EKS-MAM-00371

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00371

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	420.8	3.0E-126	234	487	254

Status

Unreviewed

Ensembl Protein

ENSMMUP00000019213

UniProt Accession

F7G2C9;

Protein Name

Protein Synonyms/Alias

Gene Name

FRK

Gene Synonyms/Alias

FRK; EGK_15421;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000014635	ENSMMUP00000019213	ENSMMUT00000020529

Organism

Macaca mulatta

Functional Description

Protein Length

505

Protein Sequence
(FASTA)

MSNICQRLWE YLEPYLPCLS TEADKSTVIE NPGAHCSPQS QRHGRYFVAL FDYQARTAED 60

LSFRAGDKLQ VLDTSHEGWW FARHLEKRRD GSSQQLQGYI PSNYVAEDRS LQAEPWFFGA 120

IRRSDAEKQL LYSKNKTGAF LIRESESQKG EFSLSVLDGG VVKHYRIRRL DEGGFFLTRR 180

ITFSTLNEFV SHYTKTSDGL CVKLGKPCLK IQVPAPFDLS YKTVDQWEID RNSIQLLKRL 240

GSGQFGEVWE GLWNNTTPVA VKTLKPGSMD PRDFLREAQI MKNLRHPKLI QLYAVCTLED 300

PIYIITELMR HGSLQEYLQS DAGSKIHLTQ QVDIAAQVAS GMAYLESRNY IHRDLAARNV 360

LVGEHNIYKV ADFGLARVFK VDNEDIYESK HEIKLPVKWT APEAIRTNKF SIKSDVWSFG 420

ILLYEIITYG KMPYSGMTGA QVIQMLAQNY RLPQPSNCPQ QFYNIMLECW NAEPKERPTF 480

ETLHWKLEDY FETDSSYSDA NNFIR 505

Nucleotide Sequence
(FASTA)

ATGAGCAACA TCTGTCAGAG GCTCTGGGAG TATCTAGAAC CCTATCTCCC CTGCTTGTCG 60

ACGGAAGCAG ACAAGTCAAC GGTGATTGAA AATCCAGGGG CCCATTGCTC TCCCCAGTCA 120

CAGAGGCATG GCCGCTACTT TGTGGCTTTG TTTGATTACC AGGCTCGGAC TGCTGAGGAT 180

CTGAGCTTCC GGGCAGGTGA CAAACTTCAA GTTCTGGACA CTTCACATGA GGGCTGGTGG 240

TTTGCCAGAC ACTTGGAGAA AAGGCGAGAT GGCTCCAGTC AGCAACTACA GGGCTATATT 300

CCTTCTAACT ACGTGGCTGA GGACAGAAGC CTACAGGCAG AGCCGTGGTT CTTTGGAGCA 360

ATCAGAAGAT CAGATGCAGA GAAACAACTG TTATATTCAA AAAATAAGAC GGGTGCCTTT 420

CTAATCAGAG AAAGTGAAAG CCAAAAAGGA GAATTCTCTC TTTCAGTTTT AGATGGAGGA 480

GTTGTAAAAC ACTACAGAAT TAGAAGACTG GATGAAGGGG GCTTTTTTCT CACCCGGAGA 540

ATAACCTTTT CAACACTGAA CGAATTTGTG AGCCACTACA CCAAGACGAG TGACGGCCTG 600

TGTGTCAAGC TGGGGAAACC ATGCTTAAAG ATCCAGGTCC CAGCTCCATT TGATTTGTCA 660

TATAAAACCG TGGACCAGTG GGAGATAGAC CGCAACTCCA TACAGCTTCT GAAGCGATTG 720

GGATCTGGTC AGTTCGGCGA AGTATGGGAA GGTCTGTGGA ACAATACCAC ACCAGTAGCA 780

GTGAAAACAT TAAAACCAGG TTCAATGGAT CCACGTGACT TCCTGAGGGA GGCACAGATA 840

ATGAAGAACC TAAGACATCC AAAGCTTATC CAGCTTTATG CTGTTTGCAC TTTAGAAGAT 900

CCAATTTATA TTATTACAGA GTTGATGAGA CATGGAAGTC TGCAAGAATA TCTCCAAAGT 960

GATGCTGGGT CAAAAATCCA TCTGACTCAA CAGGTAGACA TAGCGGCACA GGTTGCCTCT 1020

GGAATGGCCT ATCTGGAGTC TCGGAACTAC ATTCACAGAG ATCTGGCTGC CAGAAATGTC 1080

CTTGTTGGTG AACATAATAT CTACAAAGTA GCAGATTTTG GACTTGCCAG AGTTTTTAAG 1140

GTAGATAATG AAGACATCTA TGAATCTAAA CACGAAATAA AGCTGCCGGT GAAGTGGACT 1200

GCGCCCGAAG CCATTCGTAC TAATAAATTC AGCATTAAGT CCGATGTGTG GTCATTTGGA 1260

ATCCTTCTTT ATGAAATCAT TACTTATGGC AAAATGCCTT ACAGTGGTAT GACAGGTGCC 1320

CAGGTAATCC AGATGTTGGC TCAAAACTAT AGACTTCCCC AACCATCCAA TTGTCCACAG 1380

CAATTTTACA ATATCATGTT GGAGTGCTGG AATGCAGAGC CTAAGGAACG ACCTACATTT 1440

GAGACACTGC ATTGGAAACT TGAGGACTAT TTTGAAACAG ACTCTTCATA TTCAGATGCA 1500

AATAACTTCA TAAGATGA 1518

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         ++l+k+lG+GqfGevw+g+w+++++vavktlk+g+++p++fl+eaqi+k+lrh+kl++ly

Q: 234   IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPRDFLREAQIMKNLRHPKLIQLY  293

         6899********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         av++ e+Piyi+telm++Gsl+++l+++ g+k++l+++vd+aaqva+Gmayle++n+ihr

Q: 294   AVCTLEDPIYIITELMRHGSLQEYLQSDAGSKIHLTQQVDIAAQVASGMAYLESRNYIHR  353

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlie...ddeytakegaklPikWtaPeaiklgkftik  177

         dlaarnvlvge++++kvadfGlar+++   +d+y++k++ klP+kWtaPeai+++kf+ik

Q: 354   DLAARNVLVGEHNIYKVADFGLARVFKvdnEDIYESKHEIKLPVKWTAPEAIRTNKFSIK  413

         ************************998878999***************************

S: 178   sdvWsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkd  237

         sdvWsfGill+ei+t+Gk+Py+Gmt ++v++++ ++yrlp+p++cp+++y+++lecw+++

Q: 414   SDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAE  473

         ************************************************************

S: 238   peerPtfetlqevl  251

         p+erPtfetl+++l

Q: 474   PKERPTFETLHWKL  487

         **********9986

Domain Sequence
(FASTA)

IQLLKRLGSG QFGEVWEGLW NNTTPVAVKT LKPGSMDPRD FLREAQIMKN LRHPKLIQLY 60

AVCTLEDPIY IITELMRHGS LQEYLQSDAG SKIHLTQQVD IAAQVASGMA YLESRNYIHR 120

DLAARNVLVG EHNIYKVADF GLARVFKVDN EDIYESKHEI KLPVKWTAPE AIRTNKFSIK 180

SDVWSFGILL YEIITYGKMP YSGMTGAQVI QMLAQNYRLP QPSNCPQQFY NIMLECWNAE 240

PKERPTFETL HWKL 254

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

mcc:716267

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013