAHTNYTFE IEAVNGVSDL SPGARQYVSV NVTTNQAAPS PVTNVKKGKI 480
AKNSISLSWQ EPDRPNGIIL EYEIKYFEKD QETSYTIIKS KETTITAEGL KPASVYVFQI 540
RARTAAGYGV FSRRFEFETT PVSVAASSDQ SQIPIIAVSV TVGVILLAVV IGFLLSGSCC 600
ECGCGRASSL CAVAHPSLIW RCGYSKAKQD PEEEKMHFHN GHIKLPGVRT YIDPHTYEDP 660
NQAVHEFAKE IEASCITIER VIGAGEFGEV CSGRLKLPGK RELPVAIKTL KVGYTEKQRR 720
DFLGEASIMG QFDHPNIIHL EGVVTKSKPV MIVTEYMENG SLDTFLKKND GQFTVIQLVG 780
MLRGIAAGMK YLSDMGYVHR DLAARNILIN SNLVCKVSDF GLSRVLEDDP EAAYTTRGGK 840
IPIRWTAPEA IAFRKFTSAS DVWSYGIVMW EVVSYGERPY WEMTNQDVIK AVEEGYRLPS 900
PMDCPAALYQ LMLDCWQKDR NSRPKFDEIV NMLDKLIRNP SSLKTLVNAS CRVSNLLAEH 960
SPLGSGAYRS VGEWLEAIKM GRYTEIFMEN GYSSMDAVAQ VTLE 1004
Nucleotide Sequence
(FASTA)
ATGCGGGGCT CGGGGCCCCG GGGTGCGGGA CGCCGGCGGC CCCCAGGCGG AGGCGGCGAC 60
ACCCCCATCA CCCCAGCGTC CCTGGCCGGC TGCTACTCTG CACCTCGCCG GGCTCCCCTC 120
TGGACGTGCC TTCTCCTGTG CGCCGCACTC CGGACCCTCC TGGCCAGCCC CAGCAACGAA 180
GTGAATTTAT TGGATTCACG CACTGTCATG GGGGACCTGG GATGGATTGC TTTTCCAAAA 240
AATGGGTGGG AAGAGATTGG TGAAGTGGAT GAAAATTATG CCCCTATCCA CACATACCAA 300
GTATGCAAAG TGATGGAACA GAATCAGAAT AACTGGCTTT TGACCAGTTG GATCTCCAAT 360
GAAGGTGCTT CCAGAATCTT CATAGAACTC AAATTTACCC TGCGAGACTG CAACAGCCTT 420
CCTGGAGGAC TGGGGACCTG TAAGGAAACC TTTAACATGT ATTACTTTGA GTCAGATGAT 480
CAGAATGGGA GAAACATCAA GGAAAACCAG TACATCAAAA TTGATACCAT TGCTGCCGAT 540
GAGAGCTTTA CAGAACTTGA TCTTGGTGAC CGTGTTATGA AACTGAATAC AGAGGTCAGA 600
GATGTAGGAC CTCTAAGCAA AAAGGGATTT TATCTTGCTT TTCAAGATGT TGGTGCTTGC 660
ATTGCTCTGG TTTCTGTGCG TGTATACTAT AAAAAATGCC CTTCTGTGGT ACGACACTTG 720
GCTGTCTTCC CTGACACCAT CACTGGAGCC GATTCTTCCC AATTGCTCGA AGTGTCAGGC 780
TCCTGTGTCA ACCATTCCGT GACCGATGAA CCTCCCAAAA TGCACTGCAG CGCCGAAGGG 840
GAGTGGCTGG TGCCCATCGG GAAATGCATG TGCAAGGCAG GATATGAAGA GAAAAATGGC 900
ACCTGTCAAG TGTGCAGACC TGGGTTCTTC AAAGCCTCAC CTCACATCCA GAGCTGCGGC 960
AAATGTCCAC CTCACAGTTA TACCCATGAG GAAGCTTCAA CCTCTTGTGT CTGTGAAAAG 1020
GATTATTTCA GGAGAGAGTC TGATCCACCC ACAATGGCAT GCACAAGACC CCCCTCCGCT 1080
CCTCGGAATG CCATCTCAAA TATTAATGAA ACTAGTGTCT TTCTGGAATG GATTCCGCCT 1140
GCTGACACTG GTGGAAGGAA AGATGTGTCA TATTATATTG CATGCAAGAA GTGCAACTCC 1200
CATGCAGGTG TGTGTGAGGA GTGTGGCGGT CATGTCAGGT ACCTTCCCCG GCAAAGCGGC 1260
CTGAAAAACA CCTCTGTCAT GATGGTGGAT CTACTCGCTC ACACAAACTA TACCTTTGAG 1320
ATTGAGGCAG TGAATGGAGT GTCCGACTTG AGTCCAGGAG CCCGGCAGTA TGTGTCTGTA 1380
AATGTAACCA CAAATCAAGC AGCTCCATCT CCAGTTACCA ATGTGAAAAA AGGGAAGATT 1440
GCAAAAAACA GCATCTCTTT GTCTTGGCAA GAGCCAGATC GCCCCAATGG AATCATCCTG 1500
GAGTATGAAA TCAAGTATTT TGAAAAGGAC CAAGAGACCA GCTACACAAT TATCAAATCC 1560
AAAGAGACAA CTATTACTGC AGAGGGCTTG AAACCAGCTT CAGTTTATGT CTTCCAAATT 1620
CGAGCACGTA CAGCAGCAGG CTATGGTGTC TTCAGTCGAA GATTTGAGTT TGAAACCACC 1680
CCAGTGTCAG TTGCAGCATC CAGCGATCAA AGCCAGATTC CTATAATTGC TGTGTCTGTG 1740
ACAGTGGGAG TCATTTTGTT GGCAGTGGTT ATCGGCTTCC TCCTCAGTGG AAGTTGCTGC 1800
GAATGTGGCT GTGGGAGGGC TTCTTCCCTG TGCGCTGTTG CCCATCCAAG CCTAATATGG 1860
CGGTGTGGCT ACAGCAAAGC AAAACAAGAT CCAGAAGAGG AAAAGATGCA TTTTCATAAT 1920
GGGCACATTA AACTGCCAGG AGTAAGAACT TATATTGATC CACATACCTA TGAGGATCCC 1980
AATCAAGCTG TCCATGAATT TGCCAAGGAG ATAGAAGCAT CATGTATCAC CATTGAGAGA 2040
GTTATTGGAG CAGGTGAATT TGGTGAAGTT TGTAGTGGAC GTTTGAAACT ACCAGGAAAA 2100
AGAGAATTAC CTGTGGCTAT CAAAACCCTT AAAGTAGGTT ACACTGAAAA GCAACGCAGA 2160
GATTTCCTAG GTGAAGCAAG TATCATGGGA CAGTTTGATC ATCCTAACAT CATCCATTTA 2220
GAAGGTGTGG TGACCAAAAG TAAACCAGTG ATGATAGTGA CAGAGTATAT GGAGAATGGC 2280
TCTTTAGATA CATTTTTAAA GAAAAATGAT GGGCAGTTCA CTGTGATTCA GCTTGTTGGC 2340
ATGCTGAGAG GTATTGCTGC AGGAATGAAG TACCTTTCTG ACATGGGTTA TGTGCATAGA 2400
GACCTTGCTG CTAGAAACAT CTTAATCAAC AGTAACCTTG TGTGCAAAGT GTCTGACTTT 2460
GGACTTTCCC GGGTACTGGA AGATGATCCC GAGGCAGCCT ACACCACGAG GGGAGGAAAA 2520
ATTCCAATCA GATGGACTGC CCCAGAAGCA ATAGCTTTCC GAAAGTTTAC TTCTGCCAGT 2580
GATGTCTGGA GTTATGGAAT AGTAATGTGG GAAGTTGTGT CTTATGGAGA GAGACCCTAC 2640
TGGGAGATGA CCAATCAAGA TGTGATTAAA GCAGTAGAGG AAGGCTATCG TCTGCCAAGC 2700
CCCATGGATT GTCCTGCTGC TCTCTACCAA TTAATGCTGG ATTGCTGGCA GAAAGACCGA 2760
AATAGCAGGC CCAAGTTTGA TGAAATAGTC AACATGTTGG ACAAGCTGAT ACGTAACCCA 2820
AGTAGTTTGA AGACACTGGT TAATGCATCA TGCAGAGTAT CTAATTTATT GGCAGAACAT 2880
AGCCCACTAG GATCTGGGGC CTACAGATCA GTAGGTGAAT GGCTAGAGGC AATCAAGATG 2940
GGCCGGTATA CAGAGATTTT CATGGAAAAT GGATACAGTT CAATGGACGC TGTGGCTCAG 3000
GTGACCTTGG AGTGA 3015
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         ++ie+viGaGefGevcsGrlklpgkre++vaiktlk g+tekqrrdfl easi+Gqfdhp
Q: 676   ITIERVIGAGEFGEVCSGRLKLPGKRELPVAIKTLKVGYTEKQRRDFLGEASIMGQFDHP  735
         78**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         nii+leGvvtkskpvmivteymeng+ld+fl+k+dgqftviqlvgmlrGia+gmkylsdm
Q: 736   NIIHLEGVVTKSKPVMIVTEYMENGSLDTFLKKNDGQFTVIQLVGMLRGIAAGMKYLSDM  795
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvleddseaayttsggkipirwtapeaiayrk  180
         gyvhrdlaarnil+nsnlvckvsdfGlsrvledd+eaaytt+ggkipirwtapeaia+rk
Q: 796   GYVHRDLAARNILINSNLVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAFRK  855
         ************************************************************
S: 181   ftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlmldc  240
         ftsasdvwsyGiv+wev+syGerpyw+m+nqdvika+eegyrlp+pmdcpaalyqlmldc
Q: 856   FTSASDVWSYGIVMWEVVSYGERPYWEMTNQDVIKAVEEGYRLPSPMDCPAALYQLMLDC  915
         ************************************************************
S: 241   wqkdraerpkfeqivsil  258
         wqkdr++rpkf++iv++l
Q: 916   WQKDRNSRPKFDEIVNML  933
         ***************985
Domain Sequence
(FASTA)
ITIERVIGAG EFGEVCSGRL KLPGKRELPV AIKTLKVGYT EKQRRDFLGE ASIMGQFDHP 60
NIIHLEGVVT KSKPVMIVTE YMENGSLDTF LKKNDGQFTV IQLVGMLRGI AAGMKYLSDM 120
GYVHRDLAAR NILINSNLVC KVSDFGLSRV LEDDPEAAYT TRGGKIPIRW TAPEAIAFRK 180
FTSASDVWSY GIVMWEVVSY GERPYWEMTN QDVIKAVEEG YRLPSPMDCP AALYQLMLDC 240
WQKDRNSRPK FDEIVNML 258
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00005
EKS-BOT-00003
EKS-CAJ-00003
EKS-CAF-00002
EKS-CAP-00002
EKS-DAR-00003
EKS-EQC-00002
EKS-GAG-00002
EKS-GAA-00010
EKS-GOG-00011
EKS-ICT-00003
EKS-LOA-00003
EKS-MOD-00003
EKS-MUP-00005
EKS-MYL-00007
EKS-NOL-00003
EKS-ORN-00010
EKS-ORA-00002
EKS-ORL-00011
EKS-OTG-00008
EKS-PAT-00004
EKS-PES-00002
EKS-POA-00003
EKS-PTV-00002
EKS-SAH-00003
EKS-SOA-00001
EKS-SUS-00010
EKS-TAG-00002
EKS-TEN-00010
EKS-XIM-00009
Gene Ontology
GO:0030425; C:dendrite
GO:0009897; C:external side of plasma membrane
GO:0005887; C:integral to plasma membrane
GO:0043025; C:neuronal cell body
GO:0048471; C:perinuclear region of cytoplasm
GO:0005791; C:rough endoplasmic reticulum
GO:0005524; F:ATP binding
GO:0005004; F:GPI-linked ephrin receptor activity
GO:0007411; P:axon guidance
GO:0021766; P:hippocampus development
GO:0032956; P:regulation of actin cytoskeleton organization
GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0032314; P:regulation of Rac GTPase activity
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013