EKS-MAM-00379

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-MAM-00379

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/MLK	319.5	2.9E-95	17	260	244

Status

Unreviewed

Ensembl Protein

ENSMMUP00000019249

UniProt Accession

F7GQ89;

Protein Name

Protein Synonyms/Alias

Gene Name

ZAK

Gene Synonyms/Alias

ZAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSMMUG00000014672	ENSMMUP00000013728	ENSMMUT00000014654
ENSMMUG00000014672	ENSMMUP00000019249	ENSMMUT00000020571
ENSMMUG00000014672	ENSMMUP00000038133	ENSMMUT00000045114

Organism

Macaca mulatta

Functional Description

Protein Length

455

Protein Sequence
(FASTA)

MSSLGASFVQ IKFDDLQFFE NCGGGSFGSV YRAKWISQDK EVAVKKLLKI EKEAEILSVL 60

SHRNIIQFYG VILEPPNYGI VTEYASLGSL YDYINSNRSE EMDMDHIMTW ATDVAKGMHY 120

LHMEAPVKVI HRDLKSRNVV IAADGVLKIC DFGASRFHNH TTHMSLVGTF PWMAPEVIQS 180

LPVSETCDTY SYGVVLWEML TREVPFKGLE GLQVAWLVVE KNERLTIPSS CPRSFAELLH 240

QCWEADAKKR PSFKQIISIL ESMSNDTSLP DKCNSFLHNK AEWRCEIEAT LERLKKLERD 300

LSFKEQELKE RERRLKMWEQ KLTEQSNTPL LLPLAARMSE ESYFESKTEE SNSAEMSCQI 360

TATSNGEGHG MNPSLQAMML MGFGDIFSMN KAGAVMHSGM QINMQAKQNS SKTTSKRRGK 420

KVNMALGFSD FDLSEGDDDD DDDGEEEDND MDNSE 455

Nucleotide Sequence
(FASTA)

ATGTCGTCTC TCGGTGCCTC CTTTGTGCAA ATTAAATTTG ATGACTTGCA GTTTTTTGAA 60

AACTGCGGTG GAGGAAGTTT CGGGAGTGTT TATCGAGCCA AATGGATATC ACAGGACAAG 120

GAGGTGGCTG TAAAGAAGCT CCTCAAAATA GAGAAAGAGG CAGAAATACT CAGTGTCCTC 180

AGTCACAGAA ACATCATCCA GTTTTATGGA GTAATTCTTG AACCTCCCAA CTATGGCATT 240

GTCACAGAAT ATGCTTCTCT GGGATCACTC TATGATTACA TTAACAGTAA TAGAAGTGAG 300

GAGATGGATA TGGATCACAT TATGACCTGG GCCACTGATG TAGCCAAAGG AATGCACTAT 360

TTACATATGG AGGCTCCTGT CAAGGTGATT CACAGAGACC TCAAGTCAAG AAACGTTGTT 420

ATAGCTGCTG ATGGAGTATT GAAGATTTGT GACTTTGGTG CCTCTCGGTT CCATAACCAT 480

ACAACACACA TGTCCTTGGT TGGAACTTTC CCATGGATGG CTCCAGAAGT TATCCAAAGT 540

CTCCCTGTGT CAGAAACTTG TGACACATAT TCCTACGGTG TGGTTCTCTG GGAGATGCTA 600

ACAAGGGAGG TCCCCTTTAA AGGTTTGGAA GGATTACAAG TAGCTTGGCT TGTAGTGGAA 660

AAAAACGAGA GATTAACCAT TCCAAGCAGT TGCCCCAGAA GTTTTGCTGA ACTGTTACAT 720

CAGTGTTGGG AAGCTGATGC CAAGAAACGG CCATCATTCA AGCAAATCAT TTCAATCCTG 780

GAGTCCATGT CAAATGACAC AAGCCTTCCT GACAAGTGTA ACTCATTCCT GCACAACAAG 840

GCGGAGTGGA GGTGCGAAAT TGAGGCAACT CTTGAAAGGC TAAAGAAACT AGAGCGTGAT 900

CTCAGCTTTA AGGAGCAGGA GCTTAAAGAA CGAGAAAGAC GTTTAAAGAT GTGGGAGCAA 960

AAGCTGACAG AGCAGTCCAA CACCCCGCTT CTCTTGCCTC TTGCTGCAAG AATGTCTGAG 1020

GAGTCTTACT TTGAATCTAA AACAGAGGAG TCAAACAGTG CAGAGATGTC ATGTCAGATC 1080

ACAGCAACAA GTAACGGGGA GGGCCATGGC ATGAACCCAA GTCTGCAGGC CATGATGCTG 1140

ATGGGCTTTG GGGATATCTT CTCAATGAAC AAAGCAGGAG CTGTGATGCA TTCTGGGATG 1200

CAGATAAACA TGCAAGCCAA GCAGAATTCT TCCAAAACCA CATCTAAGAG AAGGGGGAAG 1260

AAAGTCAACA TGGCTCTGGG GTTCAGTGAT TTTGACTTGT CAGAAGGTGA CGATGATGAT 1320

GATGATGACG GTGAGGAGGA GGATAATGAC ATGGATAATA GTGAATGA 1368

Domain Profile

S: 2     eleeligsgafgkvykakwrkke..vavKklreeaeekekleklereakllsklshpnii  59

         ++ e +g g+fg+vy+akw +++  vavKkl +          +e+ea++ls lsh+nii

Q: 17    QFFENCGGGSFGSVYRAKWISQDkeVAVKKLLK----------IEKEAEILSVLSHRNII  66

         67799**************665444****9987..........899**************

S: 60    ellGvcleepnlllvmeyveggsLsnvlhekskreidlevlvswalqiArGmaYLhseap  119

         +++Gv+le+pn+++v+ey++ gsL++++++++++e+d++++++wa+++A+Gm+YLh eap

Q: 67    QFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAP  126

         ************************************************************

S: 120   kkiihrdLksknvLlseekktlkicdFGtarelskstkmsaagtlawmaPEvlkeekvse  179

         +k+ihrdLks+nv++ +++ +lkicdFG +r+++++t+ms  gt+ wmaPEv+++ +vse

Q: 127   VKVIHRDLKSRNVVI-AADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSE  185

         ***************.********************************************

S: 180   ksDvwSygvvLWelltrevPykdlselaiaykvalkglrlpipsscpeklkkLmkecwne  239

         ++D +SygvvLWe+ltrevP+k+l+ l++a+ v++k++rl+ipsscp+++++L+++cw++

Q: 186   TCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEA  245

         ************************************************************

S: 240   dpekRpsfseivksl  254

         d++kRpsf++i+++l

Q: 246   DAKKRPSFKQIISIL  260

         ***********9875

Domain Sequence
(FASTA)

QFFENCGGGS FGSVYRAKWI SQDKEVAVKK LLKIEKEAEI LSVLSHRNII QFYGVILEPP 60

NYGIVTEYAS LGSLYDYINS NRSEEMDMDH IMTWATDVAK GMHYLHMEAP VKVIHRDLKS 120

RNVVIAADGV LKICDFGASR FHNHTTHMSL VGTFPWMAPE VIQSLPVSET CDTYSYGVVL 180

WEMLTREVPF KGLEGLQVAW LVVEKNERLT IPSSCPRSFA ELLHQCWEAD AKKRPSFKQI 240

ISIL 244

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004709	; F:MAP kinase kinase kinase activity
GO:0007257	; P:activation of JUN kinase activity
GO:0007050	; P:cell cycle arrest
GO:0007010	; P:cytoskeleton organization
GO:0000077	; P:DNA damage checkpoint
GO:0043065	; P:positive regulation of apoptotic process
GO:0009314	; P:response to radiation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001660	; SAM.
IPR013761	; SAM/pointed.
IPR021129	; SAM_type1.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00536	; SAM_1; 1.

SMARTs

SM00454

; SAM; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50105	; SAM_DOMAIN; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013